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Stem Cells in Neuroendocrinology by Donald Pfaff,Yves Christen Pdf
This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers. The last chapter provides an overview of this particular field of research and presents a vision for its future directions.
Stem Cells in Neuroendocrinology by Yves Christen,Donald Pfaff Pdf
This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers. The last chapter provides an overview of this particular field of research and presents a vision for its future directions. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author : Linda B. Lester Publisher : Springer Science & Business Media Page : 277 pages File Size : 45,8 Mb Release : 2007-11-06 Category : Medical ISBN : 9781592599004
Stem Cells in Endocrinology by Linda B. Lester Pdf
A critical review by prominent experts of both the cutting-edge of stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders. The authors discuss current research to modify stem cells, develop an endocrine-like cell, and use adult bone marrow stem cells to treat autoimmune diseases, including endocrine-based autoimmune diseases. Topics of interest include a review of all stem cell subtypes and their characteristics, approaches to promoting endocrine development from stem cells, and evidence for endocrine cell function from stem cells. The authors also outline how best to develop preclinical studies that will determine the safety and efficacy of stem cell therapies for endocrine disorders.
The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes by Michail S. Davidoff,Ralf Middendorff,D. Müller,Adolf F. Holstein Pdf
cells, and the testicular localization of the intermediate filament protein nestin, known to be expressed in neural stem cells, by our group was the first step to define mural cells (pericytes and vascular smooth muscle cells) of the testis microvascu- ture as the stem/progenitor cells of the adult Leydig cells. In summary, we were able to demonstrate specific proliferation of vascular progenitors and their subsequent transdifferentiation into steroidogenic Leydig cells, which – in addition – rapidly acquire neuronal and glial properties. Since both newly developed fetal and adult Leydig cell populations show the same features, a common origin of both popu- tions seems likely. Pericytes are distributed throughout the body, and there is convincing evidence for their stem/progenitor cell properties in diverse organs. Under appropriate (locally defined) conditions these pericytes, which reside in the vascular stem cell niche as dormant stem cells, become activated, proliferate, migrate and differentiate towards different somatic cell types of the body. Since most mesenchymal stem/ progenitor cell types exhibit essential similarity to pericytes and certain mesenchymal stem cells represent pericyte descendants, we propose that mesenchymal stem cells in the perivascular niche are daughter cells of pericytes. Thus, pericytes are promising candidates for ancestor cells of all adult stem cells in the organism. There is strong evidence that early stem cells (cells arising during embryogenesis), such as the pericytes, exhibit both mesodermal and neural progeny, which might explain the neuroendocrine properties of the Leydig cells.
Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Vitamins and Hormones series Includes the latest information on Hormones and Synapse
Stem Cells: A Very Short Introduction by Jonathan Slack Pdf
The topic of stem cells has a high profile in the media. We've made important advances in our scientific understanding, but despite this the clinical applications of stem cells are still in their infancy and most real stem cell therapy carried out today is some form of bone marrow transplantation. At the same time, a scandalous spread of unproven stem cell treatments by private clinics represents a serious problem, with treatments being offered which are backed by limited scientific rationale, and which are at best ineffective, and at worse harmful. This Very Short Introduction introduces stem cells, exploring what they are, and what scientists do with them. Introducing the different types of stem cells, Jonathan Slack explains how they can be used to treat diseases such as retinal degeneration, diabetes, Parkinson's disease, heart disease, and spinal trauma. He also discusses the important technique of bone marrow transplantation and some other types of current stem cell therapy, used for the treatment of blindness and of severe burns. Slack warns against fake stem cell treatments and discusses how to distinguish real from fake treatments. He also describes the latest scientific progress in the field, and looks forward to what we can expect to happen in the next few years Very Short Introductions: Brilliant, Sharp, Inspiring ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Molecular Neuroendocrinology by David Murphy,Harold Gainer Pdf
Molecular Neuroendocrinology: From Genome to Physiology, provides researchers and students with a critical examination of the steps being taken to decipher genome complexity in the context of the expression, regulation and physiological functions of genes in neuroendocrine systems. The 19 chapters are divided into four sectors: A) describes and explores the genome, its evolution, expression and the mechanisms that contribute to protein, and hence biological, diversity. B) discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification. C) considers the molecular tools that today’s neuroendocrinologists can use to study the regulation and function of neuroendocrine genes within the context of the intact organism. D) presents a range of case studies that exemplify the state-of-the-art application of genomic technologies in physiological and behavioural experiments that seek to better understand complex biological processes. • Written by a team of internationally renowned researchers • Both print and enhanced e-book versions are available • Illustrated in full colour throughout This is the third volume in a new Series ‘Masterclass in Neuroendocrinology’ , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA
Neuroendocrinology and Behavior by Tomiki Sumiyoshi Pdf
Understanding of the neuroendocrine system provides an insight into a wide range of bodily and mental processes. Neuroendocrinology and Behavior brings its readers a concise guide to up-to-date knowledge on the function of the endocrine glands and organs in association with neurotransmitters, neuropeptides, and behavioral manifestations. Various forms of stress response, e.g. anxiety and cognitive changes, have been intrinsic to both ourselves and other species. Specifically, these mechanisms involve complex interplays among physical, emotional, and behavioral processes in humans. This volume provides information on peptide hormones, i.e. oxytocin and vasopressin, and how studies of these neuropeptides enrich our understanding of social and other behaviors. These neuromodulators also affect sexual behavior and water balance in the body, an issue also addressed in this Book.
Cellular Endocrinology in Health and Disease by Alfredo Ulloa-Aguirre,Ya-Xiong Tao Pdf
Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field
Author : Shlomo Melmed,J. Larry Jameson,Leslie J. De Groot Publisher : Elsevier Health Sciences Page : 417 pages File Size : 53,8 Mb Release : 2013-06-01 Category : Medical ISBN : 9780323221559
Endocrinology Adult and Pediatric: Neuroendocrinology and The Pituitary Gland E-Book by Shlomo Melmed,J. Larry Jameson,Leslie J. De Groot Pdf
Apply the latest advances in management of neuroendocrine and pituitary disorders with the Endocrinology: Adult and Pediatric: Neuroendocrinology and The Pituitary Gland eBook! Brought to you by the same expert endocrinologists responsible for the highly acclaimed two-volume Endocrinology clinical reference, this endocrinology eBook puts all of the newest latest know-how of the Pituitary Gland and Neuroendocrinology at your fingertips, instantly accessible on your favorite eReader - so you can offer your patients the best care. Stay abreast of the newest knowledge on neuroendocrinology and the pituitary gland, including our most recent understanding of the fundamental cellular and physiologic functions of the neuroendocrine system, mechanisms underlying clinical disorders, and approaches to managing patients harboring disorders of the hypothalamus and pituitary gland. Approach any subject either by specific gland or through a discussion of multi-hormonal integration of endocrine function, as led by the "master conductor of the endocrine orchestra," the pituitary gland. Gain a state-of-the-art understanding of comprehensive descriptors, integrating endocrine cell ontogeny, hormonal control of growth and maturation processes, and childhood and young adult pathophysiology with maturation and aging processes. Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and DeGroot, the go-to medical reference for endocrinologists worldwide. Make the best clinical endocrinology decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.
An Introduction to Neuroendocrinology by Richard E. Brown Pdf
This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
Epigenetics and Neuroendocrinology by Dietmar Spengler,Elisabeth Binder Pdf
The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.
Neuroanatomy of Neuroendocrine Systems by Valery Grinevich,Árpád Dobolyi Pdf
In this book, experts in the field provide comprehensive descriptions of the neuroanatomy of the hypothalamic neuroendocrine systems. The book begins with an extensive discussion on the structural components of the neuroendocrine systems. The reader will be introduced to the anatomy and biology of the hypothalamus and the pituitary. The human hypothalamus is presented in particular detail using state-of-the-art imaging techniques. In the next section, the neuroanatomy of traditional hypothalamo-hypophyseal systems is highlighted, with chapters describing magnocellular neuroendocrine cells and discussing the respective types of hypothalamic neurons that regulate various pituitary hormones. Following this detailed structural and anatomical description of the neuroendocrine system, the book’s final section focuses on the hypothalamic control of neuroendocrine functions. This includes the control of circadian rhythm, metabolism and appetite via specific peptidergic circuits. This book provides essential information on the neuroanatomy and control of neuroendocrine systems, addresses cutting-edge research questions posed by recent advances in the development of potent neuroanatomical tools, and highlights the latest technologies used in neuroendocrinology research, making it a valuable reference guide for students, trainees and established researchers alike. This is the twelfth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and to encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Chapter 12 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com
General and Comparative Endocrinology by A.M. Schreiber Pdf
General and Comparative Endocrinology: An Integrative Approach, takes a holistic approach to endocrinology, introducing students to the diverse facets of this interdisciplinary science ranging from the medical to comparative domains, while also exploring evolutionary, environmental, and conservation specializations within the field. The textbook is founded on the principle that students interested in the health sciences will benefit from understanding how proficiency in endocrine function among a diversity of organisms contributes to advances in modern medicine. Likewise, students intrigued by comparative physiology will benefit from the wealth of knowledge derived from medical/clinical endocrinology, the historical bedrock of the field. This textbook represents the modern field of endocrinology in its totality by addressing topics and recent advances not currently discussed in other introductory endocrinology textbooks. Key Features Introduces the broad and interdisciplinary scope of endocrinology. Provides clear chapter objectives and key concepts. Includes summary and synthesis questions for each chapter that are suitable for exams and quizzes. Includes a chapter devoted to endocrine-disrupting chemicals. Describes the roles played by the endocrine system in important health challenges related to appetite regulation, obesity, diabetes, and other diseases stemming from ‘mismatches to modernity’. Integrates evolutionary and comparative approaches to hormones and health.