Stem Cells In The Respiratory System

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Stem Cells in the Respiratory System

Mauricio Rojas
Stem Cells in the Respiratory System Book PDF

Author : Mauricio Rojas
Publisher : Unknown
Page : 128 pages
File Size : 52,5 Mb
Release : 2010
Category : Electronic
ISBN : 1607617765

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Stem Cells in the Respiratory System by Mauricio Rojas Pdf

In this state-of-the-art exploration of a hugely dynamic and fast-evolving field of research, leading researchers share their collective wisdom on the role that stem cells could play in the context of physiological stress and lung injury. The text focuses on reviewing the most relevant--and recent--ideas on using local, endogenous, and exogenous progenitor/stem cells in preventing and treating injury to the lung. The lungs are one of the most complex organs in the human body, with a mature adult lung boasting at least 40 morphologically differentiated cell lineages. Our entire blood supply passes through the lung's alveolar units during oxygenation. This interaction with the outside world, along with the intricacies of its structure, makes the lung a highly susceptible organ that is vulnerable to numerous types of injury and infection. This means that the mechanisms of lung repair are in themselves correspondingly complex. Because of their multipotentiality, as well as the fact of the lung's relatively rapid cell turnover, stem cells are thought to be an important alternative cell-base therapy in lung injury. Despite the controversial nature of stem cell research, there has been growing interest in both local and endogenous stem cells in the lung. This highly topical book with chapters on everything from using mesenchymal stem cells in lung repair to the effect of physical activity on the mobilization of stem and progenitor cells, represents an exciting body of work by outstanding investigators and will be required reading for those with an interest in the subject.

Lung Stem Cells in Development, Health and Disease

Nikolic, Marko Z.,Hogan, Brigid L.M.
Lung Stem Cells in Development Health and Disease Book PDF

Author : Nikolic, Marko Z.,Hogan, Brigid L.M.
Publisher : European Respiratory Society
Page : 395 pages
File Size : 41,6 Mb
Release : 2021-04-01
Category : Medical
ISBN : 9781849841344

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Lung Stem Cells in Development, Health and Disease by Nikolic, Marko Z.,Hogan, Brigid L.M. Pdf

Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

Stem Cells in the Respiratory System

Mauricio Rojas
Stem Cells in the Respiratory System Book PDF

Author : Mauricio Rojas
Publisher : Springer Science & Business Media
Page : 175 pages
File Size : 41,9 Mb
Release : 2010-08-05
Category : Science
ISBN : 9781607617754

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Stem Cells in the Respiratory System by Mauricio Rojas Pdf

In this state-of-the-art exploration of a hugely dynamic and fast-evolving field of research, leading researchers share their collective wisdom on the role that stem cells could play in the context of physiological stress and lung injury. The text focuses on reviewing the most relevant—and recent—ideas on using local, endogenous, and exogenous progenitor/stem cells in preventing and treating injury to the lung. The lungs are one of the most complex organs in the human body, with a mature adult lung boasting at least 40 morphologically differentiated cell lineages. Our entire blood supply passes through the lung’s alveolar units during oxygenation. This interaction with the outside world, along with the intricacies of its structure, makes the lung a highly susceptible organ that is vulnerable to numerous types of injury and infection. This means that the mechanisms of lung repair are in themselves correspondingly complex. Because of their multipotentiality, as well as the fact of the lung’s relatively rapid cell turnover, stem cells are thought to be an important alternative cell-base therapy in lung injury. Despite the controversial nature of stem cell research, there has been growing interest in both local and endogenous stem cells in the lung. This highly topical book with chapters on everything from using mesenchymal stem cells in lung repair to the effect of physical activity on the mobilization of stem and progenitor cells, represents an exciting body of work by outstanding investigators and will be required reading for those with an interest in the subject.

Lung Stem Cells in the Epithelium and Vasculature

Amy Firth,Jason X.-J. Yuan
Lung Stem Cells in the Epithelium and Vasculature Book PDF

Author : Amy Firth,Jason X.-J. Yuan
Publisher : Springer
Page : 345 pages
File Size : 50,6 Mb
Release : 2015-05-23
Category : Science
ISBN : 9783319162324

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Lung Stem Cells in the Epithelium and Vasculature by Amy Firth,Jason X.-J. Yuan Pdf

This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and disease as well as ex vivo lung bioengineering. Such approaches may provide novel therapeutic approaches for lung diseases. Human pluripotent stem cell differentiation to model the pulmonary epithelium and vasculature is also discussed. World-recognized scientists who specialize in studying both the lung epithelium and pulmonary vasculature contribute the chapters. Topics covered include: stem cell niches in the lung, the role of progenitor cells in fibrosis and asthma, iPSC in modeling lung disease, vascular repair by endothelial progenitor cells and circulating fibrocytes in pulmonary vascular remodeling. This volume of the Stem Cell Biology and Regenerative Medicine series is essential reading for researchers and clinicians interested in stem cells, lung biology and regenerative medicine. It is also an invaluable resource for advanced students studying cell biology, regenerative medicine and lung physiology.

Stem Cell-Based Therapy for Lung Disease

Janette K. Burgess,Irene H. Heijink
Stem Cell Based Therapy for Lung Disease Book PDF

Author : Janette K. Burgess,Irene H. Heijink
Publisher : Springer Nature
Page : 260 pages
File Size : 47,7 Mb
Release : 2019-11-23
Category : Science
ISBN : 9783030294038

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Stem Cell-Based Therapy for Lung Disease by Janette K. Burgess,Irene H. Heijink Pdf

This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies. Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung. The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application. This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.

Stem Cells in the Lung

Ivan Bertoncello
Stem Cells in the Lung Book PDF

Author : Ivan Bertoncello
Publisher : Springer
Page : 366 pages
File Size : 46,6 Mb
Release : 2015-10-31
Category : Science
ISBN : 9783319210827

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Stem Cells in the Lung by Ivan Bertoncello Pdf

This book presents a comprehensive overview of the current understanding of the organization of endogenous lung stem and progenitor cell compartments during fetal lung development, postnatal lung growth and in adulthood. Progressing stage by stage, the chapters on fetal lung development emphasize the integrated role of epithelial, stromal, vascular and neural cell elements in building a functional lung, while the subsequent chapters on adult lung regeneration describe the nature and properties of adult lung stem/progenitor cells distributed along the proximal-distal axis of the airway tree. The chapters on regulation of lung regeneration and repair discuss how regenerative cells interact with their niche microenvironment and how regulation of lung regeneration and repair in the steady state and following injury recapitulates ontogeny. And, lastly, the chapters on cellular therapies for lung disease and bioengineering the lung focus on promising emerging therapies and approaches in lung regenerative medicine. The scope of this volume of the Stem Cell Biology and Regenerative Medicine series focuses on exploring the topic of building and rebuilding the lung from a cellular rather than a molecular perspective. Thus, the section on cellular therapies does not include extensive coverage of each of the numerous lung diseases, including cancer, which could be amenable to stem cell-based therapies, although the final chapter does include some discussion on the future prospects and challenges. All of the contributors are working on the cutting edge of the lung stem cell field, making this book essential reading for those with an interest in the field of lung stem cell biology and the potential role of cellular therapies and tissue bioengineering approaches in lung regenerative medicine, including biomedical scientists, graduate students, post-graduate researchers and respiratory clinicians.

Cell Therapy for Lung Disease

Julia Polak
Cell Therapy for Lung Disease Book PDF

Author : Julia Polak
Publisher : World Scientific
Page : 529 pages
File Size : 40,9 Mb
Release : 2010
Category : Medical
ISBN : 9781848164406

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Cell Therapy for Lung Disease by Julia Polak Pdf

"The use of stem cells to help with lung regeneration and repair is a novel therapy which could help phase out the need for conventional surgical or pharmacological approaches currently employed to treat diseases of the lung or other organs. The present book explores all avenues of this new form of medical care, moving swiftly, but in depth, from the basic science of lung development, to the analyses of different stem cell types available for regeneration and on to the application of this knowledge base in initial clinical trials. In this volume a stellar group of researchers converge, from different angles, to help towards clarifying the basic mechanisms of lung repair. These range from basic concepts of regeneration and lung development, the analyses of a variety of cell types that may be involved in lung repair, to ways of creating complex lung structures, including artificial and bioartificial lungs. The book offers an insight into repair mechanisms of the diseased lung, the role of specific lung niches and provides information on initial clinical trials as well as the use of stem cells as vehicles for gene therapy. Ingenious technological aspects of assessing stem cell engraftment of stem cell bioprocessing are also included in this volume."--Publisher's website.

Stem Cells in the Lung

Ivan Bertoncello
Stem Cells in the Lung Book PDF

Author : Ivan Bertoncello
Publisher : Unknown
Page : 128 pages
File Size : 49,7 Mb
Release : 2015
Category : Electronic
ISBN : 3319210831

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Stem Cells in the Lung by Ivan Bertoncello Pdf

This comprehensive overview of endogenous lung stem and progenitor cell organization and regulation in fetal lung development, postnatal lung growth and adulthood deftly compiles and explores the current body of research. Progressing stage by stage, the chapters on fetal lung development emphasize the integrated role of epithelial, stromal, vascular and neural cell elements in building a functional lung, while the subsequent chapters on adult lung regeneration describe the nature and properties of adult lung stem/progenitor cells distributed along the proximal-distal axis of the airway tree. The chapters on regulation of lung regeneration and repair discuss how regenerative cells interact with their niche microenvironment and how regulation of lung regeneration and repair in the steady state and following injury recapitulates ontogeny. And, lastly, the chapters on cellular therapies for lung disease and bioengineering the lung focus on promising emerging therapies and approaches in lung regenerative medicine. The scope of this volume of the Stem Cell Biology and Regenerative Medicine series focuses on exploring the topic of building and rebuilding the lung from a cellular rather than a molecular perspective. All of the contributors are working at the cutting edge of the lung stem cell field, making Stem Cells in the Lung essential reading for those with an interest in the field of lung stem cell biology and the potential role of cellular therapies and tissue bioengineering approaches in lung regenerative medicine, including biomedical scientists, graduate students, post-graduate researchers and respiratory clinicians.

Stem Cells

Mariusz Z. Ratajczak
Stem Cells Book PDF

Author : Mariusz Z. Ratajczak
Publisher : Springer Nature
Page : 410 pages
File Size : 52,8 Mb
Release : 2020-01-02
Category : Science
ISBN : 9783030312060

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Stem Cells by Mariusz Z. Ratajczak Pdf

Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension Book PDF

Author : Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi
Publisher : Springer Nature
Page : 374 pages
File Size : 44,8 Mb
Release : 2020-02-28
Category : Medical
ISBN : 9789811511851

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Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension by Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi Pdf

This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

The Lung

Ahmed El-Hashash
The Lung Book PDF

Author : Ahmed El-Hashash
Publisher : Academic Press
Page : 175 pages
File Size : 42,7 Mb
Release : 2021-06-10
Category : Science
ISBN : 9780128212073

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The Lung by Ahmed El-Hashash Pdf

In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world. Provides intensive scientific background and most recent information on cutting edge research to understand respiratory stem cell functions and develop methods to bring stem cells from bench to bedside for different lung diseases Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and iPSC-derived alveolar epithelia cell therapy in the lung Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the lung

Lung, The: Developmental Morphogenesis, Mechanobiology, And Stem Cells

Ahmed El-hashash,Eiman Abdel Meguid
Lung The Developmental Morphogenesis Mechanobiology And Stem Cells Book PDF

Author : Ahmed El-hashash,Eiman Abdel Meguid
Publisher : World Scientific
Page : 204 pages
File Size : 42,7 Mb
Release : 2019-01-29
Category : Medical
ISBN : 9789813277083

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Lung, The: Developmental Morphogenesis, Mechanobiology, And Stem Cells by Ahmed El-hashash,Eiman Abdel Meguid Pdf

With detailed scientific background and up-to-date research, this book examines recent developmental and cell biology, mechanobiology and stem cell biology discoveries to help provide a better understanding of lung development, repair and regeneration.Lung regeneration is an urgent therapeutic priority. The current major challenge is the generation of complex vascularized structures that can ultimately support or replace impaired lung function. Recent discoveries in biomedical engineering are analysed within the structural context of the lung to help provide a better understanding of the innovative solutions that could be used for restoring normal morphogenesis and regeneration of the lung. This also includes insights from basic developmental mechanisms of human lung development through the derivation and identification of stem cells, both from the early embryo as well as from differentiated organs and tissues.Suitable for a wide range of readers, including physicians and surgeons, scientists and researchers, and undergraduate and postgraduate students, this guide is an essential read for those working in the field of lung disease and development.

The Pulmonary Neuroepithelial Body Microenvironment

Inge Brouns,Line Verckist,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen
The Pulmonary Neuroepithelial Body Microenvironment Book PDF

Author : Inge Brouns,Line Verckist,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen
Publisher : Springer Nature
Page : 112 pages
File Size : 46,9 Mb
Release : 2021-05-05
Category : Medical
ISBN : 9783030658175

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The Pulmonary Neuroepithelial Body Microenvironment by Inge Brouns,Line Verckist,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen Pdf

This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors

Fluorescent Nanodiamonds

Huan-Cheng Chang,Wesley Wei-Wen Hsiao,Meng-Chih Su
Fluorescent Nanodiamonds Book PDF

Author : Huan-Cheng Chang,Wesley Wei-Wen Hsiao,Meng-Chih Su
Publisher : John Wiley & Sons
Page : 294 pages
File Size : 51,5 Mb
Release : 2018-11-12
Category : Science
ISBN : 9781119477082

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Fluorescent Nanodiamonds by Huan-Cheng Chang,Wesley Wei-Wen Hsiao,Meng-Chih Su Pdf

The most comprehensive reference on fluorescent nanodiamond physical and chemical properties and contemporary applications Fluorescent nanodiamonds (FNDs) have drawn a great deal of attention over the past several years, and their applications and development potential are proving to be manifold and vast. The first and only book of its kind, Fluorescent Nanodiamonds is a comprehensive guide to the basic science and technical information needed to fully understand the fundamentals of FNDs and their potential applications across an array of domains. In demonstrating the importance of FNDs in biological applications, the authors bring together all relevant chemistry, physics, materials science and biology. Nanodiamonds are produced by powerful cataclysmic events such as explosions, volcanic eruptions and meteorite impacts. They also can be created in the lab by high-pressure high-temperature treatment of graphite or detonating an explosive in a reactor vessel. A single imperfection can give a nanodiamond a specific, isolated color center which allows it to function as a single, trapped atom. Much smaller than the thickness of a human hair, a nanodiamond can have a huge surface area that allows it to bond with a variety of other materials. Because of their non-toxicity, nanodiamonds may be useful in biomedical applications, such as drug delivery and gene therapy. The most comprehensive reference on a topic of rapidly increasing interest among academic and industrial researchers across an array of fields Includes numerous case studies and practical examples from many areas of research and industrial applications, as well as fascinating and instructive historical perspectives Each chapter addresses, in-depth, a single integral topic including the fundamental properties, synthesis, mechanisms and functionalisation of FNDs The first book published by the key patent holder with his research group in the field of FNDs Fluorescent Nanodiamonds is an important working resource for a broad range of scientists and engineers in industry and academia. It will also be a welcome reference for instructors in chemistry, physics, materials science, biology and related fields.

Cardiac Regeneration

Masaki Ieda,Wolfram-Hubertus Zimmermann
Cardiac Regeneration Book PDF

Author : Masaki Ieda,Wolfram-Hubertus Zimmermann
Publisher : Springer
Page : 274 pages
File Size : 47,7 Mb
Release : 2017-10-27
Category : Medical
ISBN : 9783319561066

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Cardiac Regeneration by Masaki Ieda,Wolfram-Hubertus Zimmermann Pdf

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.