Structural Glycobiology

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Structural Glycobiology

Elizabeth Yuriev,Paul A. Ramsland
Structural Glycobiology Book PDF

Author : Elizabeth Yuriev,Paul A. Ramsland
Publisher : CRC Press
Page : 351 pages
File Size : 45,6 Mb
Release : 2012-09-27
Category : Medical
ISBN : 9781439854600

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Structural Glycobiology by Elizabeth Yuriev,Paul A. Ramsland Pdf

Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on: X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking Alternative techniques for yielding structural information on carbohydrates from complex biological samples Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection

Essentials of Glycobiology

Ajit Varki,Maarten J. Chrispeels
Essentials of Glycobiology Book PDF

Author : Ajit Varki,Maarten J. Chrispeels
Publisher : CSHL Press
Page : 694 pages
File Size : 41,8 Mb
Release : 1999
Category : Medical
ISBN : 0879696818

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Essentials of Glycobiology by Ajit Varki,Maarten J. Chrispeels Pdf

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Microbial Glycobiology

Anthony P Moran
Microbial Glycobiology Book PDF

Author : Anthony P Moran
Publisher : Elsevier
Page : 1037 pages
File Size : 40,8 Mb
Release : 2009-10-01
Category : Science
ISBN : 9780080923246

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Microbial Glycobiology by Anthony P Moran Pdf

This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews Provides researchers with an overview and synthesis of the latest research Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed Allows researchers to see at a glance what each chapter will cover Each chapter includes a Research Focus Box Identifies important problems that still need to be solved and areas that require further investigation

Structural Glycobiology

Elizabeth Yuriev,Paul A. Ramsland
Structural Glycobiology Book PDF

Author : Elizabeth Yuriev,Paul A. Ramsland
Publisher : CRC Press
Page : 337 pages
File Size : 40,8 Mb
Release : 2012-09-27
Category : Medical
ISBN : 9781439854129

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Structural Glycobiology by Elizabeth Yuriev,Paul A. Ramsland Pdf

Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is il

Marine Glycobiology

Se-Kwon Kim
Marine Glycobiology Book PDF

Author : Se-Kwon Kim
Publisher : CRC Press
Page : 1265 pages
File Size : 47,5 Mb
Release : 2016-10-14
Category : Medical
ISBN : 9781315354217

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Marine Glycobiology by Se-Kwon Kim Pdf

Marine glycobiology is an emerging and exciting area in the field of science and medicine. Glycobiology, the study of the structure and function of carbohydrates and carbohydrate-containing molecules, is fundamental to all biological systems and represents a developing field of science that has made huge advances in the last half-century. This book revolutionizes the concept of marine glycobiology, focusing on the latest principles and applications of marine glycobiology and their relationships.

Introduction to Glycobiology

Maureen E. Taylor,Kurt Drickamer
Introduction to Glycobiology Book PDF

Author : Maureen E. Taylor,Kurt Drickamer
Publisher : Oxford University Press, USA
Page : 305 pages
File Size : 41,9 Mb
Release : 2011-04-21
Category : Medical
ISBN : 9780199569113

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Introduction to Glycobiology by Maureen E. Taylor,Kurt Drickamer Pdf

Introduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level and their clinical relevance.

Glycoinformatics

Thomas Lütteke,Martin Frank
Glycoinformatics Book PDF

Author : Thomas Lütteke,Martin Frank
Publisher : Humana
Page : 0 pages
File Size : 54,9 Mb
Release : 2016-10-05
Category : Science
ISBN : 149394195X

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Glycoinformatics by Thomas Lütteke,Martin Frank Pdf

This book provides current glycoinformatics methods and protocols used to support the determination of carbohydrate structures in biological samples as well as carbohydrate structure databases, the interaction of carbohydrates with proteins, and theoretical and experimental methods to study their three-dimensional structure and dynamics. Glycoinformatics explores this recently emerged field, which has come into being in order to address the needs of encoding, storing, and analyzing carbohydrate ‘sequences’ and their taxonomy using computers. Written in the highly successful Methods in Molecular Biology series format, chapters contain the kind of detailed description and key implementation advice to ensure successful results. Authoritative and timely, Glycoinformatics demonstrates the progress that has been achieved in glycoinformatics, which indicates that it is no longer a niche subject covered by only a few scientists but is truly coming of age.

Bioinformatics for Glycobiology and Glycomics

Claus-Wilhelm von der Lieth,Thomas Luetteke,Martin Frank
Bioinformatics for Glycobiology and Glycomics Book PDF

Author : Claus-Wilhelm von der Lieth,Thomas Luetteke,Martin Frank
Publisher : John Wiley & Sons
Page : 494 pages
File Size : 51,9 Mb
Release : 2009-10-01
Category : Medical
ISBN : 0470029609

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Bioinformatics for Glycobiology and Glycomics by Claus-Wilhelm von der Lieth,Thomas Luetteke,Martin Frank Pdf

This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein–carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein–carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. Assumes only a basic knowledge of biology and bioinformatics.

Plant Glycobiology – a sweet world of lectins, glycoproteins, glycolipids and glycans

Els J. M. Van Damme, Nausicaä Lannoo,Cécile Albenne,Elisabeth Jamet
Plant Glycobiology a sweet world of lectins glycoproteins glycolipids and glycans Book PDF

Author : Els J. M. Van Damme, Nausicaä Lannoo,Cécile Albenne,Elisabeth Jamet
Publisher : Frontiers Media SA
Page : 137 pages
File Size : 44,7 Mb
Release : 2015-02-12
Category : Botany
ISBN : 9782889194216

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Plant Glycobiology – a sweet world of lectins, glycoproteins, glycolipids and glycans by Els J. M. Van Damme, Nausicaä Lannoo,Cécile Albenne,Elisabeth Jamet Pdf

Plants synthesize a wide variety of unique glycan structures which play essential roles during the life cycle of the plant. Being omnipresent throughout the plant kingdom, ranging from simple green algae to modern flowering plants, glycans contribute to many diverse processes. Glycans can function as structural components in the plant cell wall, assist in the folding of nascent proteins, act as signaling molecules in plant defense responses or (ER) stress pathways, or serve within the energy metabolism of a plant. In most cases, glycans are attached to other macromolecules to form so-called glycoconjugates (e.g. glycoproteins, proteoglycans and glycolipids), but they can also be present as free entities residing in the plant cell. Next to the broad, complex set of glycans, plants also evolved an elaborate collection of lectins or proteins with a lectin-like domain, which can recognize and bind to endogenous (plants-own) or exogenous (foreign) glycans. Though still poorly understood in plants, the dynamic interactions between lectins and carbohydrate structures are suggested to be involved in gene transcription, protein folding, protein transport, cell adhesion, signaling as well as defense responses. As such, a complex and largely undetermined glycan-interactome is established inside plant cells, between cells and their surrounding matrix, inside the extracellular matrix, and even between organisms. Studying the biological roles of plant glycans will enable to better understand plant development and physiology in order to fully exploit plants for food, feed and production of pharmaceutical proteins. In this Research Topic, we want to provide a platform for articles describing the latest research, perspectives and methodologies related to the fascinating world of plant glycobiology, with a focus on following subjects: 1. Identification and characterization of plant glycans, their biosynthetic and degradation enzymes 2. Characterization of plant lectins and glycoproteins 3. Plant glycans in the plant’s energy metabolism 4. Role of plant glycans in plant defense signaling 5. Use of plant lectins in pest control 6. Plant lectins as new tools in human medicine 7. Glyco-engineering in plants

Glycobiology

Minoru Fukuda
Glycobiology Book PDF

Author : Minoru Fukuda
Publisher : Elsevier
Page : 422 pages
File Size : 54,7 Mb
Release : 2006-11-14
Category : Science
ISBN : 9780080468990

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Glycobiology by Minoru Fukuda Pdf

In the past decade, there has been an explosion of progress in understanding the roles of carbohydrates in biological systems. This explosive progress was made with the efforts in determining the roles of carbohydrates in immunology, neurobiology and many other disciplines, examining each unique system and employing new technology. This volume represents the first of three in the Methods in Enzymology series, including Glycomics (vol. 416) and Functional Glycomics (vol. 417), dedicated to disseminating information on methods in determining the biological roles of carbohydrates. These books are designed to provide an introduction of new methods to a large variety of readers who would like to participate in and contribute to the advancement of glycobiology. The methods covered include structural analysis of carbohydrates, biological and chemical synthesis of carbohydrates, expression and determination of ligands for carbohydrate-binding proteins, gene expression profiling including micro array, and generation of gene knockout mice and their phenotype analyses.

Glycobiology and Human Diseases

Gherman Wiederschain
Glycobiology and Human Diseases Book PDF

Author : Gherman Wiederschain
Publisher : CRC Press
Page : 334 pages
File Size : 51,8 Mb
Release : 2016-02-22
Category : Medical
ISBN : 9781498709194

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Glycobiology and Human Diseases by Gherman Wiederschain Pdf

This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal storage diseases, glycobiology of human milk (biological roles and diseases) and pectins as biological modulators of human physiological reactions. The book includes analysis of comprehensive data and some productive conclusions and perspectives.

The Glycome

Adeel Malik,Tanveer A. Dar
The Glycome Book PDF

Author : Adeel Malik,Tanveer A. Dar
Publisher : CRC Press
Page : 305 pages
File Size : 48,5 Mb
Release : 2021-07-07
Category : Science
ISBN : 9781000344325

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The Glycome by Adeel Malik,Tanveer A. Dar Pdf

This volume provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research that has been largely ignored due to its complexity. The authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process, and in disease etiology. The book bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker. The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture. The Glycome: Understanding the Diversity and Complexity of Glycobiology details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.

Techniques in Glycobiology

R. Reid Townsend,Arland T. Hotchkiss
Techniques in Glycobiology Book PDF

Author : R. Reid Townsend,Arland T. Hotchkiss
Publisher : CRC Press
Page : 666 pages
File Size : 50,6 Mb
Release : 1997-06-25
Category : Science
ISBN : 0824798228

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Techniques in Glycobiology by R. Reid Townsend,Arland T. Hotchkiss Pdf

This work covers methodologies for plant and animal glycoconjugate analysis. It details mass spectrometry, nuclear magnetic resonance spectroscopy, glycolipids and new physical methods, o-glycosylation characterization, chromophore and fluorophore labelling of oligosaccharides, separations, exoglycosidases and mapping, and plant glycobiology.

Lectins and Glycobiology

Hans-Joachim Gabius,Sigrun Gabius
Lectins and Glycobiology Book PDF

Author : Hans-Joachim Gabius,Sigrun Gabius
Publisher : Springer Science & Business Media
Page : 524 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642779442

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Lectins and Glycobiology by Hans-Joachim Gabius,Sigrun Gabius Pdf

The intriguing complexity, precision, and regulation of the wide range of biologi cal processes is determined by intricate mechanisms of molecular recognition. Their nature is under intense scrutiny. In addition to the well-appreciated interac tion of proteins either with amino acid or nucleotide sequences, the investigation of their interplay with carbohydrate elements of cellular glycoconjugates current ly exerts increasing attraction. In the group of carbohydrate-binding proteins, lec tins are distinguished from antibodies or ligand-affecting enzymes, according to the most recent definition. The thorough analysis of their structure and function is considered as a focus to collect a critical mass of information for delineating details of a further array of biochemical processes with pivotal physiological im pact. Following an already century-long history of scientific description, reflected by subjectively chosen highlights (see the Brief History of Lectin Research at page VI), the excitement in glycobiological research that prevails today can easily be ex plained by our growing awareness of the multifarious significance of a sugar-code system of biological information. This present notion unmistakably has an im pact on lines of research in diverse disciplines like cell and molecular biology, histochemistry, or clinical sciences. It also prompts inherent practical questions such as how to obtain lectins, or how to employ them as instruments in various assay systems with the best possible results. Thus, this book is devoted intentionally to cover the techniques in different research fields that deal with lectins.

The Role of Glycosylation in Health and Disease

Gordan Lauc,Irena Trbojević-Akmačić
The Role of Glycosylation in Health and Disease Book PDF

Author : Gordan Lauc,Irena Trbojević-Akmačić
Publisher : Springer Nature
Page : 392 pages
File Size : 47,7 Mb
Release : 2021-09-08
Category : Science
ISBN : 9783030701154

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The Role of Glycosylation in Health and Disease by Gordan Lauc,Irena Trbojević-Akmačić Pdf

Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.