Structure And Function Of The Aspartic Proteinases

Author : Ben M. Dunn
Publisher : Springer Science & Business Media
Page : 561 pages
File Size : 47,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468460124

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Structure and Function of the Aspartic Proteinases by Ben M. Dunn Pdf

In September, 1990, a group of 160 scientists from 19 countries and 21 of the United States met at the Red Lion Inn in Rohnert Park, Sonoma County, California. The purpose of this meeting was to share new information from recent research on the Aspartic Proteinases. This book is a compilation of the information transferred in that forum. The Aspartic Proteinases include all those enzymes from the "fourth" class of proteolytic enzymes, the first three being the Serine, Cysteine and Metalloproteinases. Of course, all the scientists in attendance at the Sonoma Aspartic Proteinase Conference would agree that our current level of understanding of the structure and function of the Aspartic Proteinase class of enzymes is clearly first class. The reasons for this require a bit of historical perspective. The group of scientists who are engaged in study of this family of enzymes first met as a separate entity in 1976, in Norman, Oklahoma, at a meeting organized by Jordan Tang of the Oklahoma Medical Research Foundation. This was an exciting time, as the first crystal structures of some of these enzymes were described by Blundell, James and Davies. During that conference, the relationship between the two halves of the mammalian and fungal enzymes was recognized and this has provided a structural foundation for analysis of the retroviral enzymes, which came later. A book was published by Plenum Press documenting l this conference, and the current book is an update to that important work.

Author : Kenji Takahashi
Publisher : Springer Science & Business Media
Page : 614 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461518716

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Aspartic Proteinases by Kenji Takahashi Pdf

The 5th International Conference on Aspartic Proteinases was held on September 19 through 24, 1993, at Naito Museum of Pharmaceutical Science and Industry, Kawashima cho, Gifu Prefecture, Japan, about 15 miles northwest of Nagoya City. About 100 scientists attended the conference, including 52 from 14 countries outside Japan, and 32 papers were presented by invited speakers, and 58 papers as posters. The purpose of this conference was to present and discuss new information on the structure, function, and biology, and related topics, including biomedical implications, of aspartic proteinases, and this book is a collec tion of nearly all the papers presented at the meeting. Aspartic proteinases belong to one of the four major classes of proteinases, the others being serine, cysteine, and metalloproteinases, and are so called since they have two catalytic aspartic acid residues in common in their active sites. Most of them are optimally active at acidic pH, hence the long-used name "acid proteinases," which, indeed, was the major title of the first conference of this series. However, some of them are active at around neutral pH, indicating their physiological roles in a wider range of pH than hitherto considered.

Author : Ben M Dunn
Publisher : Unknown
Page : 608 pages
File Size : 45,6 Mb
Release : 1992-02-29
Category : Electronic
ISBN : 1468460137

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Structure and Function of the Aspartic Proteinases by Ben M Dunn Pdf

Author : Michael N.G. James
Publisher : Springer Science & Business Media
Page : 484 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461553731

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Aspartic Proteinases by Michael N.G. James Pdf

The VIIth International Conference on Aspartic Proteinases was held in Banff, Alberta, Canada, from October 22 to 27, 1996. The venue was the Banff Centre in the Canadian Rockies, a setting well known worldwide for the scenic beauty and mountain grandeur. It was perhaps presumptuous of the organizers to call this the seventh Aspartic Proteinase Conference but it was felt that the meeting in 1982, organized by Tom Blundell and John Kay, was of an international stature and covered topics sufficiently broad to constitute a conference. Thus, there is a discontinuity in that the Gifu Conference organized by Prof. Kenji Takahashi was the fifth International Conference on Aspartic Proteinases. Officially, there has not been a sixth Conference and if there is confusion, it is the result of my desire to recognize the importance of the London meeting. Banffhosted 106 scientists from 14 different countries. There were 26 invited speak ers among the 44 oral presentations of the 7 main sessions. In addition, there were 53 con tributed poster presentations that spanned the whole range of interest in aspartic proteinases.

Author : Martin Fusek,Vaclav Vetvicka
Publisher : CRC Press
Page : 324 pages
File Size : 43,9 Mb
Release : 2019-10-10
Category : Medical
ISBN : 9780429536007

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Aspartic Proteinases Physiology and Pathology by Martin Fusek,Vaclav Vetvicka Pdf

Published in 1995: Aspartic Proteinases: Physiology and Pathology focuses on the advantages and limitations of the use of proteinases and their inhibitors in human pathology. A virus-specific aspartic proteinase enzyme is required for the maturation of a virus. If the enzyme can be eliminated, so can the maturation of the virus. This book reviews the wealth of recently published information sparked by the renewed interest in these enzymes.

Author : Klaudia Brix,Walter Stöcker
Publisher : Springer Science & Business Media
Page : 568 pages
File Size : 52,5 Mb
Release : 2014-01-21
Category : Science
ISBN : 9783709108857

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Proteases: Structure and Function by Klaudia Brix,Walter Stöcker Pdf

Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.

Author : Arun K. Ghosh
Publisher : John Wiley & Sons
Page : 616 pages
File Size : 54,7 Mb
Release : 2011-08-04
Category : Medical
ISBN : 9783527641628

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Aspartic Acid Proteases as Therapeutic Targets by Arun K. Ghosh Pdf

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

Author : Julio Polaina,Andrew P. MacCabe
Publisher : Springer Science & Business Media
Page : 629 pages
File Size : 42,7 Mb
Release : 2007-05-16
Category : Science
ISBN : 9781402053771

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Industrial Enzymes by Julio Polaina,Andrew P. MacCabe Pdf

Recent developments in genetic engineering and protein chemistry are bringing ever more powerful means of analysis to bear on the study of enzyme structure. This volume reviews the most important types of industrial enzymes. In a balanced manner it covers three interrelated aspects of paramount importance for enzyme performance: three-dimensional protein structure, physicochemical and catalytic properties, and the range of both classical and novel applications.

Author : Gerhard Klebe
Publisher : Springer
Page : 0 pages
File Size : 46,5 Mb
Release : 2013-07-10
Category : Medical
ISBN : 3642179061

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Drug Design by Gerhard Klebe Pdf

Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces.

Author : Lawrence C. Kuo,Jules A. Shafer
Publisher : Gulf Professional Publishing
Page : 494 pages
File Size : 48,5 Mb
Release : 1994-09-22
Category : Medical
ISBN : 0121821420

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Retroviral Proteases by Lawrence C. Kuo,Jules A. Shafer Pdf

Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Author : Alan J. Barrett,J. Fred Woessner,Neil D. Rawlings
Publisher : Elsevier
Page : 1182 pages
File Size : 41,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080984155

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Handbook of Proteolytic Enzymes, Volume 1 by Alan J. Barrett,J. Fred Woessner,Neil D. Rawlings Pdf

Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.

Author : Anonim
Publisher : Academic Press
Page : 459 pages
File Size : 44,5 Mb
Release : 1991-01-28
Category : Technology & Engineering
ISBN : 0080865968

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Mechanisms of Catalysis by Anonim Pdf

The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 51,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Mercedes Diaz-Mendoza,Juan Guiamet,Frank Van Breusegem
Publisher : Frontiers Media SA
Page : 157 pages
File Size : 50,7 Mb
Release : 2020-01-24
Category : Electronic
ISBN : 9782889633999

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Plant Proteases by Mercedes Diaz-Mendoza,Juan Guiamet,Frank Van Breusegem Pdf

Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism. They take part in important pathways like protein turnover by the degradation of misfolded proteins and the ubiquitin-proteasome pathway, and they are responsible for post-translational modifications of proteins by proteolysis at highly specific sites. Proteases are also implicated in a great variety of environmentally controlled processes, including mobilization of storage proteins during seed germination, development of seedlings, senescence, programmed cell death and defense mechanisms against pests and pathogens. However, in spite of their importance, little is known about the functions and mode of actions of specific plant proteases. This Research Topic collects contributions covering diverse aspects of plant proteases research.

Author : Charis M. Galanakis
Publisher : Academic Press
Page : 358 pages
File Size : 47,6 Mb
Release : 2019-05-30
Category : Health & Fitness
ISBN : 9780128172865

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Proteins: Sustainable Source, Processing and Applications by Charis M. Galanakis Pdf

Proteins: Sustainable Source, Processing and Applications addresses sustainable proteins, with an emphasis on proteins of animal origin, plant-based and insect proteins, microalgal single cell proteins, extraction, production, the stability and bioengineering of proteins, food applications (e.g. encapsulation, films and coatings), consumer behavior and sustainable consumption. Written in a scientific manner to meet the needs of chemists, food scientists, technologists, new product developers and academics, this book addresses the health effects and properties of proteins, highlights sustainable sources, processes and consumption models, and analyzes the potentiality of already commercialized processes and products. This book is an integral resource that supports the current applications of proteins in the food industry, along with those that are currently under development. Supports the current applications of proteins in the food industry, along with those that are under development Connects the properties and health effects of proteins with sustainable sources, recovery procedures, stability and encapsulation Explores industrial applications that are affected by aforementioned aspects