Sudden Arrhythmic Death From Basic Science To Clinical Practice

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Sudden arrhythmic death: from basic science to clinical practice

Gareth D. Matthews
Sudden arrhythmic death from basic science to clinical practice Book PDF

Author : Gareth D. Matthews
Publisher : Frontiers E-books
Page : 137 pages
File Size : 49,6 Mb
Release : 2014-10-02
Category : Cardiac arrest
ISBN : 9782889192694

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Sudden arrhythmic death: from basic science to clinical practice by Gareth D. Matthews Pdf

With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future

ECG Time Series Variability Analysis

Herbert F. Jelinek,David J. Cornforth,Ahsan H. Khandoker
ECG Time Series Variability Analysis Book PDF

Author : Herbert F. Jelinek,David J. Cornforth,Ahsan H. Khandoker
Publisher : CRC Press
Page : 497 pages
File Size : 54,6 Mb
Release : 2017-09-11
Category : Mathematics
ISBN : 9781482243482

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ECG Time Series Variability Analysis by Herbert F. Jelinek,David J. Cornforth,Ahsan H. Khandoker Pdf

Divided roughly into two sections, this book provides a brief history of the development of ECG along with heart rate variability (HRV) algorithms and the engineering innovations over the last decade in this area. It reviews clinical research, presents an overview of the clinical field, and the importance of heart rate variability in diagnosis. The book then discusses the use of particular ECG and HRV algorithms in the context of clinical applications.

Electrocardiography of Inherited Arrhythmias and Cardiomyopathies

Martin Green,Andrew Krahn,Wael Alqarawi
Electrocardiography of Inherited Arrhythmias and Cardiomyopathies Book PDF

Author : Martin Green,Andrew Krahn,Wael Alqarawi
Publisher : Springer Nature
Page : 165 pages
File Size : 43,6 Mb
Release : 2020-09-21
Category : Medical
ISBN : 9783030521738

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Electrocardiography of Inherited Arrhythmias and Cardiomyopathies by Martin Green,Andrew Krahn,Wael Alqarawi Pdf

This book provides a comprehensive review of the ECG findings of inherited arrhythmias and cardiomyopathies. Despite new forms of medical imaging, electrocardiography (ECG) remains the cornerstone of diagnosis, risk-stratification, and prognosis for these conditions. It is extremely important for clinicians to develop the skills required to interpret the ECG correctly as both overdiagnosis and underdiagnosis of these conditions can have a deleterious effect on patients and their families. Each chapter covers a specific condition and highlights typical or critically important ECG findings. Chapters include detailed descriptions of these findings along with pathophysiological mechanisms and clinical vignettes. In addition, the book reviews some normal ECG findings in athletes in order to differentiate some ECG findings from those which may be found in inherited arrhythmia or cardiomyopathy conditions. Electrocardiography of Inherited Arrhythmias and Cardiomyopathies: From Basic Science to Clinical Practice is an essential resource for physicians, residents, fellows, and medical students in cardiology, cardiac electrophysiology, emergency medicine, sports medicine, and primary care.

J Wave Syndromes

Charles Antzelevitch,Gan-Xin Yan
J Wave Syndromes Book PDF

Author : Charles Antzelevitch,Gan-Xin Yan
Publisher : Springer
Page : 0 pages
File Size : 44,8 Mb
Release : 2018-05-30
Category : Medical
ISBN : 3319810685

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J Wave Syndromes by Charles Antzelevitch,Gan-Xin Yan Pdf

This book delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs to be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics. J wave syndromes are one of the hottest topics in cardiology today. Cardiac arrhythmias associated with Brugada syndrome (BrS) or an early repolarization (ER) pattern in the inferior or infero-lateral ECG leads are thought to be mechanistically linked to accentuation of transient outward current (Ito)-mediated J waves. Although BrS and ER syndrome (ERS) differ with respect to magnitude and lead location of abnormal J waves, they are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. ERS is divided into three subtypes with the most severe, Type 3, displaying an ER pattern globally in the inferior, lateral and right precordial leads. BrS has been linked to mutations in 19 different genes, whereas ERS has been associated with mutations in 7 different genes. There is a great deal of confusion as to how to properly diagnose and treat the J wave syndromes as well as confusion about the underlying mechanisms. The demonstration of successful epicardial ablation of BrS has provided new therapeutic options for the management of this syndrome for which treatment alternatives are currently very limited, particularly in the case of electrical storms caused by otherwise uncontrollable recurrent VT/VF. An early repolarization pattern is observed in 2-5% of the US population. While it is clear that the vast majority of individuals exhibiting an ER pattern are not at risk for sudden cardiac death, the challenge moving forward is to identify those individuals who truly are at risk and to design safe and effective treatments.

Molecular Cardiology in Clinical Practice

Michael R. Sanders,John B. Kostis
Molecular Cardiology in Clinical Practice Book PDF

Author : Michael R. Sanders,John B. Kostis
Publisher : Springer Science & Business Media
Page : 234 pages
File Size : 55,5 Mb
Release : 2007-11-23
Category : Medical
ISBN : 9780585381411

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Molecular Cardiology in Clinical Practice by Michael R. Sanders,John B. Kostis Pdf

Cardiology is an area of great recent triumphs in pharmacological and surgical treatment, yet cardiovascular disease remains the leading cause of death and disability in the industrialized world. Coronary disease, heart failure, stroke and sudden arrhythmic cardiac death challenge both medical practitioners and scientists. With the dawning of the new `molecular' era, there is an awakened hope that a more fundamental understanding of biologic processes may eventually lead to new progress in the prevention and treatment of these persistent and seemingly intransigent problems. Molecular Cardiology in Clinical Practice brings together an outstanding panel of experts in cardiovascular disease who have been at the forefront of the application of molecular medicine to cardiology. Its intent is to help bridge the gap between modern medical practice and modern science, in the belief that an understanding of basic principles can lead to new insight into the problems of cardiac patients.

Molecular Pathology in Clinical Practice

Debra G.B. Leonard
Molecular Pathology in Clinical Practice Book PDF

Author : Debra G.B. Leonard
Publisher : Springer Science & Business Media
Page : 589 pages
File Size : 40,8 Mb
Release : 2007-11-25
Category : Medical
ISBN : 9780387332277

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Molecular Pathology in Clinical Practice by Debra G.B. Leonard Pdf

This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.

Practice and Progress in Cardiac Pacing and Electrophysiology

Ali Oto
Practice and Progress in Cardiac Pacing and Electrophysiology Book PDF

Author : Ali Oto
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400902190

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Practice and Progress in Cardiac Pacing and Electrophysiology by Ali Oto Pdf

Developments in the electrical treatment of arrhythmias have been so fast over the last few years that access to available, state-of-the-art knowledge has become a major challenge. The proceedings of scientific meetings are therefore most helpful in this regard. This volume provides highlights of many of the recent and most important technological advances and concepts in cardiac electrotherapy, written by the most prominent figures in the field, for the internists, clinical cardiologists and cardiologists who are practising in arrhythmias and antiarrhythmic therapy. The book is divided into five parts, each focusing on an exciting group of topics. Part One is a highlight of some of the hit points in arrhythmology. Part Two is a quick reference to the current concepts in non-invasive electrocardiology. Part Three, cardiac pacing, is enhanced by the introductory chapter of S. Furman, which gives the state-of-the-art in electrical cardiac stimulation for 1995. This part also reviews the technical advances, new perspectives in the indications of cardiac pacing, as well as the management of complications. Radiofrequency ablation as a challenging antiarrhythmic therapeutic strategy is thoroughly reviewed and the hottest topics are highlighted in Part Four. Part Five is dedicated to implantable cardioverter-defibrillators with several exciting topics, including driving with implantable devices.

Cardiac Repolarization

Nabil El-Sherif
Cardiac Repolarization Book PDF

Author : Nabil El-Sherif
Publisher : Springer Nature
Page : 354 pages
File Size : 48,5 Mb
Release : 2019-08-29
Category : Medical
ISBN : 9783030226725

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Cardiac Repolarization by Nabil El-Sherif Pdf

This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology.

Electrical Diseases of the Heart

Ihor Gussak,A. A. M. Wilde,P. A. Friedman,Charles Antzelevitch,M. J. Ackerman,W.-K. Shen
Electrical Diseases of the Heart Book PDF

Author : Ihor Gussak,A. A. M. Wilde,P. A. Friedman,Charles Antzelevitch,M. J. Ackerman,W.-K. Shen
Publisher : Springer Science & Business Media
Page : 600 pages
File Size : 54,6 Mb
Release : 2008-09-08
Category : Medical
ISBN : 9781846288548

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Electrical Diseases of the Heart by Ihor Gussak,A. A. M. Wilde,P. A. Friedman,Charles Antzelevitch,M. J. Ackerman,W.-K. Shen Pdf

This book provides a unique contemporary and succinct distillation of the current status of recently delineated electrical diseases of the heart, emphasizing their common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science. The book is divided into seven major parts. Each part consists of chapters (total of 64) dealing with related topics.

Sudden Cardiac Death

Ivana Vranic
Sudden Cardiac Death Book PDF

Author : Ivana Vranic
Publisher : Unknown
Page : 0 pages
File Size : 55,8 Mb
Release : 2017
Category : Arrhythmia
ISBN : 1536119830

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Sudden Cardiac Death by Ivana Vranic Pdf

This is a detailed clinical compilation on sudden cardiac death causes. From the various geographical regions of the world comes different clinical perspectives toward the SCD problem that shed light on the predictors and estimated prevalence in genetic inheritance worldwide. For many centuries, the mysterious deaths of prominent professional sportsmen have preoccupied the attention of the media and medical professionals. In some cases, it was possible to obtain the medical histories of the victims, data on the presence of some specific diseases, and conditions or potential symptoms preceding the fatal episode. Various rare inherited syndromes that are associated with congenital heart disease are focused on in this study, and the interrelationship between ventricular premature beats, sustained/non-sustained ventricular tachycardias and ventricular fibrillations are discussed. Cardio-oncology is an emerging field where more and more patients face consequences from radiotherapy and chemotherapy because these individuals become more prone to SCD. Among the most notable developments, three-dimensional echocardiography and myocardial strain imaging are worth noting and might inexpensively improve the current risk stratification process. Recently, a strain that reflects the change of length and thickness of myocardial fibres has been incorporated into the routine clinical practice. The risk of sudden cardiac death is not the same in patients with Chagas disease, and newly predicted factors are to blame. The prevalence of SCD, hypertrophic cardiomyopathy and the accurate risk are extremely challenging, so much so that they recently became a source of argument between European and American experts. This is a must-have book for those interested in a clinical approach to the SCD phenomenon.

Encyclopedia of Cardiovascular Research and Medicine

Anonim
Encyclopedia of Cardiovascular Research and Medicine Book PDF

Author : Anonim
Publisher : Elsevier
Page : 2800 pages
File Size : 51,9 Mb
Release : 2017-11-27
Category : Medical
ISBN : 9780128051542

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Encyclopedia of Cardiovascular Research and Medicine by Anonim Pdf

Encyclopedia of Cardiovascular Research and Medicine offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.

DeGroot's Endocrinology, E-Book

R. Paul Robertson
DeGroot s Endocrinology E Book Book PDF

Author : R. Paul Robertson
Publisher : Elsevier Health Sciences
Page : 2539 pages
File Size : 44,8 Mb
Release : 2022-09-29
Category : Medical
ISBN : 9780323694131

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DeGroot's Endocrinology, E-Book by R. Paul Robertson Pdf

Thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology, DeGroot’s Endocrinology, 8th Edition, remains the comprehensive, international reference of choice for today’s endocrinologists and fellows. A full peer review of the previous edition, conducted by a largely new group of renowned editors, was used to update this trusted, two-volume resource. In-depth coverage of both basic and clinical aspects of endocrinology and up-to-date information on the treatment and management of endocrine disorders are provided by a diverse group of expert contributors from six continents. A full-color format and helpful algorithms summarize clinical decision-making and practical approaches to patient management. Organizes content by all the glands that regulate the endocrine system while integrating basic science and clinical presentations of disease. Includes new chapters: Anatomy and Physiology of the Hypothalmus and Pituitary, Differentiated Thyroid Cancer, Medullary Thyroid Cancer, Drugs that Affect Thyroid Function, Genetic Disorders of the Adrenal Cortex, Adrenal Pathology, Primary Aldosteronism, Transgender Healthcare, Erectile Dysfunction, Prevalence and Causes of Male Infertility, Sexual Dysfunction in the Female, Glucose Toxicity and Oxidative Stress. Emphasizes basic science and evidence-based practice throughout. Features extensive updates to content on thyroid and adrenal disfunction, endocrine-disrupting chemicals and human disease, clinical management of diabetes, and advances in genetics. Includes algorithms to outline effective treatment protocols. Contains new emphasis boxes that highlight key points in each chapter.

Professor Hein J.J. Wellens: 33 Years of Cardiology and Arrhythmology

J. Smeets,P.A.F.M. Doevendans,M. Josephson,Ch. Kirchhof,M. Vos
Professor Hein J J Wellens 33 Years of Cardiology and Arrhythmology Book PDF

Author : J. Smeets,P.A.F.M. Doevendans,M. Josephson,Ch. Kirchhof,M. Vos
Publisher : Springer Science & Business Media
Page : 708 pages
File Size : 41,7 Mb
Release : 2000-03-31
Category : Biography & Autobiography
ISBN : 0792362098

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Professor Hein J.J. Wellens: 33 Years of Cardiology and Arrhythmology by J. Smeets,P.A.F.M. Doevendans,M. Josephson,Ch. Kirchhof,M. Vos Pdf

The first invasive evaluation of cardiac arrhythmias in humans was performed in 1967 in Paris (Prof. P. Coumel) and Amsterdam (Prof. D. Durrer). This was the start of a rapid increase in our knowledge of the diagnosis, mechanism and treatment of cardiac arrhythmias. In that same year Prof. Hein J.J. Wellens became cardiologist in the Wilhelmina Gasthuis in Amsterdam. Initially in Amsterdam (1967-1977) and later on in Maastricht (from 1977), he was the driving force for many breakthroughs in clinical cardiac electrophysiology. With an active interplay between the knowledge derived from the 12-lead electrocardiogram and the recordings made with invasive electrophysiology, he composed new ideas leading to major contributions in clinical cardiac electrophysiology and, more generally, in arrhythmology. He published over 650 scientific papers and 14 books, and had numerous functions within scientific boards of prestigious journals. In addition he trained more than 120 cardiologists in clinical cardiac electrophysiology. On the occasion of the congress `2000, Future of Arrhythmology: Lessons From the Past, Promises For Tomorrow', we highlight the scientific work of Prof. Hein J.J. Wellens. A selection of more than 60 articles over the whole time span has been selected. These articles are accompanied by comments from an expert, co-worker and/or former fellow in order to place the paper in a scientific time frame, including the relationship of the author with Prof. Hein J.J. Wellens.

Strategies to Improve Cardiac Arrest Survival

Institute of Medicine,Board on Health Sciences Policy,Committee on the Treatment of Cardiac Arrest: Current Status and Future Directions
Strategies to Improve Cardiac Arrest Survival Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on the Treatment of Cardiac Arrest: Current Status and Future Directions
Publisher : National Academies Press
Page : 456 pages
File Size : 45,5 Mb
Release : 2015-09-29
Category : Medical
ISBN : 9780309372022

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Strategies to Improve Cardiac Arrest Survival by Institute of Medicine,Board on Health Sciences Policy,Committee on the Treatment of Cardiac Arrest: Current Status and Future Directions Pdf

Cardiac arrest can strike a seemingly healthy individual of any age, race, ethnicity, or gender at any time in any location, often without warning. Cardiac arrest is the third leading cause of death in the United States, following cancer and heart disease. Four out of five cardiac arrests occur in the home, and more than 90 percent of individuals with cardiac arrest die before reaching the hospital. First and foremost, cardiac arrest treatment is a community issue - local resources and personnel must provide appropriate, high-quality care to save the life of a community member. Time between onset of arrest and provision of care is fundamental, and shortening this time is one of the best ways to reduce the risk of death and disability from cardiac arrest. Specific actions can be implemented now to decrease this time, and recent advances in science could lead to new discoveries in the causes of, and treatments for, cardiac arrest. However, specific barriers must first be addressed. Strategies to Improve Cardiac Arrest Survival examines the complete system of response to cardiac arrest in the United States and identifies opportunities within existing and new treatments, strategies, and research that promise to improve the survival and recovery of patients. The recommendations of Strategies to Improve Cardiac Arrest Survival provide high-priority actions to advance the field as a whole. This report will help citizens, government agencies, and private industry to improve health outcomes from sudden cardiac arrest across the United States.

Sudden Unexpected Death in Epilepsy

Claire M. Lathers,Paul L. Schraeder,Jan E. Leestma,Braxton B. Wannamaker,Richard L. Verrier F.A.C.C. Ph.D.,Steven C. Schachter MD
Sudden Unexpected Death in Epilepsy Book PDF

Author : Claire M. Lathers,Paul L. Schraeder,Jan E. Leestma,Braxton B. Wannamaker,Richard L. Verrier F.A.C.C. Ph.D.,Steven C. Schachter MD
Publisher : CRC Press
Page : 350 pages
File Size : 55,8 Mb
Release : 2015-04-06
Category : Law
ISBN : 9781482223880

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Sudden Unexpected Death in Epilepsy by Claire M. Lathers,Paul L. Schraeder,Jan E. Leestma,Braxton B. Wannamaker,Richard L. Verrier F.A.C.C. Ph.D.,Steven C. Schachter MD Pdf

Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks builds on earlier works focusing on the clinical problem of sudden unexpected death in epilepsy (SUDEP). This book presents a methodology for identifying and classifying clusters of risks that lead to SUDEP. Developed over the last two years, the SUDEP Classificatio