Molecular Cardiology In Clinical Practice

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Molecular Cardiology in Clinical Practice

Michael R. Sanders,John B. Kostis
Molecular Cardiology in Clinical Practice Book PDF

Author : Michael R. Sanders,John B. Kostis
Publisher : Springer Science & Business Media
Page : 234 pages
File Size : 43,8 Mb
Release : 2007-11-23
Category : Medical
ISBN : 9780585381411

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Molecular Cardiology in Clinical Practice by Michael R. Sanders,John B. Kostis Pdf

Cardiology is an area of great recent triumphs in pharmacological and surgical treatment, yet cardiovascular disease remains the leading cause of death and disability in the industrialized world. Coronary disease, heart failure, stroke and sudden arrhythmic cardiac death challenge both medical practitioners and scientists. With the dawning of the new `molecular' era, there is an awakened hope that a more fundamental understanding of biologic processes may eventually lead to new progress in the prevention and treatment of these persistent and seemingly intransigent problems. Molecular Cardiology in Clinical Practice brings together an outstanding panel of experts in cardiovascular disease who have been at the forefront of the application of molecular medicine to cardiology. Its intent is to help bridge the gap between modern medical practice and modern science, in the belief that an understanding of basic principles can lead to new insight into the problems of cardiac patients.

Principles of Molecular Cardiology

Marschall S. Runge,Cam Patterson
Principles of Molecular Cardiology Book PDF

Author : Marschall S. Runge,Cam Patterson
Publisher : Springer Science & Business Media
Page : 604 pages
File Size : 50,5 Mb
Release : 2007-11-14
Category : Medical
ISBN : 9781592598786

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Principles of Molecular Cardiology by Marschall S. Runge,Cam Patterson Pdf

An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

Molecular Cardiology in Clinical Practice

Michael R. Sanders,John B. Kostis
Molecular Cardiology in Clinical Practice Book PDF

Author : Michael R. Sanders,John B. Kostis
Publisher : Springer Science & Business Media
Page : 234 pages
File Size : 48,9 Mb
Release : 2007-11-23
Category : Medical
ISBN : 9780585381411

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Molecular Cardiology in Clinical Practice by Michael R. Sanders,John B. Kostis Pdf

Cardiology is an area of great recent triumphs in pharmacological and surgical treatment, yet cardiovascular disease remains the leading cause of death and disability in the industrialized world. Coronary disease, heart failure, stroke and sudden arrhythmic cardiac death challenge both medical practitioners and scientists. With the dawning of the new `molecular' era, there is an awakened hope that a more fundamental understanding of biologic processes may eventually lead to new progress in the prevention and treatment of these persistent and seemingly intransigent problems. Molecular Cardiology in Clinical Practice brings together an outstanding panel of experts in cardiovascular disease who have been at the forefront of the application of molecular medicine to cardiology. Its intent is to help bridge the gap between modern medical practice and modern science, in the belief that an understanding of basic principles can lead to new insight into the problems of cardiac patients.

Molecular Cardiology for the Cardiologists

Bernard Swynghedauw
Molecular Cardiology for the Cardiologists Book PDF

Author : Bernard Swynghedauw
Publisher : Springer Science & Business Media
Page : 266 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461520191

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Molecular Cardiology for the Cardiologists by Bernard Swynghedauw Pdf

Molecular Cardiology for the Cardiologist provides a short, easily readable summary of what the new biology brings to cardiology. With this in mind, special efforts have been made to present many comprehensive schemes and drawings, as well as teaching tables. The five parts of the book provide a general introduction to the new language of biology; the normal structure of the heart and blood vessels; the physiopathology and the new therapeutic avenues that have been opened up by the new biology. A concise summary of the keys that assist the cardiologist or student who seeks to learn and read more about this field. Provides practical examples to illustrate the clinical interest of the new approach.

Molecular Cardiology for the Cardiologist

Bernard Swynghedauw
Molecular Cardiology for the Cardiologist Book PDF

Author : Bernard Swynghedauw
Publisher : Springer Science & Business Media
Page : 191 pages
File Size : 51,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461549697

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Molecular Cardiology for the Cardiologist by Bernard Swynghedauw Pdf

Molecular Cardiology for the Cardiologist, Second Edition provides a short, easily readable summary of what the new biology brings to cardiology. Special efforts have been made to include comprehensive diagrams and drawings, as well as teaching tables, and also to keep the size of the second edition within the modest limits of the first edition. The book remains divided into 5 parts. The first part is a general introduction to the new terminology. The second part is devoted to the normal structure of the heart and vessels. Parts 3 and 4 deal with physiopathology. One of the important contributions of molecular biology to cardiology is a better understanding of the general process of adaptation of the heart and vessels to a permanent mechanical overloading. Such a process is generally called remodeling, and results from coordinate changes in the expression of the genes. The last part of the book includes information on gene and cellular therapy.

Translational Cardiology

Cam Patterson,Monte S. Willis
Translational Cardiology Book PDF

Author : Cam Patterson,Monte S. Willis
Publisher : Springer Science & Business Media
Page : 556 pages
File Size : 50,5 Mb
Release : 2012-07-04
Category : Medical
ISBN : 9781617798917

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Translational Cardiology by Cam Patterson,Monte S. Willis Pdf

Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.

Heart Failure: From Research to Clinical Practice

Md. Shahidul Islam
Heart Failure From Research to Clinical Practice Book PDF

Author : Md. Shahidul Islam
Publisher : Springer
Page : 418 pages
File Size : 42,7 Mb
Release : 2018-05-14
Category : Medical
ISBN : 9783319782805

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Heart Failure: From Research to Clinical Practice by Md. Shahidul Islam Pdf

“Heart Failure: From Research to Clinical Practice” contains chapters that describe the current views on the biological mechanisms, clinical assessment, diagnosis and evidence-based treatments of the condition. Topics in this volume range from basic research at cell and molecular level to patient care in everyday clinical practice and provide essential background information and analyses of recent advances for a deeper understanding of the issues involved. With contributions from international experts in their specified fields and are suitable for both beginners and more advanced readers. This volume includes not only the essential information for clinical practice but also the latest information from the contemporary guidelines and the recommendations from leading societies. It also covers ongoing research and puts forward new hypotheses that can be tested in future research. This comprehensive volume will provide a valuable resource for both research students and expert clinicians.

Cellular and Molecular Pathobiology of Cardiovascular Disease

Monte Willis,Jonathon W. Homeister,James R. Stone
Cellular and Molecular Pathobiology of Cardiovascular Disease Book PDF

Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Page : 339 pages
File Size : 52,7 Mb
Release : 2013-12-23
Category : Medical
ISBN : 9780124055254

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Cellular and Molecular Pathobiology of Cardiovascular Disease by Monte Willis,Jonathon W. Homeister,James R. Stone Pdf

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Clinical Cardiogenetics

H.F. Baars,P.A.F.M. Doevendans,J.J. van der Smagt
Clinical Cardiogenetics Book PDF

Author : H.F. Baars,P.A.F.M. Doevendans,J.J. van der Smagt
Publisher : Springer Science & Business Media
Page : 453 pages
File Size : 48,6 Mb
Release : 2010-12-25
Category : Medical
ISBN : 9781849964715

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Clinical Cardiogenetics by H.F. Baars,P.A.F.M. Doevendans,J.J. van der Smagt Pdf

Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included. This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as: Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?

Molecular Cardiology

Zhongjie Sun
Molecular Cardiology Book PDF

Author : Zhongjie Sun
Publisher : Springer Science & Business Media
Page : 410 pages
File Size : 52,6 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592598793

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Molecular Cardiology by Zhongjie Sun Pdf

The aim of Molecular Cardiology: Methods and Protocols is to document state-of-the-art molecular and genetic techniques in the area of cardiology. These modern approaches enable researchers to readily study heart diseases at the molecular level and will promote the development of new therapeutic str- egies. Methods for genetic dissection, signal transduction, and microarray analysis are excellent tools for the study of the molecular mechanisms of cardiovascular diseases. Protocols for transgenesis take advantage of recent advances in many areas of molecular and cell biology. Transgenic models of heart diseases (cardiac hypertrophy, cardiac dysfunction, and so on. ) are powerful tools for the study of heart disease pathogenesis. Methods for gene transfer to heart tissue using viral and nonviral vectors form the basis of gene therapy for heart diseases. Heart-specific promoters containing a hypox- inducible cardioprotective gene switch are key for protection of the heart from ischemia. Gene and stem cell therapies open novel and exciting avenues for the prevention and treatment of heart diseases. Molecular Cardiology: Methods and Protocols consists of 26 chapters de- ing with various aspects of molecular cardiology, including gene transfer and gene therapy for cardiovascular disease, stem cell therapy for cardiovascular disease, gene analysis in the injured and hypertrophied heart, and transgenesis in cardiovascular research. This book provides step-by-step methods for the successful completion of experimental procedures, and would be useful for both experienced and new investigators in the field of molecular cardiology.

Molecular and Subcellular Cardiology

S. Sideman,Rafael Beyar
Molecular and Subcellular Cardiology Book PDF

Author : S. Sideman,Rafael Beyar
Publisher : Springer Science & Business Media
Page : 351 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461518938

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Molecular and Subcellular Cardiology by S. Sideman,Rafael Beyar Pdf

The Henry Goldberg Workshops were set up to address the following goals: (1) To foster interdisciplinary interaction between scientists and cardiologists, identify missing links, and catalyze new ideas. (2) To relate basic microscale phenomena to the global, clinically manifested cardiac function. (3) To relate conceptual modeling and quantitative analysis to experimental and clinical data. (4) To encourage international cooperation so as to disperse medical and technological knowhow and lead to better understanding of the cardiac system. The first Henry Goldberg Workshop, held in Haifa in 1984, introduced the concept of interaction between cardiac mechanics, electrical activation, perfusion, and metabolism, emphasizing imaging in the clinical environment. The second Workshop, in 1985, discussed the same parameters with a slant towards the control aspects. The third Goldberg Workshop, held in the USA at Rutgers University in 1986, highlighted the transformation of the microscale activation phenomena to macroscale activity and performance, relating electrophysiology, energy metabolism, and cardiac mechanics. The fourth Goldberg Workshop, in 1987, continued the effort to elucidate the interactions among the various parameters affecting cardiac performance, with emphasis on the ischemic heart. The fifth Workshop, held in Cambridge, UK, in 1988, dwelt on the effects of inhomogeneity of the cardiac muscle on its performance in health and disease. The sixth Workshop highlighted the role of new modem imaging techniques, that allow us to gain more insight into local and global cardiac performance in cardiac research and clinical practice.

Molecular Defects in Cardiovascular Disease

Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal
Molecular Defects in Cardiovascular Disease Book PDF

Author : Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal
Publisher : Springer Science & Business Media
Page : 381 pages
File Size : 44,6 Mb
Release : 2011-08-09
Category : Medical
ISBN : 9781441971302

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Molecular Defects in Cardiovascular Disease by Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal Pdf

Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics. Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment. The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction. The remaining two sections provide a more clinical focus. The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling. It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure. The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end. A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology. It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.

Molecular Reviews in Cardiovascular Medicine

K. Lindpaintner,D. Ganten
Molecular Reviews in Cardiovascular Medicine Book PDF

Author : K. Lindpaintner,D. Ganten
Publisher : Springer Science & Business Media
Page : 211 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400900837

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Molecular Reviews in Cardiovascular Medicine by K. Lindpaintner,D. Ganten Pdf

This book represents a cross-sectional account of the advances that the ability to probe the very roots of biological function have produced in the field of cardiovascular medicine. It arose from a series of articles published over the last few years in the Journal of Hypertension, bringing together an illustrous panel of experts from a broad spectrum of theoretical and applied areas of science.

Clinical Cardiogenetics

Hubert F. Baars,Pieter A. F. M. Doevendans,Arjan C. Houweling,J. Peter van Tintelen
Clinical Cardiogenetics Book PDF

Author : Hubert F. Baars,Pieter A. F. M. Doevendans,Arjan C. Houweling,J. Peter van Tintelen
Publisher : Springer
Page : 405 pages
File Size : 44,6 Mb
Release : 2016-11-30
Category : Medical
ISBN : 9783319442037

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Clinical Cardiogenetics by Hubert F. Baars,Pieter A. F. M. Doevendans,Arjan C. Houweling,J. Peter van Tintelen Pdf

Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included. This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as: Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?

Genomic and Molecular Cardiovascular Medicine

Dhavendra Kumar,Arthur A.M. Wilde,Perry Mark Elliott
Genomic and Molecular Cardiovascular Medicine Book PDF

Author : Dhavendra Kumar,Arthur A.M. Wilde,Perry Mark Elliott
Publisher : Elsevier
Page : 462 pages
File Size : 51,7 Mb
Release : 2024-06-24
Category : Science
ISBN : 9780128229200

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Genomic and Molecular Cardiovascular Medicine by Dhavendra Kumar,Arthur A.M. Wilde,Perry Mark Elliott Pdf

The Genomic and Molecular Cardiovascular Medicine largely focuses on pertinent genomic and molecular aspects of cardiovascular medicine relevant to all levels of clinical practice, from primary care to preventive healthcare. The book also focuses on practice applications of translational genomic and molecular developments and advances that impact on cardiovascular system structure and function. Each chapter is evidence-based and comprehensive, with in-depth, cutting-edge knowledge relevant to the practice of clinical cardiology and cardiovascular surgery. The book aims to fill a major gap of knowledge resource focused on genomic and molecular aspects of contemporary cardiovascular medicine and surgery practice. In view of scientific and technical complexities of the field, the book is written by a team of globally acknowledged experts in respective clinical, investigative, therapeutic and preventive aspects. The current practices within cardiovascular medicine and surgery offer excellent opportunity for genomic and molecular applications to achieve the high order effectiveness with maximum efficiency. Includes clinical applications of genomic and molecular new knowledge, along with advances in the practice of cardiovascular medicine and surgery Provides wide coverage of all major clinical and preventive aspects of clinical cardiology, including multi-disciplinary team care Focuses on targeted gene and molecular therapy in clinical cardiovascular medicine and surgery