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Synchrotron Radiation and Structural Proteomics by Eugenia Pechkova,Christian Riekel Pdf
This book presents an overview of the current state of research in both synchrotron radiation and structural proteomics from different laboratories worldwide. The book presents recent research results in the most advanced methods of synchrotron radiation analysis, protein micro- and nano crystallography, X-ray scattering and X-ray optics, coherent
Synchrotron Radiation in Structural Biology by R. Sweet Pdf
The development of synchrotron radiation (SR) as a research tool was driven largely by the needs of materials scientists and solid-state physi cists. However, the availability of SR has extended significantly the capa bility of scientists who study biological structure with radiation. This volume contains some of the results reported at a symposium held at Brookhaven National Laboratory in May 1988 to discuss the application of synchrotron radiation to structural biology. We are grateful for financial support from the u. s. Department of Energy, the National Institutes of Health, Genentech, Inc., Blake Indus tries, Inc., Evans and Sutherland Co., The Upjohn Company, Eli Lilly and Company, Enraf-Nonius Service Corp., and Associated Universities, Inc. We warmly thank Ms. Nancy Siemon for her tireless efforts with correspondence and the manuscripts for this symposium volume. Symposium Committee: Robert M. Sweet, Chair Malcolm S. Capel Benno P. Schoenborn John C. Sutherland Elizabeth C. Theil Stephen W. White Avril D. Woodhead Helen Z. Kondratuk, Coordinator v CONTENTS An Introduction to the Symposium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 R. M. Sweet SYMPOSIUM LECTURE Developments in X-ray Technology and Their Contribution to Structural Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 H. E. Huxley SOME OF THE SYNCHROTRON FACILITIES FOR BIOLOGICAL STRUCTURAL STUDIES MacChess - A Macromolecular Diffraction Resource at the Cornell High Energy Synchrotron Source . . . . . . . . . . . . . . . . . . . 15 W. Schi1dkamp, K. Moffat, B. Batterman, D. Bilderback, T-Y. Teng, A. LeGrand and D. Szebenyi Facilities Available for Biophysics Research at the Stanford Synchrotron Radiation Laboratory. . . . . . . . . . . . . . . . . . . . . 19 R. P."
Proteomics in Biomedicine and Pharmacology by Anonim Pdf
Volume 95 of Advances in Protein Chemistry and Structural Biology focuses on advances in proteomic techniques and their application in biomedicine and pharmacology. This volume describes in detail the applications of these techniques in studying a number of diseases and specific protein modifications and profiles, including phosphoproteomics, glycoproteomics, and more. Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in application of powerful techniques in translational research (biomedicine and pharmacology) Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables
Functional Proteomics and Nanotechnology-Based Microarrays by Josh LaBaer,Claudio Nicolini Pdf
This volume introduces in a coherent and comprehensive fashion the Pan Stanford Series on Nanobiobiotechnology by defining and reviewing the major sectors of Nanobiotechnology and Nanobiosciences with respect to the most recent developments. Nanobiotechnology indeed appears capable of yielding a scientific and industrial revolution along the routes correctly foreseen by the numerous programs on Nanotechnology launched over the last decade by numerous Councils and Governments worldwide, beginning in the late 1995 by the Science and Technology Council in Italy and by the President Clinton in USA and ending this year with President Putin in Russian Federation.
Small Angle Scattering Part A: Methods for Structural Investigation by Anonim Pdf
Small Angle Scattering, Part A: Methods for Structural Investigation, Volume 675 in the Methods in Enzymology series, highlights new advances in the field, with new chapters in this updated release including SAXS foundations and metrics, Contrast variation sample preparation protocols, experimental procedures, and rudimentary analysis, Molecular deuteration for neutron scattering, Planning, Executing and Assessing the Feasibility of SANS Contrast Variation Experiments, Technical considerations for small-angle neutron scattering from biological macromolecules, and Advanced sample environments and capabilities at our synchrotron X-ray beamline with example applications. Additional sections in the book cover SEC-SAXS-MALS data acquisition and processing pipeline at SIBYLS, SEC-SAXS: pros and cons, experimental set-up, examples and software developments, Radiation damage and sample economy for stopped-flow methods in the time regime of millisecond and above, Stopped-flow-time-resolved SAXS, Insights on Temp-jump, time-resolved SAXS, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on Small Angle Scattering: Methods for Structural Investigation
Proteomics and Nanocrystallography by Eugenia Pechkova,C. Nicolini Pdf
The book addresses the most recent developments in structural and functional proteomics underlying the recent contributions given in these areas by our laboratory to the instrumentations, the methods and the procedures as mutuated from the nanoscale sciences and technologies. These developments introduced in the last few years make now possible protein massive identification (mass spectrometry and biomolecular arrays down to nanoamounts) and protein structural characterization in solution and in crystals down to the atomic scale to an extent and to a degree so far unmatched. Emphasis is placed in the growth by nanobiofilm template of protein crystals of any type and size from millimeter to micron, leading in combination with microfocus synchrotron technology and atomic force microscopy to the definition of a new field called nanocrystallography. The few useful examples being shown, concerning yet structurally unsolved proteins, point this very promising approach nanotechnology-based in structural proteomics using highly focused X-rays. This has not to be confused with the important study of nanocrystals, both organic and inorganic, and novel diamond like nanocomposite materials and devices having 3D protein crystals as matrices to be equilibrated with nanoparticles/gold/silver to be utilized in the most diversified electronic applications here also summarized. vii Acknowledgments We are particularly grateful to Giuseppe Zanotti at the University of Padova for his fundamental collaboration during all the crystallographic studies.
Synchrotron Radiation in Materials Science by Chunhai Fan,Zhentang Zhao Pdf
Meeting the long-felt need for in-depth information on one of the most advanced material characterization methods, a top team of editors and authors from highly prestigious facilities and institutions covers a range of synchrotron techniques that have proven useful for materials research. Following an introduction to synchrotron radiation and its sources, the second part goes on to describe the various techniques that benefit from this especially bright light, including X-ray absorption, diffraction, scattering, imaging, and lithography. The thrid and final part provides an overview of the applications of synchrotron radiation in materials science. bridging the gap between specialists in synchrotron research and material scientists, this is a unique and indispensable resource for academic and industrial researchers alike.
Biophysics and Synchrotron Radiation by Antonio Bianconi,Agostina Congiu Castellano Pdf
This book the second volume in the "Springer Series in Biophysics" col lects together contributions to the conference on "Biophysics and Syn chrotron Radiation" held in July 86 at Frascati. This meeting addressed the advances on the structure of biological molecules obtained by using synchrotron radiation. In fact it was most timely to review the results of the research in biophysics which is rapidly developing at synchrotron radiation facilities. Moreover, there was interest to discuss the new perspectives opened up by the future high brilliance synchrotron radia tion sources. With the use of synchrotron radiation, x-ray spectroscopy of biological molecules is firmly established in the techniques of EXAFS and XANES. Contributions to the detailed knowledge of local structure of active sites of metalloproteins by this approach are presented in this volume, together with a number of studies of -the interaction of metal ions with other important biological macromolecular systems. Structural determination of very large biological systems at high reso lution, including a protein and its substrate, are reported. The experi mental advances in protein crystallography presented here reduce the time for solving protein structures, thus satisfying a major require ment of the rapidly-expanding field of protein engineering.
Nuclear Magnetic Resonance by Jacek Wojcik,Krystyna Kamienska-Trela Pdf
With over 17,000 articles concerning NMR published per year, keeping up to date with the latest developments and applications of this technique can prove time-consuming. Now in its 42nd volume, the Specialist Periodical Report on NMR provides a digest of the current literature, compiled by experts in the field. The current volume devotes several chapters to the aspects and applications of spin-spin couplings, and biochemists will find seperate chapters dedicated to proteins, lipids and carbohydrates. Further chapters discuss the latest developments in nuclear sheilding, imaging and NMR in living systems. For a comprehensive account of the latest developments and research using NMR, look no further than Specialist Periodical Reports - Nuclear Magnetic Resonance. An essential book for NMR lab and university shelf.
Modern Diagnostic X-Ray Sources by Rolf Behling Pdf
Now fully updated, the second edition of Modern Diagnostic X-Ray Sources: Technology, Manufacturing, Reliability gives an up-to-date summary of X-ray source technology and design for applications in modern diagnostic medical imaging. It lays a sound groundwork for education and advanced training in the physics of X-ray production, X-ray interactions with matter, and imaging modalities and assesses their prospects. The book begins with a comprehensive and easy-to-read historical overview of X-ray tube and generator development, including key achievements leading up to the current technological and economic state of the field. The book covers the physics of X-ray generation, including the process of constructing X-ray source devices. The stand-alone chapters can be read in order or in selections. They take you inside diagnostic X-ray tubes, illustrating their design, functions, metrics for validation, and interfaces. The detailed descriptions enable objective comparison and benchmarking. This detailed presentation of X-ray tube creation and functions enables you to understand how to optimize tube efficiency, particularly with consideration for economics and environmental care. It also simplifies faultfinding. Along with covering the past and current state of the field, the book assesses the future regarding developing new X-ray sources that can enhance performance and yield greater benefits to the scientific community and to the public. After heading international R&D, marketing and advanced development for X-ray sources with Philips, and working in the X-ray industry for more than four decades, Rolf Behling retired in 2020 and is now the owner of the consulting firm XtraininX, Germany. He holds numerous patents and is continuously publishing, consulting and training.
Nanobiotechnology in Energy, Environment and Electronics by Claudio Nicolini Pdf
This book presents an overview of the current state of research in the field of nanotechnologies and biotechnologies for energy, environment, electronics, and health, as emerging from leading laboratories worldwide. It presents and describes in detail the recent research results in the most advanced nanobiotechnology-based methods and their possibl
Principles of Proteomics is designed specifically to explain the different stages of proteomic analysis, their complexities and their jargon to students and researchers in a non-technical overview of the field. The author describes the broad range of problems which proteomics can address, including structural proteomics, interaction proteomics, protein modification analysis and functional proteomics. Methodologies are described in user-friendly language, from the more traditional two-dimensional gel electrophoresis to the new developments in protein chip technologies. These are well presented in the context of overall strategies which can be adopted to address the different aspects of large-scale protein analysis.
