Synthesis Of Heterocycles Via Multicomponent Reactions I

Author : Romano V. A. Orru,Eelco Ruijter
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 40,6 Mb
Release : 2010-05-12
Category : Science
ISBN : 9783642126741

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Synthesis of Heterocycles via Multicomponent Reactions I by Romano V. A. Orru,Eelco Ruijter Pdf

Contents: L. Banfi ∙ A. Basso ∙ R. Riva: Synthesis of Heterocycles Through Classical Ugi and Passerini Reactions Followed by Secondary Transformations Involving One or Two Additional Functional Groups.- V.A. Chebanov ∙ K. A. Gura ∙ S.M. Desenko: Aminoazoles as Key Reagents in Multicomponent Heterocyclizations.- Y. Huang ∙ K. Khoury ∙ A. Dömling: Piperazine Scaffolds by Multicomponent 3 Reactions: The Piperazine Space 4 in MCR Chemistry 5 Deep MCR Piperazine Space.- N. Elders ∙ E. Ruijter ∙ V.G. Nenajdenko ∙ R.V.A. Orru: α-Acidic Isocyanides in Multicomponent Chemistry.- A. Cukalovic ∙ J.-C.M.R. Monbaliu ∙ C.V. Stevens: Microreactor Technology as an Efficient Tool for Multicomponent Reactions.- L.A. Wessjohann ∙ C.R.B. Rhoden ∙ D.G. Rivera ∙ O. Eichler Vercillo: Cyclic Peptidomimetics and Pseudopeptides from Multicomponent Reactions.- M. del Mar Sanchez Duque ∙ C. Allais ∙ N. Isambert ∙ T. Constantieux ∙ J. Rodriguez: ß-Diketo Building Blocks for MCRs-Based Syntheses of Heterocycles

Author : Romano V. A. Orru,Eelco Ruijter
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 50,7 Mb
Release : 2010-09-05
Category : Science
ISBN : 9783642154546

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Synthesis of Heterocycles Via Multicomponent Reactions II by Romano V. A. Orru,Eelco Ruijter Pdf

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery

Author : Erik Van der Eycken,Upendra K. Sharma
Publisher : John Wiley & Sons
Page : 626 pages
File Size : 42,9 Mb
Release : 2022-03-21
Category : Science
ISBN : 9783527349081

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Multicomponent Reactions towards Heterocycles by Erik Van der Eycken,Upendra K. Sharma Pdf

Presents a wide-ranging overview of essential topics and recent advances in MCR chemistry Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs. Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and C–H functionalization and multicomponent reactions. Provides a thorough overview of heterocycles as input in multicomponent reactions Discusses recent advances in the field of MCR chemistry and progress in the synthesis and functionalization of heterocycles Demonstrates the use of MCRs to simplify synthetic design and achieve complexity and diversity in novel bioactive molecules Highlights examples of multicomponent polymerizations, target-oriented synthesis, and applications of MCR in medicinal chemistry Explains the methodology of using on-resin MCRs to produce heterocycle compounds Illustrating the key role of MCRs towards heterocycles in natural product synthesis, drug discovery, organic synthesis, and other applications, Multicomponent Reactions towards Heterocycles is required reading for synthetic chemists in academia and industry alike.

Author : Anonim
Publisher : Unknown
Page : 292 pages
File Size : 42,5 Mb
Release : 2010
Category : Chemical reactions
ISBN : 3642154565

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Synthesis of Heterocycles Via Multicomponent Reactions II by Anonim Pdf

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery.

Author : K.L. Ameta, Ph.D.,Anshu Dandia
Publisher : CRC Press
Page : 394 pages
File Size : 47,5 Mb
Release : 2017-09-20
Category : Medical
ISBN : 9781498734196

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Multicomponent Reactions by K.L. Ameta, Ph.D.,Anshu Dandia Pdf

This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial applications are heterocyclic in nature. With the recent introduction of high-throughput biological evaluation, the importance of MCRs for drug discovery has been recognized and considerable efforts have been focused especially on the design and development of multi-component procedures for the generation of various bioactive heterocycles due to their significant therapeutic potential.

Author : Romano V. A. Orru,Eelco Ruijter
Publisher : Springer
Page : 292 pages
File Size : 43,7 Mb
Release : 2012-11-05
Category : Science
ISBN : 3642264891

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Synthesis of Heterocycles via Multicomponent Reactions II by Romano V. A. Orru,Eelco Ruijter Pdf

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery

Author : Jieping Zhu,Qian Wang,Meixiang Wang
Publisher : John Wiley & Sons
Page : 512 pages
File Size : 45,8 Mb
Release : 2015-02-09
Category : Science
ISBN : 9783527332373

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Multicomponent Reactions in Organic Synthesis by Jieping Zhu,Qian Wang,Meixiang Wang Pdf

Comprehensive and up-to-date, this book focuses on the latest advances in the field, such as newly developed techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. In addition to carbene-promoted MCRs and frequently applied metal-catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a "who's who" in multicomponent reaction chemistry, this is definitely a must-have for every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies.

Author : Romano V. A. Orru,Eelco Ruijter
Publisher : Springer
Page : 292 pages
File Size : 40,8 Mb
Release : 2010-07-26
Category : Science
ISBN : 9783642154553

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Synthesis of Heterocycles via Multicomponent Reactions II by Romano V. A. Orru,Eelco Ruijter Pdf

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery

Author : K. L. Ameta,Anshu Dandia
Publisher : Springer
Page : 412 pages
File Size : 51,8 Mb
Release : 2014-06-17
Category : Science
ISBN : 9788132218500

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Green Chemistry: Synthesis of Bioactive Heterocycles by K. L. Ameta,Anshu Dandia Pdf

The book presents a succinct summary of methods for the synthesis and biological activities of various different-sized bioactive heterocycles using different green chemistry synthetic methodologies, like microwave, ultrasonic, water mediated, ionic liquids, etc. The book also provides an insight of how green chemistry techniques are specific to the bioactive heterocyclic compounds.

Author : Majid M. Heravi,Vahideh Zadsirjan
Publisher : Elsevier
Page : 438 pages
File Size : 50,5 Mb
Release : 2020-05-29
Category : Science
ISBN : 9780128196953

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Recent Advances in Applications of Name Reactions in Multicomponent Reactions by Majid M. Heravi,Vahideh Zadsirjan Pdf

Recent Advances in Applications of Name Reactions in Multicomponent Reactions is an ideal reference for researchers and postgraduate students studying organic chemistry, as well as synthetic organic chemists working on the development of novel methodologies for the synthesis of various heterocyclic systems, especially drug design and discovery, in both academia and industry. The book reviews recent applications of name reactions in multicomponents for the synthesis of heterocycles and examines recent advances in applications of significant name reactions, such as Ugi and Passirini, Click, Knoevenagel, Michael, Diels-Alder, Aldol, Mannich, Heck, Huisgen, and Suzuki in MCRs. These reactions can be used in the synthesis of a wide variety of novel heterocycles with different sizes and heteroatoms, as well as in the total synthesis of natural products in order to decrease the number of synthetic steps. Since chiral inductions are necessary for most of these sequential name reactions, their asymmetric catalyzed reactions are also described. Includes the synthesis of many heterocycles, which is ideal for synthetic organic chemists engaged in the synthesis of heterocyclic systems Covers the recent advances of asymmetric synthesis of a wide range of heterocycles in satisfactory enantioselectivities (ees) or distereoselectivities (des) Reviews the synthesis of a wide variety of interesting heterocycles by using a combination of different and versatile name reactions via MCRs

Author : Jonathan G. Rudick,Alexander Dömling,Shabnam Shaabani
Publisher : Frontiers Media SA
Page : 100 pages
File Size : 54,7 Mb
Release : 2020-02-20
Category : Electronic
ISBN : 9782889634842

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Isocyanide-based Multicomponent Reactions by Jonathan G. Rudick,Alexander Dömling,Shabnam Shaabani Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Raquel P. Herrera,Eugenia Marqués-López
Publisher : John Wiley & Sons
Page : 528 pages
File Size : 41,9 Mb
Release : 2015-04-01
Category : Science
ISBN : 9781118863978

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Multicomponent Reactions by Raquel P. Herrera,Eugenia Marqués-López Pdf

Addressing a dynamic aspect of organic chemistry, this bookdescribes synthetic strategies and applications for multicomponentreactions – including key routes for synthesizing complexmolecules. • Illustrates the crucial role and theimportant utility of multicomponent reactions (MCRs) to organicsyntheses • Compiles novel and efficient syntheticmulticomponent procedures to give readers a complete picture ofthis class of organic reactions • Helps readers to design efficient andpractical transformations using multicomponent reactionstrategies • Describes reaction background,applications to synthesize complex molecules and drugs, andreaction mechanisms

Author : Erik van der Eycken,C. Oliver Kappe
Publisher : Springer
Page : 0 pages
File Size : 42,9 Mb
Release : 2014-10-18
Category : Science
ISBN : 3642068154

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Microwave-Assisted Synthesis of Heterocycles by Erik van der Eycken,C. Oliver Kappe Pdf

N. Pemberton, E. Chorell, F. Almqvist: Microwave-Assisted Synthesis and Functionalization of 2-Pyridones, 2-Quinolones and other Ring-Fused 2-Pyridones.- M.C. Bagley, M.C. Lubinu: Microwave-Assisted Multicomponent Reactions for the Synthesis of Heterocycles.- T. Besson, V. Thiery: Microwave-Assisted Synthesis of Sulfur and Nitrogen-Containing Heterocycles M. Erdélyi: Solid-Phase Methods for the Microwave-Assisted Synthesis of Heterocycles.- S. Crosignani, B. Linclau: Synthesis of Heterocycles Using Polymer-Supported Reagents under Microwave Irradiation.- B.U.W. Maes: Transition Metal-Based Carbon-Carbon and Carbon-Heteroatom Bond Formation for the Synthesis and Decoration of Heterocycles.- M. Rodriquez and M. Taddei: Synthesis of Heterocycles via Microwave-Assisted Cycloadditions and Cyclocondensations.- N. Kaval, P. Appukkuttan, E. Van der Eycken: The Chemistry of 2-(1H)-Pyrazinones in Solution and on Solid Support

Author : Jean-Philippe Goddard,Max Malacria,Cyril Ollivier
Publisher : John Wiley & Sons
Page : 198 pages
File Size : 54,6 Mb
Release : 2020-04-28
Category : Science
ISBN : 9781786305114

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Multi-component Reactions in Molecular Diversity by Jean-Philippe Goddard,Max Malacria,Cyril Ollivier Pdf

While very useful for studying syntheses of molecular diversity, multi-component reactions also offer rapid access to a variety of complex molecules that are relevant for biological applications. Multi-component Reactions in Molecular Diversity analyzes these reactions, whether they are realized by organometallic, ionic or even radical processes. It highlights popular methods based on monotype reactions (cascade, tandem, domino) and their efficiency and academic industrial domain are illustrated. This book also investigates the most efficient ways to prepare complex molecules. Multi-component reactions are in tune with the concepts of atom and steps economy, which are of prior importance in all the reported processes ? from the laboratory to the pilot scale. The essential criteria for green chemistry are also examined in the book in detail.

Author : Fabio Arico,Oliver Reiser
Publisher : Frontiers Media SA
Page : 95 pages
File Size : 45,9 Mb
Release : 2020-03-09
Category : Electronic
ISBN : 9782889635849

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Green Synthesis of Heterocycles by Fabio Arico,Oliver Reiser Pdf