Systems Biology In Practice

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Systems Biology in Practice

Edda Klipp,Ralf Herwig,Axel Kowald,Christoph Wierling,Hans Lehrach
Systems Biology in Practice Book PDF

Author : Edda Klipp,Ralf Herwig,Axel Kowald,Christoph Wierling,Hans Lehrach
Publisher : John Wiley & Sons
Page : 486 pages
File Size : 51,8 Mb
Release : 2008-07-15
Category : Medical
ISBN : 9783527604883

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Systems Biology in Practice by Edda Klipp,Ralf Herwig,Axel Kowald,Christoph Wierling,Hans Lehrach Pdf

Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation. It provides readers with guidance on how a specific complex biological question may be tackled: - How to formulate questions that can be answered - Which experiments to perform - Where to find information in databases and on the Internet - What kinds of models are appropriate - How to use simulation tools - What can be learned from the comparison of experimental data and modeling results - How to make testable predictions. The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.

Systems Biology

Edda Klipp,Wolfram Liebermeister,Christoph Wierling,Axel Kowald,Hans Lehrach,Ralf Herwig
Systems Biology Book PDF

Author : Edda Klipp,Wolfram Liebermeister,Christoph Wierling,Axel Kowald,Hans Lehrach,Ralf Herwig
Publisher : John Wiley & Sons
Page : 593 pages
File Size : 49,5 Mb
Release : 2013-06-20
Category : Medical
ISBN : 9783527644995

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Systems Biology by Edda Klipp,Wolfram Liebermeister,Christoph Wierling,Axel Kowald,Hans Lehrach,Ralf Herwig Pdf

This advanced textbook is tailored to the needs of introductory course in Systems Biology. It has a compagnion website (www.wiley-vch.de/home/systemsbiology)with solutions to questions in the book and several additional extensive working models. The book is related to the very successful previous title 'Systems Biology in Practice' and has incorporated the feedback and suggestions from many lecturers worldwide. The book addresses biologists as well as engineers and computer scientists. The interdisciplinary team of acclaimed authors worked closely together to ensure a comprehensive coverage with no overlaps in a homogenous and compelling style.

Systems Biology

Edda Klipp,Wolfram Liebermeister,Christoph Wierling,Axel Kowald
Systems Biology Book PDF

Author : Edda Klipp,Wolfram Liebermeister,Christoph Wierling,Axel Kowald
Publisher : John Wiley & Sons
Page : 504 pages
File Size : 52,9 Mb
Release : 2016-03-28
Category : Medical
ISBN : 9783527675661

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Systems Biology by Edda Klipp,Wolfram Liebermeister,Christoph Wierling,Axel Kowald Pdf

This advanced textbook is tailored for an introductory course in Systems Biology and is well-suited for biologists as well as engineers and computer scientists. It comes with student-friendly reading lists and a companion website featuring a short exam prep version of the book and educational modeling programs. The text is written in an easily accessible style and includes numerous worked examples and study questions in each chapter. For this edition, a section on medical systems biology has been included.

Translational Systems Biology: Concepts and Practice for the Future of Biomedical Research

Yoram Vodovotz,Gary An
Translational Systems Biology Concepts and Practice for the Future of Biomedical Research Book PDF

Author : Yoram Vodovotz,Gary An
Publisher : Academic Press
Page : 178 pages
File Size : 46,8 Mb
Release : 2017-11-13
Category : Computers
ISBN : 0128101474

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Translational Systems Biology: Concepts and Practice for the Future of Biomedical Research by Yoram Vodovotz,Gary An Pdf

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. Provides an explicit, reasoned, and systematic approach to dealing with the challenges of translational science across disciplines Establishes the case for including computational modeling at all stages of biomedical research and healthcare delivery, from early pre-clinical studies to long-term care, by clearly delineating efficiency and costs saving important to business investment Guides readers on how to communicate across domains and disciplines, particularly between biologists and computational researchers, to effectively develop multi- and trans-disciplinary research teams "

From Systems Biology to Systems Medicine

James A. Marcum
From Systems Biology to Systems Medicine Book PDF

Author : James A. Marcum
Publisher : Unknown
Page : 252 pages
File Size : 43,8 Mb
Release : 2020-07-09
Category : Systems biology
ISBN : 1536179604

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From Systems Biology to Systems Medicine by James A. Marcum Pdf

Throughout most of the twentieth century, the biomedical model dominated healthcare. However, the biomedical model had its critics, who proposed alternative models to replace it. Eventually, biomedicine became fragmented at its foundations with a variety of approaches to its nature and practice. Medicine's current response to this fragmentation is to combine these disparate approaches into a single system--systems medicine. In the present book, I examine the shift, during the postgenomics era, from the biomedical model to systems medicine vis-à-vis systems biology, as well as the challenges facing systems medicine's implementation in the twenty-first century. The main goal of the present book is to provide a disciplinary framework for examining the rise of systems medicine, especially in terms of the incorporation of systems biology into the biomedical model. To realize that goal, the following questions are addressed. What is a disciplinary framework? And, why is this framework important for understanding systems biology and medicine? Briefly, a disciplinary framework represents the relational structure among disparate disciplines that support and ground a discipline and its corpus. For traditional biology and medicine, that framework consists of various disciplines within the biological and biomedical sciences, including physiology, neuroscience, pathology, and epidemiology--to name a few. For the present purpose, systems biology within the last several decades is reshaping the disciplinary framework of the biological and biomedical sciences, which is also responsible for the emergence of systems medicine. In addition, the challenges facing systems medicine, especially its operationalization and implementation with respect to medical education and practice, as well as research, are also explored.

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine

Qing Yan
Translational Bioinformatics and Systems Biology Methods for Personalized Medicine Book PDF

Author : Qing Yan
Publisher : Academic Press
Page : 182 pages
File Size : 46,8 Mb
Release : 2017-04-18
Category : Computers
ISBN : 9780128043882

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Translational Bioinformatics and Systems Biology Methods for Personalized Medicine by Qing Yan Pdf

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine. Through the description of important cutting-edge technologies in bioinformatics and systems biology, readers may gain an essential understanding of state-of-the-art methodologies. The book discusses topics such as the challenges and tasks in translational bioinformatics; pharmacogenomics, systems biology, and personalized medicine; and the applicability of translational bioinformatics for biomarker discovery, epigenomics, and molecular dynamics. It also discusses data integration and mining, immunoinformatics, and neuroinformatics. With broad coverage of both basic scientific and clinical applications, this book is suitable for a wide range of readers who may not be scientists but who are also interested in the practice of personalized medicine. Introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine Presents a problem-solving oriented methodology to deal with practical problems in various applications Covers both basic scientific and clinical applications in order to enhance the collaboration between researchers and clinicians Brings integrative and multidisciplinary approaches to bridge the gaps among various knowledge domains in the field

Systems Biology

Fred Boogerd,Frank J. Bruggeman,Jan-Hendrik S. Hofmeyr,H.V. Westerhoff
Systems Biology Book PDF

Author : Fred Boogerd,Frank J. Bruggeman,Jan-Hendrik S. Hofmeyr,H.V. Westerhoff
Publisher : Elsevier
Page : 360 pages
File Size : 50,6 Mb
Release : 2007-03-20
Category : Computers
ISBN : 0080475272

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Systems Biology by Fred Boogerd,Frank J. Bruggeman,Jan-Hendrik S. Hofmeyr,H.V. Westerhoff Pdf

Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies. * Answers the question of what distinguishes the living from the non-living * An in-depth look to a vigorous and expanding discipline, from molecule to system * Explores the region between individual components and the system

Computational Systems Biology

Andres Kriete,Roland Eils
Computational Systems Biology Book PDF

Author : Andres Kriete,Roland Eils
Publisher : Academic Press
Page : 548 pages
File Size : 50,5 Mb
Release : 2013-11-26
Category : Computers
ISBN : 9780124059382

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Computational Systems Biology by Andres Kriete,Roland Eils Pdf

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

Systematic

James R. Valcourt
Systematic Book PDF

Author : James R. Valcourt
Publisher : Bloomsbury Publishing USA
Page : 289 pages
File Size : 47,9 Mb
Release : 2017-02-07
Category : Science
ISBN : 9781632860316

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Systematic by James R. Valcourt Pdf

A brilliant young scientist introduces us to the fascinating field that is changing our understanding of how the body works and the way we can approach healing. SYSTEMATIC is the first book to introduce general readers to systems biology, which is improving medical treatments and our understanding of living things. In traditional bottom-up biology, a biologist might spend years studying how a single protein works, but systems biology studies how networks of those proteins work together--how they promote health and how to remedy the situation when the system isn't functioning properly. Breakthroughs in systems biology became possible only when powerful computer technology enabled researchers to process massive amounts of data to study complete systems, and has led to progress in the study of gene regulation and inheritance, cancer drugs personalized to an individual's genetically unique tumor, insights into how the brain works, and the discovery that the bacteria and other microbes that live in the gut may drive malnutrition and obesity. Systems biology is allowing us to understand more complex phenomena than ever before. In accessible prose, SYSTEMATIC sheds light not only on how systems within the body work, but also on how research is yielding new kinds of remedies that enhance and harness the body's own defenses.

Systems-Level Modelling of Microbial Communities

Aarthi Ravikrishnan,Karthik Raman
Systems Level Modelling of Microbial Communities Book PDF

Author : Aarthi Ravikrishnan,Karthik Raman
Publisher : CRC Press
Page : 101 pages
File Size : 43,8 Mb
Release : 2018-09-06
Category : Computers
ISBN : 9780429946073

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Systems-Level Modelling of Microbial Communities by Aarthi Ravikrishnan,Karthik Raman Pdf

Overview of ecological principles underlying natural and synthetic microbial communities Techniques to infer relationships in microbial communities from metagenomic sequences Detailed account of constraint-based methods to decipher metabolic interactions in microbial communities Case studies to illustrate applications of various community modelling approaches Brief outline of experimental methods to understand and characterise microbial communities

An Introduction to Computational Systems Biology

Karthik Raman
An Introduction to Computational Systems Biology Book PDF

Author : Karthik Raman
Publisher : CRC Press
Page : 359 pages
File Size : 50,5 Mb
Release : 2021-05-30
Category : Computers
ISBN : 9780429944529

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An Introduction to Computational Systems Biology by Karthik Raman Pdf

Emphasises a hands-on approach to modelling Strong emphasis on coding and software tools for systems biology Covers the entire spectrum of modelling, from static networks, to dynamic models Thoughtful exercises to test and enable student understanding of concepts Current chapters on exciting new developments like whole-cell modelling and community modelling

Contextualizing Systems Biology

Martin Döring,Imme Petersen,Anne Brüninghaus,Regine Kollek
Contextualizing Systems Biology Book PDF

Author : Martin Döring,Imme Petersen,Anne Brüninghaus,Regine Kollek
Publisher : Springer
Page : 316 pages
File Size : 41,8 Mb
Release : 2015-12-18
Category : Science
ISBN : 9783319171067

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Contextualizing Systems Biology by Martin Döring,Imme Petersen,Anne Brüninghaus,Regine Kollek Pdf

This collective monograph aims at contributing to an improved understanding of the epistemic presumptions, sociocultural implications and historically backgrounds of the newly emerging and currently expanding approach of systems biology. In doing so, it offers empirically grounded, valuable and reflexive information about a paradigmatic shift in the biosciences for a wide range of scientists working in the interdisciplinary areas of systems biology, synthetic biology, molecular biology, biology, the philosophy of science, the sociology of science and scientific knowledge, science and technology studies, technology assessment and the like. The authors of this monograph share the theoretical methodological premise that science is a culturally and socially embedded practice which characterizes our culture as a scientific one and at the same time draws its innovative potential from its socio-cultural context. This dialectic relationship lies at the heart of the current development of systems biology which is conceived as a so-called successor of ‘-omics’ research and triggered by high-throughput information technologies. At the same time a need for a holistic conceptualization of complex biological processes emerges. The title Contextualizing Systems Biology suggests that this book analyzes the development and advent of systems biology from different theoretical and methodological perspectives. We investigate a variety of contexts ranging from the analysis of cognitive contexts (such as basic theoretical concepts) to regulative contexts (policies) to the concrete application of a systems biology in the socio-scientific context of a European research project. In empirically analyzing these different and interrelated layers and dimensions of systems biology, the scope of the book goes beyond present attempts to investigate the advent of new approaches in the biological sciences as it frames and assesses systems biology from an interdisciplinary and integrated perspective.

Systems and Synthetic Biology

Vikram Singh,Pawan K. Dhar
Systems and Synthetic Biology Book PDF

Author : Vikram Singh,Pawan K. Dhar
Publisher : Springer
Page : 385 pages
File Size : 42,7 Mb
Release : 2014-12-15
Category : Science
ISBN : 9789401795142

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Systems and Synthetic Biology by Vikram Singh,Pawan K. Dhar Pdf

This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Systems Biology: A Very Short Introduction

Eberhard O. Voit
Systems Biology A Very Short Introduction Book PDF

Author : Eberhard O. Voit
Publisher : Oxford University Press
Page : 161 pages
File Size : 47,7 Mb
Release : 2020-03-26
Category : Science
ISBN : 9780192563453

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Systems Biology: A Very Short Introduction by Eberhard O. Voit Pdf

Systems biology came about as growing numbers of engineers and scientists from other fields created algorithms which supported the analysis of biological data in incredible quantities. Whereas biologists of the past had been forced to study one item or aspect at a time, due to technical and biological limitations, it suddenly became possible to study biological phenomena within their natural contexts. This interdisciplinary field offers a holistic approach to interpreting these processes, and has been responsible for some of the most important developments in the science of human health and environmental sustainability. This Very Short Introduction outlines the exciting processes and possibilities in the new field of systems biology. Eberhard O. Voit describes how it enabled us to learn how intricately the expression of every gene is controlled, how signaling systems keep organisms running smoothly, and how complicated even the simplest cells are. He explores what this field is about, why it is needed, and how it will affect our understanding of life, particularly in the areas of personalized medicine, drug development, food and energy production, and sustainable stewardship of our environments. Throughout he considers how new tools are being provided from the fields of mathematics, computer science, engineering, physics, and chemistry to grasp the complexity of the countless interacting processes in cells which would overwhelm the cognitive and analytical capabilities of the human mind. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Systems Biology

Leszek Konieczny,Irena Roterman-Konieczna,Paweł Spólnik
Systems Biology Book PDF

Author : Leszek Konieczny,Irena Roterman-Konieczna,Paweł Spólnik
Publisher : Springer Science & Business Media
Page : 214 pages
File Size : 45,7 Mb
Release : 2013-10-01
Category : Medical
ISBN : 9783319013367

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Systems Biology by Leszek Konieczny,Irena Roterman-Konieczna,Paweł Spólnik Pdf

The objective of this book is to present the strategies employed by living organisms on a molecular level and to help understand the basics of Systems Biology. Its content is organized in a way to meet the exponential growth in the volume of biological knowledge, and the need for a multidisciplinary approach in the practice of teaching modern biology. For this reason, the whole material is divided into five chapters, each devoted to a fundamental concept: Structure-Function, Energy, Information, Regulation and Interrelationships. The book describes generic mechanisms which occur in biology and promotes a simulation-based approach to the subject of Systems Biology. The use of basic knowledge as the background for presenting biological problems obligates the teachers to deal with generalized phenomena comprising the ever increasing volume of teaching materials. This book is intended for biologists and is informative for specialists in the areas of computer science, robotics and engineering.