Translational Systems Biology Concepts And Practice For The Future Of Biomedical Research

Translational Systems Biology Concepts And Practice For The Future Of Biomedical Research Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Translational Systems Biology Concepts And Practice For The Future Of Biomedical Research book. This book definitely worth reading, it is an incredibly well-written.

Translational Systems Biology

Yoram Vodovotz,Gary An
Translational Systems Biology Book PDF

Author : Yoram Vodovotz,Gary An
Publisher : Elsevier
Page : 179 pages
File Size : 43,9 Mb
Release : 2014-10-08
Category : Technology & Engineering
ISBN : 9780123978905

Get Book

Translational Systems Biology by Yoram Vodovotz,Gary An Pdf

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. Provides an explicit, reasoned, and systematic approach to dealing with the challenges of translational science across disciplines Establishes the case for including computational modeling at all stages of biomedical research and healthcare delivery, from early pre-clinical studies to long-term care, by clearly delineating efficiency and costs saving important to business investment Guides readers on how to communicate across domains and disciplines, particularly between biologists and computational researchers, to effectively develop multi- and trans-disciplinary research teams

Complex Systems and Computational Biology Approaches to Acute Inflammation

Yoram Vodovotz,Gary An
Complex Systems and Computational Biology Approaches to Acute Inflammation Book PDF

Author : Yoram Vodovotz,Gary An
Publisher : Springer Nature
Page : 307 pages
File Size : 43,5 Mb
Release : 2020-11-04
Category : Medical
ISBN : 9783030565107

Get Book

Complex Systems and Computational Biology Approaches to Acute Inflammation by Yoram Vodovotz,Gary An Pdf

This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling. This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research.

Handbook of Systems Biology

Marian Walhout,Marc Vidal,Job Dekker
Handbook of Systems Biology Book PDF

Author : Marian Walhout,Marc Vidal,Job Dekker
Publisher : Academic Press
Page : 552 pages
File Size : 50,8 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780123859457

Get Book

Handbook of Systems Biology by Marian Walhout,Marc Vidal,Job Dekker Pdf

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines Includes the latest research developments in human and animal models to assist with translational research Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Systems Biology in Practice

Edda Klipp,Ralf Herwig,Axel Kowald,Christoph Wierling,Hans Lehrach
Systems Biology in Practice Book PDF

Author : Edda Klipp,Ralf Herwig,Axel Kowald,Christoph Wierling,Hans Lehrach
Publisher : John Wiley & Sons
Page : 486 pages
File Size : 53,7 Mb
Release : 2008-07-15
Category : Medical
ISBN : 9783527604883

Get Book

Systems Biology in Practice by Edda Klipp,Ralf Herwig,Axel Kowald,Christoph Wierling,Hans Lehrach Pdf

Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation. It provides readers with guidance on how a specific complex biological question may be tackled: - How to formulate questions that can be answered - Which experiments to perform - Where to find information in databases and on the Internet - What kinds of models are appropriate - How to use simulation tools - What can be learned from the comparison of experimental data and modeling results - How to make testable predictions. The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.

Immunomodulatory Biomaterials

Stephen F. Badylak,Jennifer Elisseeff
Immunomodulatory Biomaterials Book PDF

Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Page : 296 pages
File Size : 41,6 Mb
Release : 2021-07-30
Category : Medical
ISBN : 9780128214565

Get Book

Immunomodulatory Biomaterials by Stephen F. Badylak,Jennifer Elisseeff Pdf

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Translational Biology in Medicine

M. Montano
Translational Biology in Medicine Book PDF

Author : M. Montano
Publisher : Elsevier
Page : 228 pages
File Size : 50,7 Mb
Release : 2014-12-08
Category : Science
ISBN : 9781908818652

Get Book

Translational Biology in Medicine by M. Montano Pdf

The recent emphasis in biomedical research on translational biology and personalized medicine is revolutionizing conceptual and experimental approaches to understanding and improving human health. Translational Biology in Medicine begins with an introduction to experimental model systems for disease, such as cell lines, primary cells, stem cells and animal models for disease, followed by a systematic description of genetic and genomic profiling and biomarker validation currently used in biomedical research. Examples of translation studies that have used these models and methods are presented, including studies in aging, tissue repair and chronic infection, each with an emphasis on how personalized medicine is transforming biomedicine. Bioethical considerations in translational study design and bioethical considerations in biomedical research are then covered, before concluding remarks, and a look towards the future of personalized medicine. Describes cellular and animal model systems used in translational research Discusses the use of blood, genetic and genomic biomarkers for disease Presents translational studies in aging, tissue repair and infectious disease biomedicine

Leveraging Biomedical and Healthcare Data

Firas Kobeissy,Kevin Wang,Fadi A. Zaraket,Ali Alawieh
Leveraging Biomedical and Healthcare Data Book PDF

Author : Firas Kobeissy,Kevin Wang,Fadi A. Zaraket,Ali Alawieh
Publisher : Academic Press
Page : 225 pages
File Size : 44,9 Mb
Release : 2018-11-23
Category : Medical
ISBN : 9780128095614

Get Book

Leveraging Biomedical and Healthcare Data by Firas Kobeissy,Kevin Wang,Fadi A. Zaraket,Ali Alawieh Pdf

Leveraging Biomedical and Healthcare Data: Semantics, Analytics and Knowledge provides an overview of the approaches used in semantic systems biology, introduces novel areas of its application, and describes step-wise protocols for transforming heterogeneous data into useful knowledge that can influence healthcare and biomedical research. Given the astronomical increase in the number of published reports, papers, and datasets over the last few decades, the ability to curate this data has become a new field of biomedical and healthcare research. This book discusses big data text-based mining to better understand the molecular architecture of diseases and to guide health care decision. It will be a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in understanding more about how to process and apply great amounts of data to improve their research. Includes at each section resource pages containing a list of available curated raw and processed data that can be used by researchers in the field Provides demonstrative and relevant examples that serve as a general tutorial Presents a list of algorithm names and computational tools available for basic and clinical researchers

Systems Biology

Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski
Systems Biology Book PDF

Author : Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski
Publisher : Springer
Page : 401 pages
File Size : 44,5 Mb
Release : 2018-08-29
Category : Science
ISBN : 9783319929675

Get Book

Systems Biology by Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski Pdf

Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems. Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described. The chapter “Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses” is available open access under a CC BY 4.0 license via link.springer.com.

Translational Medicine

James Mittra,Christopher-Paul Milne
Translational Medicine Book PDF

Author : James Mittra,Christopher-Paul Milne
Publisher : CRC Press
Page : 290 pages
File Size : 49,9 Mb
Release : 2016-04-19
Category : Mathematics
ISBN : 9789814364843

Get Book

Translational Medicine by James Mittra,Christopher-Paul Milne Pdf

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various impli

Translational Biotechnology

Yasha Hasija
Translational Biotechnology Book PDF

Author : Yasha Hasija
Publisher : Academic Press
Page : 453 pages
File Size : 45,8 Mb
Release : 2021-01-17
Category : Medical
ISBN : 9780128219737

Get Book

Translational Biotechnology by Yasha Hasija Pdf

Translational Biotechnology: A Journey from Laboratory to Clinics presents an integrative and multidisciplinary approach to biotechnology to help readers bridge the gaps between fundamental and functional research. The book provides state-of-the-art and integrative views of translational biotechnology by covering topics from basic concepts to novel methodologies. Topics discussed include biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology. Additional sections cover drug discovery, precision medicine and the socioeconomic impact of translational biotechnology. This book is valuable for bioinformaticians, biotechnologists, and members of the biomedical field who are interested in learning more about this promising field. Explains biotechnology in a different light by using an application-oriented approach Discusses practical approaches in the development of precision medicine tools, systems and dynamical medicine approaches Promotes research in the field of biotechnology that is translational in nature, cost-effective and readily available to the community

Recent Advances in Systems Biology Research

A. X. C. N. Valente,Abhijit Sarkar
Recent Advances in Systems Biology Research Book PDF

Author : A. X. C. N. Valente,Abhijit Sarkar
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 48,6 Mb
Release : 2014
Category : Biological systems
ISBN : 1629487368

Get Book

Recent Advances in Systems Biology Research by A. X. C. N. Valente,Abhijit Sarkar Pdf

Driven by rapid developments in protein and DNA sequencing technologies, systems biology has become an important research paradigm. It is marked by an emphasis on integrating data on multiple scales and creating a framework for developing predictive models that are valid across the spectrum of structural hierarchies found in biological systems. This book consists of fourteen original chapters and an introduction that together provide a comprehensive introduction to the subject starting from discussions of its definition and scope and ending in detailed reviews of how the systems approach is affecting clinical research and practice. Most chapters are written to be accessible to a wide readership and contain references to the latest research. Altogether, this is a state-of-the-art description of the present and future of systems biology.

Systems Biology in Drug Discovery and Development

Qing Yan
Systems Biology in Drug Discovery and Development Book PDF

Author : Qing Yan
Publisher : Humana Press
Page : 337 pages
File Size : 54,7 Mb
Release : 2011-08-09
Category : Medical
ISBN : 160761801X

Get Book

Systems Biology in Drug Discovery and Development by Qing Yan Pdf

Due to the failing “one-drug-fits-all” model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading experts provide a practical, state-of-the-art, and holistic view of the translation of systems biology into better drug discovery and personalized medical practice. While the first part of the book describes cutting-edge technologies and methods in the field, the second part illustrates how the technologies can be applied in science for disease understanding and therapeutic discovery. As a volume in the highly successful Methods in Molecular BiologyTM series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and up-to-date, Systems Biology in Drug Discovery and Development: Methods and Protocols covers topics from fundamental concepts to advanced technologies in order to best serve biomedical students and professionals at all levels who are interested in vital integrative studies in molecular biology, genetics, bioinformatics, bioengineering, biochemistry, physiology, pathology, microbiology, immunology, pharmacology, toxicology, drug discovery, and clinical medicine.

Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations

Giorgio Raimondi,Kathryn J. Wood,Alan S. Perelson,Julia C. Arciero
Transplant Rejection and Tolerance Advancing the Field through Integration of Computational and Experimental Investigations Book PDF

Author : Giorgio Raimondi,Kathryn J. Wood,Alan S. Perelson,Julia C. Arciero
Publisher : Frontiers Media SA
Page : 132 pages
File Size : 45,6 Mb
Release : 2017-12-15
Category : Electronic book
ISBN : 9782889452927

Get Book

Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations by Giorgio Raimondi,Kathryn J. Wood,Alan S. Perelson,Julia C. Arciero Pdf

Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the transplanted tissues. Thus, there is a great medical need to understand the complex network of immune system interactions that lead to transplant rejection so that new strategies of intervention can be determined that will redirect the system toward transplant acceptance while preserving immune competence against offending agents. In the past 20 years, the discovery and growing understanding of the positive and negative regulators of the activation of the immune system have fostered new interventional procedures targeting one or the other. While pre-clinical results proved the validity of these strategies, their clinical implementation has been troublesome. These results underscore the need for additional methods to determine the most effective interventions to prevent long-term transplant rejection. New tools of genomics, proteomics and metabolomics are being implemented in powerful analyses that promise the development of better, safer personalized treatments. In parallel, theoretical modeling has emerged as a tool that transcends investigations of individual mechanistic processes and instead unravels the relevant mechanisms of complex systems such as the immune response triggered by a transplant. In this way, theoretical models can be used to identify important behavior that arises from complex systems and thereby delineate emergent properties of biological systems that could not be identified studying single components. Employing this approach, interdisciplinary collaborations among immunologists, mathematicians, and system biologists will yield novel perspectives in the development of more effective strategies of intervention. The aim of this Research Topic is to demonstrate how new insight and methods from theoretical and experimental studies of the immune response can aid in identifying new research directions in transplant immunology. First, techniques from various theoretical and experimental studies with applications to the immune response will be reviewed to determine how they can be adapted to explore the complexity of transplant rejection. Second, recent advances in the acquisition and mining of large data sets related to transplant genomics, proteomics, and metabolomics will be discussed in the context of their predictive power and potential for optimizing and personalizing patient treatment. Last, new perspectives will be offered on the integration of computational immune modeling with transplant and omics data to establish more effective strategies of intervention that promote transplant tolerance.

Biomedical Translational Research

R.C. Sobti,Aastha Sobti
Biomedical Translational Research Book PDF

Author : R.C. Sobti,Aastha Sobti
Publisher : Unknown
Page : 0 pages
File Size : 52,8 Mb
Release : 2022
Category : Electronic
ISBN : 9811643466

Get Book

Biomedical Translational Research by R.C. Sobti,Aastha Sobti Pdf

This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology. The book highlights the applications of artificial intelligence in the diagnosis of infectious diseases and examines the role of system biology approaches for understanding human complexity, variability, and its influence on health and diseases. It presents the applications of flow cytometry in monitoring the progression and treatment of disease. It covers emerging technologies in cancer research, including CRISPR-Cas9, NGS, and nanotechnology. This book is a useful source of information for clinical researchers, basic scientists, biomedical engineers, and computational biologists.

From Systems Biology to Systems Medicine

James A. Marcum
From Systems Biology to Systems Medicine Book PDF

Author : James A. Marcum
Publisher : Unknown
Page : 252 pages
File Size : 46,6 Mb
Release : 2020-07-09
Category : Systems biology
ISBN : 1536179604

Get Book

From Systems Biology to Systems Medicine by James A. Marcum Pdf

Throughout most of the twentieth century, the biomedical model dominated healthcare. However, the biomedical model had its critics, who proposed alternative models to replace it. Eventually, biomedicine became fragmented at its foundations with a variety of approaches to its nature and practice. Medicine's current response to this fragmentation is to combine these disparate approaches into a single system--systems medicine. In the present book, I examine the shift, during the postgenomics era, from the biomedical model to systems medicine vis-à-vis systems biology, as well as the challenges facing systems medicine's implementation in the twenty-first century. The main goal of the present book is to provide a disciplinary framework for examining the rise of systems medicine, especially in terms of the incorporation of systems biology into the biomedical model. To realize that goal, the following questions are addressed. What is a disciplinary framework? And, why is this framework important for understanding systems biology and medicine? Briefly, a disciplinary framework represents the relational structure among disparate disciplines that support and ground a discipline and its corpus. For traditional biology and medicine, that framework consists of various disciplines within the biological and biomedical sciences, including physiology, neuroscience, pathology, and epidemiology--to name a few. For the present purpose, systems biology within the last several decades is reshaping the disciplinary framework of the biological and biomedical sciences, which is also responsible for the emergence of systems medicine. In addition, the challenges facing systems medicine, especially its operationalization and implementation with respect to medical education and practice, as well as research, are also explored.