Targeted Therapies In Lung Cancer Management Strategies For Nurses And Practitioners

Author : Marianne Davies,Beth Eaby-Sandy
Publisher : Springer
Page : 120 pages
File Size : 43,6 Mb
Release : 2019-07-16
Category : Medical
ISBN : 9783030165505

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Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners by Marianne Davies,Beth Eaby-Sandy Pdf

This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.

Author : Federico Cappuzzo
Publisher : Unknown
Page : 128 pages
File Size : 53,9 Mb
Release : 2015
Category : Electronic
ISBN : 3319207423

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Guide to Targeted Therapies: Treatment Resistance in Lung Cancer by Federico Cappuzzo Pdf

This text is a concise and up-to-date review, which discusses the background, development and mechanisms of resistance, testing methods and technology, current and emerging therapies and resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of treatment resistance in lung cancer as well as a summary of current therapies will benefit from this succinct guide.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 51,6 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Anne Kerr
Publisher : Unknown
Page : 280 pages
File Size : 44,7 Mb
Release : 2021-02-23
Category : Medical
ISBN : 1526141027

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Personalised Cancer Medicine by Anne Kerr Pdf

Author : Manzoor Ahmad Mir
Publisher : Academic Press
Page : 262 pages
File Size : 55,6 Mb
Release : 2022-04-28
Category : Science
ISBN : 9780323961370

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Combinational Therapy in Triple Negative Breast Cancer by Manzoor Ahmad Mir Pdf

Combinational Therapy in Triple Negative Breast Cancer discusses TNBC at the molecular level from a holistic approach, focusing on combinational strategies targeting various pathways involved in this specific cancer type. Using a monotherapy for the treatment of cancer, especially high-grade tumors like TNBC, is mostly worthless due to the inherent genetic instability of tumor cells to develop intrinsic and acquired resistance. Combination therapy presents more, or at least the same, effectiveness with lower doses of every single agent and decreases the likelihood of chemoresistance, making it essential to understand for multiple therapy options. The book is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of combinational therapies to treat triple negative breast cancer. Presents up-to-date and cutting-edge knowledge of Triple negative breast cancer (TNBC) biology, clinical aspects and treatment options Discusses novel targets and pathways involved in TNBC Provides insights and approaches for future research on TNBC

Author : Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum
Publisher : National Academies Press
Page : 95 pages
File Size : 43,6 Mb
Release : 2013-06-20
Category : Medical
ISBN : 9780309269445

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Delivering Affordable Cancer Care in the 21st Century by Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum Pdf

Rising health care costs are a central fiscal challenge confronting the United States. National spending on health care currently accounts for 18 percent of gross domestic product (GDP), but is anticipated to increase to 25 percent of GDP by 2037. The Bipartisan Policy Center argues that "this rapid growth in health expenditures creates an unsustainable burden on America's economy, with far-reaching consequences". These consequences include crowding out many national priorities, including investments in education, infrastructure, and research; stagnation of employee wages; and decreased international competitiveness.In spite of health care costs that far exceed those of other countries, health outcomes in the United States are not considerably better. With the goal of ensuring that patients have access to high-quality, affordable cancer care, the Institute of Medicine's (IOM's) National Cancer Policy Forum convened a public workshop, Delivering Affordable Cancer Care in the 21st Century, October 8-9, 2012, in Washington, DC. Delivering Affordable Cancer Care in the 21st Century summarizes the workshop.

Author : Manfred Dietel
Publisher : Springer
Page : 0 pages
File Size : 40,8 Mb
Release : 2014-11-23
Category : Medical
ISBN : 3642432433

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Targeted Therapies in Cancer by Manfred Dietel Pdf

From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.

Author : National Academies of Sciences Engineering and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Childhood Cancers and Disability
Publisher : Unknown
Page : 128 pages
File Size : 50,8 Mb
Release : 2021-09-09
Category : Electronic
ISBN : 0309683491

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Childhood Cancer and Functional Impacts Across the Care Continuum by National Academies of Sciences Engineering and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Childhood Cancers and Disability Pdf

Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Identifying Disabling Medical Conditions Likely to Improve with Treatment
Publisher : National Academies Press
Page : 319 pages
File Size : 54,9 Mb
Release : 2020-07-12
Category : Medical
ISBN : 9780309670951

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Selected Health Conditions and Likelihood of Improvement with Treatment by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Identifying Disabling Medical Conditions Likely to Improve with Treatment Pdf

The Social Security Administration (SSA) administers two programs that provide disability benefits: the Social Security Disability Insurance (SSDI) program and the Supplemental Security Income (SSI) program. SSDI provides disability benefits to people (under the full retirement age) who are no longer able to work because of a disabling medical condition. SSI provides income assistance for disabled, blind, and aged people who have limited income and resources regardless of their prior participation in the labor force. Both programs share a common disability determination process administered by SSA and state agencies as well as a common definition of disability for adults: "the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of not less than 12 months." Disabled workers might receive either SSDI benefits or SSI payments, or both, depending on their recent work history and current income and assets. Disabled workers might also receive benefits from other public programs such as workers' compensation, which insures against work-related illness or injuries occurring on the job, but those other programs have their own definitions and eligibility criteria. Selected Health Conditions and Likelihood of Improvement with Treatment identifies and defines the professionally accepted, standard measurements of outcomes improvement for medical conditions. This report also identifies specific, long-lasting medical conditions for adults in the categories of mental health disorders, cancers, and musculoskeletal disorders. Specifically, these conditions are disabling for a length of time, but typically don't result in permanently disabling limitations; are responsive to treatment; and after a specific length of time of treatment, improve to the point at which the conditions are no longer disabling.

Author : Ravi Salgia
Publisher : Springer
Page : 238 pages
File Size : 41,7 Mb
Release : 2019-06-26
Category : Medical
ISBN : 9783030178321

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Targeted Therapies for Lung Cancer by Ravi Salgia Pdf

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Author : Connie Henke Yarbro,Margaret Hansen Frogge,Michelle Goodman
Publisher : Jones & Bartlett Learning
Page : 784 pages
File Size : 48,9 Mb
Release : 2004
Category : CD-ROMs
ISBN : 0763721425

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Cancer Symptom Management by Connie Henke Yarbro,Margaret Hansen Frogge,Michelle Goodman Pdf

Accompanying CD-ROM contains customizable patient self-care guides.

Author : Donna D. Ignatavicius,M. Linda Workman
Publisher : Elsevier Health Sciences
Page : 1905 pages
File Size : 42,7 Mb
Release : 2013
Category : Medical
ISBN : 9781437728019

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Medical-surgical Nursing by Donna D. Ignatavicius,M. Linda Workman Pdf

Using a uniquely collaborative and reader-friendly approach, expert authors Donna D. Ignatavicius and M. Linda Workman cover all the latest trends, evidence-based treatment guidelines, and additional updated information needed for safe clinical practice in medical-surgical nursing. This seventh edition features an expanded emphasis on patient safety and NCLEX? Examination preparation, new ties to the QSEN priorities for patient safety, and a greater alignment with the language and focus of clinical practice. A new chapter on evidence-based practice and a wealth of effective online learning tools help solidify your mastery of medical-surgical nursing.

Author : Donna D. Ignatavicius,M. Linda Workman
Publisher : Elsevier Health Sciences
Page : 1905 pages
File Size : 41,6 Mb
Release : 2013-12-27
Category : Medical
ISBN : 9780323293440

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Medical-Surgical Nursing - E-Book by Donna D. Ignatavicius,M. Linda Workman Pdf

Using a uniquely collaborative and reader-friendly approach, expert authors Donna D. Ignatavicius and M. Linda Workman cover all the latest trends, evidence-based treatment guidelines, and additional updated information needed for safe clinical practice in medical-surgical nursing. This seventh edition features an expanded emphasis on patient safety and NCLEX® Examination preparation, new ties to the QSEN priorities for patient safety, and a greater alignment with the language and focus of clinical practice. A new chapter on evidence-based practice and a wealth of effective online learning tools help solidify your mastery of medical-surgical nursing. UNIQUE! Collaborative approach presents all medical, surgical, nursing, and other interventions through the lens of the nursing process. Reader-friendly, direct writing style makes this one of the most readable medical-surgical nursing textbooks available. UNIQUE! Cutting-edge focus on the latest trends in nursing practice and nursing education prepares you for both today and tomorrow’s nursing practice. UNIQUE! Integrated tools for NCLEX preparation get you ready for your licensure examination. Chapter-opening Learning Outcomes are linked to Self-Assessment Questions for the NCLEX Examination on the Evolve website. Unique chapter-ending Get Ready for the NCLEX Examination! sections include Key Points organized by NCLEX Client Needs Categories. UNIQUE! Focus on nursing concepts helps bridge the gap between the concepts learned in Nursing Fundamentals, and disorders content learned in the medical-surgical nursing course. UNIQUE! Emphasis on clinical decision-making teaches you to apply concepts to true-to-life clinical situations. UNIQUE! Concentration on the core body of knowledge for the RN level of medical-surgical nursing practice focuses your attention on "need-to-know" content to pass the NCLEX Examination and practice safely as a beginning nurse. Rich array of effective learning aids includes: Best Practice for Patient Safety & Quality Care Best Practice for Emergency Care Patient and Family Education: Preparing for Self-Management Nursing Focus on the Older Adult Home Care Assessment Focused Assessment Common Examples of Drug Therapy Evidence-Based Practice Concept Maps Laboratory Profiles Assessment Using Gordon’s Functional Health Patterns

Author : Kenneth O'Byrne,Valerie Rusch
Publisher : Oxford University Press
Page : 128 pages
File Size : 42,9 Mb
Release : 2006-11-16
Category : Medical
ISBN : 9780191566929

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Malignant Pleural Mesothelioma by Kenneth O'Byrne,Valerie Rusch Pdf

Malignant pleural mesothelioma, a malignancy due largely to asbestos exposure, represents an increasingly common challenge to clinical and medical oncologists, respiratory physicians, and cardiothoracic surgeons, as well as researchers in the field. The disease has yet to reach its peak and is expected to kill over 100,000 people worldwide. As malignant pleural mesothelioma gains in profile, Kenneth O'Byrne and Valerie Rusch present a comprehensive overview of the subject, aimed at all health care professionals who come into contact with patients with the disease. The book includes chapters on epidemiology, diagnosis, histopathology, radiology, surgery, chemotherapy, immune therapy, radiotherapy, and palliative medicine, written by an international team of contributors. A molecular biology section focuses on the carcinogenic effects of asbestos fibres and simian virus 40, angiogenesis and angiogenic growth factors, the immune response, and genetic abnormalities detected in the disease. Future therapies are also covered, as is a perspective on the distinct legal issues related to the disease. This highly-illustrated, full colour book provides the ultimate, timely resource on this devastating disease.

Author : Institute of Medicine,Board on Global Health,Committee on Cancer Control in Low- and Middle-Income Countries
Publisher : National Academies Press
Page : 340 pages
File Size : 50,6 Mb
Release : 2007-01-26
Category : Medical
ISBN : 9780309133982

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Cancer Control Opportunities in Low- and Middle-Income Countries by Institute of Medicine,Board on Global Health,Committee on Cancer Control in Low- and Middle-Income Countries Pdf

Cancer is low or absent on the health agendas of low- and middle-income countries (LMCs) despite the fact that more people die from cancer in these countries than from AIDS and malaria combined. International health organizations, bilateral aid agencies, and major foundations—which are instrumental in setting health priorities—also have largely ignored cancer in these countries. This book identifies feasible, affordable steps for LMCs and their international partners to begin to reduce the cancer burden for current and future generations. Stemming the growth of cigarette smoking tops the list to prevent cancer and all the other major chronic diseases. Other priorities include infant vaccination against the hepatitis B virus to prevent liver cancers and vaccination to prevent cervical cancer. Developing and increasing capacity for cancer screening and treatment of highly curable cancers (including most childhood malignancies) can be accomplished using "resource-level appropriateness" as a guide. And there are ways to make inexpensive oral morphine available to ease the pain of the many who will still die from cancer.