Targeted Therapies In Cancer

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Targeted Therapies in Oncology, Second Edition

Giuseppe Giaccone,Jean-Charles Soria
Targeted Therapies in Oncology Second Edition Book PDF

Author : Giuseppe Giaccone,Jean-Charles Soria
Publisher : CRC Press
Page : 500 pages
File Size : 55,7 Mb
Release : 2013-10-21
Category : Medical
ISBN : 9781842145456

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Targeted Therapies in Oncology, Second Edition by Giuseppe Giaccone,Jean-Charles Soria Pdf

Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.

Targeted Therapies in Breast Cancer

Gw Sledge,George W. Sledge (Jr.)
Targeted Therapies in Breast Cancer Book PDF

Author : Gw Sledge,George W. Sledge (Jr.)
Publisher : Clinical Pub
Page : 0 pages
File Size : 55,9 Mb
Release : 2012-06
Category : Breast
ISBN : 1846920663

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Targeted Therapies in Breast Cancer by Gw Sledge,George W. Sledge (Jr.) Pdf

This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Advances in Cancer Treatment

Iago Dillion Lima Cavalcanti,José Cleberson Santos Soares
Advances in Cancer Treatment Book PDF

Author : Iago Dillion Lima Cavalcanti,José Cleberson Santos Soares
Publisher : Springer Nature
Page : 109 pages
File Size : 42,5 Mb
Release : 2021-02-24
Category : Medical
ISBN : 9783030683344

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Advances in Cancer Treatment by Iago Dillion Lima Cavalcanti,José Cleberson Santos Soares Pdf

This work covers the pathophysiology of cancer, exploring the difficulty of optimal treatment due to the complexity and diversity of cancer types. The search for distinctive molecular biology characteristics of tumor cells is especially relevant in the identification of overexpressed receptors and proteins that can be used as a target for cancer treatment. We highlight the main therapeutic modalities, particularly conventional systemic chemotherapy, addressing its mechanisms of action, therapeutic classes and even the toxic effects. We also describe the main tumor markers, their importance in the diagnosis and treatment of cancer, and the specificity of tumor cells. The first chapters serve as an introduction to the central topic of this book, targeted therapy. Key aspects of target therapy, such as classes of drugs, immunotherapy, monoclonal antibodies, checkpoint inhibitors, cancer vaccines and tyrosine kinase inhibitors are presented, and, for each one, the benefits, as well as the adverse effects are reported. Chapter 6 compares conventional systemic chemotherapy and targeted therapy, identifies the risks and benefits and also the eligibility criteria for patient care. The possibility of targeted therapy replacing conventional chemotherapy is discussed while reviewing studies that demonstrate the benefits of combining both types of treatment. Finally, the introduction of pharmaceutical nanotechnology to improve antineoplastic agents is addressed in the last chapter and sets the direction for future research in cancer treatment. This is a valuable resource for many health professionals including physicians, pharmacists, nurses, researchers and students interested in the field of oncology.

A Beginner's Guide to Targeted Cancer Treatments

Elaine Vickers
A Beginner s Guide to Targeted Cancer Treatments Book PDF

Author : Elaine Vickers
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 44,8 Mb
Release : 2018-05-08
Category : Medical
ISBN : 9781119126836

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A Beginner's Guide to Targeted Cancer Treatments by Elaine Vickers Pdf

The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

Successes and Limitations of Targeted Cancer Therapy

S. Peters,R.A. Stahel
Successes and Limitations of Targeted Cancer Therapy Book PDF

Author : S. Peters,R.A. Stahel
Publisher : Karger Medical and Scientific Publishers
Page : 124 pages
File Size : 54,6 Mb
Release : 2014-02-19
Category : Medical
ISBN : 9783318025422

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Successes and Limitations of Targeted Cancer Therapy by S. Peters,R.A. Stahel Pdf

The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies.

Molecularly Targeted Therapy for Childhood Cancer

Peter J. Houghton,Robert J. Arceci
Molecularly Targeted Therapy for Childhood Cancer Book PDF

Author : Peter J. Houghton,Robert J. Arceci
Publisher : Springer Science & Business Media
Page : 548 pages
File Size : 50,8 Mb
Release : 2010-09-10
Category : Medical
ISBN : 9780387690629

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Molecularly Targeted Therapy for Childhood Cancer by Peter J. Houghton,Robert J. Arceci Pdf

Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.

Targeted Therapies for Solid Tumors

Antonio Russo,Rafael Rosell,Christian Rolfo
Targeted Therapies for Solid Tumors Book PDF

Author : Antonio Russo,Rafael Rosell,Christian Rolfo
Publisher : Humana Press
Page : 269 pages
File Size : 51,9 Mb
Release : 2015-03-11
Category : Medical
ISBN : 9781493920471

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Targeted Therapies for Solid Tumors by Antonio Russo,Rafael Rosell,Christian Rolfo Pdf

This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Targeted Cancer Treatment in Silico

Natalia L. Komarova,Dominik Wodarz
Targeted Cancer Treatment in Silico Book PDF

Author : Natalia L. Komarova,Dominik Wodarz
Publisher : Springer Science & Business Media
Page : 235 pages
File Size : 46,6 Mb
Release : 2013-11-19
Category : Mathematics
ISBN : 9781461483014

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Targeted Cancer Treatment in Silico by Natalia L. Komarova,Dominik Wodarz Pdf

Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.

Targeted Therapies for Lung Cancer

Ravi Salgia
Targeted Therapies for Lung Cancer Book PDF

Author : Ravi Salgia
Publisher : Springer
Page : 238 pages
File Size : 52,8 Mb
Release : 2019-06-26
Category : Medical
ISBN : 9783030178321

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Targeted Therapies for Lung Cancer by Ravi Salgia Pdf

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Targeted Radionuclide Therapy

Tod W. Speer
Targeted Radionuclide Therapy Book PDF

Author : Tod W. Speer
Publisher : Lippincott Williams & Wilkins
Page : 564 pages
File Size : 46,7 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9781451153262

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Targeted Radionuclide Therapy by Tod W. Speer Pdf

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Handbook of Targeted Cancer Therapy and Immunotherapy

Daniel D. Karp,Gerald S. Falchook,JoAnn D. Lim
Handbook of Targeted Cancer Therapy and Immunotherapy Book PDF

Author : Daniel D. Karp,Gerald S. Falchook,JoAnn D. Lim
Publisher : Lippincott Williams & Wilkins
Page : 1277 pages
File Size : 41,5 Mb
Release : 2022-03-28
Category : Medical
ISBN : 9781975179267

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Handbook of Targeted Cancer Therapy and Immunotherapy by Daniel D. Karp,Gerald S. Falchook,JoAnn D. Lim Pdf

Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy, 3rd Edition, includes clinical trial results of more than 250 state-of-the-art targeted therapy and immunotherapy agents, providing a practical, intuitive, colorful overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Daniel D. Karp, Gerald S. Falchook, and JoAnn D. Lim, helps you navigate through the newest research reports and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents. This handbook presents information distilled by dozens of translational research clinicians and other healthcare experts with hundreds of years of cumulative experience in the revolutionary area of genomically based precision oncology.

Targeted Therapies in Oncology

Giuseppe Giaccone,Jean-Charles Soria
Targeted Therapies in Oncology Book PDF

Author : Giuseppe Giaccone,Jean-Charles Soria
Publisher : CRC Press
Page : 498 pages
File Size : 51,9 Mb
Release : 2013-10-21
Category : Medical
ISBN : 9781842145463

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Targeted Therapies in Oncology by Giuseppe Giaccone,Jean-Charles Soria Pdf

Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edi

Molecular Therapies of Cancer

Georg F. Weber
Molecular Therapies of Cancer Book PDF

Author : Georg F. Weber
Publisher : Springer
Page : 488 pages
File Size : 43,8 Mb
Release : 2015-07-22
Category : Medical
ISBN : 9783319132785

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Molecular Therapies of Cancer by Georg F. Weber Pdf

Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.

Handbook of Targeted Cancer Therapy

Daniel D. Karp,Gerald S. Falchook
Handbook of Targeted Cancer Therapy Book PDF

Author : Daniel D. Karp,Gerald S. Falchook
Publisher : Lippincott Williams & Wilkins
Page : 310 pages
File Size : 46,5 Mb
Release : 2014-09-09
Category : Medical
ISBN : 9781469894584

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Handbook of Targeted Cancer Therapy by Daniel D. Karp,Gerald S. Falchook Pdf

Make optimal use of the latest personalized therapeutic strategies with Handbook of Targeted Cancer Therapy! This concise, practical oncology reference examines more than 140 targeted therapy agents for which clinical trial data are available, and explains when and how you can use them to most effectively combat cancer. Approach clinical challenges from any direction with separate sections on Targets by Organ Site, Carcinogenesis from the Perspective of Targeted Therapy, Molecular Targets and Pathways, and Targeted Therapy Agents. Find information easily thanks to a color-coded format and an intuitive organization. Access the complete contents online and on mobile devices, with regular updates to include newly approved treatments. Important state of the art cancer information for caregivers, researchers, other health care professionals, and even patients

Resistance to Targeted Therapies in Multiple Myeloma

Silvia CW Ling,Steven Trieu
Resistance to Targeted Therapies in Multiple Myeloma Book PDF

Author : Silvia CW Ling,Steven Trieu
Publisher : Springer Nature
Page : 154 pages
File Size : 47,8 Mb
Release : 2021-07-23
Category : Medical
ISBN : 9783030734404

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Resistance to Targeted Therapies in Multiple Myeloma by Silvia CW Ling,Steven Trieu Pdf

Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.