Targeting Signaling Pathways In Solid Tumors Part A

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Targeting Signaling Pathways in Solid Tumors Part A

Anonim
Targeting Signaling Pathways in Solid Tumors Part A Book PDF

Author : Anonim
Publisher : Elsevier
Page : 276 pages
File Size : 46,6 Mb
Release : 2024-04-23
Category : Science
ISBN : 9780443235474

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Targeting Signaling Pathways in Solid Tumors Part A by Anonim Pdf

Targeting Signaling Pathways in Solid Tumors, Part A, Volume 385 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Drugging the Undruggable: Advances in Targeting KRAS Signaling in Solid Tumors, Emerging Trends in Gastrointestinal Cancers: Targeting Developmental Pathways in their Carcinogenesis and Tumor Progression, Importance of targeting various cell signaling pathways in solid cancers, Targeting signaling pathways in cancer stem cells: a potential approach for developing novel anticancer therapeutics, Factors affecting heterogeneity in breast cancer microenvironment: A narrative review, and much more. Additional sections cover Exploring TLR Signaling Pathways as Promising Targets in Cervical Cancer: The Road Less Travelled Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Targeting Signaling Pathways in Solid Tumors Part B

Anonim
Targeting Signaling Pathways in Solid Tumors Part B Book PDF

Author : Anonim
Publisher : Elsevier
Page : 260 pages
File Size : 53,6 Mb
Release : 2024-07-01
Category : Science
ISBN : 9780443235498

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Targeting Signaling Pathways in Solid Tumors Part B by Anonim Pdf

Targetting Signaling Pathways in Solid tumour Part B, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Signaling Pathways in Squamous Cancer

Adam B. Glick,Carter Van Waes
Signaling Pathways in Squamous Cancer Book PDF

Author : Adam B. Glick,Carter Van Waes
Publisher : Springer Science & Business Media
Page : 462 pages
File Size : 41,6 Mb
Release : 2010-11-25
Category : Medical
ISBN : 9781441972033

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Signaling Pathways in Squamous Cancer by Adam B. Glick,Carter Van Waes Pdf

Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer. We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.

Cancer Cell Signaling

Kasirajan Ayyanathan
Cancer Cell Signaling Book PDF

Author : Kasirajan Ayyanathan
Publisher : CRC Press
Page : 410 pages
File Size : 44,8 Mb
Release : 2014-06-20
Category : Medical
ISBN : 9781482299458

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Cancer Cell Signaling by Kasirajan Ayyanathan Pdf

This title includes a number of Open Access chapters. Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developing new treatments. The current volume provides an overview of the field and how various cell biology techniques are used to better understand cancer on a cellular level. This easily accessible reference volume offers a comprehensive look at the field of cancer cell signaling. Edited by a researcher from Florida Atlantic University, Cancer Cell Signaling: Targeting Signaling Pathways Towards Therapeutic Approaches to Cancer is an authoritative and easy-to-use reference.

Signaling Pathways in Cancer Pathogenesis and Therapy

David A. Frank
Signaling Pathways in Cancer Pathogenesis and Therapy Book PDF

Author : David A. Frank
Publisher : Springer Science & Business Media
Page : 148 pages
File Size : 49,6 Mb
Release : 2011-11-12
Category : Medical
ISBN : 1461412161

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Signaling Pathways in Cancer Pathogenesis and Therapy by David A. Frank Pdf

In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Anonim
Targeting Cell Survival Pathways to Enhance Response to Chemotherapy Book PDF

Author : Anonim
Publisher : Academic Press
Page : 308 pages
File Size : 48,6 Mb
Release : 2018-03-28
Category : Medical
ISBN : 9780128137543

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Targeting Cell Survival Pathways to Enhance Response to Chemotherapy by Anonim Pdf

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials

Targeted Therapies for Solid Tumors

Antonio Russo,Rafael Rosell,Christian Rolfo
Targeted Therapies for Solid Tumors Book PDF

Author : Antonio Russo,Rafael Rosell,Christian Rolfo
Publisher : Humana Press
Page : 269 pages
File Size : 47,7 Mb
Release : 2015-03-11
Category : Medical
ISBN : 9781493920471

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Targeted Therapies for Solid Tumors by Antonio Russo,Rafael Rosell,Christian Rolfo Pdf

This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Targeting the Wnt Pathway in Cancer

Kathleen H. Goss,Michael Kahn
Targeting the Wnt Pathway in Cancer Book PDF

Author : Kathleen H. Goss,Michael Kahn
Publisher : Springer
Page : 0 pages
File Size : 47,7 Mb
Release : 2014-10-13
Category : Medical
ISBN : 1489981640

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Targeting the Wnt Pathway in Cancer by Kathleen H. Goss,Michael Kahn Pdf

Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

Signal Transduction in Cancer

David A. Frank
Signal Transduction in Cancer Book PDF

Author : David A. Frank
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 41,7 Mb
Release : 2002-12-31
Category : Medical
ISBN : 9781402073403

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Signal Transduction in Cancer by David A. Frank Pdf

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

MTOR Signaling in Metabolism and Cancer

Shile Huang
MTOR Signaling in Metabolism and Cancer Book PDF

Author : Shile Huang
Publisher : Unknown
Page : 204 pages
File Size : 55,7 Mb
Release : 2020
Category : Electronic
ISBN : 303943554X

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MTOR Signaling in Metabolism and Cancer by Shile Huang Pdf

The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this Special Issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting mTOR pathway is a promising strategy to fight against certain human diseases.

Cancer Therapeutic Targets

John L. Marshall
Cancer Therapeutic Targets Book PDF

Author : John L. Marshall
Publisher : Springer
Page : 0 pages
File Size : 55,6 Mb
Release : 2017-06-17
Category : Medical
ISBN : 1441907165

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Cancer Therapeutic Targets by John L. Marshall Pdf

In the past decade, we have experienced an explosion of new information about cancer therapeutic targets. Many of the targets have been validated by the discovery and approval of new medicines which have been approved for the treatment of cancer. On the heels of these successes, innumerable new targets and new potential therapeutics are being developed by many different groups including government agencies, pharmaceutical companies, biotechnology companies, academic institutions, and individual investigators. Understanding the expanding "universe" of cancer therapies is therefore becoming impossible and no single source exists which serves as a reference for the involved parties. Further, the interested parties have vastly different areas of expertise, from focused laboratory based science, to clinical research, to corporate and regulatory oversight. The text would be updated every two years, more often depending on pace of change, interest and sales. While useful online, this reference book would likely be kept in hard copy as well.

Targeting Cellular Signalling Pathways in Lung Diseases

Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija
Targeting Cellular Signalling Pathways in Lung Diseases Book PDF

Author : Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija
Publisher : Springer Nature
Page : 926 pages
File Size : 46,6 Mb
Release : 2021-07-02
Category : Medical
ISBN : 9789813368279

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Targeting Cellular Signalling Pathways in Lung Diseases by Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija Pdf

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Plant-derived Bioactives

Mallappa Kumara Swamy
Plant derived Bioactives Book PDF

Author : Mallappa Kumara Swamy
Publisher : Springer Nature
Page : 592 pages
File Size : 55,7 Mb
Release : 2020-06-27
Category : Science
ISBN : 9789811523618

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Plant-derived Bioactives by Mallappa Kumara Swamy Pdf

Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, “Plant-derived Bioactives: Chemistry and Mode of Action” discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, “Plant-derived Bioactives: Production, Properties and Therapeutic Applications” explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of new drugs.

Inflammation and Cancer

Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Inflammation and Cancer Book PDF

Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 489 pages
File Size : 52,5 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378

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Inflammation and Cancer by Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta Pdf

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Heat Shock Proteins in Cancer

Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Heat Shock Proteins in Cancer Book PDF

Author : Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 46,5 Mb
Release : 2007-09-09
Category : Medical
ISBN : 9781402064012

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Heat Shock Proteins in Cancer by Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca Pdf

Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.