Techniques And Methodological Approaches In Breast Cancer Research

Author : Jose Russo,Irma H. Russo
Publisher : Springer
Page : 287 pages
File Size : 42,8 Mb
Release : 2014-05-14
Category : Medical
ISBN : 9781493907182

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Techniques and Methodological Approaches in Breast Cancer Research by Jose Russo,Irma H. Russo Pdf

This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.

Author : Susan A. Brooks,Adrian Harris
Publisher : Springer Science & Business Media
Page : 507 pages
File Size : 48,8 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592599691

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Breast Cancer Research Protocols by Susan A. Brooks,Adrian Harris Pdf

A collection of both well-established and cutting-edge methods for investigating breast cancer biology not only in the laboratory, but also in clinical settings. These readily reproducible techniques solve a variety of problems, ranging from how to collect, store, and prepare human breast tumor samples for analysis, to analyzing cells in vivo and in vitro. Additional chapters address the technology of handling biopsies, new methods for analyzing genes and gene expression, markers of clinical outcome and progress, analysis of tumor-derived proteins and antigens, validating targets, and investigating the biology of newly discovered genes.

Author : Margot M. Ip,Bonnie B. Asch
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 55,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461542957

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Methods in Mammary Gland Biology and Breast Cancer Research by Margot M. Ip,Bonnie B. Asch Pdf

approaches to the experimental problems that still face us in understanding this most fascinating of organs. Too many people contributed to the completion of this volume to allow acknowledg ment of all the individual efforts, but we particularly thank the reviewers whose input into the editorial process was invaluable and the authors of these chapters who revised their text, sometimes more than once, to bring it to the high standards set by the Editors. The Com mittee gratefully acknowledges the support ofVysis, Inc. , in the publication of a color figure in Chapter 19, by S. Weber-Hall and Trevor Dale. Finally, we wish to express our heartfelt appreciation to Margot Ip and Bonnie Asch, who worked long and hard to bring this volume to fruition. Margaret C. Neville for the Committee on Mammary Gland Biology Preface One of the most exciting and beneficial developments in research on mammary gland biology and breast cancer has been the influx of increased funding to support this work. This influx, which has been due primarily to the tireless efforts of breast cancer activists to gamer addi tional money from various federal and state sources, has led to a rapid expansion of research efforts by attracting numerous new investigators into the field. These new investigators include students, postdoctoral fellows, and scientists from other fields.

Author : Shankar Suman,Garima Suman,Sanjay Mishra
Publisher : Bentham Science Publishers
Page : 401 pages
File Size : 50,8 Mb
Release : 2020-04-30
Category : Medical
ISBN : 9789811451423

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Current Advances in Breast Cancer Research: A Molecular Approach by Shankar Suman,Garima Suman,Sanjay Mishra Pdf

Breast cancer is a recognized disease around the world with varying patient outcomes based on the type of breast cancer, access to healthcare and other factors. Survival rates for breast cancer are significantly lower in metastatic cases than localized cases. Early diagnosis and effective treatments for the efficient management of breast cancer are now in demand , as they help to prolong patient life. There have been many breakthrough developments in the molecular biology of breast cancer research in recent times. Advancements in diagnostic techniques (imaging and biomarker detection) for breast cancer have improved the screening of the disease and have improved patient outcomes. Despite these enhancements, the disease is still lethal for patients and the search for a cure requires a complete understanding of the disease. Current Advances in Breast Cancer Research: A Molecular Approach presents a comprehensive overview of current basic and translational research on the subject. The 14 chapters of the book give emphasis to current knowledge about breast cancer, ongoing challenges, and innovative research findings by different research groups. Readers will find detailed information about breast cancer biology, genetics, clinical diagnostics and treatments. Additional information for advanced readers in life sciences, such as techniques relevant to genomics (including genetic fingerprinting), proteomics, metabolomics and medicine (such as imaging and molecular diagnostics) is also provided. The combination of both basic and advanced information makes this book a useful reference to the student and researcher, alike, seeking an understanding about breast cancer at a molecular level.

Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on Breast Cancer and the Environment: The Scientific Evidence, Research Methodology, and Future Directions
Publisher : National Academies Press
Page : 468 pages
File Size : 49,8 Mb
Release : 2012-04-20
Category : Medical
ISBN : 9780309220699

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Breast Cancer and the Environment by Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on Breast Cancer and the Environment: The Scientific Evidence, Research Methodology, and Future Directions Pdf

Breast cancer remains the most common invasive cancer among women. The primary patients of breast cancer are adult women who are approaching or have reached menopause; 90 percent of new cases in U.S. women in 2009 were diagnosed at age 45 or older. Growing knowledge of the complexity of breast cancer stimulated a transition in breast cancer research toward elucidating how external factors may influence the etiology of breast cancer. Breast Cancer and the Environment reviews the current evidence on a selection of environmental risk factors for breast cancer, considers gene-environment interactions in breast cancer, and explores evidence-based actions that might reduce the risk of breast cancer. The book also recommends further integrative research into the elements of the biology of breast development and carcinogenesis, including the influence of exposure to a variety of environmental factors during potential windows of susceptibility during the full life course, potential interventions to reduce risk, and better tools for assessing the carcinogenicity of environmental factors. For a limited set of risk factors, evidence suggests that action can be taken in ways that may reduce risk for breast cancer for many women: avoiding unnecessary medical radiation throughout life, avoiding the use of some forms of postmenopausal hormone therapy, avoiding smoking, limiting alcohol consumption, increasing physical activity, and minimizing weight gain. Breast Cancer and the Environment sets a direction and a focus for future research efforts. The book will be of special interest to medical researchers, patient advocacy groups, and public health professionals.

Author : Johng S. Rhim,Anatoly Dritschilo,Richard Kremer
Publisher : Springer Nature
Page : 246 pages
File Size : 55,9 Mb
Release : 2019-10-01
Category : Science
ISBN : 9783030222543

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Human Cell Transformation by Johng S. Rhim,Anatoly Dritschilo,Richard Kremer Pdf

This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

Author : Jose Russo
Publisher : Springer Nature
Page : 195 pages
File Size : 53,7 Mb
Release : 2021-07-26
Category : Medical
ISBN : 9783030728151

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The Future of Prevention and Treatment of Breast Cancer by Jose Russo Pdf

The objective of this book is to provide a critical analysis of the present prevention strategies for breast cancer, emphasizing the cost benefits and quality of life of the patient. Rooted in the present knowledge of breast cancer biology and prevention and treatment options, the book will describe the future tools that could be available to oncologists and how these new approaches may change the landscape of recurrence and survival of the disease. Special emphasis will be given to the prevention strategies counterposing the present limitations and conflicting prevention guidelines for both hereditary and preventive non-hereditary breast cancer, and propose how the implementation of new strategies based on the present knowledge could save millions of lives and be more cost efficient. The book will present a critical status of the treatment and prevention of breast cancer and detail how a quantum leap could be achieved in the field by applying present basic research knowledge to clinical application.

Author : Judy Gould,Jennifer Nelson,Sussan Keller-Olaman
Publisher : University of Toronto Press
Page : 313 pages
File Size : 46,6 Mb
Release : 2009-05-16
Category : Medical
ISBN : 9781442691346

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Cancer on the Margins by Judy Gould,Jennifer Nelson,Sussan Keller-Olaman Pdf

Cancer on the Margins presents the findings of the Ontario Breast Cancer Community Research Iniative, an organization created to investigate the experiences of women with breast cancer from marginalized and underrepresented groups. The authors examine the psychosocial needs of women living with breast cancer, while investigating differences in treatment, care, and survivorship amongst Aboriginal women, women of colour, francophone women, lesbians, as well as young women, lower-income women, and women in rural areas. Structured as a guide for similar research, Cancer on the Margins provides a "start to finish" format that reveals the complexities of doing such work at each stage of research, beginning with the study design and ending with the dissemination of results. The authors address the challenges of working with and speaking for these groups of women, the tension between description and interpretation, and the challenge for qualitative work to present findings that positively influence the circumstances of research participants. With a strong commitment to social justice, this volume also shows how participatory research can lead to social change, and indicates effective ways to ensure that research not only reaches, but is also employed in, the communities it intends to serve. Bridging the gap between a wide range of audiences, this vitally important work will be of interest to health professionals, new researchers, policy makers, new researchers, and experienced investigators, as well as the public.

Author : Piper M. Treuting,Suzanne M. Dintzis,Kathleen S. Montine
Publisher : Academic Press
Page : 570 pages
File Size : 41,9 Mb
Release : 2017-08-29
Category : Science
ISBN : 9780128029190

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Comparative Anatomy and Histology by Piper M. Treuting,Suzanne M. Dintzis,Kathleen S. Montine Pdf

The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence Teaches biomedical researchers to examine the histologic changes in their model rodents Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 52,8 Mb
Release : 1997
Category : Electronic
ISBN : OCLC:45512692

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Training Program in Biostatistics for Breast Cancer Research by Anonim Pdf

The purpose of this training program in biostatistics for breast cancer research is to provide biostatisticians with the requisite scientific knowledge to understand current issues in breast cancer research, and training in statistical and epidemiological techniques and research methodology related to breast cancer. The training leads to the doctorate of philosophy in biostatistics. The methods of training include formal course work in biostatistics, epidemiology and biology related to breast cancer, interdisciplinary seminars on current research and biostatistical topics in breast cancer research, and mentored research in collaboration with biostatistics faculty and breast cancer investigators.

Author : Jian Cao
Publisher : Humana Press
Page : 332 pages
File Size : 47,6 Mb
Release : 2018-04-01
Category : Medical
ISBN : 1493980521

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Breast Cancer by Jian Cao Pdf

This volume provides resources, ideas, and bench manuals for the study of breast cancer. This book is divided into five sections: methods used in clinical laboratory for diagnosis (Detection of Molecular Markers of Breast Cancer); methods used in both clinical and research laboratories for testing genetic alterations (Genetic Detection of Breast Cancer) and (Isolation of Breast Cancer Cells); methods used to study the behavior of breast cancer cells (In Vitro Experimental Assays for Breast Cancer); and methods used for mimicking human breast cancer in a living organism (In Vivo Experimental Models for Breast Cancer). Breast Cancer: Methods and Protocols also explores several recently developed techniques for the study of breast cancer progression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Breast Cancer: Methods and Protocols, is a valuable handbook for both graduate and advanced undergraduate students of biological sciences, as well as scientists, technicians, and physicians working in the academic, hospital, or pharmaceutical industry aimed at studying or diagnosing breast cancer.

Author : Umberto Veronesi,Aron Goldhirsch,Paolo Veronesi,Oreste Davide Gentilini,Maria Cristina Leonardi
Publisher : Springer
Page : 0 pages
File Size : 54,8 Mb
Release : 2017-11-20
Category : Medical
ISBN : 3319488465

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Breast Cancer by Umberto Veronesi,Aron Goldhirsch,Paolo Veronesi,Oreste Davide Gentilini,Maria Cristina Leonardi Pdf

This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.

Author : Jose Russo
Publisher : Springer
Page : 235 pages
File Size : 40,6 Mb
Release : 2016-08-10
Category : Medical
ISBN : 9783319408156

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The Pathobiology of Breast Cancer by Jose Russo Pdf

This monograph, written by well renowned breast cancer expect, Dr. Jose Russo, provides new insight on the pathobiology of breast cancer from the most current advances in the field, translational research, initiation and progression of the disease, the mechanism of invasion and metastasis and the concept of stem cells in treatment and drug resistance. The role of personalized medicine and genomic testing are also explored, which will provide a window to the future progress of cancer care.

Author : Morgan Shields
Publisher : Scientific e-Resources
Page : 300 pages
File Size : 40,9 Mb
Release : 2019-08-13
Category : Electronic
ISBN : 9781839473326

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Research Methodology and Statistical Methods by Morgan Shields Pdf

The objective is to indicate instructors that the use of research standards can make them more successful in their activity of advancing learning. The fundamental point is that we don't need to quit educating to do investigate; explore is something we can do while instructing and on the off chance that we do great research, we will improve the situation educating. Research methodology and statistics is a reference direct which offers a legitimate and thorough diagram of key terms and ideas in the regions of research and statistics as concerns the field of connected etymology. The book is expected as an asset to depict the importance and utilization of different ideas, approaches, methods, plans, strategies, instruments, sorts, and procedures of connected semantics look into in a productive and open style. A few sections identifying with measurable parts of research are likewise utilized in order to help the specialist in the effective definition, examination, and execution of the exploration outline and convey the same towards its consistent end.

Author : Kimberly Glass,Maud Fagny,Marieke Lydia Kuijjer
Publisher : Frontiers Media SA
Page : 234 pages
File Size : 49,8 Mb
Release : 2022-07-01
Category : Science
ISBN : 9782889764822

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Applications and Methods in Genomic Networks by Kimberly Glass,Maud Fagny,Marieke Lydia Kuijjer Pdf