Techniques In Neuroanatomical Research

Author : C. Heym,W.-G. Forssmann
Publisher : Springer Science & Business Media
Page : 405 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642680298

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Techniques in Neuroanatomical Research by C. Heym,W.-G. Forssmann Pdf

"Anatomy is the mother of physiology" - this statement was used to characterize the evolution of physiology from anato my as an independent science in the late nineteenth century. It had particular truth for neurophysiology, which started as functional neuroanatomy based on the observation of changes in behaviour after lesions of the nervous system both in ex perimental animals and in human patients. Today, anatomy may again be considered the mother of physiology; however, the meaning of this statement is rather different from that 100 years ago: The modem mother provides a dwelling for an increasing number of children endowed with new functional capabilities. This book provides a good illustration of such se mantic metamorphosis in the case of neuroanatomy. After a long period of little progress in either macroscopic neuroanatomy or neurohistology, during which the heritage of Cajal, Golgi, and others was developed and refined to yield a functional concept of the nervous system, the past two de cades have seen tremendous progress in methods applicable to the analysis of the nervous system. The new era was heralded by the introduction of the electron microscope to investigate the nervous system. This book is an impressive witness to the more recent developments.

Author : Richard T. Robertson
Publisher : Academic Press
Page : 462 pages
File Size : 41,7 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483266404

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Neuroanatomical Research Techniques by Richard T. Robertson Pdf

Neuroanatomical Research Techniques discusses developments in major neuroanatomical research techniques. The book is organized into four parts. Part I deals generally with the preparation and study of brain tissue. It includes a chapter on the microscope, discussing optical magnification, limitations of microscopy, and optical contrasting methods. Other chapters summarize basic techniques for tissue preparation and sectioning; present guidelines for a number of standard, but essential, staining procedures; and present sophisticated and contemporary computer techniques that are proving to be invaluable as neuroanatomy evolves from a qualitative to a quantitative discipline. Part II deals with techniques often used for the study of normal tissue. These include the Golgi method, fluorescence histochemistry, techniques for staining single neurons, and the use of the electron microscope. Part III presents techniques for studying intrinsic connections of the nervous system. These include techniques for silver impregnation of degenerating fibers; autoradiographic technique for studying axonal projections; and somatopetal movement of horseradish peroxidase as a tool for studying connections and neuron morphology. Part IV discusses the interpretation of results from neuroanatomical research techniques and presents examples of the applications of neuroanatomical methods to major problems in physiological psychology.

Author : Walle J.H. Nauta,Sven O.E. Ebbesson
Publisher : Springer Science & Business Media
Page : 701 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642859861

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Contemporary Research Methods in Neuroanatomy by Walle J.H. Nauta,Sven O.E. Ebbesson Pdf

As a source of information on neuroanatomical research methods this Volume is not without precedent. In 1957, at the initiative of Dr. W. F. Windle, a conference was held at the National Institutes of Health, the proceedings of which, edited by Dr. Windle and published by C. C. Thomas under the title "New Research Tech niques of Neuroanatomy", rapidly became something like a standard reference in the field of Neuromorphology. The present editors were emboldened to seek support for a second expose of contemporary research methods in Neuroanatomy by the success of this earlier publication, as well as by the consideration that the years elapsed since its appearance have been, perhaps, more productive of new research methods and strategies in Neuroanatomy than were any dozen consecutive years since the golden decades of the 1870's and 1880's. The decision, which methods to include in this conference, has been a difficult one. For reasons of space alone it would have been impossible to do equal justice to techniques approaching the brain as a neuronal system, the brain as a tissue, or the neuron as a cell. As a brief inspection of the contents of this volume will show, the weight of choice fell upon the first of these alternatives. The reader will find, further more, that not all of the book is devoted to new methods in the strict sense.

Author : Laszlo Zaborszky,Floris G. Wouterlood,José Luis Lanciego
Publisher : Springer Science & Business Media
Page : 703 pages
File Size : 54,7 Mb
Release : 2006-11-22
Category : Medical
ISBN : 9780387289427

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Neuroanatomical Tract-Tracing by Laszlo Zaborszky,Floris G. Wouterlood,José Luis Lanciego Pdf

The first two editions of this title had a tremendous impact in neuroscience. Between the Second edition in 1989 and today, there has been an explosion of information in the field, including advances in molecular techniques, such as genomics and proteomics, which have become increasing important in neuroscience. A renaissance in fluorescence has occurred, driven by the development of new probes, new microscopes, live imagers, and computer processing. The introduction of new markers has enormously stimulated the field, moving it from tissue culture to neurophysiology to functional MRI techniques.

Author : N.J. Strausfeld,T.A. Miller
Publisher : Springer Science & Business Media
Page : 517 pages
File Size : 43,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461260189

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Neuroanatomical Techniques by N.J. Strausfeld,T.A. Miller Pdf

Most neurobiological research is performed on vertebrates, and it is only natural that most texts describing neuroanatomical methods refer almost exclusively to this Phylum. Nevertheless, in recent years insects have been studied intensively and are becoming even more popular in some areas of research. They have advantages over vertebrates with respect to studying genetics of neuronal development and with respect to studying many aspects of integration by uniquely identifiable nerve cells. Insect central nervous system is characterized by its compactness and the rather large number of nerve cells in a structure so small. But despite their size, parts of the insect eNS bear structural comparisons with parts of vertebrate eNS. This applies particularly to the organization of the thoracic ganglia (and spinal cord), to the insect and vertebrate visual sys tems and, possibly, to parts of the olfactory neuropils. The neurons that make up these areas in insects are often large enough to be impaled by microelectrodes and can be injected with dyes. Added to advantages of using a small eNS, into which the sensory periphery is precisely mapped, are the many aspects of insect behaviour whose components can be quan titized and which may find both structural and functional correlates within clearly defined regions of neuropil. Together, these various features make the insect eNS a rewarding object for study. This volume is the first of two that describe both classic and recent methods for neuroanatomical research on insect eNS.

Author : Laszlo Zaborszky,L. Heimer
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 41,8 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781475720556

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Neuroanatomical Tract-Tracing Methods 2 by Laszlo Zaborszky,L. Heimer Pdf

This new edition presents readers with the latest information on neuroscience. This book explores the advances in molecular techniques, genomics and proteomics and the progress in fluorescence.

Author : Stephen M Evans,Ann Marie Janson,Jens Randel Nyengaard
Publisher : Oxford University Press
Page : 128 pages
File Size : 49,6 Mb
Release : 2004-07-08
Category : Medical
ISBN : 9780191500091

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Quantitative Methods in Neuroscience by Stephen M Evans,Ann Marie Janson,Jens Randel Nyengaard Pdf

Stereology is a valuable tool for neuroscientists, allowing them to obtain 3-Dimensional information from 2-Dimensional measurements made on appropriately sampled sections (usually obtained from histological sections or MRI/CT/PET scans). This 3-D information is invaluable in correlating structural/functional relationships in the pursuit of far greater understanding of the function of the central nervous system. However, in carrying out such measurements, often based on limited data sets, there is a risk of experimenter bias. An important feature of modern design based stereology is to be aware of potential sources of bias and eliminate them during the data collection. With many of the major neuroscience journals now insisting that quantitative data be presented, there is a greater need than ever for neuroscientists to understand the theory and practice behind quantitative methods, such as those offered by stereology. Quantitative Methods in Neuroscience is a cookbook of stereological methods written especially for neuroscientists. It provides clear and accessible advice about when and when not to use stereology. Throughout the book, the emphasis is on practical guidance, rather than discussions and formulae. Written by leading scientists in the field of stereology, with a Foreword by D.C. Sterio, the book will be a valuable introduction to these methods for neuroscientists, and all those involved in development of new drug programmes.

Author : William Frederick Windle,National Multiple Sclerosis Society (U.S.)
Publisher : Unknown
Page : 122 pages
File Size : 42,8 Mb
Release : 1957
Category : Nervous system
ISBN : UCAL:B3721917

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New Research Techniques of Neuroanatomy by William Frederick Windle,National Multiple Sclerosis Society (U.S.) Pdf

Author : N.J. Strausfeld,T.A. Miller
Publisher : Springer
Page : 496 pages
File Size : 42,6 Mb
Release : 2011-12-14
Category : Science
ISBN : 1461260191

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Neuroanatomical Techniques by N.J. Strausfeld,T.A. Miller Pdf

Most neurobiological research is performed on vertebrates, and it is only natural that most texts describing neuroanatomical methods refer almost exclusively to this Phylum. Nevertheless, in recent years insects have been studied intensively and are becoming even more popular in some areas of research. They have advantages over vertebrates with respect to studying genetics of neuronal development and with respect to studying many aspects of integration by uniquely identifiable nerve cells. Insect central nervous system is characterized by its compactness and the rather large number of nerve cells in a structure so small. But despite their size, parts of the insect eNS bear structural comparisons with parts of vertebrate eNS. This applies particularly to the organization of the thoracic ganglia (and spinal cord), to the insect and vertebrate visual sys tems and, possibly, to parts of the olfactory neuropils. The neurons that make up these areas in insects are often large enough to be impaled by microelectrodes and can be injected with dyes. Added to advantages of using a small eNS, into which the sensory periphery is precisely mapped, are the many aspects of insect behaviour whose components can be quan titized and which may find both structural and functional correlates within clearly defined regions of neuropil. Together, these various features make the insect eNS a rewarding object for study. This volume is the first of two that describe both classic and recent methods for neuroanatomical research on insect eNS.

Author : Anonim
Publisher : Unknown
Page : 98 pages
File Size : 44,9 Mb
Release : 1957
Category : Electronic
ISBN : OCLC:491493456

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New Research Techniques of Neuroanatomy. A Symposium Sponsored by the National Multiple Sclerosis Society (New York, 1956) by Anonim Pdf

Author : Aaron Newman
Publisher : SAGE
Page : 1006 pages
File Size : 41,6 Mb
Release : 2019-03-18
Category : Psychology
ISBN : 9781473952980

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Research Methods for Cognitive Neuroscience by Aaron Newman Pdf

This fresh, new textbook provides a thorough and student-friendly guide to the different techniques used in cognitive neuroscience. Given the breadth of neuroimaging techniques available today, this text is invaluable, serving as an approachable text for students, researchers, and writers. This text provides the right level of detail for those who wish to understand the basics of neuroimaging and also provides more advanced material in order to learn further about particular techniques. With a conversational, student-friendly writing style, Aaron Newman introduces the key principles of neuroimaging techniques, the relevant theory and the recent changes in the field.

Author : Moo K. Chung
Publisher : World Scientific
Page : 424 pages
File Size : 43,6 Mb
Release : 2013
Category : Computers
ISBN : 9789814335430

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Computational Neuroanatomy by Moo K. Chung Pdf

Computational neuroanatomy is an emerging field that utilizes various non-invasive brain imaging modalities, such as MRI and DTI, in quantifying the spatiotemporal dynamics of the human brain structures in both normal and clinical populations. This discipline emerged about twenty years ago and has made substantial progress in the past decade. The main goals of this book are to provide an overview of various mathematical, statistical and computational methodologies used in the field to a wide range of researchers and students, and to address important yet technically challenging topics in further detail.

Author : Lennart Heimer
Publisher : Unknown
Page : 0 pages
File Size : 45,7 Mb
Release : 1981
Category : Electronic
ISBN : OCLC:640087565

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Neuroanatomical tract-tracing Methods by Lennart Heimer Pdf

Author : Lennart Heimer,Martine J. Robards
Publisher : Springer
Page : 567 pages
File Size : 42,6 Mb
Release : 2011-10-13
Category : Medical
ISBN : 1461331919

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Neuroanatomical Tract-Tracing Methods by Lennart Heimer,Martine J. Robards Pdf

Times of dramatic progress in brain research have often been correlated with the development of new and powerful techniques that have changed the kinds of questions one can ask. An historical example may illustrate the point. More than 50 years ago, Nissl studies (Ferraro, 1928) showed that extensive forebrain lesions resulted in chromatolysis and cell loss in the sub­ stantia nigra; thus, it was suggested that the substantia nigra gave rise to projections into the basal forebrain. In the late 1950s, another clue emerged, this time linking observations from the field of neuropathology with a dis­ covery in experimental neuropharmacology (Carlsson, 1959a,b; Ehringer and Hornykiewicz, 1960). It had long been recognized that patients with Par­ kinson's disease suffered neuronal loss in the substantia nigra and that their symptoms were somehow related to striatal dysfunction. Thus, when flu­ orescent catecholamine assays were developed and combined with pharma­ cological and neuropathological studies of Parkinson's disease, the dopamin­ ergic nature of the illness was shown. A bit later, Falck and Hillarp (Falck et at. , 1962) developed a fluorescent histochemical method to visualize mono­ amine-containing cells in the brain; this technique was soon applied to show that the rich dopaminergic terminal field in the striatum derived from neu­ rons in the substantia nigra (Anden et at. , 1964). In the following decade, refinements in the histofluorescent method and the development of sensitive silver impregnation methods permitted a detailed light microscopic explo­ ration of the dopaminergic nigrostriatal system.

Author : William Frederick Windle
Publisher : Unknown
Page : 108 pages
File Size : 44,7 Mb
Release : 2012-05-01
Category : Electronic
ISBN : 1258344254

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New Research Techniques of Neuroanatomy by William Frederick Windle Pdf

Contributing Authors Include Sanford L. Palay, Walle Nauta, Grant Rasmussen, And Many Others.