Teratology

Author : T.V.N. Persaud
Publisher : Springer Science & Business Media
Page : 357 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401166515

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Teratological Testing by T.V.N. Persaud Pdf

The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mec.;hanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The· contributions in this volume deal primarily with the areas of terato logical evaluation and the use of selected animal models for the study of con genital anomalies. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.

Author : H. Kalter
Publisher : Elsevier
Page : 166 pages
File Size : 50,9 Mb
Release : 2003-06-06
Category : Medical
ISBN : 9780080542355

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Teratology in the Twentieth Century by H. Kalter Pdf

This book is an an up-to-date survey and summary of present knowledge and future expectations regarding the environmental causes of congenital malformations in human beings, beginning with the earliest discoveries of the 20th century up to the latest ideas and problems at its end, presents views and comments on the progress made over the century in understanding human prenatal maldevelopment.

Author : C.L. Berry,D.E. Poswillo
Publisher : Springer
Page : 0 pages
File Size : 51,7 Mb
Release : 2011-11-12
Category : Medical
ISBN : 3642661742

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Teratology by C.L. Berry,D.E. Poswillo Pdf

In the fifteen years since the thalidomide disaster teratology has become a science in its own right, distinct from its progenitors, experimental embryology and develop mental biology, but bearing many of the familiar features of both parents. In this growth period there have been contributions from many different scientific disciplines as diverse as molecular biology and obstetrics, which have united in the field of study of congenital malformations. Scientists in academic departments, government research institutes and industrial pharmacology have all explored ways of evaluating the potential of drugs and chem icals to damage the embryo; strict methods of screening for teratogenicity have be come mandatory in most parts of the world. Despite a wealth of basic information in the fields of genetics and embryology, there is little concrete knowledge of the causal mechanisms of malformation in Man, and even less concerning the relevance to Man of those laboratory and animal tests which decide the fate of potentially useful drugs. It is timely, therefore, that in 1975 a group of young and active sci entists and clinicians concerned with the broader implications of teratology should review the past and look to the future of this emerging speciality. In this volume the editors have blended the opinions of teratologists; their message presages change in many of the old and accepted areas of investigative teratology.

Author : C.L. Berry,D.E. Poswillo
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642661723

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Teratology by C.L. Berry,D.E. Poswillo Pdf

In the fifteen years since the thalidomide disaster teratology has become a science in its own right, distinct from its progenitors, experimental embryology and develop mental biology, but bearing many of the familiar features of both parents. In this growth period there have been contributions from many different scientific disciplines as diverse as molecular biology and obstetrics, which have united in the field of study of congenital malformations. Scientists in academic departments, government research institutes and industrial pharmacology have all explored ways of evaluating the potential of drugs and chem icals to damage the embryo; strict methods of screening for teratogenicity have be come mandatory in most parts of the world. Despite a wealth of basic information in the fields of genetics and embryology, there is little concrete knowledge of the causal mechanisms of malformation in Man, and even less concerning the relevance to Man of those laboratory and animal tests which decide the fate of potentially useful drugs. It is timely, therefore, that in 1975 a group of young and active sci entists and clinicians concerned with the broader implications of teratology should review the past and look to the future of this emerging speciality. In this volume the editors have blended the opinions of teratologists; their message presages change in many of the old and accepted areas of investigative teratology.

Author : Thomas H. Shepard,Ronald J. Lemire
Publisher : JHU Press
Page : 564 pages
File Size : 51,7 Mb
Release : 2004
Category : Teratogenic agents
ISBN : 0801879531

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Catalog of Teratogenic Agents by Thomas H. Shepard,Ronald J. Lemire Pdf

Links information on experimental teratogenic agents with the congenital defects in human beings.

Author : T.V.N. Persaud
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401159104

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Teratogenic Mechanisms by T.V.N. Persaud Pdf

The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. This book brings together some of the more recent and important research findings related to the mechanisms and pathogenesis of abnormal develop ment. It is not only a documentation of the latest experimental work, but it also points out future directions that seem productive and challenging.

Author : Harold Kalter
Publisher : Springer Science & Business Media
Page : 368 pages
File Size : 50,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461573111

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Issues and Reviews in Teratology by Harold Kalter Pdf

Teratology is at once among the oldest and youngest of human preoccupations. Coincident with man's first observations of the stars were his recordings of human and animal deformities. But, such aberrancies must have occurred even earlier, for although it is one of those things-like evolution-that cannot be proven, it is nevertheless indisputable that dysmorphogenesis must have occurred from the time complex forms of life first arose on our planet; and that from the beginnings of human awareness our species was conscious of such happenings. From the earliest recordings of this fascination with the form and meaning of abnormality a tortuous but continuous line extends to modern struggles to understand and control these manifestations. And now, after long occupying an honorable but peripheral place in the halls of philosophical and scientific pursuits, teratology has quite suddenly come to take a prominent position at the hub of a complex crossroads of human concerns. This shift in its fortune has taken several forms. Fetal maldevelopment has become the concern of environmentalists, activists of various persuasions, indus trial organizations, government agencies, ethicists, parents-i. e. , individuals and groups whose actions are impelled by apprehension. Such motives are of course not without basis; the trauma of thalidomide left a scar yet raw. For still others clinicians, academics, experimentalists-the upsurge in the interest in fetal mal development is at a different level, and their pursuits are broad, taking external agents as but one of the causes of defective development.

Author : Maxwell T. Masters
Publisher : DigiCat
Page : 510 pages
File Size : 44,5 Mb
Release : 2022-07-31
Category : Fiction
ISBN : EAN:8596547137658

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Vegetable Teratology by Maxwell T. Masters Pdf

DigiCat Publishing presents to you this special edition of "Vegetable Teratology" (An Account of the Principal Deviations from the Usual Construction of Plants) by Maxwell T. Masters. DigiCat Publishing considers every written word to be a legacy of humankind. Every DigiCat book has been carefully reproduced for republishing in a new modern format. The books are available in print, as well as ebooks. DigiCat hopes you will treat this work with the acknowledgment and passion it deserves as a classic of world literature.

Author : Harold Kalter
Publisher : Springer Science & Business Media
Page : 266 pages
File Size : 44,9 Mb
Release : 2010-07-28
Category : Medical
ISBN : 9789048188208

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Teratology in the Twentieth Century Plus Ten by Harold Kalter Pdf

Serious congenital malformations are a major contributor to the infant death rate worldwide. Their nonhereditary causes are multiple and complex, and include infectious and metabolic dangers, disease medication, nutritional inadequacy, medicinal products, environmental agents and pollutants, among them. The cause of many however is still unknown. The wide range of these causes makes the defects of interest to those of a wide range of medical and investigatory backgrounds, especialy clinicians, fundamental scientists, and environmentalists.

Author : H. Kalter
Publisher : Springer Science & Business Media
Page : 332 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461305217

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Issues and Reviews in Teratology by H. Kalter Pdf

Why Efforts to Expand the Meaning of "Teratogen" Are Unacceptable Disagreement about nomenclature in teratology is not new. Dissent even about the very fabric of the discipline-what congenital malformations consist of-has often been voiced. Time, instead of resolving such diffi culties, has sometimes worsened them. For example, in the past it was agreed that congenital malforma tions are abnormalities of structure present at birth, but differences of opinion concerning where the line between normal and abnormal was to be drawn prevailed. It was obvious that, in order to discover the causes of congenital malformations and cast strategies for their prevention, it would be necessary to have knowledge of the baseline of their frequency, and that this required uniformity of definition of terms. Since malfor mations of primary social concern are those having grave outcomes (and are, paradoxically, also the commonest ones), it is logical that such condi tions were the first consideration of investigators and were the defects whose frequency was considered to comprise the required baseline.

Author : James Graves Wilson
Publisher : Unknown
Page : 328 pages
File Size : 42,9 Mb
Release : 1973
Category : Medical
ISBN : UOM:39015003808014

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Environment and Birth Defects by James Graves Wilson Pdf

Author : R. Vogel
Publisher : Tectum Verlag DE
Page : 228 pages
File Size : 50,9 Mb
Release : 1996
Category : Central nervous system
ISBN : 3896081209

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Proceedings on the 9th Teratology Symposium by R. Vogel Pdf

Author : Richard Vogel
Publisher : Tectum Verlag DE
Page : 308 pages
File Size : 43,7 Mb
Release : 2001
Category : Abnormalities, Human
ISBN : 382888248X

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Proceedings on the 10th Teratology Symposium by Richard Vogel Pdf

Author : E.P. Riley,C.V. Vorhees
Publisher : Springer Science & Business Media
Page : 542 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Psychology
ISBN : 9781461321897

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Handbook of Behavioral Teratology by E.P. Riley,C.V. Vorhees Pdf

This book was developed in response to a need in behavioral teratology for a comprehen sive set of reviews of the field's many topics brought together in a single source. This volume represents the first effort to synthesize and integrate research in the field since 1969 when Justin Joffe wrote Prenatal Determinants of Behaviour. Joffe's book became a standard reference for many years, particularly for the experimental design of animal investigations. It has become increasingly evident, however, that some aspects of design once considered inviolate have changed and become part of a more flexible approach. In current research the emphasis is on a set of prioritized, but focused, experimental ques tions rather than on designs which factor all possible variables into every experiment. Also, new design considerations have arisen over the last 15 years, not appreciated when Joffe wrote. Moreover, the sheer volume of new experimental evidence generated since 1969 has increased the content of the field several fold. These considerations made a new review and critical appraisal of the field compelling. The book is divided into four major sections. Part I contains four chapters. These chapters provide discussions of the general principles of behavioral teratogenesis, and information on the historical, governmental, and methodological contexts in which the field operates. The purpose of these chapters is to provide the framework within which the review chapters in the remainder of the book may best be understood.

Author : T. V. N. Persaud,A. E. Chudley,Richard G. Skalko
Publisher : Alan R. Liss
Page : 204 pages
File Size : 50,7 Mb
Release : 1985
Category : Abnormalities
ISBN : UOM:39015007116711

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Basic Concepts in Teratology by T. V. N. Persaud,A. E. Chudley,Richard G. Skalko Pdf