Textbook Of Autoinflammation

Author : Philip J. Hashkes,Ronald M. Laxer,Anna Simon
Publisher : Springer
Page : 820 pages
File Size : 42,6 Mb
Release : 2019-02-13
Category : Medical
ISBN : 9783319986050

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Textbook of Autoinflammation by Philip J. Hashkes,Ronald M. Laxer,Anna Simon Pdf

This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.

Author : Petros Efthimiou
Publisher : Springer
Page : 322 pages
File Size : 43,8 Mb
Release : 2019-01-04
Category : Medical
ISBN : 9783319969299

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Auto-Inflammatory Syndromes by Petros Efthimiou Pdf

This book provides an overview of auto-inflammatory syndromes, covering the underlying immune mechanisms that lead to their development, specific disease presentations, and clinical treatment guidelines. The book is divided into two sections, adult and pediatric, with chapters focusing on individuals diseases such as systemic arthritis, hyper-IgD, pap syndrome, idiopathic recurrent pericarditis, and familial Mediterranean fever. Chapters incorporate the most recent advances in disease pathophysiology and examine the underlying inductive and effector mechanisms and therapies that relate to each auto-inflammatory disorder at the genetic, molecular, cellular, and epidemiologic levels. The book also discusses the research behind auto-inflammatory disorders to offer detailed clinical guidelines regarding diagnostic techniques, treatment plans, and advice on how to best transition pediatric patients into adult treatment. This is an invaluable reference on auto-inflammatory syndromes for clinicians and researchers in pediatric and adult rheumatology and immunology.

Author : James T. Cassidy,Ross E Petty,Ronald M. Laxer,Carol B Lindsley
Publisher : Elsevier Health Sciences
Page : 817 pages
File Size : 53,9 Mb
Release : 2010-10-15
Category : Medical
ISBN : 9781437735963

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Textbook of Pediatric Rheumatology E-Book by James T. Cassidy,Ross E Petty,Ronald M. Laxer,Carol B Lindsley Pdf

Textbook of Pediatric Rheumatology examines the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents, detailing the presentation, differential diagnosis, course, management, and prognosis of every major condition. Drs. James T. Cassidy, Ross E. Petty, Ronald M. Laxer, and Carol B. Lindsley discuss recent developments in diagnosis, treatment, genetics, immunology, imaging, and more. Diagnose and treat effectively through exhaustive reviews of the complex symptoms and signs and lab abnormalities that characterize these clinical disorders. Choose treatment protocols based on the best scientific evidence available today. Apply the knowledge and experience of the leading experts in the field. Keep current with coverage of new topics including macrophage activation syndrome, pediatric sarcoidosis, uveitis, imaging, and occupational and physical therapy. Tap into detailed discussions of recent advances in the field, new research on the immunologic mechanisms of inflammatory disease, and new developments on biologic treatments for arthritis in ten new chapters. Master complex concepts and key techniques with a full-color design and full-color illustrations.

Author : Dirk Holzinger,Raphaela Goldbach-Mansky,Dirk Foell,Marco Gattorno
Publisher : Frontiers Media SA
Page : 119 pages
File Size : 45,9 Mb
Release : 2021-11-24
Category : Medical
ISBN : 9782889716616

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Management of Autoinflammatory Diseases in Childhood by Dirk Holzinger,Raphaela Goldbach-Mansky,Dirk Foell,Marco Gattorno Pdf

Author : Peter H. Hoeger,Veronica Kinsler,Albert C. Yan,Christine Bodemer,Margarita Larralde,David Luk,Vibhu Mendiratta,Diana Purvis
Publisher : John Wiley & Sons
Page : 0 pages
File Size : 53,5 Mb
Release : 2019-12-16
Category : Medical
ISBN : 9781119142195

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Harper's Textbook of Pediatric Dermatology, 2 Volume Set by Peter H. Hoeger,Veronica Kinsler,Albert C. Yan,Christine Bodemer,Margarita Larralde,David Luk,Vibhu Mendiratta,Diana Purvis Pdf

A consummate classic with a fresh approach to pediatric dermatology Children ́s skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment. This fourth edition of the Harper classic provides state-of-the-art information on all aspects of skin disease in children. It covers the diagnosis and treatment of all conditions - both common and rare - with a consistently evidence-based approach. Existing content has been refreshed and fully updated to reflect emerging thinking and to incorporate the latest in research and clinical data - especially at the genetic level. This new fourth edition includes: Greater focus on the genetics behind skin disease, including new genes/genodermatoses, progress in genetic analysis, and stem cell transplants Increased coverage of lasers and other technologies used to treat skin disease More summary tables, learning points, tables of differential diagnosis, and clinical algorithms for diagnosis and management Additional online features, including patient information links and multiple choice questions Harper's Textbook of Pediatric Dermatology delivers crucial clinical insights and up-to-date research information that spans the breadth of the field. As the most comprehensive reference book on this subject available, this revised fourth edition will support and guide the daily practice of both dermatologists and pediatricians across the world.

Author : Christopher E. M. Griffiths,Jonathan Barker,Tanya O. Bleiker,Walayat Hussain,Rosalind C. Simpson
Publisher : John Wiley & Sons
Page : 22867 pages
File Size : 52,8 Mb
Release : 2024-04-16
Category : Medical
ISBN : 9781119709282

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Rook's Textbook of Dermatology by Christopher E. M. Griffiths,Jonathan Barker,Tanya O. Bleiker,Walayat Hussain,Rosalind C. Simpson Pdf

The latest edition of the world’s leading dermatology textbook Rook’s Textbook of Dermatology, 10th Edition is the most definitive, comprehensive and illustrated reference work in dermatology worldwide. Fully updated by experts from around the world, the book highlights the latest key evidence-based developments in pathogenesis, diagnosis and treatment of skin disorders. A highly intuitive resource and invaluable clinical companion for both those training and those fully qualified in dermatology, other highlights of Rook’s Textbook of Dermatology, 10th Edition include: 1. Comprehensive review of essential basic science, skin biology and pharmacology 2. More than 3000 clinical illustrations 3. Histological images to aid clinicopathological correlation 4. Up-to-date management details for all major dermatological disorders including emerging infections 5. All chapters fully referenced together with highlighted key references 6. Quick reference to essential facts, treatment ladders and management algorithms 7. Chapter dedicated to global skin health and inequalities 8. Description of the spectrum of presentations in dermatoses in skin of colour 9. Thorough review of surgical and aesthetic dermatology 10. On-line videos of practical procedures Rook's Textbook of Dermatology, 10th Edition is universally recognised as the most complete reference work for dermatologists of all experience levels and dermatology students worldwide.

Author : Ross E Petty, MD, PhD, FRCPC,Ronald M. Laxer,Carol B Lindsley, MD, FAAP, MACR,Lucy Wedderburn,Robert C Fuhlbrigge, MD PhD,Elizabeth D. Mellins
Publisher : Elsevier
Page : 768 pages
File Size : 48,8 Mb
Release : 2020-12-15
Category : Medical
ISBN : 0323636527

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Textbook of Pediatric Rheumatology by Ross E Petty, MD, PhD, FRCPC,Ronald M. Laxer,Carol B Lindsley, MD, FAAP, MACR,Lucy Wedderburn,Robert C Fuhlbrigge, MD PhD,Elizabeth D. Mellins Pdf

Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease. Offers expanded coverage of autoinflammatory diseases, plus new chapters on Takayasu Arteritis and Other Vasculitides, Mechanistic Investigation of Pediatric Rheumatic Diseases, Genetics and Pediatric Rheumatic Diseases, and Global Issues in Pediatric Rheumatology. Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible. Covers the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies, helping you choose treatment protocols based on the best scientific evidence available today. Features exhaustive reviews of the complex symptoms, signs, and lab abnormalities that characterize these clinical disorders. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Author : Ali Alikhan,Jean-Marie Lachapelle,Howard I. Maibach
Publisher : Springer
Page : 455 pages
File Size : 49,9 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9783642395468

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Textbook of Hand Eczema by Ali Alikhan,Jean-Marie Lachapelle,Howard I. Maibach Pdf

Hand eczema is a major complaint worldwide and a frequent occupational disorder. This book provides a comprehensive and detailed overview of the classification, etiology, diagnosis, prevention, and therapy of hand eczema. It is innovative, up to date, and practical. The links with particular occupations are explained, the various diagnostic tests are presented, and the role of different topical and systemic treatments is clearly described. The authors are world leaders in the field. The "Textbook of Hand Eczema" reflects a new era in hand dermatitis and will be invaluable for all who deal with the condition in their clinical practice.

Author : Robert M. Kliegman,Joseph W. St. Geme III
Publisher : Elsevier Health Sciences
Page : 5923 pages
File Size : 42,9 Mb
Release : 2024-03-29
Category : Medical
ISBN : 9780323883061

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Nelson Textbook of Pediatrics, 2-Volume - E-Book by Robert M. Kliegman,Joseph W. St. Geme III Pdf

Covering every aspect of general pediatric practice, as well as details for many pediatric subspecialists, Nelson Textbook of Pediatrics, 22nd Edition, brings you fully up to date with everything from rapidly changing diagnostic and treatment protocols to new technologies to the wide range of biologic, psychologic, and social problems faced by children today. Edited and written by experts and prominent members of the pediatric medical community, this comprehensive two-volume reference covers both the science and art of pediatric practice. It remains the reference of choice among pediatricians, pediatric residents, and others involved in the care of young patients, delivering the information you need in a concise, easy-to-use format for everyday reference and study. Features a user-friendly format with short chapters and subchapters that allow you to quickly find the information you need. Includes more than 60 new chapters on topics covering the impact of social factors on children’s health, the impact of genetic discoveries on understanding diagnosing and treating childhood diseases, updating of current evidenced based diagnostic and therapeutic approaches to childhood diseases, and more. Offers new and expanded information on gene therapy; interferonopathies; reactive infectious mucocutaneous eruption (RIME); e-cigarette or vaping use-associated lung injury (EVALI); monkeypox; food protein-induced enterocolitis syndrome (FPIES); signaling pathway disorders; ciliopathies; very early onset inflammatory bowel disease; Epstein-Barr virus susceptibility disorders; marijuana smoke exposure; and much more. Features hundreds of new figures and tables throughout for visual clarity and quick reference, real-time videos, and regular updates online, written exclusively for Nelson. Provides fresh perspectives from two new associate editors: Abigail M. Schuh and Cara L. Mack, both of Medical College of Wisconsin. Remains your indispensable source for definitive, evidence-based answers on every aspect of pediatric care. Any additional digital ancillary content may publish up to 6 weeks following the publication date.

Author : Óliver Marín-Peña
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 49,7 Mb
Release : 2012-01-03
Category : Medical
ISBN : 9783642227684

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Femoroacetabular Impingement by Óliver Marín-Peña Pdf

This book is the first monograph to examine all aspects of femoroacetabular impingement (FAI), an important disease first described early in the twenty-first century. Comprising 27 chapters and including many color illustrations, the book contains a variety of points of view from more than 50 experts from 11 countries and represents an up-to-date compilation of professional knowledge on FAI. The full range of available surgical treatments is carefully described and evaluated, including arthroscopic treatment, the open and mini-open approaches, periacetabular osteotomy, hip resurfacing arthroplasty, and combined techniques. Differential diagnosis, imaging, postoperative management, and treatment outcome are also discussed in appropriate detail. It is hoped that this book will promote a comprehensive approach to what is a common pathology and thereby encourage further improvement in treatment.

Author : Ross E. Petty,Ronald M. Laxer,Carol B Lindsley,Lucy Wedderburn,Robert C Fuhlbrigge,Elizabeth D. Mellins
Publisher : Elsevier Health Sciences
Page : 1043 pages
File Size : 43,7 Mb
Release : 2020-12-03
Category : Medical
ISBN : 9780323636537

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Textbook of Pediatric Rheumatology by Ross E. Petty,Ronald M. Laxer,Carol B Lindsley,Lucy Wedderburn,Robert C Fuhlbrigge,Elizabeth D. Mellins Pdf

Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease. Offers expanded coverage of autoinflammatory diseases, plus new chapters on Takayasu Arteritis and Other Vasculitides, Mechanistic Investigation of Pediatric Rheumatic Diseases, Genetics and Pediatric Rheumatic Diseases, and Global Issues in Pediatric Rheumatology. Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible. Covers the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies, helping you choose treatment protocols based on the best scientific evidence available today. Features exhaustive reviews of the complex symptoms, signs, and lab abnormalities that characterize these clinical disorders.

Author : Ross E. Petty
Publisher : Unknown
Page : 128 pages
File Size : 47,8 Mb
Release : 2016
Category : Musculoskeletal system
ISBN : 032324145X

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Cassidy and Petty's textbook of pediatric rheumatology by Ross E. Petty Pdf

Author : Gary S. Firestein,Ralph C. Budd,Sherine E Gabriel,Iain B McInnes,James R. O'Dell
Publisher : Elsevier Health Sciences
Page : 2742 pages
File Size : 46,5 Mb
Release : 2020-07-05
Category : Medical
ISBN : 9780323639217

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Firestein & Kelley’s Textbook of Rheumatology by Gary S. Firestein,Ralph C. Budd,Sherine E Gabriel,Iain B McInnes,James R. O'Dell Pdf

Through 10 outstanding editions, Kelley & Firestein’s Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference. Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making. Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis. Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs. Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology. Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.

Author : Nader Rifai
Publisher : Elsevier Health Sciences
Page : 4232 pages
File Size : 47,9 Mb
Release : 2022-02-03
Category : Medical
ISBN : 9780323834674

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Tietz Textbook of Laboratory Medicine - E-Book by Nader Rifai Pdf

Use THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on Expert Consult — featuring the comprehensive product with fully searchable text, regular content updates, animations, podcasts, over 1300 clinical case studies, lecture series, and more. Authoritative, current content helps you perform tests in a cost-effective, timely, and efficient manner; provides expertise in managing clinical laboratory needs; and shows how to be responsive to an ever-changing environment. Current guidelines help you select, perform, and evaluate the results of new and established laboratory tests. Expert, internationally recognized chapter authors present guidelines representing different practices and points of view. Analytical criteria focus on the medical usefulness of laboratory procedures. Use of standard and international units of measure makes this text appropriate for any user, anywhere in the world. Expert Consult provides the entire text as a fully searchable eBook, and includes regular content updates, animations, podcasts, more than 1300 clinical case studies, over 2500 multiple-choice questions, a lecture series, and more. NEW! 19 additional chapters highlight various specialties throughout laboratory medicine. NEW! Updated, peer-reviewed content provides the most current information possible. NEW! The largest-ever compilation of clinical cases in laboratory medicine is included on Expert Consult. NEW! Over 100 adaptive learning courses on Expert Consult offer the opportunity for personalized education.

Author : Francesco Saverio De Ponte
Publisher : Springer Science & Business Media
Page : 181 pages
File Size : 50,5 Mb
Release : 2011-11-25
Category : Medical
ISBN : 8847020832

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Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach by Francesco Saverio De Ponte Pdf

During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.