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In this riveting medical detective story, Trent Stephens and Rock Brynner recount the history of thalidomide, from the epidemic of birth defects in the 1960's to the present day, as scientists work to create and test an alternative drug that captures thalidomide's curative properties without its cruel side effects. A parable about compassion-and the absence of it-Dark Remedy is a gripping account of thalidomide's extraordinary impact on the lives of individuals and nations over half a century.
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.
"e;This momentous book is the first comprehensive history of thalidomide...It demonstrates how many thousands of victims could have been spared very late in the day if Chemie Grunenthal had taken any notice of the early alarms: ... [It] carries conviction by its scientific rigour, and the clarity of the writing. Fifty years after the deaths and sufferings, the thalidomide tragedy is marked by ... the odour of corruption and cover up."e; - Sir Harold Evans, former editor of The Sunday Times and The Times
Surprisingly, the beginning of a modern approach This collection of articles and commentaries is an to the problems of birth defects is relatively recent integration of information from many disciplines, and dates from Gregg's classical report in 1941 that and presents a comprehensive survey of both recent mothers who contracted rubella during the first tri and previously reported work related to the major mester of pregnancy gave birth to infants with severe aspects of birth defects. In particular, an attempt multiple anomalies. For the first time, an environ has been made to provide a critical assessment of mental agent was found to be teratogenic in man current concepts and to identify areas in need of and was documented in a thoroughly convincing further investigation. manner. Since then, many important discoveries The scope of this volume and space limitations and significant developments have been made, par precluded discussion of and reference to all papers ticularly in the areas of environmental teratogenesis, of relevance or importance: a work of the present hereditary mechanisms, and prenatal diagnosis. nature must necessarily be selective. Some good In recent years, there has been an impressive papers have been left out or given relatively little surge of interest in the causes and prevention of consideration. It is my hope that the list of Further birth defects. Undoubtedly this resulted not only References will be consulted and should compensate from the thalidomide tragedy, but also from the for this lack of completeness.
Thalidomide, was hailed as a "wonder drug" that provided a "safe, sound sleep". Thalidomide was a sedative that was found to be effective when given to pregnant women to combat many of the symptoms associated with morning sickness. The drug was tested on animals. When given to pregnant women, thalidomide was a catastrophic drug with tragic side effects. It caused startling birth malformations, and death to babies. Birth defects included: deafness, blindness, disfigurement, cleft palate, and phocomelia (short limbs). The FDA did not approve thalidomide in the United States. Around the world, in the late 1960's and into the early 1970's, the victims of the drug thalidomide and their families entered into class action legal suits against the various drug companies who manufactured and/or distributed the drug. This book tells the story of thalidomide in Great Britain and how the parents overcame the formidable obstacles placed in their way to secure a just settlement for their children.
The baby started to come out. Head first, everything OK. But then I saw that there were no arms. And then no legs. The little girl had only a torso and a head. Lyn Rowe was born in Melbourne in 1962, seven months after her mother Wendy was given a new wonder drug for morning sickness called thalidomide. For fifty years the Rowe family cared for Lyn. Decades of exhausting, round-the-clock work. But then in 2011 Lyn Rowe launched a legal claim against the thalidomide companies. Against the odds, she won a multi-million-dollar settlement. Former journalist Michael Magazanik is one of the lawyers who ran Lyn’s case. In Silent Shock he exposes a fifty-year cover up concerning history’s most notorious drug, and details not only the damning case against manufacturers Grünenthal—whose enthusiastic promotion of their lucrative drug in the face of mounting evidence beggars belief—but also the moving story of the Rowe family. Spanning Australia, the United States, the United Kingdom, Japan, Canada, Sweden and, of course, Germany, Silent Shock is an epic account of corporate wrongdoing against a backdrop of heroic personal struggle and sacrifice. Michael Magazanik has worked as a journalist for the Age, the Australian and ABC-TV, and is now a lawyer with Slater & Gordon. He lives in Melbourne with his partner and three children. ‘Magazanik exposes myths and concealments on a grand scale... A compelling read. Highly recommended.’ BookMooch ‘Magazanik—a lawyer on the Rowes’ legal team and a former journalist—has woven an extraordinary story...Magazanik has moulded [the Rowes'] story into a modern Australian myth, the battlers who took on the pharmaceuticals and won.' Age/Sydney Morning Herald ‘A harrowing read of the damage wrought by this infamous drug.’ WA Today ‘A frightening account of secrets in the pharmaceutical industry and the inspiring story of a family and their legal team that just wouldn't give up.’ Law Society Journal ‘Silent Shock is an ambitious, important book...Magazanik does an excellent job.’ Australian Book Review
“A shocking saga of pharmaceutical malpractice . . . Wonder Drug is both a first-rate medical thriller and the searing account of a forgotten American tragedy.”—Patrick Radden Keefe, author of Empire of Pain A “fascinating and compassionate” (People) account of the most notorious drug of the twentieth century and the never-before-told story of its American survivors. In 1959, a Cincinnati pharmaceutical firm, the William S. Merrell Company, quietly began distributing samples of an exciting new wonder drug already popular around the world. Touted as a sedative without risks, thalidomide was handed out freely, under the guise of clinical trials, by doctors who believed approval by the Food and Drug Administration was imminent. But in 1960, when the application for thalidomide landed on the desk of FDA medical reviewer Frances Kelsey, she quickly grew suspicious. When she learned that the drug was causing severe birth abnormalities abroad, she and a team of dedicated doctors, parents, and journalists fought tirelessly to block its authorization in the United States and stop its sale around the world. Jennifer Vanderbes set out to write about this FDA success story only to discover a sinister truth that had been buried for decades: For more than five years, several American pharmaceutical firms had distributed unmarked thalidomide samples in shoddy clinical trials, reaching tens of thousands of unwitting patients, including hundreds of pregnant women. As Vanderbes examined government and corporate archives, probed court records, and interviewed hundreds of key players, she unearthed an even more stunning find: Scores of Americans had likely been harmed by the drug. Deceived by the pharmaceutical firms, betrayed by doctors, and ignored by the government, most of these Americans had spent their lives unaware that thalidomide had caused their birth defects. Now, for the first time, this shocking episode in American history is brought to light. Wonder Drug gives voice to the unrecognized victims of this epic scandal and exposes the deceptive practices of Big Pharma that continue to endanger lives today.
Medicinal Chemistry of Anticancer Drugs by Carmen Avendaño,J. Carlos Menéndez Pdf
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature
Frances Oldham Kelsey, the FDA, and the Battle Against Thalidomide by Cheryl Krasnick Warsh Pdf
In the early 1960s, Dr. Frances Oldham Kelsey of the U.S. Food and Drug Administration became one of the most celebrated women in America when she prevented the deadly sedative thalidomide from entering the U.S. market. Her lifesaving work there became the basis for the FDA's current drug approval protocols. This biography brings to light the efforts and legacy of a pioneering woman in science whose contributions are still influential today.
Master storyteller Arthur Hailey’s New York Times–bestselling novel takes readers behind the scenes of the billion-dollar pharmaceutical drug industry It starts as a routine case: Mary Rowe contracts hepatitis from unclean drinking water, and the infection should work its way out of her system in a few days. But when the illness worsens and she slips into a coma, Dr. Andrew Jordan is forced to tell Rowe’s husband that his wife is dying. It’s 1957 and there simply isn’t a drug that can save her. Pharmaceutical saleswoman Celia de Grey then offers Dr. Jordan a sample of an experimental drug that cures the dying woman overnight. This marks the beginning of an epic journey—and a great romance—for a dedicated internist and an idealistic, ambitious woman. The miracle cure establishes de Grey as a rising star within the industry. But as the years pass, she and her husband, Dr. Jordan, begin to realize that her bosses are driven not by the desire to eradicate disease, but by greed. Millions can be made in matters of life and death—for those who don’t mind getting blood on their hands.
