Thalidomide Catastrophe Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Thalidomide Catastrophe book. This book definitely worth reading, it is an incredibly well-written.
"e;This momentous book is the first comprehensive history of thalidomide...It demonstrates how many thousands of victims could have been spared very late in the day if Chemie Grunenthal had taken any notice of the early alarms: ... [It] carries conviction by its scientific rigour, and the clarity of the writing. Fifty years after the deaths and sufferings, the thalidomide tragedy is marked by ... the odour of corruption and cover up."e; - Sir Harold Evans, former editor of The Sunday Times and The Times
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.
In this riveting medical detective story, Trent Stephens and Rock Brynner recount the history of thalidomide, from the epidemic of birth defects in the 1960's to the present day, as scientists work to create and test an alternative drug that captures thalidomide's curative properties without its cruel side effects. A parable about compassion-and the absence of it-Dark Remedy is a gripping account of thalidomide's extraordinary impact on the lives of individuals and nations over half a century.
Thalidomide, was hailed as a "wonder drug" that provided a "safe, sound sleep". Thalidomide was a sedative that was found to be effective when given to pregnant women to combat many of the symptoms associated with morning sickness. The drug was tested on animals. When given to pregnant women, thalidomide was a catastrophic drug with tragic side effects. It caused startling birth malformations, and death to babies. Birth defects included: deafness, blindness, disfigurement, cleft palate, and phocomelia (short limbs). The FDA did not approve thalidomide in the United States. Around the world, in the late 1960's and into the early 1970's, the victims of the drug thalidomide and their families entered into class action legal suits against the various drug companies who manufactured and/or distributed the drug. This book tells the story of thalidomide in Great Britain and how the parents overcame the formidable obstacles placed in their way to secure a just settlement for their children.
The baby started to come out. Head first, everything OK. But then I saw that there were no arms. And then no legs. The little girl had only a torso and a head. Lyn Rowe was born in Melbourne in 1962, seven months after her mother Wendy was given a new wonder drug for morning sickness called thalidomide. For fifty years the Rowe family cared for Lyn. Decades of exhausting, round-the-clock work. But then in 2011 Lyn Rowe launched a legal claim against the thalidomide companies. Against the odds, she won a multi-million-dollar settlement. Former journalist Michael Magazanik is one of the lawyers who ran Lyn’s case. In Silent Shock he exposes a fifty-year cover up concerning history’s most notorious drug, and details not only the damning case against manufacturers Grünenthal—whose enthusiastic promotion of their lucrative drug in the face of mounting evidence beggars belief—but also the moving story of the Rowe family. Spanning Australia, the United States, the United Kingdom, Japan, Canada, Sweden and, of course, Germany, Silent Shock is an epic account of corporate wrongdoing against a backdrop of heroic personal struggle and sacrifice. Michael Magazanik has worked as a journalist for the Age, the Australian and ABC-TV, and is now a lawyer with Slater & Gordon. He lives in Melbourne with his partner and three children. ‘Magazanik exposes myths and concealments on a grand scale... A compelling read. Highly recommended.’ BookMooch ‘Magazanik—a lawyer on the Rowes’ legal team and a former journalist—has woven an extraordinary story...Magazanik has moulded [the Rowes'] story into a modern Australian myth, the battlers who took on the pharmaceuticals and won.' Age/Sydney Morning Herald ‘A harrowing read of the damage wrought by this infamous drug.’ WA Today ‘A frightening account of secrets in the pharmaceutical industry and the inspiring story of a family and their legal team that just wouldn't give up.’ Law Society Journal ‘Silent Shock is an ambitious, important book...Magazanik does an excellent job.’ Australian Book Review
Master storyteller Arthur Hailey’s New York Times–bestselling novel takes readers behind the scenes of the billion-dollar pharmaceutical drug industry It starts as a routine case: Mary Rowe contracts hepatitis from unclean drinking water, and the infection should work its way out of her system in a few days. But when the illness worsens and she slips into a coma, Dr. Andrew Jordan is forced to tell Rowe’s husband that his wife is dying. It’s 1957 and there simply isn’t a drug that can save her. Pharmaceutical saleswoman Celia de Grey then offers Dr. Jordan a sample of an experimental drug that cures the dying woman overnight. This marks the beginning of an epic journey—and a great romance—for a dedicated internist and an idealistic, ambitious woman. The miracle cure establishes de Grey as a rising star within the industry. But as the years pass, she and her husband, Dr. Jordan, begin to realize that her bosses are driven not by the desire to eradicate disease, but by greed. Millions can be made in matters of life and death—for those who don’t mind getting blood on their hands.
Pharmaceutical Medicine by Adrian Kilcoyne,Phil Ambery,Daniel O'Connor Pdf
The breadth of the pharmaceutical medicine can be daunting, but this book is designed to navigate a path through the speciality. Providing a broad overview of all topics relevant to the discipline of pharmaceutical medicine, it gives you the facts fast, in a user-friendly format, without having to dive through page upon page of dense text. With 136 chapters spread across 8 sections, the text offers a thorough grounding in issues ranging from medicines regulation to clinical trial design and data management. This makes it a useful revision aid for exams as well as giving you a taster of areas of pharmaceutical medicine adjacent to your current role. For healthcare professionals already working in the field, this book offers a guiding hand in difficult situations as well as supplying rapid access to the latest recommendations and guidelines. Written by authors with experience in the industry and drug regulation, this comprehensive and authoritative guide provides a shoulder to lean on throughout your pharmaceutical career.
Surprisingly, the beginning of a modern approach This collection of articles and commentaries is an to the problems of birth defects is relatively recent integration of information from many disciplines, and dates from Gregg's classical report in 1941 that and presents a comprehensive survey of both recent mothers who contracted rubella during the first tri and previously reported work related to the major mester of pregnancy gave birth to infants with severe aspects of birth defects. In particular, an attempt multiple anomalies. For the first time, an environ has been made to provide a critical assessment of mental agent was found to be teratogenic in man current concepts and to identify areas in need of and was documented in a thoroughly convincing further investigation. manner. Since then, many important discoveries The scope of this volume and space limitations and significant developments have been made, par precluded discussion of and reference to all papers ticularly in the areas of environmental teratogenesis, of relevance or importance: a work of the present hereditary mechanisms, and prenatal diagnosis. nature must necessarily be selective. Some good In recent years, there has been an impressive papers have been left out or given relatively little surge of interest in the causes and prevention of consideration. It is my hope that the list of Further birth defects. Undoubtedly this resulted not only References will be consulted and should compensate from the thalidomide tragedy, but also from the for this lack of completeness.
Ultimately, it illuminates public health not only as a showcase of colonial humanism and a tool of control but as an arena of mediocrity, powerlessness, and stupidity.
Frankie: The Woman Who Saved Millions from Thalidomide by James Essinger,Sandra Koutzenko Pdf
Thalidomide: patented in Germany as a non-toxic cure-all for sleeplessness and morning sickness. A wonder drug with no side effects. We know differently now. Today, thalidomide is a byword for tragedy and drug reform – a sign of what happens when things aren't done 'the right way'. But when it was released in the 1950s, it was the best thing since penicillin – something that doctors were encouraged to prescribe to all of their patients. Nobody could anticipate what it actually did: induce sleeping, prevent morning sickness, and drastically harm unborn children. But, whilst thalidomide rampaged and ravaged throughout most of the West, it never reached the United States. It landed on the desk of Dr Frances Kelsey, and there it stayed as she battled bureaucracy, patriarchy, and the Establishment in an effort to prove that it was dangerous. Frankie is her story.
Author : Philip C. Burcham Publisher : Springer Science & Business Media Page : 338 pages File Size : 47,8 Mb Release : 2013-11-19 Category : Medical ISBN : 9781447155539
An Introduction to Toxicology by Philip C. Burcham Pdf
This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that “unpack” the concepts being discussed in the text.
Teratology is the study of chemical-induced birth defects. This book is a comprehensive guide to the procedures and methods commonly employed in the safety testing of all classes of chemical for teratogenicity (also referred to as embryotoxicity, developmental toxicity or prenatal toxicity). The various international regulatory requirements are explained in detail, in order that the reader may perform all of the necessary studies for the successful registration or marketing authorisation of a new pharmaceutical, industrial chemical, crop protection product or food additive. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter gives clear complete instructions on how to perform the task in hand. The authors are respected experts in their field, all with hands-on experience of the procedures described. Teratogenicity Testing: Methods and Protocols gives crucial guidance and tips on how to deal with unexpected results and overcome regulatory difficulties.
