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Author : Richard Bucala,Patty J. Lee Publisher : World Scientific Page : 524 pages File Size : 52,7 Mb Release : 2015-12-08 Category : Medical ISBN : 9789814635011
The Aging Lungs by Richard Bucala,Patty J. Lee Pdf
"This volume provides a comprehensive and multi-disciplinary overview of the aging lung, written by the main researchers in the field. Current physiological, cellular and molecular understanding of how the lungs age and the relationship to age-associated lung diseases will be presented. The contents are aimed at a broad audience of scientists and clinicians with an interest in the respiratory system, pathogenesis of age-associated lung diseases and clinical implications."--
This volume provides a comprehensive and multi-disciplinary overview of the aging lung, written by the main researchers in the field. Current physiological, cellular and molecular understanding of how the lungs age and the relationship to age-associated lung diseases will be presented. The contents are aimed at a broad audience of scientists and clinicians with an interest in the respiratory system, pathogenesis of age-associated lung diseases and clinical implications. Contents:Normal Development, Anatomy, Histology and Aging of the Lung (Xuchen Zhang and Robert J Homer)Physiology of the Aging Lung (Brienne Miner, Thomas M Gill, and Carlos A Vaz Fragoso)Aging Lung, Environmental and Genetic Factors — Race, Ethnicity and Gender (Holly Keyt, Stephanie Levine, and Claude Jourdan Le Saux)Frailty in Pulmonary and Critical Care Medicine (Cristine E Berry and Enid R Neptune)Intensive Care Unit Outcomes in Older Adults (Margaret A Pisani and Lauren Ferrante)Severe Sepsis, Pneumonia and Aging (Olufunmilayo Falade and Sachin Yende)Sepsis and Acute Lung Injury in Aging (Anup Srivastava, Yao Wong, Shruti Erramilli, and Praveen Mannam)Acute Respiratory Distress Syndrome: The Role of Mesenchymal Stem Cells and Arising Complications Due to an Aging Lung (John Sembrat, Maria G Kapetanaki, and Mauricio Rojas)The Aging Immune System, Vaccine Efficacy, and the Lung (Jenna M Bartley and Laura Haynes)Respiratory Infection, Airway Colonization and Chronic Inflammation in Aging (Chad Marion and Charles S Dela Cruz)HIV, the Lung and Aging (Lynn M Schnapp and Kristina Crothers)Geriatric Pulmonary Hypertension: Recent Epidemiologic Trends and Treatment Update (Vanessa Yap, George A Kuchel, and Raymond J Foley)Growth Factors and Aging in Pulmonary Arterial Hypertension (Claudio Bravo, Won-Kyung Cho, and Hyung J Chun)Chronic Obstructive Lung Disease in the Elderly (Jessica F Most and Carolyn L Rochester)Genomics of Lung Aging and Idiopathic Pulmonary Fibrosis (Brenda Juan-Guardela and Naftali Kaminski)Potential Mechanistic Links Between Aging and IPF (Hongyi Pan, Mridu Gulati, and Erica L Herzog)Telomeres and Telomerase (Mary Armanios)Endoplasmic Reticulum Stress (Marta Bueno and Ana L Mora)Autophagy and Metabolism (Jaime L Schneider and Cecilia G Sanchez) Readership: Graduate and post-graduate respiratory, pulmonary, thoracic scientists and physicians; Clinical researchers interested in both pulmonary and aging issues, medical students and professionals. Key Features:Pre-eminent authors and researchers in their respective fieldsComprehensive coverage of research, clinical and therapeutic considerationsCutting-edge biology and mechanisms includedKeywords:Lungs;Aging;Senescence;COPD;Fibrosis;Asthma;Pulmonary Vascular Diseases
Author : John R. Edge,K. K. Pump,Javier Arias-Stella Publisher : Ardent Media Page : 296 pages File Size : 44,7 Mb Release : 1974 Category : Medical ISBN : 0842271651
The second edition of The Lung: Development, Aging and the Environment provides an understanding of the multi-faceted nature of lung development, aging, and how the environment influences these processes. As an essential resource to respiratory, pulmonary, and thoracic scientists and physicians it provides an interface between the “normal and “disease cluster of chapters, allowing for a natural complement to each other. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological features. This same complementarity comes across in the logical line up of chapters dealing with the “normal pediatric lung. New research, including cell-based strategies for infant lung function, epigenetics, and prenatal alcohol exposure on lung development and function are some of the important additions to this edition of this reference work. Describes the normal processes of lung development, growth and aging Considers the effects of the environmental contaminants in the air, water, soil, and diet on lung development, growth and health Describes genetic factors involved in susceptibility to lung disease Covers respiratory health risk in children
Pulmonary Disease in the Aging Patient, An Issue of Clinics in Geriatric Medicine, E-Book by Sidney S. Braman,Gwen S. Skloot Pdf
This issue of Clinics in Geriatric Medicine, guest edited by Drs. Sidney S. Braman and Gwen S. Skloot, is devoted to Pulmonary Disease in the Aging Patient. Articles in this issue include: The Effects of Aging on Lung Structure and Function; Immunosenescence and the Lungs; Epidemiology of Lung Disease in the Elderly; The Evaluation of Dyspnea in the Elderly; Asthma in the Elderly; COPD in the Elderly Patient; Pulmonary Vascular Diseases in the Elderly; Granulomatous Lung Diseases in the Elderly; Lung Cancer in the Older Patient; Sleep Disorders in the Elderly; Idiopathic Pulmonary Fibrosis in the Older Patient; and Co-morbidities of Lung Disease in the Elderly.
People age 65 and older are the fastest growing segment of the U.S. population. In the 2010 census 16% of the population, 50 million people, were age 65 and older. That number is projected to increase to 66 million by the year 2050. Life expectancy has also increased, with recent CDC reports indicating life expectancy at 77.9 years. Age-adjusted death rates have decreased significantly with the largest changes occurring in older patients. Despite these trends, the 10 leading causes of death include several pulmonary etiologies including lung cancer, chronic respiratory diseases, influenza and pneumonia. Aging and Lung Disease: A Clinical Guide is devoted to understanding the impact of respiratory diseases in older patients. It includes reviews of physiology of the aging lung, allergy and immunology of the aging, as well as sleep changes over the life cycle. There are also comprehensive reviews on specific disease topics including chronic obstructive lung disease, lung cancer, atypical mycobacteria, interstitial lung disease, pulmonary hypertension, pulmonary embolism, obstructive sleep apnea, sleep disorders in older patients. Two chapters focus on unique issues in older patients; HIV and lung transplant. Included also are important chapters on assessing functional and cognitive status and end-of-life issues in older patients with lung disease. In addition to outlining the current state of knowledge, each chapter focuses on special considerations when caring for older patients. Of particular interest to pulmonologists, internists, and gerontologists, other readers, such as pulmonary and geriatric nurse practitioners, as well as clinical researchers interested in both pulmonary and aging issues, will find Aging and Lung Disease: A Clinical Guide to be a vital resource for improving their care of older patients with lung disorders.
This book weaves all of these factors together to engage in and promote medical, biomedical and psychosocial interventions, including lifestyle changes, for healthier aging outcomes. The text begins with an introduction to age-related changes that increase in disease and disability commonly associated with old age. Written by experts in healthy aging, the text approaches the principles of disease and disability prevention via specific health issues. Each chapter highlights the challenge of not just increasing life expectancy but also deceasing disease burden and disability in old age. The text then shifts into the whole-person implications for clinicians working with older patients, including the social and cultural considerations that are necessary for improved outcomes as Baby Boomers age and healthcare systems worldwide adjust. Healthy Aging is an important resource for those working with older patients, including geriatricians, family medicine physicians, nurses, gerontologists, students, public health administrators, and all other medical professionals.
Molecular Aspects of Aging by Mauricio Rojas,Silke Meiners,Claude Jourdan Le Saux Pdf
Molecular Aspects of Aging: Understanding Lung Aging covers recent research in the mechanisms that contribute to cellular senescence. Covering universal themes in aging, such as the exhaustion of stem cells and subsequent loss of the regenerative refueling of organs as well as immunosenescence, this text illuminates new directions for research not yet explored in the still poorly investigated area of molecular mechanisms of lung aging. The molecular nature of general aging processes is explored with targeted coverage on how to analyze lung aging through experimental approaches.
Joseph H. Kahn,Brendan G. Magauran (Jr.),Jonathan S. Olshaker
Author : Joseph H. Kahn,Brendan G. Magauran (Jr.),Jonathan S. Olshaker Publisher : Cambridge University Press Page : 383 pages File Size : 52,5 Mb Release : 2014-01-16 Category : Medical ISBN : 9781107677647
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Comparative Biology of the Normal Lung by Richard A. Parent Pdf
Comparative Biology of the Normal Lung, 2nd Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system
Geriatric Anesthesiology by Jeffrey Silverstein,Alec Rooke,J. G. Reves,Charles H. McLeskey Pdf
Geriatric anesthesia is a rapidly growing and evolving field and this is the major revision of a classic anesthesia reference. The last few years have seen significant advancements and important new modalities for addressing the needs of an aging population. The editors of this second edition are uniquely situated to put together a text highlighting both essential knowledge and recent breakthroughs of importance to all who work with the elderly. This edition easily maintains the high standard for quality scholarship and useful material set by the first.
Respiratory Diseases in the Elderly by V. Bellia,R. Antonelli Incalzi Pdf
The world population is rapidly ageing. As a consequence, the portion of the elderly burdened with polipathology and disability will grow, while economic resources to support it will shrink, due to the contraction of the working force. This will require a long-term preventive political strategy but there are also selected healthcare interventions that can be easily implemented to decrease the negative impact of this demographic trend on the well being of our societies. Examples are strategies that slow functional decline and preserve personal capabilities in geriatric populations. Instrumental.
Institute of Medicine,Board on Population Health and Public Health Practice,Committee on a National Surveillance System for Cardiovascular and Select Chronic Diseases
Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on a National Surveillance System for Cardiovascular and Select Chronic Diseases Publisher : National Academies Press Page : 200 pages File Size : 52,5 Mb Release : 2011-08-26 Category : Medical ISBN : 9780309212199
A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases by Institute of Medicine,Board on Population Health and Public Health Practice,Committee on a National Surveillance System for Cardiovascular and Select Chronic Diseases Pdf
Chronic diseases are common and costly, yet they are also among the most preventable health problems. Comprehensive and accurate disease surveillance systems are needed to implement successful efforts which will reduce the burden of chronic diseases on the U.S. population. A number of sources of surveillance data--including population surveys, cohort studies, disease registries, administrative health data, and vital statistics--contribute critical information about chronic disease. But no central surveillance system provides the information needed to analyze how chronic disease impacts the U.S. population, to identify public health priorities, or to track the progress of preventive efforts. A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases outlines a conceptual framework for building a national chronic disease surveillance system focused primarily on cardiovascular and chronic lung diseases. This system should be capable of providing data on disparities in incidence and prevalence of the diseases by race, ethnicity, socioeconomic status, and geographic region, along with data on disease risk factors, clinical care delivery, and functional health outcomes. This coordinated surveillance system is needed to integrate and expand existing information across the multiple levels of decision making in order to generate actionable, timely knowledge for a range of stakeholders at the local, state or regional, and national levels. The recommendations presented in A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases focus on data collection, resource allocation, monitoring activities, and implementation. The report also recommends that systems evolve along with new knowledge about emerging risk factors, advancing technologies, and new understanding of the basis for disease. This report will inform decision-making among federal health agencies, especially the Department of Health and Human Services; public health and clinical practitioners; non-governmental organizations; and policy makers, among others.
