The Biological Resources Of Model Organisms

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The Biological Resources of Model Organisms

Author : Robert L. Jarret,Kevin McCluskey
Publisher : CRC Press
Page : 282 pages
File Size : 41,7 Mb
Release : 2019-07-16
Category : Science
ISBN : 9781351587778

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The Biological Resources of Model Organisms by Robert L. Jarret,Kevin McCluskey Pdf

This book discusses 14 model organisms and are used by thousands of researchers, teachers, and students each year in laboratories and classrooms, around the globe. Though acknowledged in innumerable scientific journal articles, little is generally known about the origin of these collections, how the organisms contained within them have been acquired, and how they are maintained and distributed. While some collections such as Drosophila have long histories others, such as the collection of Brachionus, are relatively new. They vary greatly in size. Yet, all have contributed and are continuing to contribute to global research efforts in many areas of scientific research as diverse as tissue regeneration, skin cancer, evolution, water purity, gene function, and hundreds of others. In addition to providing the raw materials for national and international research programs, these collections also provide educational tools used by colleges and high schools. The chapters in this book attempt to provide a brief look at the individual organisms, how they came to be accepted as model organisms, the history of the individual collections, examples of how the organisms have been and are being used in scientific research, and a description of the facilities and procedures used to maintain them. Features: • Provides an in-depth look at the collections of 14 model organisms that have enabled innumerable scientific breakthroughs over decades, and that continue to do so. • Includes detailed descriptions of the operating procedures used for the maintenance of each model organism collection. • Discusses the holdings of the collections of model organisms and its relevance to past, current and future scientific research. • Written by the leaders in the field of the management of model organisms.

Model Organisms

Author : Rachel A. Ankeny,Sabina Leonelli
Publisher : Cambridge University Press
Page : 156 pages
File Size : 52,8 Mb
Release : 2021-01-28
Category : Science
ISBN : 9781108665568

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Model Organisms by Rachel A. Ankeny,Sabina Leonelli Pdf

This Element presents a philosophical exploration of the concept of the 'model organism' in contemporary biology. Thinking about model organisms enables us to examine how living organisms have been brought into the laboratory and used to gain a better understanding of biology, and to explore the research practices, commitments, and norms underlying this understanding. We contend that model organisms are key components of a distinctive way of doing research. We focus on what makes model organisms an important type of model, and how the use of these models has shaped biological knowledge, including how model organisms represent, how they are used as tools for intervention, and how the representational commitments linked to their use as models affect the research practices associated with them. This title is available as Open Access on Cambridge Core.

Handbook of Marine Model Organisms in Experimental Biology

Author : Agnes Boutet,Bernd Schierwater
Publisher : CRC Press
Page : 964 pages
File Size : 47,5 Mb
Release : 2021-12-13
Category : Science
ISBN : 9781000464337

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Handbook of Marine Model Organisms in Experimental Biology by Agnes Boutet,Bernd Schierwater Pdf

The importance of molecular approaches for comparative biology and the rapid development of new molecular tools is unprecedented. The extraordinary molecular progress belies the need for understanding the development and basic biology of whole organisms. Vigorous international efforts to train the next-generation of experimental biologists must combine both levels – next generation molecular approaches and traditional organismal biology. This book provides cutting-edge chapters regarding the growing list of marine model organisms. Access to and practical advice on these model organisms have become a conditio sine qua non for a modern education of advanced undergraduate students, graduate students and postdocs working on marine model systems. Model organisms are not only tools they are also bridges between fields – from behavior, development and physiology to functional genomics. Key Features Offers deep insights into cutting-edge model system science Provides in-depth overviews of all prominent marine model organisms Illustrates challenging experimental approaches to model system research Serves as a reference book also for next-generation functional genomics applications Fills an urgent need for students Related Titles Jarret, R. L. & K. McCluskey, eds. The Biological Resources of Model Organisms (ISBN 978-1-1382-9461-5) Kim, S.-K. Healthcare Using Marine Organisms (ISBN 978-1-1382-9538-4) Mudher, A. & T. Newman, eds. Drosophila: A Toolbox for the Study of Neurodegenerative Disease (ISBN 978-0-4154-1185-1) Green, S. L. The Laboratory Xenopus sp. (ISBN 978-1-4200-9109-0)

Model Organisms in Drug Discovery

Author : Pamela M. Carroll,Kevin Fitzgerald
Publisher : Wiley
Page : 302 pages
File Size : 52,8 Mb
Release : 2004-04-21
Category : Science
ISBN : 9780470871300

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Model Organisms in Drug Discovery by Pamela M. Carroll,Kevin Fitzgerald Pdf

Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.

Emerging Model Systems in Developmental Biology

Author : Anonim
Publisher : Academic Press
Page : 728 pages
File Size : 40,7 Mb
Release : 2022-03-23
Category : Science
ISBN : 9780128201602

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Emerging Model Systems in Developmental Biology by Anonim Pdf

An ever-growing roster of model organisms is a hallmark of 21st century Developmental Biology. Emerging model organisms are well suited to asking some fascinating and important questions that cannot be addressed using established model systems. And new methods are increasingly facilitating the adoption of new research organisms in laboratories. This volume is written by some of the scientists who have played pivotal roles in developing new models or in significantly advancing tools in emerging systems. Presents some of the most interesting additions to the core set of model organisms Contains contributions from people who have developed new model systems or advanced tools Includes personal stories about how and why model systems were developed

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Publisher : National Academies Press
Page : 348 pages
File Size : 41,8 Mb
Release : 2000-12-21
Category : Nature
ISBN : 9780309070867

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Scientific Frontiers in Developmental Toxicology and Risk Assessment by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology Pdf

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Emerging Model Organisms

Author : Anonim
Publisher : Unknown
Page : 684 pages
File Size : 53,9 Mb
Release : 2009
Category : Biological models
ISBN : STANFORD:36105215171245

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Emerging Model Organisms by Anonim Pdf

Emerging Model Organisms

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 43,7 Mb
Release : 2009
Category : Science
ISBN : 0879698721

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Emerging Model Organisms by Anonim Pdf

In this volume leading experts provide chapters on 23 emerging model systems, ranging from bat and butterfly to cave fish and choanoflagellates; cricket and finch to quail, snail and tomato.

Nematodes as Model Organisms

Author : Itamar Glazer,David I. Shapiro-Ilan,Paul W. Sternberg
Publisher : Cab International
Page : 0 pages
File Size : 42,5 Mb
Release : 2022
Category : Biological models
ISBN : 1789248809

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Nematodes as Model Organisms by Itamar Glazer,David I. Shapiro-Ilan,Paul W. Sternberg Pdf

"Nematodes, especially Caenorhabditis elegans have been used as a model for research in molecular biology since the 1960's. This is a much-needed update on research on fundamental processes in areas such as genetics, developmental biology, nutrition, toxicology, ecology, pharmacology and medicine"--

The Microbial Models of Molecular Biology

Author : Rowland H. Davis
Publisher : Oxford University Press
Page : 352 pages
File Size : 48,8 Mb
Release : 2003-09-11
Category : Science
ISBN : 9780190288556

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The Microbial Models of Molecular Biology by Rowland H. Davis Pdf

This book explains the role of simple biological model systems in the growth of molecular biology. Essentially the whole history of molecular biology is presented here, tracing the work in bacteriophages in E. coli, the role of other prokaryotic systems, and also the protozoan and algal models - Paramecium and Chlamydomonas, primarily - and the move into eukaryotes with the fungal systems - Neurospora, Aspergillus and yeast. Each model was selected for its appropriateness for asking a given class of questions, and each spawned its own community of investigators. Some individuals made the transition to a new model over time, and remnant communities of investigators continue to pursue questions in all these models, as the cutting edge of molecular biological research flowed onward from model to model, and onward into higher organisms and, ultimately, mouse and man.

Emerging Model Organisms

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 52,9 Mb
Release : 2009
Category : Electronic
ISBN : OCLC:699947649

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Emerging Model Organisms by Anonim Pdf

Xenopus

Author : Abraham Fainsod,Sally A. Moody
Publisher : CRC Press
Page : 768 pages
File Size : 47,5 Mb
Release : 2022-04-19
Category : Science
ISBN : 9781000529814

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Xenopus by Abraham Fainsod,Sally A. Moody Pdf

This book focuses on the amphibian, Xenopus, one of the most commonly used model animals in the biological sciences. Over the past 50 years, the use of Xenopus has made possible many fundamental contributions to our knowledge in cell biology, developmental biology, molecular biology, and neurobiology. In recent years, with the completion of the genome sequence of the main two species and the application of genome editing techniques, Xenopus has emerged as a powerful system to study fundamental disease mechanisms and test treatment possibilities. Xenopus has proven an essential vertebrate model system for understanding fundamental cell and developmental biological mechanisms, for applying fundamental knowledge to pathological processes, for deciphering the function of human disease genes, and for understanding genome evolution. Key Features Provides historical context of the contributions of the model system Includes contributions from an international team of leading scholars Presents topics spanning cell biology, developmental biology, genomics, and disease model Describes recent experimental advances Incorporates richly illustrated diagrams and color images Related Titles Green, S. L. The Laboratory Xenopus sp. (ISBN 978-1-4200-9109-0) Faber, J. & P. D. Nieuwkoop. Normal Table of Xenopus laevis (Daudin): A Systematical & Chronological Survey of the Development from the Fertilized Egg till the End of Metamorphosis (ISBN 978-0-8153-1896-5) Jarret, R. L. & K. McCluskey. The Biological Resources of Model Organisms (ISBN 978-1-0320-9095-5) The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

Evo-Devo: Non-model Species in Cell and Developmental Biology

Author : Waclaw Tworzydlo,Szczepan M. Bilinski
Publisher : Springer Nature
Page : 551 pages
File Size : 41,7 Mb
Release : 2019-10-09
Category : Science
ISBN : 9783030234591

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Evo-Devo: Non-model Species in Cell and Developmental Biology by Waclaw Tworzydlo,Szczepan M. Bilinski Pdf

Evolutionary developmental biology or evo-devo is a field of biological research that compares the underlying mechanisms of developmental processes in different organisms to infer the ancestral condition of these processes and elucidate how they have evolved. It addresses questions about the developmental bases of evolutionary changes and evolution of developmental processes. The book’s content is divided into three parts, the first of which discusses the theoretical background of evo-devo. The second part highlights new and emerging model organisms in the evo-devo field, while the third and last part explores the evo-devo approach in a broad comparative context. To the best of our knowledge, no other book combines these three evo-devo aspects: theoretical considerations, a comprehensive list of emerging model species, and comparative analyses of developmental processes. Given its scope, the book will offer readers a new perspective on the natural diversity of processes at work in cells and during the development of various animal groups, and expand the horizons of seasoned and young researchers alike.

Model Organisms: A Precious Resource for Understanding of the Molecular Mechanisms Underlying Human Physiology and Disease

Author : Maria Grazia Giansanti,Roberta Fraschini
Publisher : Frontiers Media SA
Page : 176 pages
File Size : 43,5 Mb
Release : 2019-11-20
Category : Electronic
ISBN : 9782889631834

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Model Organisms: A Precious Resource for Understanding of the Molecular Mechanisms Underlying Human Physiology and Disease by Maria Grazia Giansanti,Roberta Fraschini Pdf

Sourcebook of Models for Biomedical Research

Author : P. Michael Conn
Publisher : Springer Science & Business Media
Page : 756 pages
File Size : 42,9 Mb
Release : 2008-03-07
Category : Medical
ISBN : 9781597452854

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Sourcebook of Models for Biomedical Research by P. Michael Conn Pdf

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.