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Author : Hugo Gil Ferreira,M. W. Marshall Publisher : Cambridge University Press Page : 512 pages File Size : 45,8 Mb Release : 1985-10-31 Category : Medical ISBN : 0521301513
The Biophysical Basis of Excitability by Hugo Gil Ferreira,M. W. Marshall Pdf
Defines the basic concepts from biology, mathematics, physics and chemistry that are needed to understand how excitable cells function. Applies them specifically to the study of membrane transport, artificial membranes, signal capturing and analysis in biological systems.
The Russian edition of this book appeared in 1969 and im mediately gained widespread recognition as a reference work for research workers interested in the physiology, biophysics, and pharmacology of excitable tissues. There are several reasons for the book's success. It deals with a key problem in biology which has recently been the subject of very intensive study and it is of great interest to a wide scientific audience. Not only the fundamentals of the modern membrane theory of biopotentials, but also the vast factual material collected in the last decades by the study of the biophysical and pharmacological properties of the ionic permeability pores of the cell membrane, are described in the book in an authoritative yet readable form. Special attention is paid in the book to the systematic analysis of the consequences of the Hodgkin-Huxley mathematical theory of the nervous impulse for the problem of excitability. The relationship between the various parameters of excitability (threshold potential, threshold current, useful time), accommodation, and the action potential on the one hand, and the constants of ionic permeability of the nerve fiber membrane, on the other hand, is subjected to detailed examination in this context. To do this, the author has made extensive use not only of experimental results obtained on isolated fibers (especially single nodes of Ran vier), but also the results of his own investigations on mathematical models of excitable membranes.
Ionic Channels of Excitable Membranes by Bertil Hille Pdf
This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.
Cell Physiology Source Book by Nicholas Sperelakis Pdf
This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
Foundations of Cellular Neurophysiology by Daniel Johnston,Samuel Miao-Sin Wu Pdf
with simulations and illustrations by Richard Gray Problem solving is an indispensable part of learning a quantitative science such as neurophysiology. This text for graduate and advanced undergraduate students in neuroscience, physiology, biophysics, and computational neuroscience provides comprehensive, mathematically sophisticated descriptions of modern principles of cellular neurophysiology. It is the only neurophysiology text that gives detailed derivations of equations, worked examples, and homework problem sets (with complete answers). Developed from notes for the course that the authors have taught since 1983, Foundations of Cellular Neurophysiology covers cellular neurophysiology (also some material at the molecular and systems levels) from its physical and mathematical foundations in a way that is far more rigorous than other commonly used texts in this area.
Biophysics is the science of physical principles underlying the "phenomenon of life" on all levels of organization. This book begins by explaining molecular and ionic interactions, movements, excitation and energy transfer, and the self-organization of supramolecular structures. Then the biological organism is introduced as a non-equilibrium system. Finally, system analyses are discussed as well as environmental biophysics, ecological interactions, growth, differentiation, and evolution. A growing number of applications in biotechnology are based on these biophysical concepts.
Deep Brain Stimulation by Kendall H. Lee,Penelope S. Duffy,Allan J. Bieber Pdf
Deep brain stimulation (DBS) is a widely used therapy for movement disorders such as Parkinson's disease, essential tremor, and dystonia. Its therapeutic success has led to the application of DBS for an increasing spectrum of conditions. However, the fundamental relationships between neural activation, neurochemical transmission, and clinical outcomes during DBS are not well understood. Drawing on the clinical and research expertise of the Mayo Clinic Neural Engineering Laboratories, this book addresses the history of therapeutic electrical stimulation of the brain, its current application and outcomes, and theories about its underlying mechanisms. It reviews research on measures of local stimulation–evoked neurochemical release, imaging research on stimulation-induced neural circuitry activation, and the state of the art on closed-loop feedback devices for stimulation delivery.
Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritic trees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium and potassium currents and their role in information processing; the role of diffusion, buffering and binding of calcium, and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation.Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics.
Mathematical Analysis of Complex Cellular Activity by Richard Bertram,Joel Tabak,Wondimu Teka,Theodore Vo,Martin Wechselberger,Vivien Kirk,James Sneyd Pdf
This book contains two review articles on mathematical physiology that deal with closely related topics but were written and can be read independently. The first article reviews the basic theory of calcium oscillations (common to almost all cell types), including spatio-temporal behaviors such as waves. The second article uses, and expands on, much of this basic theory to show how the interaction of cytosolic calcium oscillators with membrane ion channels can result in highly complex patterns of electrical spiking. Through these examples one can see clearly how multiple oscillatory processes interact within a cell, and how mathematical methods can be used to understand such interactions better. The two reviews provide excellent examples of how mathematics and physiology can learn from each other, and work jointly towards a better understanding of complex cellular processes. Review 1: Richard Bertram, Joel Tabak, Wondimu Teka, Theodore Vo, Martin Wechselberger: Geometric Singular Perturbation Analysis of Bursting Oscillations in Pituitary Cells Review 2: Vivien Kirk, James Sneyd: Nonlinear Dynamics of Calcium
Practical Methods in Cardiovascular Research by Stefan Dhein,Friedrich Wilhelm Mohr,Mario Delmar Pdf
Scientists working or planning to work in the field of cardiovascular research will welcome Methods in Cardiovascular Research as the reference book they have been waiting for. Not only general aspects of cardiovascular research are well presented but also detailed descriptions of methods, protocols and practical examples. Written by leading scientists in their field, chapters cover classical methods such as the Langendorff heart or working heart models as well as numerous new techniques and methods. Newcomers and experienced researchers alike will benefit from the troubleshooting guide in each chapter, the extensive reference lists for advanced reading and the great practical experience of the authors. Methods in Cardiovascular Research is a "must have" for anybody with an interest in cardiovascular research.
This book provides a comprehensive, authoritative, and contemporary discussion of the physiology and pathophysiology of the chest wall as well as an overview of the diagnostic and therapeutic modalities. It is an invaluable aid to clinical investigators.
Annelids offer a diversity of experimentally accessible features making them a rich experimental subject across the biological sciences, including evolutionary development, neurosciences and stem cell research. This volume introduces the Annelids and their utility in evolutionary developmental biology, neurobiology, and environmental/ecological studies, including extreme environments. The book demonstrates the variety of fields in which Annelids are already proving to be a useful experimental system. Describing the utility of Annelids as a research model, this book is an invaluable resource for all researchers in the field.
Author : L. Donald Partridge,Lloyd D. Partridge Publisher : Springer Science & Business Media Page : 498 pages File Size : 52,5 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461504252
Nervous System Actions and Interactions by L. Donald Partridge,Lloyd D. Partridge Pdf
Nervous System Actions and Interactions: Concepts in Neurophysiology approaches the nervous system from a functional, rather than structural, point of view. While all of the central topics of functional neuroscience are covered, these topics are organized from a neurophysiological perspective yielding chapters on subjects such as information storage and effector actions. Each chapter is organized around general concepts that then are further developed in the text. The authors attempt to establish a dialogue with the reader by means of proposed experiments and open ended questions that are designed to both reinforce and question the text. This volume is intended to be a book of ideas for the novice or seasoned researcher in neuroscience.
Transcranial Brain Stimulation by Carlo Miniussi,Walter Paulus,Paolo M. Rossini Pdf
Since the discovery of transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), these non-invasive brain stimulation (NIBS) techniques have been used to investigate the state of cortical excitability, and the excitability of the cortico-cortical and corticospinal pathways. In addition, these techniques have been found to induce neuroplasticity—a significant breakthrough in our understanding of the brain at work. Transcranial Brain Stimulation presents a wide range of possible brain stimulation applications and discusses what new information can be gained from using this technique on the dynamics of brain functions, hierarchical organization, and effective connectivity. Implications of recent findings related to the therapeutic application are discussed by an international group of leading experts, who present practical guidance on the use of each technique, and catalog the results of numerous TMS and tES studies on biological and behavioral effects.