Author : B. Khodorov
Publisher : Unknown
Page : 352 pages
File Size : 46,5 Mb
Release : 2011-11-08
Category : Electronic
ISBN : 1461344883
The Problem of Excitability
B. Khodorov
The Problem Of Excitability
The Problem Of Excitability Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of The Problem Of Excitability book. This book definitely worth reading, it is an incredibly well-written.
The Problem of Excitability
B. Khodorov
Author : B. Khodorov
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 53,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461344872
The Problem of Excitability by B. Khodorov Pdf
The Russian edition of this book appeared in 1969 and im mediately gained widespread recognition as a reference work for research workers interested in the physiology, biophysics, and pharmacology of excitable tissues. There are several reasons for the book's success. It deals with a key problem in biology which has recently been the subject of very intensive study and it is of great interest to a wide scientific audience. Not only the fundamentals of the modern membrane theory of biopotentials, but also the vast factual material collected in the last decades by the study of the biophysical and pharmacological properties of the ionic permeability pores of the cell membrane, are described in the book in an authoritative yet readable form. Special attention is paid in the book to the systematic analysis of the consequences of the Hodgkin-Huxley mathematical theory of the nervous impulse for the problem of excitability. The relationship between the various parameters of excitability (threshold potential, threshold current, useful time), accommodation, and the action potential on the one hand, and the constants of ionic permeability of the nerve fiber membrane, on the other hand, is subjected to detailed examination in this context. To do this, the author has made extensive use not only of experimental results obtained on isolated fibers (especially single nodes of Ran vier), but also the results of his own investigations on mathematical models of excitable membranes.
Dynamical Systems in Neuroscience
Eugene M. Izhikevich
Author : Eugene M. Izhikevich
Publisher : MIT Press
Page : 459 pages
File Size : 42,7 Mb
Release : 2010-01-22
Category : Medical
ISBN : 9780262514200
Dynamical Systems in Neuroscience by Eugene M. Izhikevich Pdf
Explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition. In order to model neuronal behavior or to interpret the results of modeling studies, neuroscientists must call upon methods of nonlinear dynamics. This book offers an introduction to nonlinear dynamical systems theory for researchers and graduate students in neuroscience. It also provides an overview of neuroscience for mathematicians who want to learn the basic facts of electrophysiology. Dynamical Systems in Neuroscience presents a systematic study of the relationship of electrophysiology, nonlinear dynamics, and computational properties of neurons. It emphasizes that information processing in the brain depends not only on the electrophysiological properties of neurons but also on their dynamical properties. The book introduces dynamical systems, starting with one- and two-dimensional Hodgkin-Huxley-type models and continuing to a description of bursting systems. Each chapter proceeds from the simple to the complex, and provides sample problems at the end. The book explains all necessary mathematical concepts using geometrical intuition; it includes many figures and few equations, making it especially suitable for non-mathematicians. Each concept is presented in terms of both neuroscience and mathematics, providing a link between the two disciplines. Nonlinear dynamical systems theory is at the core of computational neuroscience research, but it is not a standard part of the graduate neuroscience curriculum—or taught by math or physics department in a way that is suitable for students of biology. This book offers neuroscience students and researchers a comprehensive account of concepts and methods increasingly used in computational neuroscience. An additional chapter on synchronization, with more advanced material, can be found at the author's website, www.izhikevich.com.
Seizures and Epilepsy
Jerome Engel Jr
Author : Jerome Engel Jr
Publisher : Oxford University Press
Page : 737 pages
File Size : 55,9 Mb
Release : 2013-01-31
Category : Medical
ISBN : 9780195328547
Seizures and Epilepsy by Jerome Engel Jr Pdf
This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.
Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System
Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 74 pages
File Size : 42,7 Mb
Release : 2011-07-05
Category : Medical
ISBN : 9780309212243
Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf
Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
Magnesium in the Central Nervous System
Robert Vink,Mihai Nechifor
Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 49,9 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051
Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Cellular Biophysics and Modeling
Greg Conradi Smith
Author : Greg Conradi Smith
Publisher : Cambridge University Press
Page : 395 pages
File Size : 53,8 Mb
Release : 2019-03-14
Category : Mathematics
ISBN : 9781107005365
Cellular Biophysics and Modeling by Greg Conradi Smith Pdf
What every neuroscientist should know about the mathematical modeling of excitable cells, presented at an introductory level.
The Sarcolemma
International Study Group for Research in Cardiac Metabolism
Author : International Study Group for Research in Cardiac Metabolism
Publisher : Baltimore : University Park Press
Page : 520 pages
File Size : 52,8 Mb
Release : 1976
Category : Science
ISBN : UOM:39015000270390
The Sarcolemma by International Study Group for Research in Cardiac Metabolism Pdf
Discovering the Brain
National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Page : 195 pages
File Size : 46,7 Mb
Release : 1992-01-01
Category : Medical
ISBN : 9780309045292
Discovering the Brain by National Academy of Sciences,Institute of Medicine,Sandra Ackerman Pdf
The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
The Problem of Determining the Excitation Forces in Vibration Testing
G. de Vries
Author : G. de Vries
Publisher : Unknown
Page : 1156 pages
File Size : 45,7 Mb
Release : 1965
Category : Damping (Mechanics)
ISBN : STANFORD:36105024834629
The Problem of Determining the Excitation Forces in Vibration Testing by G. de Vries Pdf
Molecular Biology of The Cell
Bruce Alberts
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 41,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Molecular Biology of The Cell by Bruce Alberts Pdf
Structure and Function in Excitable Cells
T.C. Cheng
Author : T.C. Cheng
Publisher : Springer
Page : 0 pages
File Size : 50,8 Mb
Release : 2012-02-12
Category : Medical
ISBN : 1461593395
Structure and Function in Excitable Cells by T.C. Cheng Pdf
This book is a collection of up-to-date research reviews dealing with various aspects of the structure and function of excitable cells. Its overall objective is to further the search for a better understanding of the mechanism of excitation on a structural and physicochemical basis. The chapters are written by active investigators from a variety of disciplines, repre senting many different points of view. Their complementary fields of expertise give this book the rare feature of extraordinary breadth. Excitability is a fundamental property of many biological systems. The mechanisms by which nerve impulses are initiated and propagated, and by which rhythmical activities are produced in nerve, muscle, and cardiac cells, can be fully elucidated only when the process of excitation is derived from fundamental principles applied to known structural forms, at both the macroscopic and the molecular level. The problems of excitation are complex, requiring knowledge of many aspects of cells, including their morphology, elec trobiology, chemical physics, and biochemistry.
Ionic Channels of Excitable Membranes
Bertil Hille
Author : Bertil Hille
Publisher : Sinauer Associates, Incorporated
Page : 632 pages
File Size : 45,6 Mb
Release : 1992
Category : Excitable membranes
ISBN : UOM:39015024124383
Ionic Channels of Excitable Membranes by Bertil Hille Pdf
This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.
Neuronal Dynamics
Wulfram Gerstner,Werner M. Kistler,Richard Naud,Liam Paninski
Author : Wulfram Gerstner,Werner M. Kistler,Richard Naud,Liam Paninski
Publisher : Cambridge University Press
Page : 591 pages
File Size : 41,9 Mb
Release : 2014-07-24
Category : Computers
ISBN : 9781107060838
Neuronal Dynamics by Wulfram Gerstner,Werner M. Kistler,Richard Naud,Liam Paninski Pdf
This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.
The Biophysical Basis of Excitability
Hugo Gil Ferreira,M. W. Marshall
Author : Hugo Gil Ferreira,M. W. Marshall
Publisher : Cambridge University Press
Page : 512 pages
File Size : 44,8 Mb
Release : 1985-10-31
Category : Medical
ISBN : 0521301513
The Biophysical Basis of Excitability by Hugo Gil Ferreira,M. W. Marshall Pdf
Defines the basic concepts from biology, mathematics, physics and chemistry that are needed to understand how excitable cells function. Applies them specifically to the study of membrane transport, artificial membranes, signal capturing and analysis in biological systems.