The Brugada Syndrome

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The Brugada Syndrome

Charles Antzelevitch
The Brugada Syndrome Book PDF

Author : Charles Antzelevitch
Publisher : John Wiley & Sons
Page : 248 pages
File Size : 50,8 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405146814

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The Brugada Syndrome by Charles Antzelevitch Pdf

Until recently, the cellular basis for sudden death, the BrugadaSyndrome, has largely remained an unknown to modernarrhythmologists and cardiologists, particularly in the absence ofany structural heart disease. Detailed observations of age-groups,especially the young, families and populations where sudden deathfrequently occurs, and improved understanding of its contributoryfactors and mechanisms are, however, showing the way forward. This addition to the Clinical Approaches to Tachyarrhythmias(CATA) Series, written by the investigators who discovered andprobed the Brugada Syndrome, discusses the history, etiology,pathology and clinical manifestations of sudden death. Fromdiagnosis, prognosis, to therapeutic approaches using the latest incathater ablation techniques, electrophysiological surgery, andgenetic appraisal, the work is a testimony to the author'sinvestigation. Using clinical cases in Thailand and Laos, theyfurther unravel the syndrome's molecular mechanisms, studyingrelated syndromes, such as the long-QT syndrome, infant death, andarryhthmogenic right ventricular cardiomyopathy. By being informed of the electrophysiological abnormalities thatcontribute to familial and genetic diseases, physicians,cardiologists and all those who care for patients with cardiacarrhythmias will be better able to identify and treat patients inwhom the Brugada Syndrome may strike next.

Brugada Phenocopy

Adrian Baranchuk
Brugada Phenocopy Book PDF

Author : Adrian Baranchuk
Publisher : Academic Press
Page : 154 pages
File Size : 54,6 Mb
Release : 2018-03-28
Category : Medical
ISBN : 9780128111529

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Brugada Phenocopy by Adrian Baranchuk Pdf

Brugada Phenocopy: The Art of Recognizing the Brugada ECG Pattern details all aspects associated with alternative diagnosis to Brugada Syndrome (BrS). Coverage includes how to identify the proper ECG pattern, what to do to investigate for BrP, and how to avoid misinterpretations and the use of unnecessary and expensive treatments. Chapters are written by experienced professionals, many of whom are colleagues that initially described this condition. This easy to use volume is a must have reference for researchers of cardiology, cardiologists, electrocardiologists, internists, emergency care doctors and students, residents and fellows. Assists in the proper recognition of the Brugada ECG patterns and how to distinguish true BrS from other conditions with identical ECG Expands understanding on how to properly recognize the ECG of Brugada patterns Contains access to a companion website with video to enhance understanding of proper measurement of the beta angle (Chevallier) and the base of the triangle (Serra)

Brugada Syndrome

Hubert Shaw
Brugada Syndrome Book PDF

Author : Hubert Shaw
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 46,8 Mb
Release : 2015
Category : Brugada syndrome
ISBN : 163483691X

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Brugada Syndrome by Hubert Shaw Pdf

Brugada syndrome (BrS) is a sudden cardiac death disease characterised by right bundle-branch block with ST segment elevation in the lead V1 and V2 in the absence of any structural diseases. This syndrome is highly associated with sudden cardiac death, especially in young adults. It is associated with a history of SCD in up to four first-degree family members. The authors of this book examine Brugada Syndrome (BS), and its possible link to arrhythmogenic cardiomyopathy. Furthermore, Type 1 ECG is considered a diagnostic sign for the Brugada Syndrome and its clinical significance is explored in this book. Lastly, the book presents the readers with a case report of a patient with Brugada syndrome characterised by an abnormal electrocardiogram (ECG).

J Wave Syndromes

Charles Antzelevitch,Gan-Xin Yan
J Wave Syndromes Book PDF

Author : Charles Antzelevitch,Gan-Xin Yan
Publisher : Springer
Page : 0 pages
File Size : 52,9 Mb
Release : 2018-05-30
Category : Medical
ISBN : 3319810685

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J Wave Syndromes by Charles Antzelevitch,Gan-Xin Yan Pdf

This book delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs to be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics. J wave syndromes are one of the hottest topics in cardiology today. Cardiac arrhythmias associated with Brugada syndrome (BrS) or an early repolarization (ER) pattern in the inferior or infero-lateral ECG leads are thought to be mechanistically linked to accentuation of transient outward current (Ito)-mediated J waves. Although BrS and ER syndrome (ERS) differ with respect to magnitude and lead location of abnormal J waves, they are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. ERS is divided into three subtypes with the most severe, Type 3, displaying an ER pattern globally in the inferior, lateral and right precordial leads. BrS has been linked to mutations in 19 different genes, whereas ERS has been associated with mutations in 7 different genes. There is a great deal of confusion as to how to properly diagnose and treat the J wave syndromes as well as confusion about the underlying mechanisms. The demonstration of successful epicardial ablation of BrS has provided new therapeutic options for the management of this syndrome for which treatment alternatives are currently very limited, particularly in the case of electrical storms caused by otherwise uncontrollable recurrent VT/VF. An early repolarization pattern is observed in 2-5% of the US population. While it is clear that the vast majority of individuals exhibiting an ER pattern are not at risk for sudden cardiac death, the challenge moving forward is to identify those individuals who truly are at risk and to design safe and effective treatments.

Electrical Diseases of the Heart

Ihor Gussak,A. A. M. Wilde,P. A. Friedman,Charles Antzelevitch,M. J. Ackerman,W.-K. Shen
Electrical Diseases of the Heart Book PDF

Author : Ihor Gussak,A. A. M. Wilde,P. A. Friedman,Charles Antzelevitch,M. J. Ackerman,W.-K. Shen
Publisher : Springer Science & Business Media
Page : 600 pages
File Size : 52,5 Mb
Release : 2008-09-08
Category : Medical
ISBN : 9781846288548

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Electrical Diseases of the Heart by Ihor Gussak,A. A. M. Wilde,P. A. Friedman,Charles Antzelevitch,M. J. Ackerman,W.-K. Shen Pdf

This book provides a unique contemporary and succinct distillation of the current status of recently delineated electrical diseases of the heart, emphasizing their common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science. The book is divided into seven major parts. Each part consists of chapters (total of 64) dealing with related topics.

Consults in Obstetric Anesthesiology

Suzanne K. W. Mankowitz
Consults in Obstetric Anesthesiology Book PDF

Author : Suzanne K. W. Mankowitz
Publisher : Springer
Page : 628 pages
File Size : 45,9 Mb
Release : 2018-11-15
Category : Medical
ISBN : 9783319596808

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Consults in Obstetric Anesthesiology by Suzanne K. W. Mankowitz Pdf

This text addresses the need for a book specifically aimed at obstetric anesthesia and covers topics such as pulmonary, cardiac renal, hepatic, hematologic, neurologic, endocrine and other diseases. The real anesthetic challenge arises when patients present to Labor and Delivery with unusual or complicated medical problems and, in recent years, a few of the larger institutions have developed an Obstetric Anesthesiology Consultation Service to prepare for the management of these patients. While most pregnant women who present to Labor and Delivery require anesthetic intervention, they typically meet the anesthesiologist for the first time in labor. Since the majority of laboring women are healthy without significant comorbidities, this does not present much of a challenge to the anesthesiologist and the anesthetic management tends to be straight-forward with favorable outcomes. However, using this new model, the anesthesiologist has the opportunity to discuss the various treatment modalities and potentially suggest diagnostic testing to be performed prior to delivery, similar to the pre-operative testing that is done in other surgical environments.

Clinical Cardiogenetics

H.F. Baars,P.A.F.M. Doevendans,J.J. van der Smagt
Clinical Cardiogenetics Book PDF

Author : H.F. Baars,P.A.F.M. Doevendans,J.J. van der Smagt
Publisher : Springer Science & Business Media
Page : 455 pages
File Size : 44,7 Mb
Release : 2010-12-25
Category : Medical
ISBN : 9781849964715

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Clinical Cardiogenetics by H.F. Baars,P.A.F.M. Doevendans,J.J. van der Smagt Pdf

Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included. This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as: Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?

Ferri's Clinical Advisor 2020 E-Book

Fred F. Ferri
Ferri s Clinical Advisor 2020 E Book Book PDF

Author : Fred F. Ferri
Publisher : Elsevier Health Sciences
Page : 2136 pages
File Size : 49,5 Mb
Release : 2019-06-01
Category : Medical
ISBN : 9780323679770

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Ferri's Clinical Advisor 2020 E-Book by Fred F. Ferri Pdf

Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri’s Clinical Advisor 2020 features the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today’s medical practice. Contains significant updates throughout, covering all aspects of current diagnosis and treatment. Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients.

Clinical Approach to Sudden Cardiac Death Syndromes

Ramon Brugada
Clinical Approach to Sudden Cardiac Death Syndromes Book PDF

Author : Ramon Brugada
Publisher : Springer Science & Business Media
Page : 340 pages
File Size : 53,6 Mb
Release : 2010-01-18
Category : Medical
ISBN : 9781848829275

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Clinical Approach to Sudden Cardiac Death Syndromes by Ramon Brugada Pdf

Clinical cardiologists are encountering an important challenge in the caring of families with inherited cardiac diseases. The majority of the inherited cardiac diseases causing sudden death express themselves at variable ages in the form of altered muscle function (i.e hypertrophic or dilated cardiomyopathy) or in the form of arrhythmias (i.e. Brugada syndrome, long QT syndrome). However, it is not uncommon that the first sign of the disease may actually be sudden cardiac death, even before the identification of clear clinical abnormalities. In this last decade, with more than 50 new disease-associated genes identified, the possibility of genetic testing has opened a new opportunity to disease diagnosis and prevention. Clinical and genetic research is continuously on-going not only to identify those at risk, but to better define their level or risk still with limited success.

Ventricular Arrhythmias

John M. Miller
Ventricular Arrhythmias Book PDF

Author : John M. Miller
Publisher : Unknown
Page : 0 pages
File Size : 53,6 Mb
Release : 2008
Category : Arrhythmia
ISBN : 1416062750

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Ventricular Arrhythmias by John M. Miller Pdf

Ventricular arrhythmias cause most cases of sudden cardiac death, which is the leading cause of death in the US. This issue reviews the causes of arrhythmias and the promising new drugs and devices to treat arrhythmias.

Electrocardiogram in Clinical Medicine

Michael J. Lipinski,Andrew E. Darby,Michael C. Bond,Nathan P. Charlton,Korin B. Hudson,Kelly Williamson
Electrocardiogram in Clinical Medicine Book PDF

Author : Michael J. Lipinski,Andrew E. Darby,Michael C. Bond,Nathan P. Charlton,Korin B. Hudson,Kelly Williamson
Publisher : John Wiley & Sons
Page : 510 pages
File Size : 44,5 Mb
Release : 2020-12-07
Category : Medical
ISBN : 9781118754559

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Electrocardiogram in Clinical Medicine by Michael J. Lipinski,Andrew E. Darby,Michael C. Bond,Nathan P. Charlton,Korin B. Hudson,Kelly Williamson Pdf

Offers a guide for a complete understanding of the disease and conditions most frequently revealed in ECGs recorded in the acute, critical, and emergency care settings Electrocardiogram in Clinical Medicine offers an authoritative guide to ECG interpretation that contains a focus and perspective from each of the three primary areas of medical care: acute care, critical care and emergency care. It can be used as a companion with the book ECGs for the Emergency Physician I & II (by Mattu and Brady) or as a stand-alone text. These three books can be described as a cumulative EGG reference for the medical provider who uses the electrocardiogram on a regular basis. Electrocardiogram in Clinical Medicine includes sections on all primary areas of ECG interpretation and application as well as sections that highlight use, devices and strategies. The medical content covers acute coronary syndromes and all related issues, other diseases of the myocardium, morphologic syndromes, toxicology and paediatrics; dysrhythmias will also be covered in detail. This important resource: • Goes beyond pattern recognition in ECGs to offer a real understanding of the clinical syndromes evidenced in ECGs and implications for treatment • Covers the indications, advantages and pitfalls of the use of ECGs for diagnosis in all acute care settings, from EMS to ED to Critical Care • Examines the ECG in toxic, metabolic and environmental presentations; critical information for acute care clinicians who need to be able to differentiate ODs, poisoning and other environmental causes from MI or other cardiac events • Facilitates clinical decision-making Written for practicing ER, general medicine, family practice, hospitalist and ICU physicians and medical students, Electrocardiogram in Clinical Medicine is an important book for the accurate interpretation of EGG results.

Cardiac Electrophysiology

Andrea Natale,Amin Al-Ahmad,Paul J. Wang,John DiMarco
Cardiac Electrophysiology Book PDF

Author : Andrea Natale,Amin Al-Ahmad,Paul J. Wang,John DiMarco
Publisher : Springer Science & Business Media
Page : 667 pages
File Size : 55,9 Mb
Release : 2011-03-01
Category : Medical
ISBN : 9781849963909

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Cardiac Electrophysiology by Andrea Natale,Amin Al-Ahmad,Paul J. Wang,John DiMarco Pdf

Clinical cardiac electrophysiology is one of the most rapidly expanding fields in cardiology. There are currently no comprehensive case based books in this field. A Case Review of Cardiac Electrophysiology is a case based review of cardiac electrophysiology. The aim of this book is to provide a comprehensive case based review of cardiac electrophysiology. It will include implantable device cases as well as ablation cases and difficult clinical cases and may be used as a useful review in cardiac electrophysiology for those taking board examinations. There will also be cases that will be useful for associate professionals working in the field of cardiac electrophysiology including those individuals working for industry.

Sex-Specific Analysis of Cardiovascular Function

Peter L. M. Kerkhof,Virginia M. Miller
Sex Specific Analysis of Cardiovascular Function Book PDF

Author : Peter L. M. Kerkhof,Virginia M. Miller
Publisher : Springer
Page : 725 pages
File Size : 50,7 Mb
Release : 2018-07-26
Category : Medical
ISBN : 9783319779324

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Sex-Specific Analysis of Cardiovascular Function by Peter L. M. Kerkhof,Virginia M. Miller Pdf

This book gathers together contributions from internationally renowned authors in the field of cardiovascular systems and provides crucial insight into the importance of sex- and gender-concepts during the analysis of patient data. This innovative title is the first to offer the elements necessary to consider sex-related properties in both clinical and basic studies regarding the heart and circulation on multiscale levels (i.e. molecular, cellular, electrophysiologically, neuroendocrine, immunoregulatory, organ, allometric, and modeling). Observed differences at (ultra)cellular and organ level are quantified, with focus on clinical relevance and implications for diagnosis and patient management. Since the cardiovascular system is of vital importance for all tissues, Sex-Specific Analysis of Cardiovascular Function is an essential source of information for clinicians, biologists, and biomedical investigators. The wide spectrum of differences described in this book will also act as an eye-opener and serve as a handbook for students, teachers, scientists and practitioners.

Cardiac Arrhythmias 1999

Antonio Raviele
Cardiac Arrhythmias 1999 Book PDF

Author : Antonio Raviele
Publisher : Springer Science & Business Media
Page : 626 pages
File Size : 47,9 Mb
Release : 1999
Category : Medical
ISBN : 8847000718

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Cardiac Arrhythmias 1999 by Antonio Raviele Pdf

The volume includes more than seventy articles written by well-recognized world leaders in the field of clinical electrophysiology and arrhythmology. It represents an important update on the most recent advances in the diagnosis, prognosis and treatment of cardiac arrhythmias.

Brugada Syndrome

Gregory Dendramis
Brugada Syndrome Book PDF

Author : Gregory Dendramis
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 47,5 Mb
Release : 2015-12
Category : Brugada syndrome
ISBN : 163483948X

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Brugada Syndrome by Gregory Dendramis Pdf

Electrocardiographically characterised by a distinct ST-segment elevation in the right precordial leads, Brugada syndrome (BrS) is an arrhythmogenic disease reported to be responsible for at least 4% of all sudden deaths (at least 20% of sudden deaths in those without structural heart disease), and is a leading cause of death in subjects under the age of forty years. Global prevalence of the BrS varies from 5% to 20% in every 10,000 inhabitants worldwide, and it is considered endemic in Asian and Southeast Asian countries. The diagnosis is mainly based on electrocardiographic features and may be hampered by incomplete penetrance, particularly because of dynamic ECG manifestations. As far as we know, inheritance occurs via an autosomal dominant mode of transmission, and about eighteen genes have been associated with BrS; thus far, genetic abnormalities are found in 30-50% of genotyped BrS patients. Mutations in the cardiac sodium channel gene SCN5A are identified in 1128% of patients with BrS, with over 300 different mutations of SCN5A having been identified as the list still grows. Because a genotype remains lacking for at least half of BrS probands, a negative genetic test does not rule out BrS. Febrile states, dysionia and many drugs such as vagotonic agents, sodium channel blockers, α-adrenergic agonists, β-adrenergic blockers, antidepressants, and alcohol and cocaine toxicity may unmask the electrocardiographic concealed ECG manifestations of BrS. Identifying patients with BrS at risk of malignant arrhythmias and sudden cardiac death remains the most important objective and therefore the fundamental question remains on the best strategy for assessing the real disease-associated arrhythmic risk, especially in asymptomatic patients. The therapeutic approach for patients with BrS is centered on the prevention of cardiac arrest and syncopal events due to ventricular arrhythmias. Lifestyle changes, such as never using drugs that may potentially induce ventricular arrhythmias and an immediate treatment of fever, should be recommended in all patients with diagnosis of BrS. Some drugs have been tested in BrS patients, but controlled data and/or randomised studies proving their real effective have not been performed. Currently, the cornerstone of therapy for the prevention of sudden cardiac death (SCD) is an implantable cardioverter defibrillator (ICD). An accurate individual risk stratification to select patients for ICD implantation should be accurately performed, particularly in asymptomatic patients. Lastly, catheter ablation of the substrate located in the anterior epicardial region of the right ventricular outflow tract may be considered in patients with a history of arrhythmic storms or repeated appropriate ICD shocks. The study of the areas of delayed depolarisation in patients with BrS and the procedure of catheter ablation of the substrate located in the anterior epicardial region therefore opens new horizons in regards to the management of patients with extremely frequent ventricular tachycardia/ventricular fibrillation (VT/VF), for patients at high risk who refuse the implantation of an ICD, and for a better prognostic stratification of patients with BrS not classified as high risk for SCD.