Clinical Approach To Sudden Cardiac Death Syndromes

Author : Ramon Brugada
Publisher : Springer Science & Business Media
Page : 340 pages
File Size : 54,7 Mb
Release : 2010-01-18
Category : Medical
ISBN : 9781848829275

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Clinical Approach to Sudden Cardiac Death Syndromes by Ramon Brugada Pdf

Clinical cardiologists are encountering an important challenge in the caring of families with inherited cardiac diseases. The majority of the inherited cardiac diseases causing sudden death express themselves at variable ages in the form of altered muscle function (i.e hypertrophic or dilated cardiomyopathy) or in the form of arrhythmias (i.e. Brugada syndrome, long QT syndrome). However, it is not uncommon that the first sign of the disease may actually be sudden cardiac death, even before the identification of clear clinical abnormalities. In this last decade, with more than 50 new disease-associated genes identified, the possibility of genetic testing has opened a new opportunity to disease diagnosis and prevention. Clinical and genetic research is continuously on-going not only to identify those at risk, but to better define their level or risk still with limited success.

Author : Silvia Priori,Douglas Zipes
Publisher : John Wiley & Sons
Page : 304 pages
File Size : 54,6 Mb
Release : 2009-02-05
Category : Medical
ISBN : 9781405173353

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Sudden Cardiac Death by Silvia Priori,Douglas Zipes Pdf

This book draws on the established European guidelines from the ESCthat address the key issues in sudden cardiac death, such asidentifying individuals at risk prior to an episode of aventricular tachyarrhythmia or a sudden cardiac arrest, andresponding in a timely fashion to the person suffering the eventout-of-the-hospital. It presents an update on what is known aboutsudden cardiac arrest, from basic experimental studies to clinicaltrials, and serves as a complement to the ESC Core Syllabus on thissubject. Topics include epidemiology, genetics, arrhythmogenicmechanisms, risk stratification, autonomic nervous system andphenotypes. Disease states and special populations are alsocovered, as well as drug, device and ablation treatments, and costeffectiveness. All chapters are co-authored by experts from bothEurope and the US. The ESC Education Series This book is part of the ESC Education Series. The series isdesigned to provide medical professionals with the latestinformation about the understanding, diagnosis and management ofcardiovascular diseases. Where available, managementrecommendations are based on the established European Guidelines,which encompass the best techniques to use with each cardiacdisease. Throughout the series, the leading international opinionleaders have been chosen to edit and contribute to the books. Theinformation is presented in a succinct and accessible format with aclinical focus.

Author : Charles Antzelevitch
Publisher : John Wiley & Sons
Page : 248 pages
File Size : 41,9 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405146814

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The Brugada Syndrome by Charles Antzelevitch Pdf

Until recently, the cellular basis for sudden death, the BrugadaSyndrome, has largely remained an unknown to modernarrhythmologists and cardiologists, particularly in the absence ofany structural heart disease. Detailed observations of age-groups,especially the young, families and populations where sudden deathfrequently occurs, and improved understanding of its contributoryfactors and mechanisms are, however, showing the way forward. This addition to the Clinical Approaches to Tachyarrhythmias(CATA) Series, written by the investigators who discovered andprobed the Brugada Syndrome, discusses the history, etiology,pathology and clinical manifestations of sudden death. Fromdiagnosis, prognosis, to therapeutic approaches using the latest incathater ablation techniques, electrophysiological surgery, andgenetic appraisal, the work is a testimony to the author'sinvestigation. Using clinical cases in Thailand and Laos, theyfurther unravel the syndrome's molecular mechanisms, studyingrelated syndromes, such as the long-QT syndrome, infant death, andarryhthmogenic right ventricular cardiomyopathy. By being informed of the electrophysiological abnormalities thatcontribute to familial and genetic diseases, physicians,cardiologists and all those who care for patients with cardiacarrhythmias will be better able to identify and treat patients inwhom the Brugada Syndrome may strike next.

Author : Peter Magnusson,Jo Ann LeQuang
Publisher : BoD – Books on Demand
Page : 198 pages
File Size : 50,7 Mb
Release : 2020-11-19
Category : Medical
ISBN : 9781838800697

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Sudden Cardiac Death by Peter Magnusson,Jo Ann LeQuang Pdf

Sudden cardiac death is a global health threat for which we have only partial answers. With growing elucidation of the underlying pathophysiological mechanisms of sudden cardiac death, better patient identification and treatment options are being developed. These include risk stratification paradigms, ICD therapy, pharmacological options, ablative procedures, and other treatments. This book covers many of these options, including defibrillator technology and clinical applications. It also examines pathophysiological pathways and etiologies as well as highlights risk-stratification in ion channel diseases and structural heart disease such as dilated cardiomyopathy.

Author : Jiashin Wu,Jessica Wu
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 42,9 Mb
Release : 2013
Category : Cardiac arrest
ISBN : 1626188254

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Sudden Death by Jiashin Wu,Jessica Wu Pdf

This book dedicates the first seven chapters to cardiac electrophysiological dysfunction that can lead to ventricular fibrillation and sudden death. The next six chapters expand the topics of sudden death to other causes. Brugada Syndrome is the top cause of non-traumatic sudden death in young males of Southeastern Asian and southern European origins. Chapters One and Two review extensively the history and current status, mechanisms of arrhythmias, and related gene mutations in Brugada Syndrome, and discuss gaps in the current knowledge. Chapter Three presents clinical studies on the A1180V and R1193Q mutations of the cardiac sodium channel gene, SCN5A. The authors identified R1193Q mutation in 12.8%-16% of a healthy Chinese population. This result prompted the question of whether SCN5A mutations are still the top genetic bases of Brugada and long QT syndromes. Chapters Four, Five and Seven discuss the pathophysiology causes, risk factors, predictors, prevention, and possible therapeutical strategies of sudden cardiac death. Chapter Six reviews the scope and causes of sudden cardiac death in athletics.Chapter Seven is dedicated to the roles of electrical cardiac systole in sudden death. Chapter Eight reviews sudden death related to cardiac and brain tumours, pulmonary tumour embolism, asphyxia, massive exsanguinations, and their pathophysiology. Chapter Nine summarises the pathophysiology of sudden death caused by myocardial tuberculosis. Chapter Ten introduces pathophysiology of sudden death during hot baths in deep bathtubs, which occurs frequently in elderly people in Japan. Chapter Eleven discusses air pollution as a trigger of sudden death. Chapter Twelve presents biochemical, cytological and histopathological examination of sudden unexpected death in infancy. The last chapter of the book, Chapter Thirteen, reviews post-mortem cardiac markers in different body fluids and their application in forensic pathology diagnosis of sudden cardiac death. In combination, these chapters cover a broad range of topics about sudden death.

Author : Mohammad Shenasa,N.A. Mark Estes III,Gordon F. Tomaselli
Publisher : Elsevier Health Sciences
Page : 128 pages
File Size : 42,5 Mb
Release : 2017-11-30
Category : Medical
ISBN : 9780323552691

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Contemporary Challenges in Sudden Cardiac Death, An Issue of Cardiac Electrophysiology Clinics, E-Book by Mohammad Shenasa,N.A. Mark Estes III,Gordon F. Tomaselli Pdf

This issue of Cardiac Electrophysiology Clinics, edited by Drs. Mohammad Shenasa, N. A. Mark Estes III, and Gordon F. Tomaselli, will cover Contemporary Challenges in Sudden Cardiac Death. Topics covered in this issue include Pathophysiology; Basic electrophysiological mechanism; Channelopathy and Myopathy as causes of sudden cardiac death; Public access to defibrillation; Sudden cardiac death in children adolescence; Sudden cardiac death in specific cardiomyopathies; Ventricular arrhythmias and sudden cardiac death; lessons learned from cardiac implantable rhythm devices; future directions, and more.

Author : Giannis G. Baltogiannis,Giulio Conte,Pedro Brugada,Juan Sieira,Gaetano M. De Ferrari
Publisher : Frontiers Media SA
Page : 135 pages
File Size : 42,7 Mb
Release : 2021-01-11
Category : Medical
ISBN : 9782889663705

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Sudden Cardiac Death and Channelopathies by Giannis G. Baltogiannis,Giulio Conte,Pedro Brugada,Juan Sieira,Gaetano M. De Ferrari Pdf

Author : Jiashin Wu,Wu Jiashin Wu Jessica
Publisher : Unknown
Page : 269 pages
File Size : 49,9 Mb
Release : 2013-01-01
Category : Medical
ISBN : 1626188440

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Sudden Death by Jiashin Wu,Wu Jiashin Wu Jessica Pdf

This book dedicates the first seven chapters to cardiac electrophysiological dysfunction that can lead to ventricular fibrillation and sudden death. The next six chapters expand the topics of sudden death to other causes. Brugada Syndrome is the top cause of non-traumatic sudden death in young males of Southeastern Asian and southern European origins. Chapters One and Two review extensively the history and current status, mechanisms of arrhythmias, and related gene mutations in Brugada Syndrome, and discuss gaps in the current knowledge. Chapter Three presents clinical studies on the A1180V and R1193Q mutations of the cardiac sodium channel gene, SCN5A. The authors identified R1193Q mutation in 12.8%-16% of a healthy Chinese population. This result prompted the question of whether SCN5A mutations are still the top genetic bases of Brugada and long QT syndromes. Chapters Four, Five and Seven discuss the pathophysiology causes, risk factors, predictors, prevention, and possible therapeutical strategies of sudden cardiac death. Chapter Six reviews the scope and causes of sudden cardiac death in athletics. Chapter Seven is dedicated to the roles of electrical cardiac systole in sudden death. Chapter Eight reviews sudden death related to cardiac and brain tumors, pulmonary tumor embolism, asphyxia, massive exsanguinations, and their pathophysiology. Chapter Nine summarizes the pathophysiology of sudden death caused by myocardial tuberculosis. Chapter Ten introduces pathophysiology of sudden death during hot baths in deep bathtubs, which occurs frequently in elderly people in Japan. Chapter Eleven discusses air pollution as a trigger of sudden death. Chapter Twleve presents biochemical, cytological and histopathological examination of sudden unexpected death in infancy. The last chapter of the book, Chapter Thirteen, reviews postmortem cardiac markers in different body fluids and their application in forensic pathology diagnosis of sudden cardiac death. In combination, these chapters cover a broad range of topics about sudden death.

Author : Ivana Vranic
Publisher : Unknown
Page : 0 pages
File Size : 54,9 Mb
Release : 2017
Category : Arrhythmia
ISBN : 1536119830

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Sudden Cardiac Death by Ivana Vranic Pdf

This is a detailed clinical compilation on sudden cardiac death causes. From the various geographical regions of the world comes different clinical perspectives toward the SCD problem that shed light on the predictors and estimated prevalence in genetic inheritance worldwide. For many centuries, the mysterious deaths of prominent professional sportsmen have preoccupied the attention of the media and medical professionals. In some cases, it was possible to obtain the medical histories of the victims, data on the presence of some specific diseases, and conditions or potential symptoms preceding the fatal episode. Various rare inherited syndromes that are associated with congenital heart disease are focused on in this study, and the interrelationship between ventricular premature beats, sustained/non-sustained ventricular tachycardias and ventricular fibrillations are discussed. Cardio-oncology is an emerging field where more and more patients face consequences from radiotherapy and chemotherapy because these individuals become more prone to SCD. Among the most notable developments, three-dimensional echocardiography and myocardial strain imaging are worth noting and might inexpensively improve the current risk stratification process. Recently, a strain that reflects the change of length and thickness of myocardial fibres has been incorporated into the routine clinical practice. The risk of sudden cardiac death is not the same in patients with Chagas disease, and newly predicted factors are to blame. The prevalence of SCD, hypertrophic cardiomyopathy and the accurate risk are extremely challenging, so much so that they recently became a source of argument between European and American experts. This is a must-have book for those interested in a clinical approach to the SCD phenomenon.

Author : Gareth D. Matthews
Publisher : Frontiers E-books
Page : 137 pages
File Size : 47,8 Mb
Release : 2014-10-02
Category : Cardiac arrest
ISBN : 9782889192694

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Sudden arrhythmic death: from basic science to clinical practice by Gareth D. Matthews Pdf

With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future

Author : Paul J. Wang,Henry H. Hsia,Amin Al-Ahmad,Paul C. Zei
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 41,5 Mb
Release : 2009-01-26
Category : Medical
ISBN : 1444300318

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Ventricular Arrhythmias and Sudden Cardiac Death by Paul J. Wang,Henry H. Hsia,Amin Al-Ahmad,Paul C. Zei Pdf

Ventricular arrhythmias and sudden death are responsible forhundreds of thousands of deaths each year throughout the world.Covering the most recent developments in this field, this leadingtext serves as a guide to this area of increasing clinicalimportance, addressing a wide range of topics, including: basic mechanisms of ventricular tachycardia and ventricularfibrillation clinical syndromes and etiologies epidemiology and risk stratification pharmacologic therapy ablation and surgery implantable defibrillators Ventricular Arrhythmias and Sudden Cardiac Death providesthe information that cardiologists, cardiac electrophysiologists,cardiac electrophysiology fellows, scientists, industry, andassociated professionals need to know about current and evolvingVentricular Tachyarrhythmia treatment and diagnosis. As the mostcomprehensive book on this topic, it will serve as the text thatthis readership will turn to first.

Author : Gaetano Thiene,Domenico Corrado,Cristina Basso
Publisher : Springer
Page : 190 pages
File Size : 45,9 Mb
Release : 2016-03-04
Category : Medical
ISBN : 9788847057760

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Sudden Cardiac Death in the Young and Athletes by Gaetano Thiene,Domenico Corrado,Cristina Basso Pdf

This text atlas focuses on the pathology and molecular genetics of sudden cardiac death in the young and in athletes, presenting the state of the art in the field as the basis for development and implementation of more effective prevention strategies, including, ultimately, molecular therapy that will cure the underlying biological defect. A wealth of high-resolution color images, accompanied by clear supporting text, are presented to document the anatomic pathology of the cardiac diseases most frequently responsible for sudden cardiac death in this population, including coronary artery diseases, cardiomyopathies, myocarditis, valve diseases, conduction system abnormalities, congenital heart diseases, and ion channel diseases. The role of the molecular autopsy in overcoming the limitations of morphological investigations and offering new insights and avenues for prevention is explained. The approach is, however, interdisciplinary, with close attention also to epidemiologic and clinical aspects. The authors draw throughout on their experience gained over 30 years in the course of a prospective study carried out in the Veneto Region, North East Italy. This text atlas will be of great value not only for cardiologists but also for geneticists, sports physicians, and residents in cardiology and pathology.

Author : Hubert Shaw
Publisher : Unknown
Page : 105 pages
File Size : 48,6 Mb
Release : 2015
Category : HEALTH & FITNESS
ISBN : 1634837096

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Brugada Syndrome by Hubert Shaw Pdf

Brugada syndrome (BrS) is a sudden cardiac death disease characterized by right bundle-branch block with ST segment elevation in the lead V1 and V2 in the absence of any structural diseases. This syndrome is highly associated with sudden cardiac death, especially in young adults. It is associated with a history of SCD in up to four first-degree family members. The authors of this book examine Brugada Syndrome (BS), and its possible link to arrhythmogenic cardiomyopathy. Furthermore, Type 1 ECG is considered a diagnostic sign for the Brugada Syndrome and its clinical significance is explored in this book. Lastly, the book presents the readers with a case report of a patient with Brugada syndrome characterized by an abnormal electrocardiogram (ECG).

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on the Treatment of Cardiac Arrest: Current Status and Future Directions
Publisher : National Academies Press
Page : 456 pages
File Size : 44,8 Mb
Release : 2015-09-29
Category : Medical
ISBN : 9780309372022

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Strategies to Improve Cardiac Arrest Survival by Institute of Medicine,Board on Health Sciences Policy,Committee on the Treatment of Cardiac Arrest: Current Status and Future Directions Pdf

Cardiac arrest can strike a seemingly healthy individual of any age, race, ethnicity, or gender at any time in any location, often without warning. Cardiac arrest is the third leading cause of death in the United States, following cancer and heart disease. Four out of five cardiac arrests occur in the home, and more than 90 percent of individuals with cardiac arrest die before reaching the hospital. First and foremost, cardiac arrest treatment is a community issue - local resources and personnel must provide appropriate, high-quality care to save the life of a community member. Time between onset of arrest and provision of care is fundamental, and shortening this time is one of the best ways to reduce the risk of death and disability from cardiac arrest. Specific actions can be implemented now to decrease this time, and recent advances in science could lead to new discoveries in the causes of, and treatments for, cardiac arrest. However, specific barriers must first be addressed. Strategies to Improve Cardiac Arrest Survival examines the complete system of response to cardiac arrest in the United States and identifies opportunities within existing and new treatments, strategies, and research that promise to improve the survival and recovery of patients. The recommendations of Strategies to Improve Cardiac Arrest Survival provide high-priority actions to advance the field as a whole. This report will help citizens, government agencies, and private industry to improve health outcomes from sudden cardiac arrest across the United States.

Author : Ihor Gussak,Charles Antzelevitch,Arthur A.M. Wilde,Brian D. Powell,Michael J. Ackerman,Win-Kuang Shen
Publisher : Springer Science & Business Media
Page : 682 pages
File Size : 41,6 Mb
Release : 2013-05-23
Category : Medical
ISBN : 9781447149781

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Electrical Diseases of the Heart by Ihor Gussak,Charles Antzelevitch,Arthur A.M. Wilde,Brian D. Powell,Michael J. Ackerman,Win-Kuang Shen Pdf

Electrical Disease of the Heart, 2nd Edition, volume 2, covers the diagnostic and treatment options available in the management of electrical diseases and with its companion volume provides the latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities. This book is highly relevant to a broad audience, ranging from medical and graduate students, to clinicians and scientists.