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Author : William Klyne
Publisher : Unknown
Page : 232 pages
File Size : 47,5 Mb
Release : 1960
Category : Steroids
ISBN : UOM:39015004320753
Author : Charles W. Shoppee
Publisher : Unknown
Page : 332 pages
File Size : 49,6 Mb
Release : 1958
Category : Steroids
ISBN : CORNELL:31924002975039
Author : J. R. Hanson
Publisher : Elsevier
Page : 112 pages
File Size : 52,8 Mb
Release : 2016-06-23
Category : Science
ISBN : 9781483139289
Introduction to Steroid Chemistry is a six-chapter introductory text of the analysis, conformation, and production of steroids. After providing a brief overview of steroid chemistry, this book goes on discussing the application of physical methods to the analysis of structural and stereochemical correlations in steroids, such as UV, infrared, NMR, and mass spectroscopy, optical rotary dispersion, and circular dichroism. The subsequent two chapters describe the influence of steroid conformation and molecular rearrangements on reactions rates and reaction products. The remaining chapters explore the improvements in the synthesis of the estrogenic hormones and the biosynthetic pathways and metabolism of cholesterol. This book will be of value to general and organic chemists, biochemists, and research workers in related subjects.
Author : Jorge António Ribeiro Salvador,Maria Manuel Cruz Silva
Publisher : BoD – Books on Demand
Page : 144 pages
File Size : 45,6 Mb
Release : 2020-02-26
Category : Science
ISBN : 9781789855159
The steroid scaffold continues to be the structural basis of new drugs for a variety of targets and diseases. Indeed, steroids interact with enzymes and receptors in a strikingly specific manner. Chemistry and Biological Activity of Steroids aims to provide an updated overview of recent advances in the medicinal chemistry of steroids. Novel synthetic methods in the steroids field, including steroid biotransformations, new steroids able to tackle steroid receptors, and steroid enzymes with clinical relevance, are critically reviewed in this book. Furthermore, the diverse physiopathological roles of oxysterols and their therapeutic value are also discussed.
Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 154 pages
File Size : 46,5 Mb
Release : 2011-06-20
Category : Science
ISBN : 9781119957294
The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids - androgens - actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable number of which are commercial drugs that share the same structural carbon skeleton. The development of these drugs has led to a large body of organic chemistry often denoted as "Steroid Chemistry". Steroid Chemistry At A Glance provides a concise overview of the main principles and reactions of steroid chemistry. Topics covered include: history, isolation and structure determination of steroids steroid nomenclature and stereochemistry natural sources of steroids synthesis and reactions of aromatic a-ring steroids, androstanes, and pregnanes steroids with a spirolactone at position 17 steroids with hetrocyclic ring A compounds derived from cholesterol Based on the highly successful and student friendly "at a glance" approach, the information is presented in integrated, self contained double page spreads of text and illustrative material. Students of chemistry and pharmacy using Steroid Chemistry at a Glance will find they have a resource with which they can quickly, concisely and confidently acquire, regularly review and revise the basic facts that underpin the properties, synthesis and reactions of this important class of natural products. It will also serve as a handy bench reference for postgraduates and professional chemists.
Author : F. J. Zeelen
Publisher : Elsevier Publishing Company
Page : 380 pages
File Size : 54,6 Mb
Release : 1990
Category : Medical
ISBN : UOM:39015019394280
The many new and fascinating data which have been gathered in the period 1985-1990 have made molecular endocrinology into a mature discipline stimulating creative chemists to design innovative drugs. Within a few years, the primary structures of all the steroid receptor proteins and most of the steroid-converting enzymes have been determined and detailed studies of their mechanism of action at a molecular level have become possible. Medicinal chemists have developed steroidal affinity probes to examine the binding sites of enzymes and receptors, and these investigations were supplemented with studies of modified enzymes and receptors prepared with the aid of site-directed mutagenesis. In view of these rapid scientific developments, the author deemed it appropriate to review the present knowledge of the medicinal chemistry of the steroids. In this book, the discussion is supported by the addition of some chapters which summarize the available data on the biological counterparts of the steroids, the steroid-converting enzymes and the steroid receptors.
Author : Klyne
Publisher : Unknown
Page : 241 pages
File Size : 40,7 Mb
Release : 1973-01-01
Category : Electronic
ISBN : 0470494603
Author : John Fried,John Ansley Edwards
Publisher : Unknown
Page : 486 pages
File Size : 40,6 Mb
Release : 1972
Category : Organic compounds
ISBN : UCAL:B5178670
Author : J. R. Hanson
Publisher : Pergamon
Page : 104 pages
File Size : 42,6 Mb
Release : 1968
Category : Steroids
ISBN : 0080128084
Author : H.-L. Krüskemper
Publisher : Elsevier
Page : 246 pages
File Size : 44,8 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483265049
Anabolic Steroids attempts to trace the development of anabolic steroids in the chemical, experimental biological, and clinical disciplines, and presents a precise outline of the current state of substantiated knowledge. This book deals with anabolic steroids derived from natural androgens and characterized by their stimulatory action on the biosynthesis of tissue protein and by their simultaneous low androgenicity. The biochemical part is a review of substantiated and current knowledge based largely on experimental results with animals, while the clinical part attempts to bring out the pathophysiological rationale of therapy with anabolic steroids, again based on experimental data. The book begins with a discussion of the nomenclature and chemistry of anabolic steroids. This is followed by separate chapters on the metabolism, activities, and mechanism of action of anabolic steroids; clinical application of anabolic steroids, side effects, and test procedures.
Author : W. Klyne
Publisher : Unknown
Page : 128 pages
File Size : 43,6 Mb
Release : 1865
Category : Electronic
ISBN : OCLC:499981420
Author : Professor Satyajit D. Sarker,Lutfun Nahar
Publisher : John Wiley & Sons
Page : 414 pages
File Size : 44,5 Mb
Release : 2012-04-13
Category : Science
ISBN : 9781119972846
Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create “molecular umbrellas” for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimers naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins biological and pharmacological functions of steroid dimers and their application in drug design and discovery steroid dimers as “molecular umbrellas” for drug delivery Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.
Author : A. A. Akhrem
Publisher : Springer Science & Business Media
Page : 368 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781475705874
Since the appearance of the Russian edition of this monograph (1967), the main tendencies of the development of total synfuesis have not changed. The accelerated accumulation of experimental material is continuing, mainly in the form of the improvement of already-existing synthesis schemes. The main new advance is the development of asymmetric syn theses with intermediates that have made it possible to avoid the main dis advantage of total synthesis - the formation of racemic final compounds. The most important work that has appeared since the appearance of the Russian edition is given in an Appendix to the book. Apart from this, only a very slight rearrangement of the material and of some of the schemes has been carried out for the American edition. A. A. Akhrem Yu. A. Titov Moscow, July 1968 v Preface to the Russian Edition Steroids are one of the most interesting and most widely distributed and, at the same time, one of the most structurally complex groups of natural compounds. In spite of this, the great theoretical and practical importance of steroids for biology and medicine has led to very intensive scientific research work on their synthesis. The numerous methods for obtaining steroids developed at the present time can be divided into four main groups: isolation from natural sources, microbiological synthesis, partial synthesis from natural raw material already containing the steroid skeleton, and, finally, total chemical synthesis from precursors of com paratively simple structure.
Author : Leland J. Chinn
Publisher : Unknown
Page : 180 pages
File Size : 43,9 Mb
Release : 1969
Category : Steroids
ISBN : UOM:39015000796048
Author : S. Görög
Publisher : Elsevier
Page : 440 pages
File Size : 45,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780444597526
Studies in Analytical Chemistry, Volume 5: Quantitative Analysis of Steroids covers the pharmaceutical aspects of the analysis of steroid hormones. This book is divided into nine chapters that examine the biological-clinical analysis of other important groups of steroids, including sterols, vitamin D, bile acids, cardiac glycosides, and sapogenins. The material in the book is classified according to the main groups of steroids, individual chapters being devoted to sex hormones, corticosteroids, sterols, vitamins D, bile acids, cardiac glycosides, sapogenins, and miscellaneous steroids. The structure of each chapter is the same. In section 1 the fundamentals of the chemistry of the group of steroids in question are outlined. Section 2 provides a detailed description of the use of various spectroscopic, chromatographic, protein-binding and other methods, while Section 3 deals with the main problems encountered in the analysis of the group of steroids in question and with their solution using the methods described in Section 2. This book will prove useful to steroid and analytical chemists.