The Chemistry Of Ynamides

Author : Gwilherm Evano,Junfeng Zhao
Publisher : CRC Press
Page : 733 pages
File Size : 52,9 Mb
Release : 2024-06-14
Category : Medical
ISBN : 9781003831525

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The Chemistry of Ynamides by Gwilherm Evano,Junfeng Zhao Pdf

Ynamides contain a triple bond directly connected to a nitrogen atom that bears an electron-withdrawing group. They represent an especially useful and emerging class of reagents, notably because of their strongly polarized triple bond, which enables the development of unique chemical transformations. While they were discovered by Viehe in 1972, their chemistry has remained little investigated and the renaissance of ynamide chemistry started at the dawn of the 20th century with the development of efficient methods for their synthesis. Since then, ynamide chemistry has developed at a remarkably high rate, notably in the past 20 years. Although there are several reviews on ynamide chemistry, most of them are out of date or only focus on special aspects of ynamide chemistry and there is no book about ynamide chemistry yet. Thus, a comprehensive book on ynamide chemistry would be timely and is highly needed. This book covers all aspects of ynamide chemistry, including their discovery, their syntheses, their application in heterocyclic chemistry, natural product synthesis, and organometallic chemistry, and their use as coupling reagents. It provides a systematic and comprehensive overview on ynamide chemistry for the researchers in this field, general readers interested in synthesis, and those who want to enter this field and need a comprehensive and up-to-date overview. Undoubtedly, this book will play a key role in connecting the past with the future to further foster the development of ynamide chemistry.

Author : Tim Wezeman
Publisher : Logos Verlag Berlin GmbH
Page : 253 pages
File Size : 44,5 Mb
Release : 2016-12-31
Category : Science
ISBN : 9783832543976

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Sulfonyl Ynamides as Useful Tools for N-Heterocyclic Chemistry by Tim Wezeman Pdf

Sulfonyl ynamides are highly versatile and synthetically useful reagents. This thesis details the modular synthesis and use of sulfonyl ynamides in order to access N-heterocyclic scaffolds, such as quinolines and pyrazoles. The synthesis of a wide array of sulfonyl ynamides can be realized via copper-catalyzed amidative cross-couplings or by elimination of dichloroenamide precursors. Additionally the use of Sonogashira chemistry to further diversify terminal ynamides and the synthesis of solid-supported ynamides was investigated. Electrophilically-activated amides can be reacted with sulfonyl ynamides in order to access highly functionalized 4-aminoquinolines. The straightforward amide activation procedure with triflic anhydride and 2-chloropyridine was found to tolerate a wide range of substrates, which allowed for the development of a library of 4-aminoquinolines with ease. Moreover, 4-aminopyrazoles can be prepared by reacting terminal sulfonyl ynamides with sydnones under copper catalysis. However, as the copper catalysts were also found to promote the degradation of the ynamides, a copper-free strain-promoted alternative was developed. An in situ prepared 3-azacyclohexyne was found to tolerate a wide array of C-4 substituted sydnones, producing a mixture of both the 3,4- and 4,3-fused pyrazoles in good yields. Additional investigations into heterocyclic methodology led to the development of highly sophisticated, non-symmetrical and axially-chiral dibenzo-1,3-diazepines, -oxazepines and -thiazepines from simple, commercially available anilines. The anilines were coupled to their corresponding reaction partners via a chloromethyl intermediate and the 7-membered ring was subsequently formed using direct arylation.

Author : Whitney Leanne Johnson
Publisher : Unknown
Page : 208 pages
File Size : 40,7 Mb
Release : 2008
Category : Electronic
ISBN : WISC:89099131237

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The Chemistry of Ynamides in the Synthesis of Chiral Biaryls and Heterocycles by Whitney Leanne Johnson Pdf

Author : Henri Groult,Frederic Leroux,Alain Tressaud
Publisher : Elsevier
Page : 760 pages
File Size : 51,7 Mb
Release : 2016-11-04
Category : Science
ISBN : 9780128037904

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Modern Synthesis Processes and Reactivity of Fluorinated Compounds by Henri Groult,Frederic Leroux,Alain Tressaud Pdf

Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with the correlation of those properties to valuable applications of fluorinated compounds. Contains quality content edited, and contributed, by leading scholars in the field Presents applied guidance on the preparation of original fluorinated compounds, potentially transferable from the lab scale to industrial applications Provides practical synthesis information for a wide audience interested in fluorine compounds in many branches of chemistry, materials science, and physics

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Page : 333 pages
File Size : 42,7 Mb
Release : 2020-11-03
Category : Science
ISBN : 9789811405082

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Advances in Organic Synthesis: Volume 13 by Atta-ur-Rahman Pdf

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. This volume presents the following reviews: Electroluminescent polymers - a review on synthesis from organic compounds Remarkable advances in the asymmetric synthesis of biologically active natural compounds from the advent of chiral auxiliaries The chemistry of ynamides and their application in organic synthesis Carbon-heteroatom bond formation for medium ring heterocycles Tin(ii) salts: versatile and efficient lewis acid catalysts in reactions to add value to the glycerol and terpenic alcohols (E)-n-methyl-1-(methylthio)-2-nitroethenamine (nmsm) as a versatile ambiphilic synthon in organic synthesis.

Author : Huanfeng Jiang,Chuanle Zhu,Wanqing Wu
Publisher : Springer
Page : 77 pages
File Size : 41,9 Mb
Release : 2015-11-23
Category : Science
ISBN : 9783662490013

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Haloalkyne Chemistry by Huanfeng Jiang,Chuanle Zhu,Wanqing Wu Pdf

This book presents efficient and practical methods for the synthesis of various functionalized organic molecules from haloalkynes through different reaction processes such as cross-coupling reactions, nucleophilic additions and cycloadditions. It consists of four chapters demonstrating interesting examples of these transformations, and showcasing the synthetic power of haloalkynes for rapid assembly of complex molecular structures. Most of the protocols allow multiple bond-forming events to occur in a single operation, offering opportunities to advance chemical synthesis and address the increasing demands for green and sustainable chemistry. It also presents a wide range of functionalized products, including many synthetically useful conjugated cyclic and acyclic structures that have potential applications in materials science, chemical biology and natural product synthesis. This book is a valuable reference not only for organic chemists, but also for biologists and materials scientists involved in the modern synthesis of organic compounds and materials. Huanfeng Jiang and Wanqing Wu are both Professors at the School of Chemistry and Chemical Engineering, South China University of Technology, China. Chuanle Zhu is a Postdoctoral Fellow at the School of Chemistry and Chemical Engineering, South China University of Technology, China.

Author : Gwilherm Evano,Nicolas Blanchard
Publisher : John Wiley & Sons
Page : 682 pages
File Size : 49,7 Mb
Release : 2013-09-23
Category : Science
ISBN : 9781118690475

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Copper-Mediated Cross-Coupling Reactions by Gwilherm Evano,Nicolas Blanchard Pdf

Providing comprehensive insight into the use of copper in cross-coupling reactions, Copper-Mediated Cross-Coupling Reactions provides a complete up-to-date collection of the available reactions and catalytic systems for the formation of carbon-heteroatom and carbon-carbon bonds. This essential reference covers a broad scope of copper-mediated reactions, their variations, key advances, improvements, and an array of academic and industrial applications that have revolutionized the field of organic synthesis. The text also discusses the mechanism of these transformations, the use of copper as cost-efficient alternative to palladium, as well as recently developed methods for conducting copper-mediated reactions with supported catalysts.

Author : Marvin J. Miller
Publisher : John Wiley & Sons
Page : 470 pages
File Size : 55,5 Mb
Release : 2007-10-08
Category : Science
ISBN : 9780470099018

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Organic Syntheses, Volume 84 by Marvin J. Miller Pdf

Organic Syntheses: Volume 84 continues the tradition of providing significant and interesting procedures, which should prove worthwhile to many synthetic chemists working in increasingly diverse areas.

Author : John L Wood
Publisher : John Wiley & Sons
Page : 648 pages
File Size : 41,6 Mb
Release : 2020-04-14
Category : Science
ISBN : 9781119707769

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Organic Syntheses, Volume 96 by John L Wood Pdf

The current volume continues the tradition of the Organic Syntheses series, providing carefully checked and edited experimental procedures that describe important synthetic methods, transformations, reagents, and synthetic building blocks or intermediates with demonstrated utility in organic synthesis. These significant and interesting procedures should prove worthwhile to many synthetic chemists working in increasingly diverse areas. A trusted guide for professionals in organic and medicinal chemistry in academia, government, and industries, including pharmaceuticals, fine chemicals, agrochemicals, and biotechnological products.

Author : Robert A. Stockland, Jr.
Publisher : John Wiley & Sons
Page : 704 pages
File Size : 43,5 Mb
Release : 2016-03-16
Category : Science
ISBN : 9781119015772

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Practical Functional Group Synthesis by Robert A. Stockland, Jr. Pdf

A practical handbook for chemists performing bond forming reactions, this book features useful information on the synthesis of common functional groups in organic chemistry. • Details modern functional group synthesis through carbon-heteroelement (N, O, P, S, B, halogen) bond forming reactions with a focus on operational simplicity and sustainability. • Summarizes key and recent developments – which are otherwise scattered across journal literature – into a single source • Contains over 100 detailed preparations of common functional groups • Included 25 troubleshooting guides with suggestions and potential solutions to common problems. • Complements the text in enhanced ebook editions with tutorial videos where the author provides an introduction to microwave assisted chemistry

Author : Gwilherm Evano,Nicolas Blanchard
Publisher : John Wiley & Sons
Page : 0 pages
File Size : 47,8 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781118060452

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Copper-Mediated Cross-Coupling Reactions by Gwilherm Evano,Nicolas Blanchard Pdf

Providing comprehensive insight into the use of copper in cross-coupling reactions, Copper-Mediated Cross-Coupling Reactions provides a complete up-to-date collection of the available reactions and catalytic systems for the formation of carbon-heteroatom and carbon-carbon bonds. This essential reference covers a broad scope of copper-mediated reactions, their variations, key advances, improvements, and an array of academic and industrial applications that have revolutionized the field of organic synthesis. The text also discusses the mechanism of these transformations, the use of copper as cost-efficient alternative to palladium, as well as recently developed methods for conducting copper-mediated reactions with supported catalysts.

Author : Jason Alan Mulder
Publisher : Unknown
Page : 854 pages
File Size : 46,8 Mb
Release : 2004
Category : Electronic
ISBN : MINN:31951P00620349J

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I. Synthesis of Chiral Ynamides ; II. Reactions Involving Chiral Ynamides by Jason Alan Mulder Pdf

Author : Anonim
Publisher : ScholarlyEditions
Page : 1232 pages
File Size : 52,7 Mb
Release : 2013-05-01
Category : Science
ISBN : 9781490106311

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Issues in Chemistry and General Chemical Research: 2013 Edition by Anonim Pdf

Issues in Chemistry and General Chemical Research: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Chirality. The editors have built Issues in Chemistry and General Chemical Research: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chirality in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Chemistry and General Chemical Research: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 823 pages
File Size : 41,6 Mb
Release : 2021-02-26
Category : Science
ISBN : 9780323851336

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Green Synthetic Approaches for Biologically Relevant Heterocycles by Goutam Brahmachari Pdf

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume Two: Green Catalytic Systems and Solvents reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume Two explores green catalytic systems and solvents and the techniques surrounding this approach, including metal and magnetic catalysis to organocatalysis and solid acid catalysis, cycloaddition reactions, and varied approaches using ionic liquids. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field with an emphasis on sustainability Highlights a range of different eco-friendly solvents and environmentally-friendly catalysts Collates the experience of a global team of expert contributors

Author : Anonim
Publisher : Unknown
Page : 686 pages
File Size : 53,7 Mb
Release : 2008
Category : Chemistry
ISBN : UCSD:31822036046027

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Bulletin of the Chemical Society of Japan by Anonim Pdf