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Author : Shirley Bonnem
Publisher : Unknown
Page : 128 pages
File Size : 47,5 Mb
Release : 1995-05-01
Category : Electronic
ISBN : 0961737026
Author : Shirley Bonnem
Publisher : Unknown
Page : 272 pages
File Size : 51,6 Mb
Release : 1995
Category : Electronic
ISBN : 0961737018
Author : Gianluca Tadini,Eric Legius,Hilde Brems
Publisher : Springer Nature
Page : 316 pages
File Size : 47,9 Mb
Release : 2020-06-02
Category : Medical
ISBN : 9783319924502
This volume offers an update of the clinical signs, diagnostic criteria (including molecular diagnosis) and targeted therapies for a particular type of genodermatosis, providing a handy and unique tool for early diagnosis. In recent years, our understanding of genodermatosis and neurocutaneous syndromes has increased, but although Type 1 Neurofibromatosis (NF1) is the most common neuroectodermal disorder and involves a large number of patients and medical disciplines, this syndrome remains underestimated, often misdiagnosed thus leading to inaccurate treatment. The literature on the molecular and pathogenetic aspects is ample, but current clinical approaches, classification, diagnostic criteria and treatment protocols are outdated, creating difficulties in early diagnosis and treatment. As such, a chapter is devoted renewing current diagnostic criteria; it includes clinical and molecular data, to offer a sound, updated discussion basis for a consensus conference. NF1 is a “time-dependent” disorder, meaning that the onset of clinical signs are closely linked to patient age and the book discusses this particularly neglected aspect extensively, as well as the latest molecular diagnosis techniques, which are highly sensitive have not been included in the diagnostic criteria. It also explains the role of the RAS-MAPK pathway and genotype-phenotype correlations. In addition it explores new concepts concerning the pathogenesis of neurofibromas and other hamarthomas and their relevance for a modern therapeutical approach with targeted molecular drugs, as well as newly discovered aspects of NF1 in all internal organs, together with their diagnostic counterparts. A chapter on mosaic neurofibromatosis is also included. There is a particular focus on differential diagnosis (i.e. other diseases with café-au-lait macules), and the recently described Legius syndrome will be presented directly by Prof Eric Legius. All chapters are easy-to-understand, up-to-date, comprehensive and concise tools and are intended for a wide range of professionals involved with genetic disorders of the skin and neurocutaneous diseases: dermatologists, pediatricians, neurologists, oncologists and general practitioners.
Author : Dennis Drotar
Publisher : Springer Science & Business Media
Page : 556 pages
File Size : 47,5 Mb
Release : 2013-11-11
Category : Psychology
ISBN : 9781461541653
The professional development of researchers is critical for the future development ofthe fields of pediatric and clinical child psychology. In order to conduct research in pediatric and clinical child psychology, researchers need to work with a wide range of populations and master an increasingly wide range of skills, many of which are either not formally taught or considered in sufficient depth in clinical training. Such skills include the development of resources for research by writing grants to government agencies and foundations; skills in preparing research for publications concerning original research, review articles, or case reports; scien tific presentation skills; the ability to review and edit scientific manuscripts; and to implement and manage research in applied settings. Moreover, the increasing complexity of research in pediatric and clinical child psychology requires success ful researchers in these fields to develop their expertise with a wide range of new specialized methodologies, data analytic methods, models of data analysis, and methods of assessment. Finally, to enhance the relevance of their research to practice, researchers in pediatric and clinical child psychology need to integrate their work with clinical service delivery programs that are based on empirical research. The necessity to train researchers in pediatric and clinical child psychology in such multifaceted knowledge and skills places extraordinary burdens on profes sional training programs. Professional researchers in pediatric and child clinical psychology also are challenged to develop new knowledge and skills through continuing education and faculty development programs.
Author : Catherine J. Cullinane,Jeremy A. Squire
Publisher : Oxford Medical Publications
Page : 360 pages
File Size : 54,9 Mb
Release : 2003
Category : Medical
ISBN : 9780192630797
There has been an explosion of knowledge and enormous progress in the fundamental understanding of the biology of cancer in recent years. This has included the realisation that cancer occurs when normal cellular functions are disturbed leading to a malignant phenotype. Much research has focused on understanding the types of disturbances that can occur, the contribution that these abnormalities can make to the development and behavior of particular cancers and more recently, the recognition that these cellular and genetic abnormalities can provide rational targets for new therapeutic approaches. Information about the biology of cancers that occur in children has increased in parallel with these more general advances and this book is intended to provide a focus for readers who wish to have an understanding of our current state of knowledge. An international group of editors and contributors provide guidelines on the molecular biology and pathology of paediatric oncology, aimed at clinicians and scientists working in the specialty who wish to understand current developments in molecular pathology as applied to their field. The book is broad ranging review focusing on the impact of molecular and cytogenetic techniques on our understanding of the aetiology, clinical behaviour, diagnosis and management of paediatric cancer. The first section outlines the laboratory handling of tissue samples, theory and methodology of cytogenetic and molecular techniques and discusses predisposition syndromes. The second section highlights the application of cytogenetic and molecular methods in diagnosis and treatment of the major paediatric cancers.
Author : Shirley Bonnem
Publisher : Unknown
Page : 368 pages
File Size : 53,5 Mb
Release : 2003
Category : Children
ISBN : 0961737042
Author : Jatin P. Shah,American Cancer Society
Publisher : PMPH-USA
Page : 504 pages
File Size : 47,5 Mb
Release : 2001
Category : Medical
ISBN : 1550090844
Dr. Jatin P. Shah has brought together contributing authors in a single volume that represents the head and neck management team at Memorial Sloan-Kettering Cancer Center. The strength of the volume is in its internal consistency of diagnostic approaches, therapeutic decisions, multidisciplinary treatment programs, and surgical techniques. An effort has also been made to be comprehensive and to give a balanced view to other treatment approaches. Essential to the diagnosis and treatment of the disease is the involvement of a multidisciplinary management team of medical experts. Such disease management teams develop treatment algorithms and establish treatment guidelines to unify an approach to maintain internal consistency, initiate investigative protocols, and push the frontiers in the battle against cancer.
Author : Bruce R. Korf
Publisher : Elsevier Inc. Chapters
Page : 892 pages
File Size : 44,9 Mb
Release : 2013-04-24
Category : Medical
ISBN : 9780128077443
The “neurofibromatoses” are a set of distinct genetic disorders that have in common the occurrence of tumors of the nerve sheath. They include NF1, NF2, and schwannomatosis. All are dominantly inherited with a high rate of new mutation and variable expression. NF1 includes effects on multiple systems of the body. The major NF1-associated tumor is the neurofibroma. In addition, clinical manifestations include bone dysplasia, learning disabilities, and an increased risk of malignancy. NF2 includes schwannomas of multiple cranial and spinal nerves, especially the vestibular nerve, as well as other tumors such as meningiomas and ependymomas. The schwannomatosis phenotype is limited to multiple schwannomas, and usually presents with pain. The genes that underlie each of the disorders are known: NF1 for neurofibromatosis type 1, NF2 for neurofibromatosis type 2, and INI1/SMARCB1 for schwannomatosis. Genetic testing is possible to identify mutations. Insights into pathogenesis are beginning to suggest new treatment strategies, and therapeutic trials with several new forms of treatment are underway.
Author : Jeffrey A. Dean,David R. Avery,Ralph E. McDonald
Publisher : Elsevier Health Sciences
Page : 719 pages
File Size : 50,6 Mb
Release : 2010-04-22
Category : Medical
ISBN : 9780323079662
A leading text in pediatric dentistry, McDonald and Avery’s Dentistry for the Child and Adolescent provides expert, complete coverage of oral care for infants, children, and teenagers. All the latest diagnostic and treatment recommendations are included! Comprehensive discussions are provided on pediatric examination, development, morphology, eruption of the teeth, and dental caries. This edition helps you improve patient outcomes with up-to-date coverage of restorative materials, cosmetic tooth whitening, care of anxious patients, and sedation techniques for children. Complete, one-source coverage includes the best patient outcomes for all of the major pediatric treatments in prosthodontics, restorative dentistry, trauma management, occlusion, gingivitis and periodontal disease, and facial esthetics. A clinical focus includes topics such as such as radiographic techniques, dental materials, pit and fissure sealants, and management of cleft lip and palate. Practical discussions include practice management and how to deal with child abuse and neglect. Full-color photographs and illustrations accurately depict trauma, restorative dentistry, implants, and prosthetics. A new Pediatric Oral Surgery chapter discusses the latest developments in office-based pediatric oral surgery, along with head and neck infections and medical conditions in the pediatric patient. Emphasis is added to preventive care and to treatment of the medically compromised patient. An Evolve website includes case studies, an image library, links to ADEA, ADA, and CDC reports on pediatric dentistry, and other web links.
Author : Paolo Curatolo,Daria Riva
Publisher : John Libbey Eurotext
Page : 247 pages
File Size : 47,5 Mb
Release : 2006
Category : Children
ISBN : 9782742006090
Neurocutaneous Syndromes unify a group of rare neurological disorders in which the initial identification depends on simple visual disgnosis. They include a large group of neurological disorders which feature cutaneous and ocular lesions, brain malformations, central and peripheral brain tumours, mental retardation, seizures and psychiatric problems. In the last few years, our knowledge of neurocutaneous syndromes has increased substantially. The aim of this volume is to provide an updated developmental perspective on these multifaceted conditions and to review their major clinical features, in particular their embryological basis, clinical molecular genetics, diagnostic protocols and novel therapeutic approaches.
Author : John M. O'Donnell
Publisher : Science History Publications/USA
Page : 300 pages
File Size : 50,8 Mb
Release : 2002
Category : Biography & Autobiography
ISBN : 0881352683
Author : Charles D. Bluestone
Publisher : PMPH-USA
Page : 2000 pages
File Size : 53,8 Mb
Release : 2013-06-01
Category : Pediatric otolaryngology
ISBN : 9781607950189
Suitable for fellows wishing to train in the specialty, given that the standard of training requires knowledge in laryngotracheal reconstruction, congenital airway anomalies, or-facial anomalies, speech and voice disorders, head and neck, and diagnosis and treatment of hearing loss, this book covers the development in the field..
Author : P. Ashley Wackym,James B. Snow
Publisher : PMPH USA
Page : 2044 pages
File Size : 53,7 Mb
Release : 2017-02-28
Category : Medical
ISBN : 9781607951773
Preceded by: Pediatric otolaryngology / [edited by] Charles D. Bluestone ... [et al.]. 4th ed. c2003.
Author : Anonim
Publisher : Unknown
Page : 1792 pages
File Size : 45,7 Mb
Release : 1998
Category : Medicine
ISBN : UIUC:30112041301174
Author : Leon Barnes
Publisher : CRC Press
Page : 1800 pages
File Size : 50,5 Mb
Release : 2019-01-15
Category : Medical
ISBN : 9781420020373
Surgical Pathology of the Head and Neck, Third Edition is a complete stand-alone reference covering all aspects of head and neck pathology. Providing an interdisciplinary approach to the diagnosis, treatment, and management of head and neck diseases, this source promotes clear communication between pathologists and surgeons. This is the reference o