The Endocannabinoidome

Author : Vincenzo Di Marzo,Jenny Wang
Publisher : Academic Press
Page : 208 pages
File Size : 49,6 Mb
Release : 2014-09-18
Category : Medical
ISBN : 9780128004296

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The Endocannabinoidome by Vincenzo Di Marzo,Jenny Wang Pdf

The Endocannabinoidome: The World of Endocannabinoids and Related Mediators is dedicated to the latest research and studies on endocannabinoids and cannabinoid receptors to illustrate their important role in the discovery of new, endocannabinoid-related, lipid mediators. Written by leading experts across different disciplines, this book focuses on the biochemical and anlayticial aspects of novel lipid signals, their pharmacological activities and their potential utilization for the development of new and effective therapeutic strategies. The first book of its kind, The Endocannabinoidome is a meaningful reference for all those involved in experimental efforts to further the development of this field. Explores the novel and exciting aspects of several endocannabinoid-like molecules for which researchers are still seeking a function Discusses the novel metabolic pathways for endocannabinoids in order to explain the failure of some clinical trials with inhibitors of more conventional metabolic pathways Incorporates pharmacology, biochemistry and potential clinical applications to provide researchers with a complete look at endocannabinoids

Author : Claude Cyr,Mellar P. Davis,Danial Schecter,Paul Daeninck
Publisher : Springer Nature
Page : 325 pages
File Size : 51,7 Mb
Release : 2022-02-11
Category : Medical
ISBN : 9783030899189

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Cannabis and Cannabinoid-Based Medicines in Cancer Care by Claude Cyr,Mellar P. Davis,Danial Schecter,Paul Daeninck Pdf

The use of cannabinoid-based medicines (CBM), and cannabis in particular, has risen steadily among cancer and palliative care patients over the last few years. This textbook aims to address the multiple challenges facing healthcare providers regarding the use of CBM in this vulnerable patient population. It provides insight into the latest preclinical and clinical data and offers a practical approach on the use of CBM in a rapidly evolving landscape. It answers questions regarding the prescribing process and elucidates controversies regarding cannabis’ disease-modifying effects. The first chapters will review basic concepts of the endocannabinoid system and pharmacology of CBM, while focusing more specifically on the unique characteristics of two main cannabinoids: THC and CBD. Indicating which benefits can be expected from using either or both of these compounds, the book then addresses issues of drug-drug interactions and other challenges involved in prescribing CBM to frail patients with polypharmacy and multiple comorbidities. Comparing available products, both approved and non-approved by the FDA, the book discusses regional challenges for accessing reliably tested and labelled products in the context of standardization efforts. After carefully determining objectives and addressing patient expectations, further chapters will examine the different clinical settings in which CBM may be useful in cancer care and explore symptom management, including cancer pain, anxiety, nausea, and insomnia among others. The possible benefits of cannabis psychoactivity will also be discussed, including harm reduction strategies for patients who wish to explore these effects. Cannabis and Cannabinoid-Based Medicines in Cancer Care: A Comprehensive Guide to Medical Management serves as a comprehensive text for oncologists, palliative care specialists, general practitioners, and nurse practitioners working with cancer patients or in palliative care settings.

Author : Robin Saar,Sarah Dodd
Publisher : John Wiley & Sons
Page : 389 pages
File Size : 47,6 Mb
Release : 2023-08-17
Category : Medical
ISBN : 9781119862628

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Small Animal Microbiomes and Nutrition by Robin Saar,Sarah Dodd Pdf

Small Animal Microbiomes and Nutrition Comprehensive resource providing holistic coverage of the effect of body microbiomes on the health status of dogs and cats Small Animal Microbiomes and Nutrition offers new perspective on the prevention and treatment of common health conditions in dogs and cats that arise from or result in dysbiosis of the body’s microbiomes, along with providing alternative first-line solutions of utilizing nutrients—less invasive procedures in comparison to prescription drugs to treat dysbiosis in the body’s microbiomes. This practical manual guides the reader through body systems that are commonly influenced by the microbiota in the microbiomes as well as accompanying dietary recommendations. Initially, an overview of the body’s microbiome including common terminology and functions of microbiomes precede the chapters on development of the body’s microbiomes and factors influencing their diversity and density. The following three sections provide readers with a different perspective of commonly observed health conditions by focusing on the state of the microbiome and how the condition may be prevented and/or treated with the use of nutrients. Written by a highly qualified author with significant experience in the field, Small Animal Microbiomes and Nutrition includes information on sample topics such as: Results of research on alternative diets and emerging ingredients’ effect on the microbiomes and how to have the discussions with pet parents Nutrition focused calculations, feeding directions, and templates for history, and recommendation for follow-up conversations with pet parents Factors affecting the diversity and density of the microbiomes, such as genetics, age, sex, environment, stress, antibiotic therapy, and nutrition Integumentary microbiomes, covering the skin’s microbiome, dysfunctional barrier syndrome, atopy (atopic dermatitis), and key nutritional factors Small Animal Microbiomes and Nutrition is an essential resource for students completing companion animal health courses in two- and four-year programs, particularly those in veterinary technology, veterinary technician, and animal health technology diplomas and degrees, and it is also highly useful for students in other veterinary and animal science focused programs. Additionally, this book is essential in veterinary practices as a reference guide to support the transition into the utilization of microbiome medicine.

Author : Isabelle Lemieux,Jean-Pierre Després
Publisher : MDPI
Page : 346 pages
File Size : 47,9 Mb
Release : 2021-01-28
Category : Medical
ISBN : 9783039439898

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Metabolic Syndrome by Isabelle Lemieux,Jean-Pierre Després Pdf

Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

Author : Stephen Cital,Katherine Kramer,Liz Hughston,James S. Gaynor
Publisher : Springer Nature
Page : 343 pages
File Size : 45,7 Mb
Release : 2021-05-16
Category : Science
ISBN : 9783030683177

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Cannabis Therapy in Veterinary Medicine by Stephen Cital,Katherine Kramer,Liz Hughston,James S. Gaynor Pdf

This book provides in-depth information on the applications of cannabis products as a legitimate medicine in treating a variety of diseases and disorders in domestic animals. Pharmacology and toxicology of cannabinoids and their effects on the endocannabinoid system, which is involved in the regulation of diverse physiological and cognitive processes, are discussed in detail. Furthermore, the book reviews development and testing of cannabis based medical products and introduces the nutritional components of cannabis plants. Cannabis as a therapeutic in veterinary medicine is gaining interest among owners and practitioners. Numerous studies have been completed or are currently underway that analyze the potential of clinical application of cannabinoid and terpenoid molecules. In this book the authors take a comprehensive look at previous studies in animal and human models and discuss translational applications based on these scientific data. This seminal text serves as a go-to resource for veterinary practitioners on cannabinoid therapy. It will also serve as a foundation for clinicians and researchers interested in this emerging field of veterinary medicine.

Author : Silvia Melgar,Robert-J. Brummer,Maria José Rodríguez Lagunas
Publisher : Frontiers Media SA
Page : 250 pages
File Size : 40,8 Mb
Release : 2024-04-30
Category : Medical
ISBN : 9782832548592

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Interplay Between Diets, Microbiota, Bacterial Metabolites and Host for Intestinal Health and Disease by Silvia Melgar,Robert-J. Brummer,Maria José Rodríguez Lagunas Pdf

An interplay between the diet and the microbiota appears to regulate the host responses. It is now well acknowledged that the microbiota and their metabolites such as short chain fatty acids, bile acids, etc modulates the metabolic status, educates the host’s intestinal immune system, and protects the host against invading pathogens and injury. Concomitantly, environmental factors such as diets and dietary components play a major role in shaping the microbiota, thereby modulating the host immune and epithelial responses, and ultimately directing the individual’s health status. Disruption in any of these elements or their interactions have been linked to the development and progression of a wide range of conditions including Inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colorectal cancer, obesity, Parkinson’s disease, autism, asthma etc. While westernised diets (rich in fat/sugar and low in fibres) and dietary additives (e.g. emulsifiers) have been identified as risk factors for these disorders, other diets such as Mediterranean, Ketogenic and probiotics and prebiotics can serve as treatment strategies due to their impact on the microbiota and possibly the host.

Author : Kylie O'Brien,Philip Blair
Publisher : Springer Nature
Page : 591 pages
File Size : 49,5 Mb
Release : 2021-10-27
Category : Medical
ISBN : 9783030785598

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Medicinal Cannabis and CBD in Mental Healthcare by Kylie O'Brien,Philip Blair Pdf

This book functions as a clinician’s guide to the use of cannabidiol (CBD) in the treatment of mental health conditions. It conveys the scientific evidence of efficacy of CBD as well as THC and addresses the social stigma attached to its medical use. The book describes the endocannabinoid system, how stress and the endocannabinoid system interact and key constituents, pharmacokinetics and safety aspects of medicinal cannabis, focusing on CBD and THC. Chapters on specific mental health conditions describe the underpinning pathomechanisms including how the endocannabinoid system is involved, and summarises the scientific evidence including animal and human research for the use of CBD and THC in treatment of such conditions. Topics covered include anxiety, depression, post-traumatic stress disorder, insomnia, Alzheimer's Disease and autism spectrum disorder. Chapters also discuss treatment guidelines and case studies. Unique and focused, Medicinal Cannabis and CBD in Mental Healthcare is an invaluable reference for medical practitioners seeking to adopt CBD-use in their treatment plans.

Author : Anonim
Publisher : Academic Press
Page : 492 pages
File Size : 40,6 Mb
Release : 2017-08-18
Category : Medical
ISBN : 9780128112335

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Cannabinoid Pharmacology by Anonim Pdf

Cannabinoid Pharmacology, Volume 80 is a new volume in the Advances in Pharmacology that presents reviews of recent breakthroughs. This volume aims to present current knowledge of the endogenous cannabinoid system, and looks at molecular, cellular, tissue and organismal effects of endogenous and exogenous cannabinoids. Topics of note in this new volume include Endocannabinoids and their congeners, Endocannabinoid turnover, Plant cannabinoids, Synthetic cannabinoids and ‘legal highs’, CB1 and CB2 cannabinoid receptors, Novel signaling modalities, Novel cannabinoid receptors, and Ion channel regulation by cannabinoids. There is a broad coverage of the essential elements associated with the cannabinoid system. The Editors have sought to include authors who represent authoritative voices on these themes, but have not previously worked together to allow a fresh approach to the individual aspects covered. Presents reviews of recent breakthroughs in the cannabinoid system Features chapters from the best authors in the field Provides an essential resource for scientists, advanced undergraduate students through to established faculty members

Author : Florent Allais,Simone Brogi,Veroniki P. Vidali,Guillermo Raul Castro
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 50,7 Mb
Release : 2023-03-30
Category : Science
ISBN : 9782832519349

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Advances in green synthesis for drug discovery by Florent Allais,Simone Brogi,Veroniki P. Vidali,Guillermo Raul Castro Pdf

Author : Gert Folkerts,Johan Garssen
Publisher : Springer
Page : 483 pages
File Size : 51,6 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9783319061511

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Pharma-Nutrition by Gert Folkerts,Johan Garssen Pdf

Natural products and functional/medical foods are now widely acknowledged as having an effect on the microbiome of the intestine, which in turn influences the outcome of certain disease. This book reviews the impact and effects of natural products and functional/medical foods (nutritional programming) on disease management, specifically focusing on diseases related to 1) Inflammation and Immunity, 2) Cancer, COPD and Cachexia, 3) Allergy and 4) Brain Neuro/Immune. Hippocrates said "let medicine be thy food and food be thy medicine". While most of us are familiar with Hippocrates famous words, we admit that in recent times, the disciplines of pharma and nutrition have evolved separately. Today, with the ever growing burden of diseases in modern society, we see a convergence of the two in relation to specific disease prevention and treatment. This re-discovered common ground between the complementary values of pharma and nutrition can be conceptualized in the term pharma-nutrition. Various chapters in the book review the aspects of molecular characteristics of food ingredients towards clinical effectiveness and relevance.

Author : Liana Fattore
Publisher : Academic Press
Page : 499 pages
File Size : 54,8 Mb
Release : 2015-01-23
Category : Medical
ISBN : 9780124171244

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Cannabinoids in Neurologic and Mental Disease by Liana Fattore Pdf

The application of cannabis sativa for the treatment of neurologic and mental disease is expanding. Cannabinoids in Neurologic and Mental Disease collects and presents for the first time recent research involving the use of pharmacological cannabinoids for the treatment of neurodegenerative and neuroinflammatory disease. The neurologic application of cannabinoid therapy builds upon psychiatric and psychological use for the treatment of a variety of core mental disorders. This comprehensive reference on the known uses of cannabinoids will be useful for clinical neurologists, neuroscience and clinical neuroscience researchers, clinical psychologists and psychiatrists and the general medical community. A comprehensive reference on the clinical uses of cannabinoids for treating major neurologic and mental diseases Detailed coverage of cannabinoid use for neuroinflammatory and neurodegenerative disease including Multiple Sclerosis, Epilepsy, Huntington's disease, Parkinson's disease, and Alzheimer's disease Detailed coverage of cannabinoid use for major psychiatric and psychological diseases and disorders including schizophrenia, bipolar disorders, Tourette's syndrome, and post-traumatic stress disorder (PTSD)

Author : James David Adams
Publisher : Bentham Science Publishers
Page : 133 pages
File Size : 45,8 Mb
Release : 2021-09-12
Category : Health & Fitness
ISBN : 9789814998970

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Balance in Healthcare by James David Adams Pdf

Balance in Healthcare is an easy to understand guide to maintaining a balanced medium of activities for healthy living. The book points out key aspects of balance in living a healthy life, and gives information on toxic lifestyle elements that can cause imbalance. These aspects include lifestyle, diet, family relationships, spirituality, the immune system, the endocannabinoid system, the antioxidant system and the concept of energy balance in the human body. The contents are expressed in a simple way, while delving into the relevant scientific explanations and also place an emphasis on the positive aspects of relationships and spirituality. Balance in Healthcare therefore, serves as a simple detoxification reference to readers from all walks of life, enabling anyone to understand and relearn the traditional concept of balance from a scientific angle so that they can achieve their highest potential when making choices for their mental and physical well-being.

Author : Wael Mohamed
Publisher : Springer Nature
Page : 511 pages
File Size : 43,8 Mb
Release : 2024-06-30
Category : Electronic
ISBN : 9789819726813

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Nutrition and Psychiatric Disorders by Wael Mohamed Pdf

Author : Vincenzo Di Marzo
Publisher : John Wiley & Sons
Page : 326 pages
File Size : 45,7 Mb
Release : 2014-07-18
Category : Science
ISBN : 9781118451274

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Cannabinoids by Vincenzo Di Marzo Pdf

Cannabinoids ‘Cannabinoids’ is a broad term covering a group of natural products from Cannabis sativa, one of which locks on to specific receptors – protein molecules on the surface of cells – known as cannabinoid receptors. Over the past decades scientists have found that cannabinoid receptors and their endogenous ligands, the endocannabinoids, are involved in a vast array of physiological functions, including helping to control brain activity, energy metabolism, heart function, the immune system and even reproduction. In Cannabinoids, Vincenzo Di Marzo has assembled contributions from international experts to provide the definitive guide to what continues to be a rapidly developing research field. After an introductory historical chapter, the book continues by looking at the biochemical, genetic and molecular elements of cannabinoids, followed by chapters covering their role in health and disease. The final chapter outlines the need for a new nomenclature to reflect the complex and multi-disciplinary nature of this area. An authoritative guide to the history, development and possible future of cannabinoid research. Includes contributions from leading international experts in the field. Clearly written, well organised and logically presented. Cannabinoids will prove invaluable to researchers, practitioners and students across a wide range of disciplines, needing an up-to-date guide to this significant area of research.

Author : Rahul Shukla,Mayank Handa,Dhirendra Pratap Singh,Ashish Dhir
Publisher : Elsevier
Page : 386 pages
File Size : 55,7 Mb
Release : 2024-06-01
Category : Science
ISBN : 9780443154904

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Cannabis and its Derivatives by Rahul Shukla,Mayank Handa,Dhirendra Pratap Singh,Ashish Dhir Pdf

Cannabis and its Derivatives: Guide to Medical Application and Regulatory Challenges summarizes the current state of research and clinical pharmacology of cannabis-based therapeutics, and the associated regulatory framework.The content is organized in twelve chapters. The first four comprise the introduction section covering historical, botanical, and taxonomical platform of cannabis, chemical derivatives of the cannabis plant, a literature review of therapeutic applications, and the biological fate of cannabis and its metabolic products. Part two of the book covers therapeutic applications, including pain management, neurological disorders, cancer management, it’s interactions with other drugs, veterinary applications and the adverse effects of Cannabis overuse in humans. The final section is devoted to discussions around regulatory challenges and future considerations.Cannabis and its Derivatives: Guide to Medical Application and Regulatory Challenges is the ideal reference pharmaceutical scientists, clinicians, and academic researchers who want access to updated information on the therapeutic applications of cannabis and its derivates. Corporate researchers will also benefit from this book’s presentation of the associated regulatory environment. Explores the potential of Cannabis derivatives and medicinal properties in several medical fields Highlights the regulatory challenges around the clinical use and research of Cannabis Covers applications to conditions like cancer, neurological disorders, pain management, and interactions with other drugs