The Gene Trap

Author : Stephen N Berberich
Publisher : Xlibris Corporation
Page : 358 pages
File Size : 48,5 Mb
Release : 2011-05-17
Category : Fiction
ISBN : 9781462873746

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THE GENE TRAP by Stephen N Berberich Pdf

Change is inevitable and it is coming to the modern world as it had for a thousand centuries. A mysterious force, hidden in the shadows of the cosmos, holds sway over the destiny of all living things, and the final chapter for mankind is about to be written. A superior species, borne of humans, is poised to assume dominion over the Earth. Enter The Gene Trap. This manuscript is the second in a series of techno-thrillers by Dr. Stephen Berberich. Similar in story line to a Michael Crichton novel, the book’s plot depicts the struggle of contemporary man in his effort to avoid the inexorable consequences of evolution. As the story unfolds, John Lynch and his girlfriend, Gigi Thompson, are on their way to Pittsburgh to begin their new careers, John as a medical intern and Gigi as geneticist at the prestigious Hawthorne Institute. Though they remain perplexed by the mysterious disappearance of their best friends, Peter Gault and Kate Donavon (main characters of Berberich’s first novel, No Known Species), John and Gigi find themselves consumed by the rigors of their new positions. The last thing they need is to be caught in a titanic struggle for human survival—a struggle that would pit them against Peter’s clan of mutants. Influenced by unexpected events, the couple is drawn into a sinister plot hatched by a worldwide cabal of intellectual elites who are determined to eliminate the gifted species. It is a move that could solidify mankind’s rightful place of primacy. Though the elite’s scheme seems flawless, unforeseen mistakes begin to occur. A deadly synthetic germ is accidently released into the biosphere, creating a plague the likes of which the world has never known. Worse yet, a deadly trap lurks within secret recesses of the human genome. It is genetic time bomb that will be detonated if scientists attempt to tinker with the essence of mankind’s DNA. The Gene Trap details the age-old struggle between the old and the new, with Gigi and John caught somewhere between the two worlds. The final act makes clear the meaning of the genesis cycle.

Author : Weisheng Victor Chen
Publisher : Unknown
Page : 388 pages
File Size : 49,9 Mb
Release : 2004
Category : Genomes
ISBN : UOM:39015056800553

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Functional Genomics in Mice by Microarray-coupled Gene Trap Mutagenesis by Weisheng Victor Chen Pdf

Author : Stephen N Berberich
Publisher : Xlibris Corporation
Page : 433 pages
File Size : 49,8 Mb
Release : 2018-04-26
Category : Fiction
ISBN : 9781984522375

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The Gene Trap by Stephen N Berberich Pdf

Change is inevitable, and it is coming to the modern world as it had for a thousand centuries. A mysterious force, hidden in the shadows of the cosmos, holds sway over the destiny of all living things, and the final chapter for mankind is about to be written. A superior species, borne of humans, is poised to assume dominion over the earth. Enter The Gene Trap. This manuscript is the second in a series of techno-thrillers by Dr. Stephen Berberich. Similar in story line to a Michael Crichton novel, the books plot depicts the struggle of contemporary man in his effort to avoid the inexorable consequences of evolution. As the story unfolds, John Lynch and his girlfriend, Gigi Thompson, are on their way to Pittsburgh to begin their new careersJohn as a medical intern and Gigi as geneticist at the prestigious Hawthorne Institute. Though they remain perplexed by the mysterious disappearance of their best friends, Peter Gault and Kate Donavon (main characters of Berberichs first novel, No Known Species), John and Gigi find themselves consumed by the rigors of their new positions. The last thing they need is to be caught in a titanic struggle for human survivala struggle that would pit them against Peters clan of mutants. Influenced by unexpected events, the couple is drawn into a sinister plot hatched by a worldwide cabal of intellectual elites who are determined to eliminate the gifted species. It is a move that could solidify mankinds rightful place of primacy. Though the elites scheme seems flawless, unforeseen mistakes begin to occur. A deadly synthetic germ is accidently released into the biosphere, creating a plague the likes of which the world has never known. Worse yet, a deadly trap lurks within secret recesses of the human genome. It is genetic time bomb that will be detonated if scientists attempt to tinker with the essence of mankinds DNA. The Gene Trap details the age-old struggle between the old and the new, with Gigi and John caught somewhere between the two worlds. The final act makes clear the meaning of the genesis cycle.

Author : Ralf Kühn,Wolfgang Wurst
Publisher : Humana Press
Page : 0 pages
File Size : 43,9 Mb
Release : 2009-03-27
Category : Science
ISBN : 1934115266

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Gene Knockout Protocols by Ralf Kühn,Wolfgang Wurst Pdf

Following the completion of the mouse and human genome sequences, a major challengeisthefunctionalcharacterizationofeverymammaliangeneandthedeciph- ing of their molecular interaction network. The mouse offers many advantages for the use of genetics to study human biology and disease, unmatched among other m- mals. Its development, body plan, physiology, behavior, and diseases have much in common, based on the fact that 99% of the human genes have a mouse ortholog. The investigation of gene function using mouse models is based on many years of tech- logical development. In the two decades since gene targeting in murine embryonic stem (ES) cells was first described by Mario Capecchi and colleagues, more than 3000 predesigned mouse mutants have been developed. To date, a variety of mouse mutagenesis techniques, either gene- or phenotype-driven, are used as systematic approaches. The availability of the genome sequence supports gene-driven approaches such as gene-trap and targeted mutagenesis in ES cells, allowing efficient and precise gene disruption. In combination with the use of site-specific DNA recombinases, in particular the Cre/loxP system, gene disruptioncan be directed to specific cell types in conditionalmousemutants. Furthermore,chemicalandtransposonmutagenesisofthe mouse genome enables us to perform phenotype-driven screens for the unbiased identification of phenotype–genotype correlations involved in models of human d- ease. Over the next several years, the mouse genome will be systematically altered, and the techniques for achieving predesigned manipulations will be constantly developed further and improved. The second edition of Gene Knockout Protocols brings together distinguished c- tributorswithextensiveexperienceinthegenetargetingandmousegeneticsfields.

Author : Juliusz Ashot Kozak,James W. Putney, Jr.
Publisher : CRC Press
Page : 343 pages
File Size : 51,6 Mb
Release : 2017-07-14
Category : Science
ISBN : 9781498752732

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Calcium Entry Channels in Non-Excitable Cells by Juliusz Ashot Kozak,James W. Putney, Jr. Pdf

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Author : Anonim
Publisher : Academic Press
Page : 536 pages
File Size : 51,6 Mb
Release : 2010-09-09
Category : Science
ISBN : 0123747759

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Guide to Techniques in Mouse Development, Part A by Anonim Pdf

Guide to Techniques in Mouse Development, Part A comprehensively covers new technologies and methodologies that have appeared for the study of mouse development. Update of volume 225 of Methods in Enzymology, Guide to Techniques in Mouse Development, edited by P.M. Wassarman and M.L. DePamphilis and published in 1993 Covers new technologies and methodologies, including: new techniques for the cryopreservation of gametes and embryos production of transgenic and null (knockout) animals (use of ES cells) generation of conditional/inducible mutant animals use of gene-trap mutagenesis analysis of allele-specific expresion use of new reporter constructs humanizing of transgenic animals transcript profiling of mouse development imaging of mouse development rederivation of animals and use of mouse genomics

Author : Brian W. Metcalf,Susan Dillon
Publisher : Elsevier
Page : 296 pages
File Size : 44,6 Mb
Release : 2011-04-28
Category : Medical
ISBN : 0080465978

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Target Validation in Drug Discovery by Brian W. Metcalf,Susan Dillon Pdf

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Author : Ke-Qin Zhang,Kevin D. Hyde
Publisher : Springer Science & Business
Page : 400 pages
File Size : 52,8 Mb
Release : 2014-04-22
Category : Science
ISBN : 9789401787307

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Nematode-Trapping Fungi by Ke-Qin Zhang,Kevin D. Hyde Pdf

These chapters provide up-to-date information on nematophagous fungi, particularly those of the Orbiliaceae in Ascomycota, whose asexual states produce nematode-trapping devices. The authors consider fungal-nematode interactions, fossil fungi, the biodiversity, ecology and geographical distribution of nematode-trapping fungi, and their potential use in biocontrol of nematodes, all in detail. Nematode-trapping fungi with adhesive or mechanical hyphal traps are the main focus of this book which begins with an overview of the data on nematode-trapping fungi, including their taxonomy, phylogeny and evolution. Subsequent chapters expand upon the methods and techniques used to study these fascinating fungi. Keys for genera of Arthrobotrys, Drechslerella and Dactylellina, which include all reported species of predatory orbiliaceous fungi are presented and numerous species from these genera are morphologically described and illustrated. The ecology of nematode-trapping fungi is expertly presented: their occurrence and habitats, their geographical and seasonal distribution and the effects of soil conditions and nematode density on their distribution all feature amongst the relevant themes. Further chapters examine the use of nematode-trapping fungi in biological control and the authors consider nematicidal activities in detail, exploring the many compounds from fungi that feature in nematicidal activities and of course useful paths for further study on this topic. This is a highly informative and carefully presented book, providing scientific insight for scholars with an interest in fungi and in biological control of nematodes.

Author : Silja Samerski
Publisher : Andrews UK Limited
Page : 191 pages
File Size : 46,5 Mb
Release : 2015-06-15
Category : Medical
ISBN : 9781845408305

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The Decision Trap by Silja Samerski Pdf

The Decision Trap questions a dogma of our time: the assumption that genetic education empowers citizens and increases their autonomy. It argues that professional instructions about genes, genetic risks, and genetic test options convey a genetic worldview which destroys self-confidence and makes clients dependent on genetic experts and technologies. Part one of the book introduces the reader to the idea of genetic education. It clarifies the notion of the "gene" as it is commonly understood, and shows that, scientifically, the concept of genes as definable, causal agents is outdated. Part two of the book investigates the hidden curriculum of genetic education, using genetic counselling as a prime example. Genetic counselling is a professional service that aims to enable clients to make autonomous decisions about genetic test options and cope with the results.

Author : Marcela Pierce
Publisher : Unknown
Page : 500 pages
File Size : 55,9 Mb
Release : 2003
Category : Abscisic acid
ISBN : UCR:31210017935618

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Gene- and Enhancer-trap Tagging of Genes Involved in the Response to Water-deficit Stress of Arabidopsis Thaliana by Marcela Pierce Pdf

Author : Paul Wassarman,Philippe M Soriano
Publisher : Academic Press
Page : 628 pages
File Size : 44,6 Mb
Release : 2010-09-24
Category : Science
ISBN : 0123848814

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Guide to Techniques in Mouse Development, Part B by Paul Wassarman,Philippe M Soriano Pdf

This volume comprehensively covers new technologies and methodologies that have appeared for the study of mouse development. This volume is Part B of an update of volume 225, Guide to Techniques in Mouse Development, edited by P.M. Wassarman and M.L. DePamphilis and published in 1993. Comprehensively covers new techniques for the cryopreservation of gametes and embryos, production of transgenic and null (knockout) animals (use of ES cells), generation of conditional/inducible mutant animals, use of gene-trap mutagenesis, analysis of allele-specific expression, use of new reporter constructs, humanizing of transgenic animals, transcript profiling of mouse development, imaging of mouse development, and rederivation of animals and use of mouse genomics.

Author : Alexandra L. Joyner
Publisher : Oxford University Press, USA
Page : 266 pages
File Size : 44,6 Mb
Release : 1993
Category : Language Arts & Disciplines
ISBN : UOM:39015027149189

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Gene Targeting by Alexandra L. Joyner Pdf

An introduction for beginners and a bench reference generally to the techniques now available by which scientists can create essentially any mutation in the germline of mice by using recombination and embryonic stem cells (ESC). Genetic researchers, most from the US but also representing Britain, Canada, and Germany, cover principles and practice in mammalian cells, site-specific recombination in cells and mice, producing targeted ESC clones, producing chimeras by blastocyst and morula injection of targeted ESC, producing and analyzing ESC aggregation, gene trap strategies, and classical genetics and gene targeting. The appendix lists suppliers and contact information but not products. Annotation copyrighted by Book News, Inc., Portland, OR

Author : Karl J. Clark
Publisher : Unknown
Page : 262 pages
File Size : 51,5 Mb
Release : 2003
Category : Genes
ISBN : MINN:31951P00603099D

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The Development of Sleeping Beauty Gene-trap Transposons for Insertional Mutagenesis of Vertebrates by Karl J. Clark Pdf

Author : Roger N. Rosenberg,Juan M. Pascual
Publisher : Elsevier
Page : 1464 pages
File Size : 44,6 Mb
Release : 2014-10-28
Category : Medical
ISBN : 9780124105492

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Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease by Roger N. Rosenberg,Juan M. Pascual Pdf

Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations

Author : Suzanna Danuta Walters
Publisher : NYU Press
Page : 345 pages
File Size : 49,8 Mb
Release : 2014
Category : Social Science
ISBN : 9780814770580

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The Tolerance Trap by Suzanna Danuta Walters Pdf

Froma Glee ato gay marriage, from lesbian senators to out gay Marines, we have undoubtedly experienced a seismic shift in attitudes about gays in American politics and culture. Our reigning national story is that a new era of rainbow acceptance is at hand. But dig a bit deeper, and this seemingly brave new gay world is disappointing. For all of the undeniable changes, the plea for tolerance has sabotaged the full integration of gays into American life. Same-sex marriage is unrecognized and unpopular in the vast majority of states, hate crimes proliferate, and even in the much vaunted gay friendly world of Hollywood and celebrity culture, precious few stars are openly gay. Ina The Tolerance Trap, Suzanna Walters takes on received wisdom about gay identities and gay rights, arguing that we are not almost there, but on the contrary have settled for a watered-down goal of tolerance and acceptance rather than a robust claim to full civil rights. After all, wea tolerate aunpleasant realities: medicine with strong side effects, a long commute, an annoying relative. Drawing on a vast array of sources and sharing her own personal journey, Walters shows how the low bar of tolerance demeans rather than ennobles both gays and straights alike. Her fascinating examination covers the gains in political inclusion and the persistence of anti-gay laws, the easy-out sexual freedom of queer youth and the suicides and murders of those in decidedly intolerant environments. She challenges both born that way storylines that root civil rights in biology, and god made me that way arguments that similarly situate sexuality as innate and impervious to decisions we make to shape it. A sharp and provocative cultural critique, this book deftly argues that a too-soon declaration of victory short-circuits full equality and deprives us all of the transformative possibilities of full integration.Tolerance is not the end goal, but a dead end. Ina The Tolerance Trap, Walters presents a complicated snapshot of a world-shifting moment in American historyOCoone that is both a wake-up call and a call to arms for anyone seeking true equality."