The Human Pathway

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 48,5 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

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Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 50,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Nenad Blau,Marinus Duran,K Michael Gibson,Carlo Dionisi Vici
Publisher : Springer
Page : 880 pages
File Size : 52,6 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9783642403378

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Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases by Nenad Blau,Marinus Duran,K Michael Gibson,Carlo Dionisi Vici Pdf

This book, combining and updating two previous editions, is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases. The clinical and laboratory data characteristic of rare metabolic conditions can be bewildering for both clinicians and laboratory personnel. Reference laboratory data are scattered, and clinical descriptions may be obscure. The Physician’s Guide documents the features of more than five hundred conditions, grouped according to type of disorder, organ system affected (e.g. liver, kidney, etc) or phenotype (e.g. neurological, hepatic, etc). Relevant clinical findings are provided and pathological values for diagnostic metabolites highlighted. Guidance on appropriate biochemical genetic testing is provided. Established experimental therapeutic protocols are described, with recommendations on follow-up and monitoring. The authors are acknowledged experts, and the book will be a valuable desk reference for all who deal with inherited metabolic diseases.

Author : Ulrich Schiefer,Helmut Wilhelm,William Hart
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 49,8 Mb
Release : 2007-09-11
Category : Medical
ISBN : 9783540327080

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Clinical Neuro-Ophthalmology by Ulrich Schiefer,Helmut Wilhelm,William Hart Pdf

This book covers all relevant techniques of diagnosis as well as interpretations of clinical signs in Clinical Neuro-Ophthalmology. All information is highly structured, highlighting ‘definition’, ‘note’ and ‘pearl’, so that it can also be used by the physician during the patient encounter. The included flow chart posters remind the physician of the most important information. This unique and practical guide offers invaluable and practical advice for physicians treating patients with neuro-ophthalmic problems.

Author : Eugene V. Koonin,Michael Galperin
Publisher : Springer Science & Business Media
Page : 482 pages
File Size : 50,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781475737837

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Sequence — Evolution — Function by Eugene V. Koonin,Michael Galperin Pdf

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

Author : Jim Larsson
Publisher : Jim Knut Larsson
Page : 343 pages
File Size : 45,5 Mb
Release : 2010-11-15
Category : Philosophy
ISBN : 9780615413877

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"The Human Pathway" by Jim Larsson Pdf

Jim Knut Larsson establishes that the foundation for freewill, meaning and purpose is anchored in the latest findings in quantum mechanics and cosmology-empowering us to create the future. The Human Pathway is destined to become the catalyst for a transformation in politics, justice, government, economics and spiritualism. What choices does humanity need to make now, in order to avoid destruction? What goals can we set up to maximize meaning and purpose both for the individual and also for all of humanity? The Human Pathway might be the most important, inspiring and interesting book you will ever read. Our future depends upon your participation! Also included as an addendum: "What to do in case of arrest!" It could save your life or ... someone close to you! A must read! Some more questions ... What is "enlightenment"? Why the earth created humans? What would be the ultimate goals for humanity? How can you unleash your creative powers and create your own future? Why every act, movement and thought is a manifestation of freewill and why it affects the evolution of the universe? Why the living standard in the US declines daily? Why there are more than 3 million people in jail and more than 50 million with a criminal record? People in America always talk about "they". "Back then, 'they' castrated people who were homosexuals. "They" had strict laws against sodomy." They" did radiation experiments on the population. The question is; who are "they"? Revelation: Does it matter if you are resurrected at some point in the future? It is your desire to know the "truth" that drives your desire for resurrection. You will live forever as long as humanity-or if human intelligence lives on forever-because what is living, even if your ego is dead, is you being one with humanity. Individuals only manifest by their "clinging" to their egos. This "clinging" prevents you from becoming creative, happy and blissful. If you get rid of your ego, which should be everybody's goal, you will dedicate yourself to the eternal "now" and to serve humanity. A great quest is to help humanity reach its highest potential and to achieve "absolute" knowledge, "finish" the creation of the universe and acquire the power to recreate everything that existed forever. Then, at that point, you will be resurrected! However there is a final revelation and, if it is revealed to you, it will give you "absolute" knowledge and peace. This final revelation is the logical conclusion of this book. Understand what is written and the truth will be revealed to you. When it is, you will understand that it cannot be directly communicated and understood by others unless they have the same revelation! You will know that you have the final knowledge when you get the revelation and you don't need to seek validation for it! However, you want to share it with others! Study the revelations in this book and hopefully you will get it. You will know it when you do. We need to dismantle many laws and make society free again. We must get the government out of our lives. The benefit you get from reading my book is that you will be able to see through the myths. When you read my book, you will become an enlightened person. Actually after you read this book you will say, "I'm enlightened now". You will have revelations that will make you enjoy life more and become a happier person, but also you will no longer be seduced by propaganda. This, in the end, is a book of cosmic and spiritual enlightenment and enlightenment with regard to politics, economics and justice. What does it mean to be an enlightened person who helps secure the future prosperity and excitement of living for yourself and for humanity as a whole? Another bonus from this book is that you may no longer fear death. You will become a participant in the conversation and the future goals and aspirations of humanity.

Author : Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev
Publisher : Elsevier
Page : 732 pages
File Size : 52,8 Mb
Release : 2019-10-18
Category : Science
ISBN : 9780128170878

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Disease Pathways by Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev Pdf

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Author : Antonio Blanco,Gustavo Blanco
Publisher : Academic Press
Page : 910 pages
File Size : 41,7 Mb
Release : 2022-03-23
Category : Science
ISBN : 9780323916004

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Medical Biochemistry by Antonio Blanco,Gustavo Blanco Pdf

This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language. This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis. The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance. Integrates basic biochemistry principles with molecular biology and molecular physiology Illustrates basic biochemical concepts through medical and physiological examples Utilizes a systems approach to understanding biological phenomena Fully updated for recent studies and expanded to include clinically relevant examples and succinct chapter summaries

Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Page : 195 pages
File Size : 41,5 Mb
Release : 1992-01-01
Category : Medical
ISBN : 9780309045292

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Discovering the Brain by National Academy of Sciences,Institute of Medicine,Sandra Ackerman Pdf

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Author : Werner Dubitzky,Olaf Wolkenhauer,Hiroki Yokota,Kwang-Hyun Cho
Publisher : Springer
Page : 0 pages
File Size : 41,6 Mb
Release : 2013-06-05
Category : Science
ISBN : 1441998624

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Encyclopedia of Systems Biology by Werner Dubitzky,Olaf Wolkenhauer,Hiroki Yokota,Kwang-Hyun Cho Pdf

Systems biology refers to the quantitative analysis of the dynamic interactions among several components of a biological system and aims to understand the behavior of the system as a whole. Systems biology involves the development and application of systems theory concepts for the study of complex biological systems through iteration over mathematical modeling, computational simulation and biological experimentation. Systems biology could be viewed as a tool to increase our understanding of biological systems, to develop more directed experiments, and to allow accurate predictions. The Encyclopedia of Systems Biology is conceived as a comprehensive reference work covering all aspects of systems biology, in particular the investigation of living matter involving a tight coupling of biological experimentation, mathematical modeling and computational analysis and simulation. The main goal of the Encyclopedia is to provide a complete reference of established knowledge in systems biology – a ‘one-stop shop’ for someone seeking information on key concepts of systems biology. As a result, the Encyclopedia comprises a broad range of topics relevant in the context of systems biology. The audience targeted by the Encyclopedia includes researchers, developers, teachers, students and practitioners who are interested or working in the field of systems biology. Keeping in mind the varying needs of the potential readership, we have structured and presented the content in a way that is accessible to readers from wide range of backgrounds. In contrast to encyclopedic online resources, which often rely on the general public to author their content, a key consideration in the development of the Encyclopedia of Systems Biology was to have subject matter experts define the concepts and subjects of systems biology.

Author : Simon Cross
Publisher : Elsevier Health Sciences
Page : 784 pages
File Size : 53,8 Mb
Release : 2018-03-09
Category : Medical
ISBN : 9780702072109

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Underwood's Pathology by Simon Cross Pdf

Underwood’s Pathology (formerly General and Systematic Pathology) is an internationally popular and highly acclaimed textbook, written and designed principally for students of medicine and the related health sciences. Pathology is presented in the context of modern cellular and molecular biology and contemporary clinical practice. After a clear introduction to basic principles, it provides comprehensive coverage of disease mechanisms and the pathology of specific disorders ordered by body system. An unrivalled collection of clinical photographs, histopathology images and graphics complement the clear, concise text. For this seventh edition, the entire book has been revised and updated. Well liked features to assist problem-based learning – including body diagrams annotated with signs, symptoms and diseases and a separate index of common clinical problems – have been retained and refreshed. The advent of whole genome sequencing and increased knowledge of the genetics of disease has been recognised by updated sections in many chapters. Download the enhanced eBook version (from studentconsult.com) for anytime access to the complete contents plus bonus learning materials, including: clinical case studies – to help apply essential principles to modern practice the fully revised, interactive self-assessment section with over 200 questions and answers – to check your understanding and aid exam preparation especially produced video and podcast tutorials – to further explain and bring to life key topics bonus pathology crosswords – to recall key words and topics in a fun and interactive way This all combines to make Underwood’s an unsurpassed learning package in this fascinating and most central medical specialty. From reviews of previous editions: "...it truly is an outstanding textbook...highly recommended" Histopathology "...no doubt it will remain a bestseller – excellent value for undergraduates" Journal of Clinical Pathology "A book of this kind deserves a wide readership" Modern Pathology ".. the definitive textbook of pathology...expands on previous success and cements its position as the market leader for undergraduate pathology" The Bulletin A prize winner: Previous editions have won First Prize in the Medical Writers Group of the Society of Authors Awards, the British Book Design and Production Awards and the British Medical Association Student Textbook Award.

Author : Douglas B Webster,Richard R. Fay
Publisher : Springer Science & Business Media
Page : 494 pages
File Size : 53,8 Mb
Release : 2013-12-01
Category : Science
ISBN : 9781461244165

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The Mammalian Auditory Pathway: Neuroanatomy by Douglas B Webster,Richard R. Fay Pdf

The Springer Handbook of Auditory Research presents a series of com prehensive and synthetic reviews of the fundamental topics in modem auditory research. It is aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes will introduce new investigators to important aspects of hearing science and will help established inves tigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume is intended to present a particular topic comprehensively, and each chapter will serve as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The series focusses on topics that have developed a solid data and con ceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.

Author : Bob Yari
Publisher : AuthorHouse
Page : 108 pages
File Size : 43,7 Mb
Release : 2021-04-21
Category : Self-Help
ISBN : 9781665522281

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The Human Condition by Bob Yari Pdf

”In his philosophical treatise, THE HUMAN CONDITION, author Bob Yari offers a pathway to fulfillment and happiness -- based on a balanced lifestyle, a positive attitude, and gratitude for the world's abundance.”

Author : David R. Hawkins, M.D., Ph.D.
Publisher : Hay House, Inc
Page : 401 pages
File Size : 45,8 Mb
Release : 2014-01-15
Category : Body, Mind & Spirit
ISBN : 9781401945015

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Letting Go by David R. Hawkins, M.D., Ph.D. Pdf

This groundbreaking bestseller describes a simple and effective way to let go of challenges from world-renowned author, psychiatrist, clinician, spiritual teacher, and researcher of consciousness, David R. Hawkins, M.D., Ph.D. “Letting Go” is a guide to helping to remove the obstacles we all have that keep us from living a more conscious life, it is truly a life-changing book. Many of us have trouble Letting Go in our lives even though it can have profound impact on our life.” —Wayne Dyer During the many decades of Dr. David Hawkins’, clinical psychiatric practice, the primary aim was to seek the most effective ways to relieve human suffering in all of its many forms. In Letting Go, he shares from his clinical and personal experience that surrender is the surest route to total fulfillment. This motivational book provides a mechanism for letting go of blocks to happiness, love, joy, success, health, and ultimately Enlightenment. The mechanism of surrender that Dr. Hawkins describes can be done in the midst of everyday life. The book is equally useful for all dimensions of human life: physical health, creativity, financial success, emotional healing, vocational fulfillment, relationships, sexuality and spiritual growth. It is an invaluable resource for all professionals who work in the areas of mental health, psychology, medicine, self-help, addiction recovery and spiritual development. "Letting go is one of the most efficacious tools by which to reach spiritual goals." — David Hawkins, M.D., Ph.D. This profound self-development book offers a roadmap to release emotional burdens, unlock inner peace, and embrace a life of fulfillment. It is a classic that will help you break free from limitations and unlock your true potential. Learn how to navigate challenges with grace and emerge as a stronger, more resilient version of yourself. By incorporating the principles of surrender, "Letting Go" provides practical tools for personal growth and transformation. This consciousness-expanding book will help you: · Release past traumas, negative beliefs, and self-imposed limitations. · Experience a newfound sense of freedom, joy, and authenticity. · Recover from addiction · Enhance your personal relationships · Achieve success in your career Join millions who have experienced profound transformations through the principles outlined in "Letting Go." "Letting Go" is a must-read for anyone on a quest for personal growth, spirituality, and self-improvement. Whether you're new to the realm of self-help books or a seasoned seeker, Dr. David Hawkins' insights will inspire you to embrace a life of conscious living, emotional well-being, positive thinking, and unlimited possibilities. Experience the transformative power of letting go and unlock a life of healing, success, and spiritual growth.

Author : Anton Yuryev
Publisher : John Wiley & Sons
Page : 332 pages
File Size : 40,6 Mb
Release : 2008-09-17
Category : Science
ISBN : 9780470399262

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Pathway Analysis for Drug Discovery by Anton Yuryev Pdf

This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.