The Hypothalamic Pituitary Adrenal Axis In Health And Disease

Author : Eliza B. Geer
Publisher : Springer
Page : 327 pages
File Size : 45,9 Mb
Release : 2016-12-01
Category : Medical
ISBN : 9783319459509

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The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease by Eliza B. Geer Pdf

Cushing ́s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing’s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing’s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.

Author : Anonim
Publisher : Elsevier
Page : 416 pages
File Size : 41,9 Mb
Release : 2008-09-12
Category : Medical
ISBN : 0080559360

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The Hypothalamus-Pituitary-Adrenal Axis by Anonim Pdf

The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. * Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle. * Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later.

Author : Paolo Sassone-Corsi,Yves Christen
Publisher : Springer
Page : 132 pages
File Size : 53,6 Mb
Release : 2016-04-04
Category : Medical
ISBN : 9783319270692

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A Time for Metabolism and Hormones by Paolo Sassone-Corsi,Yves Christen Pdf

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Author : Alan F. Schatzberg,Charles B. Nemeroff
Publisher : Unknown
Page : 230 pages
File Size : 53,7 Mb
Release : 1988
Category : Corticotropin releasing hormone
ISBN : UOM:39015012580737

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The Hypothalamic-pituitary-adrenal Axis by Alan F. Schatzberg,Charles B. Nemeroff Pdf

Author : Michael Wilkinson,S. Ali Imran
Publisher : Cambridge University Press
Page : 207 pages
File Size : 48,7 Mb
Release : 2019-01-03
Category : Medical
ISBN : 9781316645192

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Clinical Neuroendocrinology by Michael Wilkinson,S. Ali Imran Pdf

A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.

Author : Alfredo Ulloa-Aguirre,Ya-Xiong Tao
Publisher : Academic Press
Page : 488 pages
File Size : 55,6 Mb
Release : 2021-02-02
Category : Science
ISBN : 9780128198025

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Cellular Endocrinology in Health and Disease by Alfredo Ulloa-Aguirre,Ya-Xiong Tao Pdf

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field

Author : Kerry Ressler,Daniel Pine,Barbara Rothbaum
Publisher : Oxford University Press
Page : 448 pages
File Size : 44,9 Mb
Release : 2015-04-15
Category : Medical
ISBN : 9780199395132

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Anxiety Disorders by Kerry Ressler,Daniel Pine,Barbara Rothbaum Pdf

Anxiety affects millions, manifesting as generalized anxiety disorder (GAD), obsessive compulsive disorder, panic disorder, phobias, post-traumatic-stress disorder (PTSD), and social anxiety disorder. Not only are anxiety disorders common, but they are also crippling, frequently co-occurring and predict high risk for depressive disorders. Shared mechanisms may explain the overlapping features of many anxiety disorders and account for associations with other highly-impairing conditions, such as major depression and substance use. Beyond risk for specific disorders, anxiety also predicts a number of other adverse outcomes, including suicidal behavior, medical problems, social, and economic difficulties. Conversely, disorder-specific mechanisms may also exist and explain the unique features of each syndrome. Thus, it is important to understand both shared and specific aspects of anxiety. The Primer on Anxiety Disorders provides early-stage practitioners and trainees, as well as seasoned clinicians and researchers, with need-to-know knowledge on diagnosis and treatment. Clinical cases are used throughout the book to enhance understanding of and illustrate specific disorders, comorbid conditions and clinical issues. To facilitate an integrative approach, content allows clinicians to understand patient characteristics and tailor interventions. The integrated approach of each chapter includes recent research on genetics and neuroscience to understand the mechanisms of anxiety disorders, focusing on the forthcoming new nosology in DSM-5. Chapters further integrate innovative advances in clinical research providing research on a range of discoveries regarding biomarkers of illness, biological predictors of treatments and the effect of treatment on neurocircuitry.

Author : Felipe F. Casanueva,Ezio Ghigo
Publisher : Springer
Page : 0 pages
File Size : 53,6 Mb
Release : 2018-04-13
Category : Medical
ISBN : 3319444433

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Hypothalamic-Pituitary Diseases by Felipe F. Casanueva,Ezio Ghigo Pdf

This book presents the state of the art in the pathophysiology, diagnosis, and therapy of hypothalamic and pituitary disorders. After an introduction devoted to the physiology of the neuroendocrine control of the hypothalamic-pituitary unit, the diverse disorders involving hormonal excess or deficiency are systematically addressed axis by axis. For each disorder, pathophysiology, clinical presentation, and management are discussed in detail. In addition, individual chapters focus on the neuroendocrinology of energy homeostasis and of bone metabolism, metabolic derangement secondary to pituitary dysfunction, and pituitary control of the endocrine pancreas. While the focus of the book is predominantly on pathophysiological and clinical aspects, due attention is also devoted to potential diagnostic and therapeutic innovations. The book is intended as a major reference for endocrinologists and basic and clinical scientists.

Author : Kasia Kozlowska,Stephen Scher,Helene Helgeland
Publisher : Springer Nature
Page : 397 pages
File Size : 41,5 Mb
Release : 2020-09-30
Category : Psychology
ISBN : 9783030461843

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Functional Somatic Symptoms in Children and Adolescents by Kasia Kozlowska,Stephen Scher,Helene Helgeland Pdf

This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being.

Author : William Locke,Andrew V. Schally
Publisher : Charles C. Thomas Publisher
Page : 646 pages
File Size : 48,7 Mb
Release : 1972
Category : Medical
ISBN : UOM:39015002416926

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The Hypothalamus and Pituitary in Health and Disease by William Locke,Andrew V. Schally Pdf

Author : D. Platt
Publisher : Springer Science & Business Media
Page : 509 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642682179

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Geriatrics 2 by D. Platt Pdf

Author : Stephen H. Koslow,Pedro Ruiz,Charles B. Nemeroff
Publisher : Cambridge University Press
Page : 409 pages
File Size : 49,8 Mb
Release : 2014-09-18
Category : Medical
ISBN : 9781107033238

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A Concise Guide to Understanding Suicide by Stephen H. Koslow,Pedro Ruiz,Charles B. Nemeroff Pdf

A concise review of current research into suicide providing a guide to understanding this disease and its increasing incidence globally.

Author : Anne M. Doherty,Aoife M. Egan,Sean Dinneen
Publisher : Cambridge University Press
Page : 167 pages
File Size : 40,6 Mb
Release : 2021-10-28
Category : Biography & Autobiography
ISBN : 9781911623618

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Mental Health, Diabetes and Endocrinology by Anne M. Doherty,Aoife M. Egan,Sean Dinneen Pdf

Mental Health, Diabetes and Endocrinology examines key areas of clinical overlap between endocrinology and mental health. Written for clinicians, it draws together developments from literature and clinical practice, with a focus on clinical conundrums and treatment challenges which arise across endocrinology, psychiatry, psychology and primary care.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 46,6 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Alexander Choukèr
Publisher : Springer Nature
Page : 756 pages
File Size : 48,5 Mb
Release : 2019-11-27
Category : Medical
ISBN : 9783030169961

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Stress Challenges and Immunity in Space by Alexander Choukèr Pdf

This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.