The Integrin Interactome

Author : Miguel Vicente-Manzanares
Publisher : Humana
Page : 315 pages
File Size : 54,9 Mb
Release : 2021-12-04
Category : Science
ISBN : 1071609645

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The Integrin Interactome by Miguel Vicente-Manzanares Pdf

This volume provides the most cutting edge technologies related to the study of integrin activation and the characterization of their vast interactomes. Chapters detail protocols on experimental approached to quantify focal adhesion parameters, integrin activation, and the lateral interaction of integrins with transmembrane binding partners. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Integrin Interactome: Methods and Protocols aims to give the reader a multi-scale journey from single bonds inside protein structures to the function of these crucial adhesion receptors at a whole organism level in physiology and pathology.

Author : Miguel Vicente-Manzanares
Publisher : Humana
Page : 315 pages
File Size : 50,8 Mb
Release : 2020-11-20
Category : Science
ISBN : 1071609610

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The Integrin Interactome by Miguel Vicente-Manzanares Pdf

This volume provides the most cutting edge technologies related to the study of integrin activation and the characterization of their vast interactomes. Chapters detail protocols on experimental approached to quantify focal adhesion parameters, integrin activation, and the lateral interaction of integrins with transmembrane binding partners. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Integrin Interactome: Methods and Protocols aims to give the reader a multi-scale journey from single bonds inside protein structures to the function of these crucial adhesion receptors at a whole organism level in physiology and pathology.

Author : Johannes A. Elbe
Publisher : Springer Science & Business Media
Page : 277 pages
File Size : 44,7 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781475740646

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Integrin-Ligand Interaction by Johannes A. Elbe Pdf

Author : Johannes A. Eble,Klaus Kühn
Publisher : Unknown
Page : 273 pages
File Size : 48,5 Mb
Release : 1997
Category : Integrins
ISBN : 1570594295

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Integrin-ligand Interaction by Johannes A. Eble,Klaus Kühn Pdf

Author : Andrea Becchetti,Annarosa Arcangeli
Publisher : Springer Science & Business Media
Page : 124 pages
File Size : 47,8 Mb
Release : 2010-12-28
Category : Medical
ISBN : 9781441960665

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Integrins and Ion Channels by Andrea Becchetti,Annarosa Arcangeli Pdf

Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.

Author : Kenneth O'Byrne,Valerie Rusch
Publisher : Oxford University Press
Page : 128 pages
File Size : 46,7 Mb
Release : 2006-11-16
Category : Medical
ISBN : 9780191566929

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Malignant Pleural Mesothelioma by Kenneth O'Byrne,Valerie Rusch Pdf

Malignant pleural mesothelioma, a malignancy due largely to asbestos exposure, represents an increasingly common challenge to clinical and medical oncologists, respiratory physicians, and cardiothoracic surgeons, as well as researchers in the field. The disease has yet to reach its peak and is expected to kill over 100,000 people worldwide. As malignant pleural mesothelioma gains in profile, Kenneth O'Byrne and Valerie Rusch present a comprehensive overview of the subject, aimed at all health care professionals who come into contact with patients with the disease. The book includes chapters on epidemiology, diagnosis, histopathology, radiology, surgery, chemotherapy, immune therapy, radiotherapy, and palliative medicine, written by an international team of contributors. A molecular biology section focuses on the carcinogenic effects of asbestos fibres and simian virus 40, angiogenesis and angiogenic growth factors, the immune response, and genetic abnormalities detected in the disease. Future therapies are also covered, as is a perspective on the distinct legal issues related to the disease. This highly-illustrated, full colour book provides the ultimate, timely resource on this devastating disease.

Author : Mandi Murph
Publisher : BoD – Books on Demand
Page : 430 pages
File Size : 54,5 Mb
Release : 2011-09-12
Category : Medical
ISBN : 9789533072937

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Research on Melanoma by Mandi Murph Pdf

The book Research on Melanoma: A Glimpse into Current Directions and Future Trends, is divided into sections to represent the most cutting-edge topics in melanoma from around the world. The emerging epigenetics of disease, novel therapeutics under development and the molecular signaling aberrations are explained in detail. Since there are a number of areas in which unknowns exist surrounding the complex development of melanoma and its response to therapy, this book illuminates and comprehensively discusses such aspects. It is relevant for teaching the novice researcher who wants to initiate projects in melanoma and the more senior researcher seeking to polish their existing knowledge in this area. Many chapters include visuals and illustrations designed to easily guide the reader through the ideas presented.

Author : Robert Mecham
Publisher : Springer Science & Business Media
Page : 426 pages
File Size : 51,9 Mb
Release : 2011-02-16
Category : Science
ISBN : 9783642165559

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The Extracellular Matrix: an Overview by Robert Mecham Pdf

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Author : Donald Gullberg
Publisher : Springer
Page : 179 pages
File Size : 41,8 Mb
Release : 2014-07-14
Category : Medical
ISBN : 9789401791533

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I Domain Integrins by Donald Gullberg Pdf

The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.

Author : Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Publisher : Cambridge University Press
Page : 1325 pages
File Size : 43,5 Mb
Release : 2007-08-16
Category : Medical
ISBN : 9781139461641

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Human Herpesviruses by Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi Pdf

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Author : Helen Michelle McGettrick,Sian M. Henson,Vicky L. Morrison,Ronen Sumagin
Publisher : Frontiers Media SA
Page : 172 pages
File Size : 49,8 Mb
Release : 2022-02-04
Category : Medical
ISBN : 9782889742851

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Targeting Leukocyte Trafficking: Insights and Future Directions by Helen Michelle McGettrick,Sian M. Henson,Vicky L. Morrison,Ronen Sumagin Pdf

Author : Thomas J. Hope,Mario Stevenson,Douglas Richman
Publisher : Unknown
Page : 128 pages
File Size : 55,5 Mb
Release : 2024-06-03
Category : AIDS (Disease)
ISBN : 1461496101

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Encyclopedia of AIDS by Thomas J. Hope,Mario Stevenson,Douglas Richman Pdf

Author : Andreja Ambriovic-Ristov,Vassiliki Kostourou,Ben Goult
Publisher : Frontiers Media SA
Page : 252 pages
File Size : 44,5 Mb
Release : 2023-03-17
Category : Science
ISBN : 9782832517789

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Integrin adhesion receptors in health and disease by Andreja Ambriovic-Ristov,Vassiliki Kostourou,Ben Goult Pdf

Author : Markus J. Seibel,Simon P. Robins,John P. Bilezikian
Publisher : Elsevier
Page : 920 pages
File Size : 50,5 Mb
Release : 2006-07-24
Category : Medical
ISBN : 008045626X

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Dynamics of Bone and Cartilage Metabolism by Markus J. Seibel,Simon P. Robins,John P. Bilezikian Pdf

This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Author : Wanderley De Souza
Publisher : Frontiers E-books
Page : 98 pages
File Size : 55,6 Mb
Release : 2014-12-10
Category : Immunologic diseases. Allergy
ISBN : 9782889193370

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Interaction of Trypanosoma cruzi with Host Cells by Wanderley De Souza Pdf

Trypanosoma cruzi is a pathogenic protozoan of the Trypanosomatidade Family, which is the etiological agent of Chagas’ disease. Chagas’ disease stands out for being endemic among countries in Latin America, affecting about 15 million people. Recently, Chagas has become remarkable in European countries as well due to cases of transmission via infected blood transfusion. An important factor that has exacerbated the epidemiological picture in Brazil, Colombia and Venezuela is infection after the oral intake of contaminated foods such as sugar cane, açai and bacaba juices. Trypanosoma cruzi is an intracellular protozoan that exhibits a complex life cycle, involving multiple developmental stages found in both vertebrate and invertebrate hosts. In vertebrate hosts, the trypomastigote form invades a large variety of nucleated cells using multiple mechanisms. The invasion process involves several steps: (a) attraction of the protozoan to interact with the host cell surface; (b) parasite-host cell recognition; (c) adhesion of the parasite to the host cell surface; (d) cell signalling events that culminate in the internalization of the parasite through endocytic processes; (e) biogenesis of a large vacuole where the parasite is initially located, and is also known as parasitophorous vacuole (PV); (f) participation of endocytic pathway components in the internalization process; (g) participation of cytoskeleton components in the internalization process; (h) transformation of the trypomastigote into the amastigote form within the PV; (i) lysis of the membrane of the PV; (j) multiplication of amastigotes within the host cell in direct contact with cell structures and organelles; (k) transformation of amastigotes into trypomastigotes, and (l) rupture of the host cell releasing trypomastigotes into the extracellular space. The kinetics of the interaction process and even the fate of the parasite within the cell vary according to the nature of the host cell and its state of immunological activation.