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‘These stories make the wall between worlds thrillingly thin. Their enchantment calls to us ever from the other side of the door’ Michael Sheen, from the foreword If you think you’ve heard all the fairy tales out there, think again. Inside this book you will find eleven epic Welsh tales from long ago, but not so far away, that are bound to enchant you. The Mab is a collection full to the brim with brand new versions of really, really old stories from the Mabinogi – maybe the oldest written-down stories in the history of Britain. But as well as being really, really old, the stories in The Mab are strange and funny and thrilling. Alive with mystery and magic, they speak of a time when the gates between the Real World and the Otherworld were occasionally left open. And sometimes, just sometimes, it was possible to step through. The stories in this illustrated edition have been reimagined by an extraordinary team of writers, and each appears alongside a Welsh-language translation.
WINNER - McDougall Previews Award for Best Fantasy Book of the Year From the mind of USA TODAY Bestselling author, Kate Danley, comes a new fairytale. When Faunus, the god of daydreams, breaks the heart of Queen Mab, revenge can be the only answer. Using the most powerful families in Verona, they wage their war against one another. But when Queen Mab falls in love with a man named Mercutio, she will do anything, even if it means destroying the world, to save him. Will it be enough to stop the tragedy? Or only spur it forward to its terrible end? Weaving Shakespeare's original text into a new fantasy, fans of The Woodcutter will delight in this loving retelling by award-winning author Kate Danley. Experience the romance and passion of Romeo & Juliet from a different point of view - through the eyes of the bringer of dreams... Queen Mab.
Islamic Movements of Europe by Frank Peter,Rafael Ortega Pdf
'Islam in Europe' and 'Islamophobia' are subjects of vital global importance which currently preoccupy policy-makers and academics alike. Through the examination of various European Muslim groups and institutions that have branched off from Islamic movements - including the Muslim Brotherhood, Hizb ut-Tahrir and Jama'at-i Islami - this book outlines the configuration of social, political and religious processes that have given rise to new kinds of European Muslim organisations. The authors offer a new perspective on these Muslim groups and seek to reclaim them from the often highly-charged public debates by placing them within the context of their origins as politicised religious movements on the one hand and their ongoing incorporation into European societal structures on the other. They also consider the relationship of these organisations to their 'parent' movements and examine the presence of Islam in European education and higher education institutions. Taking into account the connection between Islamic movements and the perceived surge of 'Islamophobia' in Europe, this book does not debate the question of whether these groups fit into normative or cultural structures of European nation-states, but rather examines how these structures have changed through their interaction with these groups and the growing Muslim population within Europe. It does not consider political Islam as the antithesis to a refined notion of secularism, but as a form of public religion which contributes to the ever-changing structure of Europe's secular regimes. Featuring the work of more than 40 scholars from around the world, this is the comprehensive guide to Islamic movements in Europe, offering original, definitive perspectives on Muslims and Islam in Europe today. It will be essential reading for policy-makers, political commentators and scholars alike.
Biosphere Reserves and Sustainable Development Goals 2 by Bruno Romagny,Catherine Cibien,Angela Barthes Pdf
Since 1971, UNESCO's Man and the Biosphere (MAB) Programme has embraced a number of principles that link the political, scientific and academic spheres. Biosphere Reserves and Sustainable Development Goals 2 is a reminder of the fundamental issues involved in governance. The diversity and multiplicity of stakeholders, and the complexity of the interplay between them, as well as their organization, are decisive factors in the proper management of resources and territories. The book also presents a number of case studies demonstrating that, between the strong development aspirations of their populations, the impact of human activities and the need to conserve their biological heritage, the biosphere reserves of the southern Mediterranean are facing major issues: agricultural pollution, forest fires, water use in a context of climate change, etc.
Database and Expert Systems Applications by Trevor Bench-Capon,Giovanni Soda,A Min Tjoa Pdf
The Database and Expert Systems Applications (DEXA) conferences bring together researchers and practitioners from all over the world to exchange ideas, experiences and opinions in a friendly and stimulating environment. The papers are at once a record of what has been achieved and the first steps towards shaping the future of information systems. DEXA covers a broad field, and all aspects of database, knowledge base and related technologies and their applications are represented. Once again there were a good number of submissions: 241 papers were submitted and of these the programme committee selected 103 to be presented. DEXA’99 took place in Florence and was the tenth conference in the series, following events in Vienna, Berlin, Valencia, Prague, Athens, London, Zurich, Toulouse and Vienna. The decade has seen many developments in the areas covered by DEXA, developments in which DEXA has played its part. I would like to express thanks to all the institutions which have actively supported and made possible this conference, namely: • University of Florence, Italy • IDG CNR, Italy • FAW – University of Linz, Austria • Austrian Computer Society • DEXA Association In addition, we must thank all the people who have contributed their time and effort to make the conference possible. Special thanks go to Maria Schweikert (Technical University of Vienna), M. Neubauer and G. Wagner (FAW, University of Linz). We must also thank all the members of the programme committee, whose careful reviews are important to the quality of the conference.
Biosimilars by Hiten J. Gutka,Harry Yang,Shefali Kakar Pdf
This book provides a comprehensive overview of the biosimilar regulatory framework, the development process and clinical aspects for development of biosimilars. The development path of a biosimilar is just as unique as a development path of a new drug, tailored by the mechanism of action, the quality of the molecule, published information on the reference product, the current competitive environment, the target market and regulatory guidance, and most importantly, the emerging totality of evidence for the proposed biosimilar during development. For the ease of readers, the book comprises of six sections as follows: Section I: Business, Health Economics and Intellectual Property Landscape for Biosimilars Section II: Regulatory Aspects of Development and Approval for Biosimilars Section III: Biopharmaceutical Development and Manufacturing of Biosimilars Section IV: Analytical Similarity Considerations for Biosimilars Section V: Clinical aspects of Biosimilar Development Section VI: Biosimilars- Global Development and Clinical Experience Chapters have been written by one or more experts from academia, industry or regulatory agencies who have been involved with one or more aspects of biosimilar product development. The authors and editors have an expertise in commercialization and pricing of biosimilars, intellectual property considerations for biosimilars, chemistry manufacturing controls (CMC) and analytical development for biosimilars, regulatory and clinical aspects of biosimilar development. Besides the industry practitioners, the book includes several contributions from regulators across the globe.
Avian Immunology by Karel A. Schat,Bernd Kaspers,Pete Kaiser Pdf
The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research
Use of X-Ray Crystallography in the Design of Antiviral Agents by W Laver Pdf
Use of X-Ray Crystallography in the Design of Antiviral Agents describes materials presented at an International Workshop held in Kona, Hawaii on February 6-8, 1989, which discussed the use of X-ray crystallography in the design of antiviral agents. This book focuses on the approach that determines the three-dimensional structures of viruses and virus proteins with biological activity, such as computer molecular modeling. The three-dimensional structures of a number of immune complexes that involve complexes of antigen with antibodies or peptide antigens complexed with an MHC molecule are also deliberated. This text emphasizes that the three-dimensional structures allow the rational design of virus replication inhibitors that control virus infections in man and economically important domestic animals. This publication is a good reference for pharmacists, biochemists, and clinicians researching on the design of antiviral agents.
Biobetters by Amy Rosenberg,Barthélemy Demeule Pdf
“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.
Author : R. van Furth Publisher : Springer Science & Business Media Page : 677 pages File Size : 41,6 Mb Release : 2013-04-17 Category : Medical ISBN : 9789401580700
Mononuclear phagocytes, which include macrophages, monocytes and their precursor cells, are the most important cells in the host defence against micro-organisms and tumor cells. During the last twenty-five years research on the biology of mononuclear phagocytes has increased tremendously. This motivated Professor R. van Furth to organize five international conferences on this subject in Leiden, the Netherlands. The edited proceedings of these meethings were published: in 1970 Mononuclear Phagocytes; in 1975 Mononuclear Phagocytes in Immunity, Infections and Pathology; in 1980 Mononuclear Phagocytes -- Functional Aspects; and in 1985 Mononuclear Phagocytes -- Characteristics, Physiology and Function. Reviews of these volumes, published in international journals, praised them as the most up-to-date state of the art publications. The publication of 1991 includes 88 chapters written by more than 200 authors.