The Malaria Project

Author : Karen M. Masterson
Publisher : Penguin
Page : 384 pages
File Size : 53,9 Mb
Release : 2014-10-07
Category : History
ISBN : 9780698140134

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The Malaria Project by Karen M. Masterson Pdf

A fascinating and shocking historical exposé, The Malaria Project is the story of America's secret mission to combat malaria during World War II—a campaign modeled after a German project which tested experimental drugs on men gone mad from syphilis. American war planners, foreseeing the tactical need for a malaria drug, recreated the German model, then grew it tenfold. Quickly becoming the biggest and most important medical initiative of the war, the project tasked dozens of the country’s top research scientists and university labs to find a treatment to remedy half a million U.S. troops incapacitated by malaria. Spearheading the new U.S. effort was Dr. Lowell T. Coggeshall, the son of a poor Indiana farmer whose persistent drive and curiosity led him to become one of the most innovative thinkers in solving the malaria problem. He recruited private corporations, such as today's Squibb and Eli Lilly, and the nation’s best chemists out of Harvard and Johns Hopkins to make novel compounds that skilled technicians tested on birds. Giants in the field of clinical research, including the future NIH director James Shannon, then tested the drugs on mental health patients and convicted criminals—including infamous murderer Nathan Leopold. By 1943, a dozen strains of malaria brought home in the veins of sick soldiers were injected into these human guinea pigs for drug studies. After hundreds of trials and many deaths, they found their “magic bullet,” but not in a U.S. laboratory. America 's best weapon against malaria, still used today, was captured in battle from the Nazis. Called chloroquine, it went on to save more lives than any other drug in history. Karen M. Masterson, a journalist turned malaria researcher, uncovers the complete story behind this dark tale of science, medicine and war. Illuminating, riveting and surprising, The Malaria Project captures the ethical perils of seeking treatments for disease while ignoring the human condition.

Author : Sandra M. Sufian
Publisher : University of Chicago Press
Page : 406 pages
File Size : 51,5 Mb
Release : 2008-11-15
Category : Science
ISBN : 9780226779386

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Healing the Land and the Nation by Sandra M. Sufian Pdf

A novel inquiry into the sociopolitical dimensions of public medicine, Healing the Land and the Nation traces the relationships between disease, hygiene, politics, geography, and nationalism in British Mandatory Palestine between the world wars. Taking up the case of malaria control in Jewish-held lands, Sandra Sufian illustrates how efforts to thwart the disease were intimately tied to the project of Zionist nation-building, especially the movement’s efforts to repurpose and improve its lands. The project of eradicating malaria also took on a metaphorical dimension—erasing anti-Semitic stereotypes of the “parasitic” Diaspora Jew and creating strong, healthy Jews in Palestine. Sufian shows that, in reclaiming the land and the health of its people in Palestine, Zionists expressed key ideological and political elements of their nation-building project. Taking its title from a Jewish public health mantra, Healing the Land and the Nation situates antimalarial medicine and politics within larger colonial histories. By analyzing the science alongside the politics of Jewish settlement, Sufian addresses contested questions of social organization and the effects of land reclamation upon the indigenous Palestinian population in a decidedly innovative way. The book will be of great interest to scholars of the Middle East, Jewish studies, and environmental history, as well as to those studying colonialism, nationalism, and public health and medicine.

Author : Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs
Publisher : National Academies Press
Page : 384 pages
File Size : 53,6 Mb
Release : 2004-09-09
Category : Medical
ISBN : 9780309165938

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Saving Lives, Buying Time by Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs Pdf

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

Author : Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control
Publisher : National Academies Press
Page : 312 pages
File Size : 55,6 Mb
Release : 1991-02-01
Category : Medical
ISBN : 0309045274

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Malaria by Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control Pdf

Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.

Author : L. Molineaux,G. Gramiccia
Publisher : Unknown
Page : 332 pages
File Size : 41,7 Mb
Release : 1980
Category : Malaria
ISBN : UCAL:B4285752

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The Garki Project by L. Molineaux,G. Gramiccia Pdf

Author : Margaret Humphreys
Publisher : JHU Press
Page : 209 pages
File Size : 52,9 Mb
Release : 2001-10-23
Category : Law
ISBN : 9780801866371

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Malaria by Margaret Humphreys Pdf

This is the story of a war against a disease that we can never win but must continue to fight. In Malaria: Poverty, Race, and Public Health in the United States, Margaret Humphreys presents the first book-length account of the parasitic, insect-borne disease that has infected millions and influenced settlement patterns, economic development, and the quality of life at every level of American society, especially in the south. Humphreys approaches malaria from three perspectives: the parasite's biological history, the medical response to it, and the patient's experience of the disease. It addresses numerous questions including how the parasite thrives and eventually becomes vulnerable, how professionals came to know about the parasite and learned how to fight them, and how people view the disease and came to the point where they could understand and support the struggle against it. In addition Malaria: Poverty, Race, and Public Health in the United States argues that malaria control was central to the evolution of local and federal intervention in public health, and demonstrates the complex interaction between poverty, race, and geography in determining the fate of malaria.

Author : Program on Forced Migration and Health at the Mailman School of Public Health of Columbia University,National Research Council,Committee on Population,Roundtable on the Demography of Forced Migration,Holly A. Williams,Peter B. Bloland
Publisher : National Academies Press
Page : 181 pages
File Size : 44,8 Mb
Release : 2003-01-16
Category : Medical
ISBN : 9780309086158

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Malaria Control During Mass Population Movements and Natural Disasters by Program on Forced Migration and Health at the Mailman School of Public Health of Columbia University,National Research Council,Committee on Population,Roundtable on the Demography of Forced Migration,Holly A. Williams,Peter B. Bloland Pdf

Admittedly, the world and the nature of forced migration have changed a great deal over the last two decades. The relevance of data accumulated during that time period can now be called into question. The roundtable and the Program on Forced Migration at the Mailman School of Public Health of Columbia University have commissioned a series of epidemiological reviews on priority public health problems for forced migrants that will update the state of knowledge. Malaria Control During Mass Population Movements and Natural Disasters- the first in the series, provides a basic overview of the state of knowledge of epidemiology of malaria and public health interventions and practices for controlling the disease in situations involving forced migration and conflict.

Author : Leo Barney Slater
Publisher : Rutgers University Press
Page : 266 pages
File Size : 42,5 Mb
Release : 2009
Category : History
ISBN : 9780813544380

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War and Disease by Leo Barney Slater Pdf

Fighting around the globe, American soldiers were at high risk for contracting malaria, yet quinine - a natural cure - became hard to acquire. This historical study shows the roots and branches of an enormous drug development project during World War II.

Author : Guoqiao Li,Ying Li,Zelin Li,Meiyi Zeng
Publisher : Academic Press
Page : 736 pages
File Size : 51,9 Mb
Release : 2017-11-28
Category : Medical
ISBN : 9780128132111

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Artemisinin-Based and Other Antimalarials by Guoqiao Li,Ying Li,Zelin Li,Meiyi Zeng Pdf

Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology. Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery

Author : João Biehl,Adriana Petryna
Publisher : Princeton University Press
Page : 454 pages
File Size : 41,8 Mb
Release : 2013-07-07
Category : Social Science
ISBN : 9780691157399

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When People Come First by João Biehl,Adriana Petryna Pdf

A people-centered approach to global health When People Come First critically assesses the expanding field of global health. It brings together an international and interdisciplinary group of scholars to address the medical, social, political, and economic dimensions of the global health enterprise through vivid case studies and bold conceptual work. The book demonstrates the crucial role of ethnography as an empirical lantern in global health, arguing for a more comprehensive, people-centered approach. Topics include the limits of technological quick fixes in disease control, the moral economy of global health science, the unexpected effects of massive treatment rollouts in resource-poor contexts, and how right-to-health activism coalesces with the increased influence of the pharmaceutical industry on health care. The contributors explore the altered landscapes left behind after programs scale up, break down, or move on. We learn that disease is really never just one thing, technology delivery does not equate with care, and biology and technology interact in ways we cannot always predict. The most effective solutions may well be found in people themselves, who consistently exceed the projections of experts and the medical-scientific, political, and humanitarian frameworks in which they are cast. When People Come First sets a new research agenda in global health and social theory and challenges us to rethink the relationships between care, rights, health, and economic futures.

Author : Vinay R. Kamat
Publisher : University of Arizona Press
Page : 321 pages
File Size : 47,6 Mb
Release : 2013-12-05
Category : Social Science
ISBN : 9780816599202

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Silent Violence by Vinay R. Kamat Pdf

Silent Violence engages the harsh reality of malaria and its effects on marginalized communities in Tanzania. Vinay R. Kamat presents an ethnographic analysis of the shifting global discourses and practices surrounding malaria control and their impact on the people of Tanzania, especially mothers of children sickened by malaria. Malaria control, according to Kamat, has become increasingly medicalized, a trend that overemphasizes biomedical and pharmaceutical interventions while neglecting the social, political, and economic conditions he maintains are central to Africa’s malaria problem. Kamat offers recent findings on global health governance, neoliberal economic and health policies, and their impact on local communities. Seeking to link wider social, economic, and political forces to local experiences of sickness and suffering, Kamat analyzes the lived experiences and practices of people most seriously affected by malaria—infants and children. The persistence of childhood malaria is a form of structural violence, he contends, and the resultant social suffering in poor communities is closely tied to social inequalities. Silent Violence illustrates the evolving nature of local responses to the global discourse on malaria control. It advocates for the close study of disease treatment in poor communities as an integral component of global health funding. This ethnography combines a decade of fieldwork with critical review and a rare anthropological perspective on the limitations of the bureaucratic, technological, institutional, medical, and political practices that currently determine malaria interventions in Africa.

Author : World Health Organization
Publisher : World Health Organization
Page : 139 pages
File Size : 48,5 Mb
Release : 2016-04-05
Category : Medical
ISBN : 9789241549394

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Malaria Microscopy Quality Assurance Manual - Version 2 by World Health Organization Pdf

The first version of the WHO Malaria microscopy quality assurance manual (2009) was based on recommendations made at a series of informal consultations organized by WHO particularly a bi-regional meeting of the WHO regional offices for South-East Asia and the Western Pacific in April 2005 in Kuala Lumpur Malaysia followed by informal consultations held in March 2006 and February 2008 in Geneva Switzerland. Subsequently extensive consultations among international malaria experts led to consensus and preparation of the manual. This second version of the Manual is based on the recommendations of experts made at a WHO technical consultation in March 2014 in Geneva Switzerland. The aim of the meeting was to review the experiences of national malaria control programmes (NMCPs) national reference laboratories (NRLs) and technical agencies in using the Manual and country experience in order to improve systems for managing the quality of malaria microscopy. This second version takes into account the many years of experience of several agencies in the various aspects of quality assurance (QA) described in the Manual. In particular the sections on assessment of competence in malaria microscopy are based on use of this method by the WHO regional offices for South-East Asia and the Western Pacific in collaboration with the WHO Coordinating Centre for Malaria in Australia and by the WHO Regional Office for Africa in collaboration with Amref Health Africa. The section on setting up and managing an international reference malaria slide bank is based on the work of the WHO Regional Office for the Western Pacific in collaboration with the WHO Coordinating Centre for Malaria Diagnosis in the Philippines. The section on proficiency testing for malaria microscopy is based on work in the WHO Regional Office for Africa in collaboration with the National Institute for Communicable Diseases in South Africa and experience in regional initiatives by Amref Health Africa. The section on slide validation is based on work by Médecins sans Frontières and the section on outreach training and supportive supervision (OTSS) is based on work by the President's Malaria Initiative Malaria Care Project Medical Care Development International and Amref Health Africa. The Manual is designed primarily to assist managers of NMCPs and general laboratory services responsible for malaria control. The information is also applicable to nongovernmental organizations (NGOs) and funding agencies involved in improving quality management systems for malaria microscopy. The Manual is not designed for QA of microscopy in research situations such as in clinical trials of new drugs and vaccines or for monitoring parasite drug resistance. It forms part of a series of WHO documents designed to assist countries in improving the quality of malaria diagnosis in clinical settings including the revised training manuals on Basic malaria microscopy (2010) and the Bench aids for malaria microscopy (2010).

Author : MISTRA
Publisher : The Mapungubwe Institute for Strategic Reflection (MISTRA)
Page : 440 pages
File Size : 50,8 Mb
Release : 2019-07-25
Category : Social Science
ISBN : 9780639995595

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Epidemics and the Health of African Nations by MISTRA Pdf

News footage of disease in Africa is a familiar sight. Yet these outbreaks are often presented out of context, with no reference to the conditions that have triggered them. MISTRA’s new book, Epidemics and the Health of African Nations, aims to redress that. Researchers and practitioners from within the continent explore why Africa is so vulnerable to disease, and show how this vulnerability is closely linked to political and economic factors. They demonstrate how these same factors determine the way epidemics are treated. Authors extract lessons from case studies in different parts of Africa; challenge conventional frameworks about disease to argue for a ‘syndemics’ approach that takes into account the interrelationship between disease and political and socio-economic contexts; explore challenges of Africa’s future. They argue that a well-functioning health system is at the core of a country’s capacity to counter an epidemic. This volume brings African experts together to probe possible solutions to the continent’s heavy burden of disease. The insights offered will be helpful in devising policy for the control of disease and the combatting of epidemics in Africa.

Author : Richard C. Wilkerson,Yvonne-Marie Linton,Daniel Strickman
Publisher : Johns Hopkins University Press
Page : 1332 pages
File Size : 53,9 Mb
Release : 2021-01-19
Category : Science
ISBN : 9781421438146

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Mosquitoes of the World by Richard C. Wilkerson,Yvonne-Marie Linton,Daniel Strickman Pdf

The most complete reference work on mosquitoes ever produced, Mosquitoes of the World is an unmatched resource for entomologists, public health professionals, epidemiologists, and reference libraries.

Author : Randall M. Packard
Publisher : JHU Press
Page : 351 pages
File Size : 52,6 Mb
Release : 2021-07-13
Category : Medical
ISBN : 9781421441795

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The Making of a Tropical Disease by Randall M. Packard Pdf

A global history of malaria that traces the natural and social forces that have shaped its spread and made it deadly, while limiting efforts to eliminate it. Malaria sickens hundreds of millions of people—and kills nearly a half a million—each year. Despite massive efforts to eradicate the disease, it remains a major public health problem in poorer tropical regions. But malaria has not always been concentrated in tropical areas. How did malaria disappear from other regions, and why does it persist in the tropics? From Russia to Bengal to Palm Beach, Randall M. Packard's far-ranging narrative shows how the history of malaria has been driven by the interplay of social, biological, economic, and environmental forces. The shifting alignment of these forces has largely determined the social and geographical distribution of the disease, including its initial global expansion, its subsequent retreat to the tropics, and its current persistence. Packard argues that efforts to control and eliminate malaria have often ignored this reality, relying on the use of biotechnologies to fight the disease. Failure to address the forces driving malaria transmission have undermined past control efforts. Describing major changes in both the epidemiology of malaria and efforts to control the disease, the revised edition of this acclaimed history, which was chosen as the 2008 End Malaria Awards Book of the Year in its original printing, • examines recent efforts to eradicate malaria following massive increases in funding and political commitment; • discusses the development of new malaria-fighting biotechnologies, including long-lasting insecticide-treated nets, rapid diagnostic tests, combination artemisinin therapies, and genetically modified mosquitoes; • explores the efficacy of newly developed vaccines; and • explains why eliminating malaria will also require addressing the social forces that drive the disease and building health infrastructures that can identify and treat the last cases of malaria. Authoritative, fascinating, and eye-opening, this short history of malaria concludes with policy recommendations for improving control strategies and saving lives.