The Molecular Basis Of Viral Infection

Author : Anonim
Publisher : Academic Press
Page : 468 pages
File Size : 45,9 Mb
Release : 2015-01-13
Category : Science
ISBN : 9780128025871

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The Molecular Basis of Viral Infection by Anonim Pdf

Virology is in a sense both one of the most important precursors and one of the most significant beneficiaries of structural and cellular molecular biology. Numerous breakthroughs in our understanding of the molecular interactions of viruses with host cells are ready for translation into medically important applications such as the prevention and treatment of viral infections. This book collects a wide variety of examples of frontline research into molecular aspects of viral infections from virological, immunological, cell- and molecular-biological, structural, and theoretical perspectives. Contributors are world leaders in their fields of study and represent prestigious academic and research institutions Review articles vary vastly in scope: some focus on a narrowly defined scientific problem of one particular virus with careful introduction for the non-specialist; others are essays in general and comparative virology with forays into specific viral species or molecules The different perspectives complement each other and collectively the contributions provide an impression of the fast-moving frontlines of virology while showing how the problems have evolved Structural data are presented through high-quality illustrations

Author : Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Publisher : Cambridge University Press
Page : 1325 pages
File Size : 48,7 Mb
Release : 2007-08-16
Category : Medical
ISBN : 9781139461641

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Human Herpesviruses by Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi Pdf

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Author : A. L. Notkins,M. B. A. Oldstone
Publisher : Springer Science & Business Media
Page : 418 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461252504

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Concepts in Viral Pathogenesis by A. L. Notkins,M. B. A. Oldstone Pdf

The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.

Author : Rudolf Rott,Werner Goebel
Publisher : Springer Science & Business Media
Page : 194 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642732140

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Molecular Basis of Viral and Microbial Pathogenesis by Rudolf Rott,Werner Goebel Pdf

Elucidation of the mechanisms of pathogenesis underlying the diseases caused by viruses and bacteria has fascinated scientists for many years in two ways. Firstly, these pathogenic agents represent relatively sim ple biological systems for the study of basic biological processes such as replication, gene regulation, genetic variability and host-pathogen interactions. Secondly, process in this field is valuable in a practi cal sence, since it can help in the control of these diseases. The avail ability of new genetic and immunological techniques, especially recom binant DNA methods and monoclonal antibody technology, has provided powerful tools for unravelling the genetic, biochemical and immunologi cal basis of viral and microbial pathogenesis. Molecular cloning has allowed the isolation of single genes or groups of genes related to phenotypes which appear to be immunologically important for pathogene sis. The specific elimination of such genes from the complex genomes of the pathogens can now be achieved with similar genetic techniques. These genetic studies have provided additional information on the role played by specific phenotypic traits in pathogenesis, especially when combined with relevant animal model systems. Furthermore, the struc tural analysis of important virulence factors and surface antigens may allow the prediction of antigenic domains suitable for the development of new vaccines. The 38th Mosbacher Colloquium focuses on the molecular basis of viral and microbial pathogenesis. The virology part begins with the well studied plant viroids. The unusual structure of their genome, as well as knowledge about their replication and pathogenicity, are presented.

Author : R. Bercoff
Publisher : Springer Science & Business Media
Page : 584 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468453508

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The Molecular Basis of Viral Replication by R. Bercoff Pdf

the discovery of the "splicing" of the gene transcripts, the list would include the whole molecular genetics of the lambda bacteriophage, the notions of "promotor," "repressor," and "integration," the discovery of the reverse flow of genetic information, the very existence of oncogenes, the S'-terminal "cap" struc ture of eukaryotic mRNAs, ... Electronmicroscopy, ultracentrifugation and tissue culture were the landmarks on the way of the young science. During the past few years, however, a major (and not so silent) revolution took place: recombinant DNA technology with all its might entered in our laboratories, and restriction mapping of cloned genomes and sequencing gels have replaced plaque counting and sucrose gradients. The new techniques have made it possible to "dissect" the entire genome of a virus at the molecular level, and studies that would have been dreamt of just in the mid-seventies became the everyday experiments of our days. With new insight into the structure of viral genomes, and a deeper understanding of the mechanisms that regulate their expression, our view of viruses was bound to change: this volume bears witness to this impressive advance.

Author : Heinz Fraenkel-Conrat
Publisher : Unknown
Page : 664 pages
File Size : 40,5 Mb
Release : 1968
Category : Science
ISBN : WISC:89042592428

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Molecular Basis of Virology by Heinz Fraenkel-Conrat Pdf

Author : Adrian J. Gibbs,Charles H. Calisher,Fernando García-Arenal
Publisher : Cambridge University Press
Page : 625 pages
File Size : 45,8 Mb
Release : 1995-10-19
Category : Medical
ISBN : 9780521455336

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Molecular Basis of Virus Evolution by Adrian J. Gibbs,Charles H. Calisher,Fernando García-Arenal Pdf

Advances in molecular biology have enabled leaps forward in the determination of virus phylogenetic history. This detailed 1995 book results from the invitation to foremost experts to give essays on aspects of virus biology. Initial chapters cover impacts of viruses and their control. Further chapters detail genetic variation of viruses and the molecular basis of interrelations with hosts. This leads to discussions of interactions with the host at the population level, and their molecular basis and evolution. Seventeen chapters follow, by specialists on particular groups of viruses describing their impact, genetic origins, sources of variation, population genetics and interactions with hosts. Practical virologists will find the chapters on phylogenetic analysis techniques very useful. The adaptive nature of viruses makes this work highly relevant to evolutionists.

Author : Rudolf Rott,Werner Goebel
Publisher : Unknown
Page : 196 pages
File Size : 45,9 Mb
Release : 1988-02-25
Category : Electronic
ISBN : 3642732151

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Molecular Basis of Viral and Microbial Pathogenesis by Rudolf Rott,Werner Goebel Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 52,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Yechiel Becker
Publisher : Springer Science & Business Media
Page : 452 pages
File Size : 43,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461338048

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Antiviral Drugs and Interferon: The Molecular Basis of Their Activity by Yechiel Becker Pdf

Research on antiviral drugs and their mode of action in infected cells. in animals and in man. has led to a better understanding of the molecular pro cesses involved in virus replication. Screeninq of large numbers of natural and semisynthetic compounds resulted in the characterization of certain sub stances that had a limited efficiency as antiviral druqs. A few chemically synthesized compounds were also found to be effective as antiviral agents in the chemotherapy of human virus diseases. A major difficulty in the develop ment of effective antiviral agents has been the lack of selectivity. and toxicity for uninfected cells. of drugs that effectively inhibited virus replication in vitro. Further understanding of the molecular processes of virus replication in infected cells has resulted in the development of new antivirals directed at virus-coded enzymes or proteins. Recent studies on antivirals that are activated by the herpes simplex virus type l-coded thy midine kinase from a prod rug to an antiviral drug have opened new directions in the development of effective antiviral drugs. The present book deals with a number of antiviral drugs effective against herpes simplex viruses and provides some insight into the molecular aspects of virus replication. It also throws light on the new approaches to the development of antiviral drugs. The molecular basis of the antiviral activity of new and known drugs and their possible use in chemotherapy of viral disease are presented in this book.

Author : Phoebe Lostroh
Publisher : Garland Science
Page : 971 pages
File Size : 44,8 Mb
Release : 2019-05-06
Category : Science
ISBN : 9780429664304

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Molecular and Cellular Biology of Viruses by Phoebe Lostroh Pdf

Viruses interact with host cells in ways that uniquely reveal a great deal about general aspects of molecular and cellular structure and function. Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered, with separate chapters for their replication and expression strategies, and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given at the back of the book. Examples come from the most-studied and medically important viruses such as HIV, influenza, and poliovirus. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses, with a separate chapter on medical applications such as anti-viral drugs and vaccine development. The final chapter is on virus diversity and evolution, incorporating contemporary insights from metagenomic research. Key selling feature: Readable but rigorous coverage of the molecular and cellular biology of viruses Molecular mechanisms of all major groups, including plant viruses and bacteriophages, illustrated by example Host-pathogen interactions at the cellular and molecular level emphasized throughout Medical implications and consequences included Quality illustrations available to instructors Extensive questions and answers for each chapter

Author : Michael G. Katze,Marcus J. Korth,G. Lynn Law,Neal Nathanson
Publisher : Academic Press
Page : 366 pages
File Size : 44,7 Mb
Release : 2015-12-30
Category : Science
ISBN : 9780128011744

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Viral Pathogenesis by Michael G. Katze,Marcus J. Korth,G. Lynn Law,Neal Nathanson Pdf

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field

Author : R. Ahmed,Irvin Chen
Publisher : Wiley-Blackwell
Page : 754 pages
File Size : 40,8 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015041993448

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Persistent Viral Infections by R. Ahmed,Irvin Chen Pdf

Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.

Author : Lois K. Miller
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 47,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489918345

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The Baculoviruses by Lois K. Miller Pdf

The past decade has witnessed an explosion of information on the molecular biology of insect viruses and a frenzy of activity in applying this information to medicine and agriculture. Genetically engineered baculoviruses are presently being tested for commercial use as pesticides, and the study of such viruses is also revealing remarkable insights into basic cellular processes such as apoptosis. This comprehensive volume provides readers with knowledge of basic and applied baculovirology so that current literature in the field can be appreciated.

Author : Committee on the Assessment of Future Scientific Needs for Variola Virus,Institute of Medicine
Publisher : National Academies Press
Page : 126 pages
File Size : 43,6 Mb
Release : 1999-05-14
Category : Medical
ISBN : 9780309596985

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Assessment of Future Scientific Needs for Live Variola Virus by Committee on the Assessment of Future Scientific Needs for Variola Virus,Institute of Medicine Pdf

In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines: -- Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. -- What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. -- What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases.