The Moreau Factor Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of The Moreau Factor book. This book definitely worth reading, it is an incredibly well-written.
THE EVOLUTION OF TERROR A hard-living reporter long past his Pulitzer Prize-winning prime, Chuck Vallone is about to meet a renowned geneticist who needs to clear his conscience. But when Vallone arrives at their rendezvous, he finds the D.C. hotel swarming with government agents. The scientist's room is now a grisly slaughterhouse splattered with blood--but no sign of a body. Vallone knows he has the story of the century, especially when he receives a mysterious package filled with a computer disk and strange samples of DNA. Now he's determined to uncover the truth. But it's no brave new world Vallone will be exploring; rather, a deadly depraved one ruled by preeminent scientists. And this powerful cadre intends to make Vallone both eyewitness and executor of their final ferocious plan . . .
In 1977, the Heart Break Killer haunted Brooklyn. Victims were found stabbed in the chest with a cartoon heart carved sickeningly into their skin. The serial killer was Elliot Hurley, and a policeman responding to a disturbance call killed her just as she completed her final murder—although some suspect there was a cover up. Ten years later, young Oliver Hann moves to Brooklyn to attend a prestigious police academy. He writes a paper outlining the story of 1977, and his doubts about the veracity of it, so his professor invites Oliver to join the Theory Club, in which brilliant students spin theories about murder and mayhem. When a young woman is discovered in a bush, killed in the same way as victims in 1977, it appears that the Heart Break Killer has returned from the grave. Oliver and his Theory Club friends take to the streets to find the copycat killer, exposing the cover-up and solving a decade old mystery.
Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
Growth Factors and their Receptors in Cancer Metastasis by Wen G. Jiang,K. Matsumoto,T. Nakamura Pdf
Written by experts worldwide, this book provides the current knowledge of growth factors and their receptors in cancer metastasis. It covers basic cellular and molecular biology of growth factors and their receptors, as well as their role in cancer and cancer metastasis in clinical settings. The book is intended for cancer biologists, cell biologists, biochemists, geneticists, oncologists, surgeons and physicians. It is also a valuable reference for those who work in the area of cancer research, cancer therapies, cancer care, pharmaceutical industry. Postgraduates and undergraduates who pursue a research career in cancer and growth factors will find it an extremely useful reference book.
Author : Michael B. Sporn,Anita B. Roberts Publisher : Springer Science & Business Media Page : 740 pages File Size : 54,7 Mb Release : 2012-12-06 Category : Medical ISBN : 9783642747816
Peptide Growth Factors and Their Receptors II by Michael B. Sporn,Anita B. Roberts Pdf
This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entired field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost im anyone person to stay informed on this subject by reading the possible for At the same time it is becoming increasingly apparent that primary literature. these substances are of universal importance in biology and medicine and that the original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony-stimulating factors," was quite artifactual; they are in fact the basis of a common language for intercellular communication. As a set they affect es sentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research.
Author : Michael B. Sporn,Anita B. Roberts Publisher : Springer Science & Business Media Page : 842 pages File Size : 49,6 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461232100
Peptide Growth Factors and Their Receptors I by Michael B. Sporn,Anita B. Roberts Pdf
This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entire field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost impossible for anyone person to stay informed on this subject by reading the primary literature. At the same time it is becoming increasingly apparent that these of universal importance in biology and medicine and that the substances are original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony stimulating factors," was quite artifactual; they are in fact the basis of a com mon language for intercellular communication. As a set they affect essentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research. This treatise is divided into four main sections. After three introductory chapters, its principal focus is the detailed description of each of the major peptide growth factors in 26 individual chapters.
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
James Neuberger,James Ferguson,Philip N. Newsome,Michael R. Lucey
Author : James Neuberger,James Ferguson,Philip N. Newsome,Michael R. Lucey Publisher : John Wiley & Sons Page : 592 pages File Size : 41,6 Mb Release : 2021-02-25 Category : Medical ISBN : 9781119634027
Liver Transplantation by James Neuberger,James Ferguson,Philip N. Newsome,Michael R. Lucey Pdf
Explore this practical and step-by-step guide to managing liver transplant patients from leading international clinicians in Hepatology The newly revised Second Edition of Liver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care. Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient. Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management. Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy: A thorough discussion of when to refer a patient for liver transplantation, including general considerations and the use and abuse of prognostic models An exploration of the selection, assessment, and management of patients on the transplant list, including how to manage a patient with chronic liver disease while on the waiting list A treatment of liver transplantation for acute liver failure (ALF), including assessment and management of ALF patients on the transplant waiting list A discussion of care of the liver transplant recipient after the procedure in the short and long term Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation, Liver Transplantation: Clinical Assessment and Management will also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation.
Author : Terry W. Moody Publisher : Springer Science & Business Media Page : 454 pages File Size : 40,7 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461528463
Growth Factors, Peptides, and Receptors by Terry W. Moody Pdf
The Twelfth Annual Washington Spring Symposium on Health Sciences attracted over 300 scientists from 20 countries. It was held at the Lisner Auditorium of the George Washington University in Washington, D.C. during June 1-5, 1992. The theme of the meeting was "Growth Factors, Peptides, and Receptors," and speakers emphasized both basic and clinical research in these areas. The seven plenary sessions emphasized Peptides, Growth Factors, Peptide Receptors, Growth Factor Receptors, Second Messengers, Proliferation, and Clinical Correlations. The chapters in this volume are derived from each of these scientific sessions plus the poster and special sessions. The Abraham White Distinguished Scientist Award was presented to Dr. Solomon H. Snyder for his numerous contributions to the field of neurochemistry. He presented the keynote address "Nitric Oxide: A Novel Neuronal Messenger." Dr. Snyder discussed the pathway of nitric oxide (NO) synthesis by the enzyme NO synthase. Released NO may be responsible for the neuronal toxicity associated with NMDA, an excitatory amino acid analogue. Dr. Snyder noted that NO may be the first of a new class of transmitters, with carbon monoxide being another candidate. The Distinguished Public Service Award was presented to Senator Fritz Hollings in of his leadership and outstanding achievements in the United States Senate recognition and for his legislative support for biomedical research and education. In the symposium banquet address, Senator Hollings stressed the need for continued support of research to combat serious diseases such as cancer.
Vascular Aging: Facts and Factors by Elisabet Vila,Francesc Jiménez-Altayó,Paula Dantas Pdf
The increasing mean age of the population in developed countries has turned out to be an economic and social problem. Cardiovascular disease has long been considered to be age related in terms of their onset and progression. As such, we can say that the increase in life expectancy goes in parallel with increased incidence of cardiovascular disease. With age, a number of changes occur in the vasculature altering the homeostasis of the irrigated organs promoting target organ damage. While different adaptive mechanisms to protect vessels against mild stress have been described, the aging process induces a progressive failure of protective mechanisms, leading to vascular changes and higher susceptibility to cardiovascular diseases. Indeed, vascular aging is exacerbated by coexisting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Compelling evidence indicates that diminished endothelial relaxation and increase, decrease, or no change in contractile responses to several agonists is associated with aging. There is an increase of vasoconstrictor factors expression and a decrease of vasodilators. Morphologic changes include lumen diameter enlargement, wall thickening and alterations of matrix substances as increased collagen or decreased elastin deposition, ultimately leading to greater arterial stiffening (reduced compliance). Importantly, arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Cellular and molecular mechanisms have also been documented. Senescence at the cellular level involves alterations in Ca2+ signaling and down regulation of anti-aging proteins. Both endothelial and smooth muscle cells change their number, morphology, function and their regenerative ability. Aging is also associated with a gradual loss of antioxidant defense mechanisms, a proinflammatory shift in the cytokine expression profile and a production of reactive oxygen species such as superoxide (O2-) that promotes the breakdown of nitric oxide. Nitric oxide and O2- interact to form peroxynitrite known to nitrosylate proteins affecting their physiological function. However, vascular wall proteins may also suffer from other potentially deleterious modifications as glycation (Maillard reaction) and glyco-oxidative reactions with increasing age, which could be linked to the age-associated changes in vascular function. Various strategies have shown benefit in preventing, delaying or attenuating vascular aging. For instance, a healthy lifestyle including low fat diet and/or exercise have a favorable effect. Nevertheless, it yet remains to be fully demonstrated whether vascular aging can be pharmacologically prevented. This Research Topic is intended to bring together research efforts to understand the causes and consequences of vascular aging and propose new therapeutic strategies for the management of vascular senescence.
Platelet Activating Factor Receptor by Shivendra D. Shukla Pdf
Platelet activating factor (PAF) is the most potent phospholipid agonist known to date. PAF has a wide variety of physiological effects and has also been implicated in patho-physiology of cells. Since the structural elucidation of PAF in 1979, several laboratories have embarked upon characterizing the PAF receptor and its signaling pathways. This book focuses on this aspect and presents the first comprehensive account of research in the area. It also examines developments on the PAF receptor, its cloning, molecular features, coupling to multiple signaling pathways, and relationship to nuclear gene expression. This is an excellent reference volume for all researchers studying PAF.
Cytokines and Cytokine Receptors by Constantin A. Bona,Jean-Pierre Revillard Pdf
The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic
The Lost Book of Adana Moreau by Michael Zapata Pdf
*Winner of the Chicago Review of Books Award for Fiction* A Heartland Booksellers Award Nominee An NPR Best Book of the Year A BookPage Best Book of the Year A Library Journal Best Winter/Spring Debut of 2020 A Most Anticipated Book of 2020 from the Boston Globe and The Millions A Best Book of February 2020 at Salon, The Millions, LitHub and Vol 1. Brooklyn “A stunner—equal parts epic and intimate, thrilling and elegiac.”—Laura Van den Berg, author of The Third Hotel The mesmerizing story of a Latin American science fiction writer and the lives her lost manuscript unites decades later in post-Katrina New Orleans In 1929 in New Orleans, a Dominican immigrant named Adana Moreau writes a science fiction novel. The novel earns rave reviews, and Adana begins a sequel. Then she falls gravely ill. Just before she dies, she destroys the only copy of the manuscript. Decades later in Chicago, Saul Drower is cleaning out his dead grandfather’s home when he discovers a mysterious manuscript written by none other than Adana Moreau. With the help of his friend Javier, Saul tracks down an address for Adana’s son in New Orleans, but as Hurricane Katrina strikes they must head to the storm-ravaged city for answers. What results is a brilliantly layered masterpiece—an ode to home, storytelling and the possibility of parallel worlds.
Engineering Mineralized and Load Bearing Tissues by Luiz E. Bertassoni,Paulo G. Coelho Pdf
This book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue engineering has long held great promises as an improved treatment option for conditions affecting mineralized and load-bearing structures in the body. Although significant progress has been achieved in recent years, a number of challenges still exist. Scaffold vascularization, new biofabrication methods (3D printing, lithography, microfabrication), peptide conjugation methods, interface engineering, scaffold mechanical properties, iPS cells, organs-on-a-chip, are some of the topics discussed in this book. More specially, in the first section readers will find an overview of emerging biofabrication methods. In section 2, applied strategies for regeneration of (2.1) bone, cartilage and ligament, as well as (2.2) dentin, cementum, enamel and periodontal ligament are discussed across 14 chapters. While other volumes have addressed the regeneration of individual tissues, or exclusively focused on different regenerative strategies, the focus of this work is to bring together researchers integrating backgrounds in materials sciences, engineering, biology, mechanics, fluidics, etc, to address specific challenges common to regeneration of several load-bearing and calcified tissues. Therefore, this book provides a unique platform to stimulate progress in the regeneration of functional tissue substitutes. We envision that this book will represent a valuable reference source for university and college faculties, post‐doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues.
