The Orexin System Basic Science And Role In Sleep Pathology

Author : M.A. Steiner,M. Yanagisawa,M. Clozel
Publisher : Karger Medical and Scientific Publishers
Page : 165 pages
File Size : 40,6 Mb
Release : 2021-05-28
Category : Health & Fitness
ISBN : 9783318068443

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The Orexin System. Basic Science and Role in Sleep Pathology by M.A. Steiner,M. Yanagisawa,M. Clozel Pdf

The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Author : Michel Steiner,Michael A Steiner, Ed,Masashi Yanagisawa,Martine Clozel
Publisher : S. Karger AG (Switzerland)
Page : 154 pages
File Size : 51,6 Mb
Release : 2021
Category : Electronic
ISBN : 3318068438

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The Orexin System by Michel Steiner,Michael A Steiner, Ed,Masashi Yanagisawa,Martine Clozel Pdf

The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer's disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Author : S. R. Pandi-Perumal,Milton Kramer
Publisher : Cambridge University Press
Page : 128 pages
File Size : 47,8 Mb
Release : 2010-04-01
Category : Medical
ISBN : 9781139483704

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Sleep and Mental Illness by S. R. Pandi-Perumal,Milton Kramer Pdf

The diagnosis of mental illness is frequently accompanied by sleep problems; conversely, people experiencing sleep problems may subsequently develop mental illness. Sleep and Mental Illness looks at this close correlation and considers the implications of research findings that have emerged in the last few years. Additionally, it surveys the essential concepts and practical tools required to deal with sleep and co-morbid psychiatric problems. The volume is divided into three main sections: basic science, neuroendocrinology, and clinical science. Included are over 30 chapters on topics such as neuropharmacology, insomnia, depression, dementia, autism, and schizophrenia. Relevant questionnaires for the assessment of sleep disorders, including quality-of-life measurement tools, are provided. There is also a summary table of drugs for treating sleep disorders. This interdisciplinary text will be of interest to clinicians working in psychiatry, behavioral sleep medicine, neurology, pulmonary and critical care medicine.

Author : Luis De Lecea,J. Gregor Sutcliffe
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 42,7 Mb
Release : 2007-04-25
Category : Medical
ISBN : 9780387254463

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Hypocretins by Luis De Lecea,J. Gregor Sutcliffe Pdf

The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Sleep Medicine and Research
Publisher : National Academies Press
Page : 425 pages
File Size : 45,6 Mb
Release : 2006-10-13
Category : Medical
ISBN : 9780309101110

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Sleep Disorders and Sleep Deprivation by Institute of Medicine,Board on Health Sciences Policy,Committee on Sleep Medicine and Research Pdf

Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.

Author : John W. Winkelman,David T. Plante
Publisher : Cambridge University Press
Page : 435 pages
File Size : 54,8 Mb
Release : 2010-12-23
Category : Medical
ISBN : 9781139494342

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Foundations of Psychiatric Sleep Medicine by John W. Winkelman,David T. Plante Pdf

Sleep-related complaints are extremely common across the spectrum of psychiatric illness. Accurate diagnosis and management of sleep disturbances requires an understanding of the neurobiological mechanisms underlying sleep and wakefulness, the characteristics of sleep disturbance inherent to psychiatric illness and primary sleep disorders, as well as the psychopharmacologic and behavioral treatments available. Foundations of Psychiatric Sleep Medicine provides a uniquely accessible, practical, and expert summary of current clinical concepts at the sleep-psychiatry interface. Topics covered include: basic principles in sleep science, clinical sleep history taking, primary sleep disorders in psychiatric contexts, and sleep disturbance across a range of mood, anxiety, psychotic, substance use, cognitive and developmental disorders. Written by outstanding experts in the field of sleep medicine and psychiatry, this academically rigorous and clinically useful text is an essential resource for psychiatrists, psychologists and other health professionals interested in the relationship between sleep and mental illness.

Author : Anonim
Publisher : Academic Press
Page : 2626 pages
File Size : 46,9 Mb
Release : 2013-01-17
Category : Science
ISBN : 9780123786111

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Encyclopedia of Sleep by Anonim Pdf

In a world of 24-hour media saturation, sleep has become an increasingly fraught enterprise. The award-winning four-volume Encyclopedia of Sleep, Four Volume Set is the largest reference, either online or in print, on the subject of sleep. Written to be useful for the novice and the established researcher and clinician, Topic areas will include sleep across the life cycle and in other species, sleep and women, sleep and the elderly, pediatric sleep, sleep deprivation and loss, sleep mechanisms, sleep physiology and pathophysiology, sleep disorders, neurobiology, chronobiology, pharmacology, and impact of other disorders on sleep. Recognizing the many fields that are connected to sleep science, the editorial team has been carefully chosen to do justice to this highly interdisciplinary field of study. The steady growth of researchers and clinicians in the sleep field attests to the continued interest in the scientific study of sleep and the management of patients with sleep disorders, and anyone involved in this exciting field should find this work to be an invaluable reference. 2013 PROSE Award winner for Multivolume Reference in Science from the Association of American Publishers Thoroughly interdisciplinary: looks at sleep throughout the life cycle, with exceptional coverage of basic sleep concepts, the physiology of sleep as well as sleep disorders of all descriptions Excellent coverage of sleep and special populations, covering the lifespan, as well as gender and ethnic differences, among others Chapters focusing on sleep disorders are grouped under the broad categories classified in the ICSD-2 for clear organization so that the reader can effectively access the steps involved in diagnosing and treating these disorders Online version is linked both within the encyclopedia (to related content) and to external sources (such as primary journal content) so that users have easy access to more detailed information if needed

Author : Eric Nofzinger,Pierre Maquet,Michael J. Thorpy
Publisher : Cambridge University Press
Page : 446 pages
File Size : 44,7 Mb
Release : 2013-03-07
Category : Medical
ISBN : 9781107018631

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Neuroimaging of Sleep and Sleep Disorders by Eric Nofzinger,Pierre Maquet,Michael J. Thorpy Pdf

An up-to-date, superbly illustrated practical guide to the effective use of neuroimaging in the patient with sleep disorders. The only book to date to provide comprehensive coverage of this topic. A must for all healthcare workers interested in understanding the causes, consequences and treatment of sleep disorders.

Author : Anantha Shekhar
Publisher : Elsevier
Page : 208 pages
File Size : 49,6 Mb
Release : 2012-09-05
Category : Medical
ISBN : 9780444594891

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Orexin/Hypocretin System by Anantha Shekhar Pdf

"In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations." "Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding and body weight regulation."--Résumé de l'éditeur.

Author : Sue Wilson,David Nutt
Publisher : OUP Oxford
Page : 160 pages
File Size : 44,5 Mb
Release : 2013-09-26
Category : Medical
ISBN : 9780191662089

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Sleep Disorders by Sue Wilson,David Nutt Pdf

Sleep dysfunction is one of the primary symptoms reported by patients with psychiatric disorders, and specifically those suffering from anxiety and depressive disorders. Conversely, primary insomnia and other sleep disorders produce symptoms of mood disturbance that are quite similar to those reported by patients with psychiatric disorders. Because of this overlap in the symptoms and treatments for insomnias and psychiatric disorders, it is important for clinicians to be able to accurately identify the root cause of sleep dysfunction in individual patients in order to optimize treatment. Part of the Oxford Psychiatry Library series, Sleep Disorders provides clinicians with an overview of current understanding of sleep physiology, the pathophysiology of sleep disturbance, and the diagnosis and treatment of sleep disorders. This second edition includes new sections covering sleep problems in children, sleep in the elderly, and sleep in pregnancy and menopause, as well as new algorithms from the British Association of Psychopharmacology's (BAP's) new Consensus Guidelines on the management of sleep disorders.

Author : Eduardo E. Benarroch,Jeremy K. Cutsforth-Gregory,Kelly D. Flemming
Publisher : Oxford University Press
Page : 850 pages
File Size : 54,6 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9780190209421

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Mayo Clinic Medical Neurosciences by Eduardo E. Benarroch,Jeremy K. Cutsforth-Gregory,Kelly D. Flemming Pdf

Fully updated and revised according to student feedback, the sixth edition of Mayo Clinic Medical Neurosciences: Organized by Neurologic System and Level provides a systematic approach to anatomy, physiology, and pathology of the nervous system inspired by the neurologist's approach to solving clinical problems. This volume has 4 sections: 1) an overview of the neurosciences necessary for understanding anatomical localization and pathophysiologic characterization of neurologic disorders; 2) an approach to localizing lesions in the 7 longitudinal systems of the nervous system; 3) an approach to localizing lesions in the 4 horizontal levels of the nervous system; and 4) a collection of clinical problems. This book provides the neuroscience framework to support the neurologist in a clinical setting and is also a great resource for neurology and psychiatry board certifications. This is the perfect guide for all medical students and neurology, psychiatry, and physical medicine residents at early stages of training. New to This Edition - A chapter devoted to multiple-choice questions for self-assessment - Discussion of emerging concepts in molecular, cellular, and system neurosciences - New chapters on emotion and consciousness systems - Incorporation of new discoveries in neuroimaging and an appendix for tables of medications commonly used to treat neurologic disorders

Author : Sudhansu Chokroverty
Publisher : Butterworth-Heinemann
Page : 516 pages
File Size : 44,6 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483165196

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Sleep Disorders Medicine by Sudhansu Chokroverty Pdf

Sleep Disorders Medicine: Basic Science, Technical Considerations, and Clinical Aspects presents the scientific basis for understanding sleep. This book provides information on the diagnosis and treatment of a wide variety of sleep disorders. Organized into 28 chapters, this book begins with an overview of the cerebral activity of wakefulness and the cerebral activity of sleep. This text then discusses the effects on mental and physical health of non-rapid eye movement (NREM) sleep, rapid eye movement (REM) sleep, and all sleep. Other chapters consider the neurophysiology and cellular pharmacology of sleep mechanisms. This book discusses as well the physiologic changes that occur in both the autonomic and somatic nervous system during sleep. The final chapter deals with the application of nasal continuous positive airway pressure for the treatment of obstructive apnea in adults. This book is a valuable resource for neurologists, internists, psychiatrists, pediatricians, otolaryngologists, neurosurgeons, psychologists, neuroscientists, and general practitioners.

Author : S. R. Pandi-Perumal,Jaime M. Monti,Andrew A. Monjan
Publisher : Cambridge University Press
Page : 128 pages
File Size : 53,5 Mb
Release : 2009-11-26
Category : Medical
ISBN : 9781139483629

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Principles and Practice of Geriatric Sleep Medicine by S. R. Pandi-Perumal,Jaime M. Monti,Andrew A. Monjan Pdf

Sleep disorders cause considerable morbidity and distress in the aging population. By highlighting the clinical diagnosis and management of sleep disorders, this volume provides a valuable resource for all those involved in health care of older individuals. The changes in sleep patterns that occur during normal aging are described, followed by authoritative chapters on the presentation of various age-related sleep disorders. The book deals with the range of therapeutic measures available for managing these disorders and gives insight to potential areas of research that have emerged in the last few years, such as the study of circadian rhythms in later life, sleep patterns associated with co-morbidities and the use of quality-of-life measurement tools to determine sleep quality as we age. This volume is relevant to sleep disorders specialists, psychiatrists, geriatricians and gerontologists, and any professionals and researchers working in the interdisciplinary areas of sleep and aging.

Author : Yinong Chong,Cheryl D. Fryar,Qiuping Gu
Publisher : Unknown
Page : 10 pages
File Size : 42,5 Mb
Release : 2013
Category : Hypnotics
ISBN : UCR:31210023709130

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Prescription Sleep Aid Use Among Adults by Yinong Chong,Cheryl D. Fryar,Qiuping Gu Pdf

Author : Soňa Nevšímalová,Oliviero Bruni
Publisher : Springer
Page : 422 pages
File Size : 44,9 Mb
Release : 2016-10-03
Category : Medical
ISBN : 9783319286402

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Sleep Disorders in Children by Soňa Nevšímalová,Oliviero Bruni Pdf

This book is both an exam guide to children ́s sleep medicine and a practical manual for diagnosis and management of sleep disorders in children. An overview of the most frequent sleep disorders encountered in newborns, infants, children and adolescents is provided. This book discusses the main sleep disorders in detail, including insomnia, respiratory disturbances, movement disorders during sleep, circadian rhythm disorders, parasomnias, and disorders associated with increased sleepiness. It also covers sleep disorders associated with neurological, psychiatric, and medical diseases. This book is divided into two parts. The first part is an introduction to childhood sleep physiology and pathology, epidemiology of sleep disorders, and diagnostic procedures. The second part describes the most frequent sleep disorders in greater depth. Sleep Disorders in Children is aimed at sleep researchers, pediatricians, child neurologists and child psychiatrists, as well as patient organizations and families with affected children.