The P53 Tumor Suppressor Pathway And Cancer

Author : Gerard P. Zambetti
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 47,7 Mb
Release : 2007-07-03
Category : Medical
ISBN : 9780387301273

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The p53 Tumor Suppressor Pathway and Cancer by Gerard P. Zambetti Pdf

The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona ?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi?cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 ?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the ?eld exploded and p53 became a major focus of scientists around the world.

Author : Swati Palit Deb,Sumitra Deb
Publisher : Springer
Page : 373 pages
File Size : 51,9 Mb
Release : 2014-09-08
Category : Medical
ISBN : 9789401792110

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Mutant p53 and MDM2 in Cancer by Swati Palit Deb,Sumitra Deb Pdf

This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.

Author : Guillermina Lozano,Arnold Jay Levine
Publisher : Unknown
Page : 0 pages
File Size : 42,7 Mb
Release : 2016
Category : Medical
ISBN : 1621821331

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The P53 Protein by Guillermina Lozano,Arnold Jay Levine Pdf

Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a "guardian of the genome," protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on genome stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations. Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease.

Author : Katherine R. Polinsky
Publisher : Nova Publishers
Page : 332 pages
File Size : 52,7 Mb
Release : 2007
Category : Antioncogenes
ISBN : 1600216935

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Tumor Suppressor Genes by Katherine R. Polinsky Pdf

A tumour suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. A mutation or deletion of such a gene will increase the probability of the formation of a tumor. Unlike oncogenes, tumor suppressor genes generally follow the 'two-hit hypothesis', which implies that both alleles that code for a particular gene must be affected before an effect is manifested. This is due to the fact that if only one allele for the gene is damaged, the second can still produce the correct protein. However, there are cases where mutations in only one allele will cause an effect. A notable example is the gene that codes for p53. Tumor suppressor genes, or more precisely, the proteins for which they code, either have a dampening or repressive effect on the regulation of the cell cycle or promote apoptosis, and sometimes do both. This book presents new and important research from throughout the world.

Author : Tapas Mukhopadhyay,Steven A. Maxwell,Jack A. Roth
Publisher : Springer Science & Business Media
Page : 132 pages
File Size : 45,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662222751

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p53 Suppressor Gene by Tapas Mukhopadhyay,Steven A. Maxwell,Jack A. Roth Pdf

This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.

Author : Pierre Hainaut,Klas G. Wiman
Publisher : Springer Science & Business Media
Page : 444 pages
File Size : 52,6 Mb
Release : 2007-10-05
Category : Medical
ISBN : 9781402029226

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25 Years of p53 Research by Pierre Hainaut,Klas G. Wiman Pdf

p53 has emerged as a key tumor suppressor and important target for novel cancer therapy. This book, written by world-leading p53 researchers including many of those who have shaped the field over the past 25 years, provides unique insights into the progress of the field and the prospects for better cancer diagnosis and therapy in the future.

Author : Pierre Hainaut,Magali Olivier,Klas G. Wiman
Publisher : Springer Science & Business Media
Page : 357 pages
File Size : 43,7 Mb
Release : 2012-08-30
Category : Medical
ISBN : 9781461436768

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p53 in the Clinics by Pierre Hainaut,Magali Olivier,Klas G. Wiman Pdf

This project follows on the success of the book "25 years of p53", published by Springer in 2006. Since this publication, there have been considerable advances on the potential application of p53 into the clinics. The goal of this book is to capture these developments and to appeal to a clinical and medical audience beyond the one which was the primary target of "25 years of p53".

Author : Wafik S. El-Deiry
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 48,8 Mb
Release : 2008-02-03
Category : Medical
ISBN : 9781592593286

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Tumor Suppressor Genes by Wafik S. El-Deiry Pdf

It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 40,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Marco Cordani,Dawid Walerych,Jerson L. Silva,Oleg Timofeev,Mara Cirone
Publisher : Frontiers Media SA
Page : 174 pages
File Size : 43,7 Mb
Release : 2021-10-22
Category : Medical
ISBN : 9782889715374

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Mutant p53 in Cancer Progression and Personalized Therapeutic Treatments by Marco Cordani,Dawid Walerych,Jerson L. Silva,Oleg Timofeev,Mara Cirone Pdf

Author : Arnold Jay Levine,David P. Lane
Publisher : Unknown
Page : 0 pages
File Size : 43,7 Mb
Release : 2010
Category : p53 antioncogene
ISBN : 0879698306

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The P53 Family by Arnold Jay Levine,David P. Lane Pdf

This volume offers a comprehensive review of the functions of the p53 family. The contributors examine the normal roles of these transcription factors, their evolution, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis.

Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 43,8 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9781597452229

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Gene Therapy for Cancer by Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher Pdf

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Author : David E. Fisher
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 50,6 Mb
Release : 2000-10-26
Category : Medical
ISBN : 9781592592302

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Tumor Suppressor Genes in Human Cancer by David E. Fisher Pdf

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

Author : Wafik S. El-Deiry
Publisher : Springer Science & Business Media
Page : 657 pages
File Size : 43,9 Mb
Release : 2008-02-03
Category : Medical
ISBN : 9781592593293

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Tumor Suppressor Genes by Wafik S. El-Deiry Pdf

It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.

Author : B.A. Ponder,M.J. Waring
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 40,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401106771

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The Genetics of Cancer by B.A. Ponder,M.J. Waring Pdf

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.