The Pathology Of The Endocrine Pancreas In Diabetes

Author : Pierre J. Lefebvre,Daniel G. Pipeleers
Publisher : Springer Science & Business Media
Page : 550 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642726910

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The Pathology of the Endocrine Pancreas in Diabetes by Pierre J. Lefebvre,Daniel G. Pipeleers Pdf

Diabetes mellitus represents one of the most frequent and serious clinical syn dromes in contemporary medicine. Since the end of the nineteenth century, the endocrine pancreas has been implicated in the pathogenesis of this disease. Several pathologists of the twentieth century detected various lesions and mor phologic alterations in the pancreatic islets of diabetic patients, but the patho physiologic basis of their findings remained long obscure. The systematic mi croscopic work of WILLY GEPTS clarified the views and related the variety in histopathology to differences in origin, duration and clinical expression of the disease. Over the past two decades, the concept of a multifactorial origin of diabetes has become widely accepted. Various agents and mechanisms have been identified which can lead to a quantitative or qualitative deficit in pancre atic B-cells. The purpose of this book is to bring an update on the many path ways which may induce an absolute or relative insufficiency in insulin release and hence a diabetic state. Rather than bringing a complete account on all re search relevant to the understanding of the pathology of the diabetic pancreas, the authors of the various chapters of this volume have focussed on selected processes which can impair B-cell function, survival or regeneration.

Author : Pierre J. Lefebvre,Daniel G. Pipeleers
Publisher : Springer
Page : 336 pages
File Size : 49,7 Mb
Release : 1988-04-29
Category : Medical
ISBN : 3540178368

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The Pathology of the Endocrine Pancreas in Diabetes by Pierre J. Lefebvre,Daniel G. Pipeleers Pdf

Diabetes mellitus represents one of the most frequent and serious clinical syn dromes in contemporary medicine. Since the end of the nineteenth century, the endocrine pancreas has been implicated in the pathogenesis of this disease. Several pathologists of the twentieth century detected various lesions and mor phologic alterations in the pancreatic islets of diabetic patients, but the patho physiologic basis of their findings remained long obscure. The systematic mi croscopic work of WILLY GEPTS clarified the views and related the variety in histopathology to differences in origin, duration and clinical expression of the disease. Over the past two decades, the concept of a multifactorial origin of diabetes has become widely accepted. Various agents and mechanisms have been identified which can lead to a quantitative or qualitative deficit in pancre atic B-cells. The purpose of this book is to bring an update on the many path ways which may induce an absolute or relative insufficiency in insulin release and hence a diabetic state. Rather than bringing a complete account on all re search relevant to the understanding of the pathology of the diabetic pancreas, the authors of the various chapters of this volume have focussed on selected processes which can impair B-cell function, survival or regeneration.

Author : David M. Klachko
Publisher : Springer Science & Business Media
Page : 209 pages
File Size : 55,8 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781468485080

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The Endocrine Pancreas and Juvenile Diabetes by David M. Klachko Pdf

Dr. Robert L. Jackson, Professor of Child Health at the Uni versity of Missouri-Columbia, decided to retire from clinical practice in 1977 and the Department of Child Health planned a con ference in his honor. The Thirteenth Annual MidweSt Conference on Endocrinology and Metabolism also was in the planning stages and scheduled for two days in the fall. It seemed appropriate to com bine the two into an expanded three-day conference. In view of Dr. Jackson's international reputation in the study and care of children with diabetes mellitus, the conference topic was not dif ficult to find. Experts in this field were delighted to be asked to speak at a conference in Dr. Jackson's honor. We selected a number of excellent speakers to survey the physiology and pathophy siology of pancreatic hormones and their effects in diabetes mel litus, to discuss current knowledge of the microvascular complica tions of the disease, and to put it all into the proper historical perspective of where we have been and where we are going. We think the conference achieved its objective to pay meaningful trib ute to a distinguished member of the scientific community. As with any conference, the conversion of the presentations and discussions to the printed page is a long and arduous process. Many manuscripts were completed well after the conference and references often are more recent than the date of the conference.

Author : W. Montague
Publisher : Springer Science & Business Media
Page : 168 pages
File Size : 48,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401163798

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Diabetes and the Endocrine Pancreas by W. Montague Pdf

This book attempts to explore the contribution that biochemistry has made, thus far, to our understanding of the endocrine pancreas and its relationship to diabetes mellitus. It was written with the aim of using an important clinical problem to illustrate, to medical students, that there are many aspects of the biochemistry taught in the early years which have direct relevance to clinical medicine. Furthermore, it is hoped that such information might provide biochemistry students with a frame work on which to base further studies. To this end a selection of recent references has been placed at the end of each chapter. In spite of considerable advances in our understanding of diabetes mellitus, it is still a disease which many physicians do not seem to com prehend. This is in part related to their lack of understanding of the molecular biology of the disease. Advances in this area have been dramatic in recent years and we are now able to offer a molecular basis for a rational approach to therapy. It may be therefore that this book will provide some physicians with the information they require to help them gain a deeper understanding of the disease. I hope that everyone who reads this book is able to capture some of the fascination that the islets of Langerhans hold for myself and the many other workers actively engaged in trying to unravel their mys teries.

Author : Bruno Volk
Publisher : Springer Science & Business Media
Page : 951 pages
File Size : 50,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468423259

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The Diabetic Pancreas by Bruno Volk Pdf

I consider it an honor to have been asked to write the Foreword for The Diabetic Pancreas. Although I have been involved in the study of the pancreas since 1921, my interest goes back even further to the time, in 1918, that my father's sister, a nurse who had trained at the Massachusetts General Hospit.al, devel oped diabetes, lost weight, and died in diabetic coma. This sad event made a deep impression on me and was certainly pardy responsible for my choosing to join the Department of Physiology of the University of Toronto to begin a career in research into diabetes. This is not the place to describe in detail the wide-ranging research and study of the diabetic pancreas in which I have engaged in the past 56 years. Suffice it to say that I am familiar enough with the subject area to be able to predict a great future for this book. The editors have undertaken a very ambitious and worthwhile project, and their efforts have been supported and strengthened by contributors who are respected authorities in their fields, thus ensuring a successful presentation of this major work.

Author : Ellis Samols
Publisher : Lippincott Williams & Wilkins
Page : 568 pages
File Size : 53,8 Mb
Release : 1991
Category : Diabetes
ISBN : UOM:39015019849929

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The Endocrine Pancreas by Ellis Samols Pdf

Author : E. Ghigo,M. Porta
Publisher : Karger Medical and Scientific Publishers
Page : 196 pages
File Size : 48,5 Mb
Release : 2014-04-10
Category : Medical
ISBN : 9783318025989

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Diabetes Secondary to Endocrine and Pancreatic Disorders by E. Ghigo,M. Porta Pdf

The 1997 classification of diabetes mellitus, now accepted worldwide, includes a large section of ‘Other specific types of diabetes’, a good part of which is made up of diabetes secondary to other endocrine or pancreatic disorders. However, a comprehensive overview on how these disorders may lead to diabetes, and how to diagnose and treat them, was not available so far. Filling this gap, this book includes detailed descriptions of glucose metabolism derangements in other endocrine and pancreatic disorders. Leading experts in their fields present an exhaustive overview of the most-updated evidence on the etiopathological mechanisms underlying the development of diabetes in patients with endocrine and pancreatic disorders, and the relevant diagnostic and therapeutic approaches. Because of its multidisciplinary approach, this book is of great interest to endocrinologists, diabetologists, general practitioners, internal medicine specialists and surgeons, and will remain a reference source for years to come.

Author : William. Montague
Publisher : Springer
Page : 158 pages
File Size : 48,9 Mb
Release : 2012-12-27
Category : Science
ISBN : 1461598788

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Diabetes and the Endocrine Pancreas by William. Montague Pdf

This book attempts to explore the contribution that biochemistry has made, thus far, to our understanding of the endocrine pancreas and its relationship to diabetes mellitus. It was written with the aim of using an important clinical problem to illustrate, to medical students, that there are many aspects of the biochemistry taught in the early years which have direct relevance to clinical medicine. Furthermore, it is hoped that such information might provide biochemistry students with a frame work on which to base further studies. To this end a selection of recent references has been placed at the end of each chapter. In spite of considerable advances in our understanding of diabetes mellitus, it is still a disease which many physicians do not seem to com prehend. This is in part related to their lack of understanding of the molecular biology of the disease. Advances in this area have been dramatic in recent years and we are now able to offer a molecular basis for a rational approach to therapy. It may be therefore that this book will provide some physicians with the information they require to help them gain a deeper understanding of the disease. I hope that everyone who reads this book is able to capture some of the fascination that the islets of Langerhans hold for myself and the many other workers actively engaged in trying to unravel their mys teries.

Author : John A. Lott
Publisher : Springer Science & Business Media
Page : 224 pages
File Size : 47,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461239642

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Clinical Pathology of Pancreatic Disorders by John A. Lott Pdf

The pancreas is about the size and shape of the hand; the tail points to the spleen, and the head is nestled in a loop of the duodenum. Loss of the exocrine (digestive) func tions commonly leads to severe gastrointestinal disturbances, malabsorption, a cata bolic state, and weight loss in the face of an adequate diet. Loss of endocrine pancreatic function leads to a large spectrum of disorders associated with the loss of hormone secretions; the most common and most severe is diabetes mellitus. Loss of the entire pancreas owing to trauma, surgery, atherosclerosis, or other medical problems leaves the patient in a digestive and metabolic crisis. The correct diagnosis of pancreatic disorders remains a challenge given the multi faceted function of the pancreas. The clinical laboratory plays an important role, and other tools such as CAT scans, ultrasound, radiographs, biopsies, and even surgery are used to make a diagnosis. The emphasis of Clinical Pathology of Pancreatic Disorders is on the clinical laboratory definition of pancreatic pathology. Disorders of the endocrine pancreas can be highly complex, and sophisticated tests are needed to determine the nature of the disease, its prognosis, and its optimal treat ment. Diabetes is the most common of the endocrine diseases; it presents in many ways, and has varied etiologies. We now know that the diabetes of childhood is usually an autoimmune disease, and this has a major effect on the treatment of these individuals.

Author : Giuseppe Orlando,Lorenzo Piemonti,Camillo Ricordi,Robert J. Stratta,Rainer W.G. Gruessner
Publisher : Academic Press
Page : 890 pages
File Size : 45,7 Mb
Release : 2019-11-09
Category : Science
ISBN : 9780128148341

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Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas by Giuseppe Orlando,Lorenzo Piemonti,Camillo Ricordi,Robert J. Stratta,Rainer W.G. Gruessner Pdf

Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 1, sets a new standard in transplant and regenerative medicine. The book details the-state-of-the-art in modern whole pancreas and islet transplantation, including donor selection, immunosuppression, complications, allograft pathology, and more. As regenerative medicine is changing the premise of solid organ transplantation, this volume catalogs the technologies being developed and the methods being implemented to bioengineer or regenerate the endocrine pancreas in order to more effectively treat diabetes. Edited and authored by unparalleled leaders in the field, this new volume argues for a much needed synergy between organ transplantation and regenerative medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Includes sections that address donor selection, immunosuppression, complications, allograft pathology, and more Offers an update on the progress of regenerative medicine research aimed at beta cells replacement in the treatment of diabetes

Author : Mark A. Sperling
Publisher : Unknown
Page : 0 pages
File Size : 44,9 Mb
Release : 2005
Category : Children
ISBN : 141602753X

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Diabetes Mellitus in Children by Mark A. Sperling Pdf

Author : Yogeshwar Dayal
Publisher : CRC Press
Page : 352 pages
File Size : 46,5 Mb
Release : 1991-03-14
Category : Medical
ISBN : 0849359937

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Endocrine Pathology of the Gut and Pancreas by Yogeshwar Dayal Pdf

This important new book presents critical information on the clinical and morphological aspects of various endocrinological disorders of the gut and pancreas. Topics include a historical perspective and broad overview of the neuroendocrine component of the gut; hyperplastic proliferations of gastrointestinal endocrine cells; pancreatic endocrine cells and their non-neoplastic proliferations; tumors and lesions; and endocrine differentiation in nonendocrine tumors. The book stresses clinical and pathological aspects of these topics, as well as the pathogenesis, clinicopathological correlations, and diagnostic approaches. Gastroenterologists, pathologists, internists, surgeons, endocrinologists and others interested in endocrinological disorders of the gut and pancreas will discover that this book will be a welcome addition to your reference library.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 53,7 Mb
Release : 2000
Category : Electronic
ISBN : OCLC:64148408

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Diabetes and the Endocrine Pancreas 2 by Anonim Pdf

Author : Joel F. Habener,Mehboob Hussain
Publisher : Springer Science & Business Media
Page : 413 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461516699

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Molecular Basis of Pancreas Development and Function by Joel F. Habener,Mehboob Hussain Pdf

Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide. In the USA alone, 15 million individuals are diabetic, nearly half of them unaware of their condition. Complications of diabetes mellitus are the leading causes for blindness, limb amputation and chronic renal failure and kidney transplantation in industrialized countries. Further, diabetes mellitus per se and the metabolic derangement associated with diabetes are important risk factors for cardiovascular disease. Diabetes, as defined by an elevated fasting blood glucose level is presently subdivided in etiologically distinct groups. The most prevalent being type 2 (adult onset) diabetes characterized by insulin resistance and failure of the ~-cell to supply insulin in amounts sufficient to meet the body's needs. Type 1 (juvenile) diabetes, most commonly with an onset during childhood and adolescence, is caused by an auto-immune destruction of the pancreatic ~-cells. The causations of both type 1 and type 2 diabetes involve a combination of complex genetic traits and environmental influences. A third category are the mature onset diabetes of the young (MODY). This comparatively small group of patients (-10% of diabetes) presents relative early in life «30 years of age) compared to the more common late onset type 2 diabetes.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 48,9 Mb
Release : 1977
Category : Electronic
ISBN : OCLC:164154200

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Endocrine Pancreas and diabetes by Anonim Pdf