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Author : Brian L. Shigekawa
Publisher : Unknown
Page : 294 pages
File Size : 53,8 Mb
Release : 1978
Category : Cell physiology
ISBN : UCR:31210002392411
Author : Anonim
Publisher : Unknown
Page : 860 pages
File Size : 55,5 Mb
Release : 1997
Category : Dissertations, Academic
ISBN : STANFORD:36105020028218
Author : Anonim
Publisher : Unknown
Page : 818 pages
File Size : 42,8 Mb
Release : 1984
Category : Dissertations, Academic
ISBN : UOM:39015065651625
Vols. for 1973- include the following subject areas: Biological sciences, Agriculture, Chemistry, Environmental sciences, Health sciences, Engineering, Mathematics and statistics, Earth sciences, Physics, Education, Psychology, Sociology, Anthropology, History, Law & political science, Business & economics, Geography & regional planning, Language & literature, Fine arts, Library & information science, Mass communications, Music, Philosophy and Religion.
Author : Anonim
Publisher : Unknown
Page : 574 pages
File Size : 50,8 Mb
Release : 1984
Category : Dissertation abstracts
ISBN : UOM:39015086908434
Author : University Microfilms International
Publisher : Ann Arbor, Mich. : University Microfilms International
Page : 712 pages
File Size : 45,9 Mb
Release : 1984
Category : Dissertations, Academic
ISBN : STANFORD:36105118942312
Author : Anonim
Publisher : Unknown
Page : 858 pages
File Size : 50,6 Mb
Release : 1984
Category : Dissertations, Academic
ISBN : STANFORD:36105118942296
Author : John J. Correia,Leslie Wilson
Publisher : Academic Press
Page : 472 pages
File Size : 55,6 Mb
Release : 2013-08-20
Category : Science
ISBN : 9780124078888
There continues to be intense interest in the microtubule cytoskeleton; the assembly, structure and regulation of microtubules; and the numerous motors and accessory proteins that control cell cycle, dynamics, organization and transport. The field continues to grow and explore new aspects of these issues driven immensely by developments in optical imaging and tracking techniques. This Second Edition brings together current research and protocols in the field of microtubules in vitro and will serve as a valuable tool for cell biologists, biophysicists and pharmacologists who study the microtubule cytoskeleton, as well as for researchers in the biomedical and biotechnology communities with interest in developing drugs that target microtubules, MAPS and motors. Chapters reflect experimental procedures and new developments in the field of microtubule in vitro research Combines classical approaches and modern technologies Presents easy-to-use protocols and thorough background information, compiled by leaders in the field
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 42,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Federation of American Societies for Experimental Biology
Publisher : Unknown
Page : 980 pages
File Size : 51,6 Mb
Release : 1979
Category : Biology
ISBN : UOM:39015010004102
Vols. for 1942- include proceedings of the American Physiological Society.
Author : Jesus Avila,Naruhiko Sahara
Publisher : Frontiers E-books
Page : 114 pages
File Size : 44,9 Mb
Release : 2014-08-18
Category : Medicine (General)
ISBN : 9782889192618
Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Author : Tobias Ntuli
Publisher : BoD – Books on Demand
Page : 448 pages
File Size : 46,9 Mb
Release : 2015-12-16
Category : Science
ISBN : 9789535122364
This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.
Author : Anonim
Publisher : Unknown
Page : 1224 pages
File Size : 52,5 Mb
Release : 2024-07-01
Category : Medicine
ISBN : STANFORD:36105119623606
Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Page : 1212 pages
File Size : 46,8 Mb
Release : 1975
Category : Medicine
ISBN : UOM:39015072175394
Author : John H. Byrne,Ruth Heidelberger,M. Neal Waxham
Publisher : Academic Press
Page : 692 pages
File Size : 40,6 Mb
Release : 2014-05-23
Category : Medical
ISBN : 9780123982674
An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches 80% updated and new content New Chapter on "Biophysics of Voltage-Gated Ion Channels" New Chapter on "Synaptic Plasticity" Includes a chapter on the Neurobiology of Disease Highly referenced, comprehensive and quantitative Full color, professional graphics throughout All graphics are available in electronic version for teaching purposes
Author : Jose C. Jimenez-Lopez
Publisher : BoD – Books on Demand
Page : 344 pages
File Size : 48,5 Mb
Release : 2017-05-17
Category : Science
ISBN : 9789535131694
The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.