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Author : Howard Rasmussen,Philippe Bordier
Publisher : Unknown
Page : 364 pages
File Size : 54,7 Mb
Release : 1975
Category : Electronic
ISBN : OCLC:804016077
Author : Borje Edgar Christopher Nordin,Howard Arthur Morris,Paul Anderson
Publisher : CRC Press
Page : 236 pages
File Size : 43,8 Mb
Release : 2014-05-19
Category : Medical
ISBN : 9781439899427
Research into metabolic bone disease has made remarkable progress over the last 20 years, with the identification of numerous new molecules and pathways regulating bone cells as well as their plasma milieu. Their activities are largely regulated by the physiological status of the body incorporating the biochemical, physical and mechanical functions of bone, kidney and intestinal tissues. The Physiological Basis of Metabolic Bone Disease integrates the knowledge derived from molecular techniques with the fundamental principles of the physiology of these organs. The book places particular emphasis on bone cell activities and the regulation of plasma calcium, phosphate homeostasis, and whole body nutrition. It reviews the nutritional requirements for calcium and vitamin D for the prevention of osteoporosis. It covers vitamin D, calcium and phosphate absorption; calcium sensing receptors; the role of parathyroid hormone; physiological actions of calcitonin; and the diagnosis and significance of osteoporosis. Reviewing the physiological significance of advances in the molecular biology of metabolic bone disease, this book provides a valuable reference for researchers as well as practicing clinicians.
Author : Börje Edgar Christopher Nordin
Publisher : Unknown
Page : 226 pages
File Size : 45,9 Mb
Release : 2014
Category : Bones
ISBN : 1306906105
"Physiology and medicine are interrelated disciplines, and this is perhaps nowhere more apparent than in the field of mineral metabolism. This book presents information on the physiological principles regulating the response of mineral homeostasis on genetic, molecular, environmental, and nutritional factors. Chapters cover calcium and vitamin D nutrition, intestinal calcium absorption, plasma calcium homeostasis, renal handling of calcium, calcium sensing receptors, plasma phosphate homeostasis, endocrine actions of vitamin D, parathyroid hormone, calcitonin, and the calcification process"--
Author : Juliet E. Compston,Jane B. Lian
Publisher : John Wiley & Sons
Page : 559 pages
File Size : 43,7 Mb
Release : 2009-12-22
Category : Science
ISBN : 9780470623985
EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.
Author : Louis V. Avioli,Stephen M. Krane
Publisher : Saunders
Page : 942 pages
File Size : 52,6 Mb
Release : 1990
Category : Medical
ISBN : 0721627668
Emphasizes a practical approach to the diagnosis and management of metabolic bone disorders. Covers biochemistry and physiology of bone cell function, calcitonin, pathophysiology of calcium absorptive disorders, bone biopsies, osteoporosis, diagnosis and management of bone tumors, metabolic bone disorders in children, and much more.
Author : United States Public Health Service,Surgeon General of the United States
Publisher : Unknown
Page : 0 pages
File Size : 45,9 Mb
Release : 2004-12
Category : Health & Fitness
ISBN : 1410219275
This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.
Author : Howard Rasmussen,Philippe Bordier
Publisher : Unknown
Page : 384 pages
File Size : 47,6 Mb
Release : 1974
Category : Bones
ISBN : UOM:39015003255430
Author : Alfredo Ulloa-Aguirre,Ya-Xiong Tao
Publisher : Academic Press
Page : 488 pages
File Size : 53,8 Mb
Release : 2021-02-02
Category : Science
ISBN : 9780128198025
Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field
Author : Shaul Massry
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 40,8 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781461342175
We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.
Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Publisher : Academic Press
Page : 878 pages
File Size : 53,5 Mb
Release : 2017-10-31
Category : Medical
ISBN : 9780128041987
Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Author : John P. Bilezikian,Lawrence G. Raisz,T. John Martin
Publisher : Academic Press
Page : 2074 pages
File Size : 55,7 Mb
Release : 2008-09-29
Category : Medical
ISBN : 9780080568751
Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition
Author : J. Allgrove,N.J. Shaw
Publisher : Karger Medical and Scientific Publishers
Page : 434 pages
File Size : 46,7 Mb
Release : 2015-06-11
Category : Medical
ISBN : 9783318054675
There has been a rapid expansion of knowledge in the field of paediatric calcium and bone disorders over the past twenty years. Advances have been made in the underlying genetic basis for many conditions in conjunction with progress in bone density and geometry imaging and the development of new treatment options. The 2nd revised edition of ‘Calcium and Bone Disorders in Children and Adolescents’ presents up-to-date information on many aspects included in the 1st edition such as the physiology, pathology, diagnosis and management of numerous conditions including a chapter of case histories illustrating clinical aspects. New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. Providing a comprehensive update, this book is a useful clinical resource for paediatricians and specialists in endocrinology, metabolic bone disease, nephrology, rheumatology, radiology, orthopaedics and clinical genetics who may be faced with a child with a calcium and/or bone disorder.
Author : Louis V. Avioli,Stephen M. Krane
Publisher : Academic Press
Page : 472 pages
File Size : 46,8 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483216317
Metabolic Bone Disease, Volume I covers the approach to a variety of disorders of mineral metabolism. The book discusses bone metabolism and calcium regulation; kidney function in calcium and phosphate metabolism; as well as the role of alkaline phosphatase in metabolic bone disorders. The text also describes the diagnostic value of bone biopsies; the etiology, clinical aspects, therapy, and the main syndromes of vitamin D deficiency, rickets, and osteomalacia; and the pathogenesis and therapy of osteoporosis. The pathogenesis and treatment of nephrolothiasis are also encompassed. Orthopedic doctors, physicians, endocrinologists, and people involved in the research of metabolic bone diseases will find the book invaluable.
Author : J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Publisher : Unknown
Page : 0 pages
File Size : 47,5 Mb
Release : 2013-04-25
Category : Electronic
ISBN : 1947172808
Author : Edward F. McCarthy,Frank J. Frassica
Publisher : Cambridge University Press
Page : 385 pages
File Size : 47,8 Mb
Release : 2014-11-20
Category : Medical
ISBN : 9781107041233
Fully updated new edition covering all aspects of bone and joint diseases in one easily readable volume. Color illustrations throughout.