The Role Of Chromenes In Drug Discovery And Development

Author : Ashutosh Kumar Dash,Deepak Kumar
Publisher : Bentham Science Publishers
Page : 302 pages
File Size : 41,9 Mb
Release : 2023-08-08
Category : Science
ISBN : 9789815124347

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The Role of Chromenes in Drug Discovery and Development by Ashutosh Kumar Dash,Deepak Kumar Pdf

Chromene is a naturally abundant heterocyclic compound found in alkaloids, tocopherols, terpenes and other compounds. Its derivatives can be used as a scaffold that exhibits pharmacological activity in the human body. Chromene drugs and related bioactive molecules are the prime focus of this reference. It presents 13 thoroughly researched chapters that comprehensively cover all aspects about the molecule. Starting with a detailed introduction to its role and importance in drug discovery, the book goes into the details of chromene structure, synthesis and pharmacology. Readers can gain knowledge of different commercial medicines based on chromene and its pharmacological activity against different diseases. The elaborate topics in the book will help researchers working on chromene based drugs. Key highlights of the book include: - Complete coverage of chromene’s role in nature and drug development with references to historical background and current developments - References to commercial and preclinical drugs and patents of interest - Explanation of chromene bioacivity in different diseases (antioxidant, antidiabetic, antinflammatory, antibacterial and antifungal activities, antitumour, immunomodulatory activity) - Explanation of chromene activity against SARS-Cov2

Author : Atta-ur-Rahman, Muhammad Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 212 pages
File Size : 42,8 Mb
Release : 2020-10-05
Category : Medical
ISBN : 9789811432866

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Anti-Angiogenesis Drug Discovery and Development: Volume 5 by Atta-ur-Rahman, Muhammad Iqbal Choudhary Pdf

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, and wound healing disorders. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians. The fifth volume brings together reviews on the following topics: - Targeted therapy for tumor vasculature - Anti-angiogenic therapy for breast and prostate cancers (including information updates on clinical trials) - Microbe-based and other novel antiangiogenesis therapies such as chromene-based agents

Author : Michael Kassiou
Publisher : Frontiers Media SA
Page : 290 pages
File Size : 43,6 Mb
Release : 2021-05-21
Category : Science
ISBN : 9782889667956

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Medicinal and Pharmaceutical Chemistry Editor’s Pick 2021 by Michael Kassiou Pdf

Author : Virginia Litwin,Philip Marder
Publisher : John Wiley & Sons
Page : 404 pages
File Size : 40,7 Mb
Release : 2011-04-20
Category : Medical
ISBN : 9780470922781

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Flow Cytometry in Drug Discovery and Development by Virginia Litwin,Philip Marder Pdf

This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.

Author : Anonim
Publisher : John Wiley & Sons
Page : 6057 pages
File Size : 46,5 Mb
Release : 2021-04-20
Category : Science
ISBN : 9781119530305

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Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set by Anonim Pdf

Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.

Author : Larry Yet
Publisher : John Wiley & Sons
Page : 560 pages
File Size : 45,7 Mb
Release : 2018-03-07
Category : Medical
ISBN : 9781118686355

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Privileged Structures in Drug Discovery by Larry Yet Pdf

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.

Author : Robert M. Rydzewski
Publisher : Elsevier
Page : 600 pages
File Size : 41,9 Mb
Release : 2010-07-07
Category : Medical
ISBN : 0080914888

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Real World Drug Discovery by Robert M. Rydzewski Pdf

Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher. Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.

Author : Maria Rosalia Pasca,Yossef Av-Gay,Giorgia Mori
Publisher : Frontiers Media SA
Page : 153 pages
File Size : 52,8 Mb
Release : 2021-06-09
Category : Science
ISBN : 9782889668694

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New Approaches Against Drug-Resistant M. tuberculosis by Maria Rosalia Pasca,Yossef Av-Gay,Giorgia Mori Pdf

Author : Valdir Cechinel-Filho
Publisher : John Wiley & Sons
Page : 600 pages
File Size : 40,6 Mb
Release : 2012-05-22
Category : Science
ISBN : 9780470582268

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Plant Bioactives and Drug Discovery by Valdir Cechinel-Filho Pdf

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Author : Celestino Santos-Buelga,Gary Williamson
Publisher : Unknown
Page : 406 pages
File Size : 47,6 Mb
Release : 2003
Category : Science
ISBN : STANFORD:36105026557434

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Methods in Polyphenol Analysis by Celestino Santos-Buelga,Gary Williamson Pdf

Polyphenols make a vital contribution to the colour, tanning, taste and astringency of so many of society's favourites - from the unique taste of the British cup of tea to a glass of red wine. Found widely in many foods of plant origin, polyphenols are also becoming increasingly recognised as antioxidants in the body, with action on long-term health and reduction in the risk of chronic disease. Due to the importance of polyphenols, it is vital to conduct accurate and sensitive analysis. Providing detailed state-of-the-art research, presented in a practical and effective way, Methods in Polyphenol Analysis looks at the latest techniques in this developing field and includes, among others: New modern techniques, such as LC-MS, LC-NMR and LC-coulometric detection; Chemical and enzymatic synthesis of polyphenol conjugates; and Characterization of oligomeric and polymeric tannins and complex polyphenols. This timely publication is written by highly experienced practitioners in this field and will be invaluable to all academics and industrialists involved in phytochemistry, biochemistry and food science.

Author : Hugo Kubinyi,Gerd Folkers,Yvonne C. Martin
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 43,6 Mb
Release : 2006-04-11
Category : Science
ISBN : 9780306468575

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3D QSAR in Drug Design by Hugo Kubinyi,Gerd Folkers,Yvonne C. Martin Pdf

Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication by Richard Cramer in 1988 and the first volume in the series. 3D QSAR in Drug Design. Theory, Methods and Applications, published in 1993. The aim of that early book was to contribute to the understanding and the further application of CoMFA and related approaches and to facilitate the appropriate use of these methods. Since then, hundreds of papers have appeared using the quickly developing techniques of both 3D QSAR and computational sciences to study a broad variety of biological problems. Again the editor(s) felt that the time had come to solicit reviews on published and new viewpoints to document the state of the art of 3D QSAR in its broadest definition and to provide visions of where new techniques will emerge or new appli- tions may be found. The intention is not only to highlight new ideas but also to show the shortcomings, inaccuracies, and abuses of the methods. We hope this book will enable others to separate trivial from visionary approaches and me-too methodology from in- vative techniques. These concerns guided our choice of contributors. To our delight, our call for papers elicited a great many manuscripts.

Author : Vijai Singh,Ajay Kumar
Publisher : Springer Nature
Page : 446 pages
File Size : 55,8 Mb
Release : 2021-07-31
Category : Science
ISBN : 9789813361911

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Advances in Bioinformatics by Vijai Singh,Ajay Kumar Pdf

This book presents the latest developments in bioinformatics, highlighting the importance of bioinformatics in genomics, transcriptomics, metabolism and cheminformatics analysis, as well as in drug discovery and development. It covers tools, data mining and analysis, protein analysis, computational vaccine, and drug design. Covering cheminformatics, computational evolutionary biology and the role of next-generation sequencing and neural network analysis, it also discusses the use of bioinformatics tools in the development of precision medicine. This book offers a valuable source of information for not only beginners in bioinformatics, but also for students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of bioinformatics in many areas.

Author : Valdir Cechinel Filho
Publisher : Springer
Page : 531 pages
File Size : 48,9 Mb
Release : 2018-12-07
Category : Science
ISBN : 9783030005450

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Natural Products as Source of Molecules with Therapeutic Potential by Valdir Cechinel Filho Pdf

This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.

Author : Mallappa Kumara Swamy
Publisher : Springer Nature
Page : 592 pages
File Size : 52,6 Mb
Release : 2020-06-27
Category : Science
ISBN : 9789811523618

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Plant-derived Bioactives by Mallappa Kumara Swamy Pdf

Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, “Plant-derived Bioactives: Chemistry and Mode of Action” discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, “Plant-derived Bioactives: Production, Properties and Therapeutic Applications” explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of new drugs.

Author : Ahindra Nag
Publisher : CRC Press
Page : 370 pages
File Size : 45,7 Mb
Release : 2022-05-30
Category : Science
ISBN : 9781000545104

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Greener Synthesis of Organic Compounds by Ahindra Nag Pdf

This book provides an interdisciplinary, integrative overview of environmental problem-solving using mild reaction conditions, green reagents, waste free and energy efficient synthesis in both industry and academic world. Discussions include a broad, integrated perspective on sustainability, integrated risk, multi-scale changes and impacts taking place within ecosystems worldwide. Features: This book serves as a reference book for scientific investigators who need to do greener synthesis of organic compounds, drugs and natural products under mild reaction condition using green reagents, eco-friendly catalysts and benign reaction mediums over traditional synthetic processes which is a key driving force of scientists. Greener synthesis of multiple value-added heterocycles opens up a new horizon towards the organic catalysis and for this purpose, development of natural resources acts as an effective catalyst. Using environmentally friendly reaction medium e.g. ACC, WETSA, WEBSA have been used for the synthesis of some crucial heterocyclic scaffolds such as bisenols and 2-amino-4H-pyrans, tetraketones, pyrans, and biaryls. This book can also be used as a textbook for graduate and post graduate level courses for students. Furthermore, the problems with answers in book will add better understanding for students.