Plant Bioactives And Drug Discovery

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Plant Bioactives and Drug Discovery

Valdir Cechinel-Filho
Plant Bioactives and Drug Discovery Book PDF

Author : Valdir Cechinel-Filho
Publisher : John Wiley & Sons
Page : 600 pages
File Size : 51,5 Mb
Release : 2012-04-11
Category : Science
ISBN : 9781118259924

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Plant Bioactives and Drug Discovery by Valdir Cechinel-Filho Pdf

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Plant Bioactives and Drug Discovery

Valdir Cechinel-Filho
Plant Bioactives and Drug Discovery Book PDF

Author : Valdir Cechinel-Filho
Publisher : John Wiley & Sons
Page : 600 pages
File Size : 40,8 Mb
Release : 2012-05-22
Category : Science
ISBN : 9780470582268

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Plant Bioactives and Drug Discovery by Valdir Cechinel-Filho Pdf

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Bioactive Natural products in Drug Discovery

Joginder Singh,Vineet Meshram,Mahiti Gupta
Bioactive Natural products in Drug Discovery Book PDF

Author : Joginder Singh,Vineet Meshram,Mahiti Gupta
Publisher : Springer Nature
Page : 733 pages
File Size : 40,5 Mb
Release : 2020-04-30
Category : Medical
ISBN : 9789811513947

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Bioactive Natural products in Drug Discovery by Joginder Singh,Vineet Meshram,Mahiti Gupta Pdf

This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.

Bioactive Phytochemicals: Drug Discovery to Product Development

Javed Ahmad,Javed Ahamad
Bioactive Phytochemicals Drug Discovery to Product Development Book PDF

Author : Javed Ahmad,Javed Ahamad
Publisher : Bentham Science Publishers
Page : 238 pages
File Size : 47,8 Mb
Release : 2020-10-28
Category : Medical
ISBN : 9789811464461

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Bioactive Phytochemicals: Drug Discovery to Product Development by Javed Ahmad,Javed Ahamad Pdf

Natural bioactive compounds from medicinal plants are inexplicably diverse in chemical structure and biological properties. The unmet therapeutic requirements for various diseases serve as a guide for researchers to study natural compounds. These studies are intended to isolate, identify the structural characterization and eventually discover the pharmacological activity of natural compounds from their plant sources with the goal of treating specific diseases. Bioactive Phytochemicals: Drug Discovery to Product Development explores the scope and approaches of drug discovery from natural products. Chapters in the book cover information about the cultivation, collection and processing of medicinal plants, the methods and high throughput techniques for isolation and characterization of bioactive phytochemicals and pharmacological screening for activity, formulation and quality control. Information about the regulations specified for natural medicinal products in different region of the world is also presented, followed by a concluding chapter devoted to the role of natural herbal products for treatment of human diseases such as cancer, cardiovascular diseases, diabetes, obesity, inflammation and neurological disorders. Each chapter concludes with a general reference section, which is a bibliographic guide to more advanced texts. The contributing authors for this volume are drawn from a rich blend of experts in various areas of herbal medicine which encompass herbal drug discovery to product development. The concise and organized layout along with a broad coverage of phytochemistry and drug discovery makes this book a suitable reference for students of medicinal chemistry, researchers and industry professionals interested in herbal product development.

Phytochemicals as Lead Compounds for New Drug Discovery

Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal
Phytochemicals as Lead Compounds for New Drug Discovery Book PDF

Author : Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal
Publisher : Elsevier
Page : 382 pages
File Size : 54,5 Mb
Release : 2019-09-07
Category : Science
ISBN : 9780128178911

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Phytochemicals as Lead Compounds for New Drug Discovery by Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal Pdf

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Bioactive Molecules and Medicinal Plants

Kishan Gopal Ramawat,Jean-Michel Mérillon
Bioactive Molecules and Medicinal Plants Book PDF

Author : Kishan Gopal Ramawat,Jean-Michel Mérillon
Publisher : Springer Science & Business Media
Page : 379 pages
File Size : 54,9 Mb
Release : 2008-10-16
Category : Science
ISBN : 9783540746034

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Bioactive Molecules and Medicinal Plants by Kishan Gopal Ramawat,Jean-Michel Mérillon Pdf

This book on medicinal plant biotechnology covers recent developments in this field. It includes a comprehensive up-to-date survey on established medicinal plants and on molecules which gained importance in recent years. No recently published book has covered these carefully selected topics. The contributing scientists have been selected on the basis of their involvement in the related plant material as evident by their internationally recognised published work.

Natural Bio-active Compounds

Mallappa Kumara Swamy,Mohd Sayeed Akhtar
Natural Bio active Compounds Book PDF

Author : Mallappa Kumara Swamy,Mohd Sayeed Akhtar
Publisher : Springer Nature
Page : 492 pages
File Size : 55,6 Mb
Release : 2019-09-19
Category : Science
ISBN : 9789811372056

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Natural Bio-active Compounds by Mallappa Kumara Swamy,Mohd Sayeed Akhtar Pdf

Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.

Plant Bioactives as Natural Panacea against Age-Induced Diseases

Kanti Bhooshan Pandey,Maitree Suttajit
Plant Bioactives as Natural Panacea against Age Induced Diseases Book PDF

Author : Kanti Bhooshan Pandey,Maitree Suttajit
Publisher : Elsevier
Page : 500 pages
File Size : 52,7 Mb
Release : 2022-10-17
Category : Science
ISBN : 9780323913294

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Plant Bioactives as Natural Panacea against Age-Induced Diseases by Kanti Bhooshan Pandey,Maitree Suttajit Pdf

Plant Bioactives as Natural Panacea Against Age-induced Diseases: Nutraceuticals and Functional Lead Compounds for Drug Development presents comprehensive information on the complications of aging and the bioactive phytochemicals that in specific herbal formulations, including beverages, can mitigate them. The book extensively describes the current information on the role of plant bioactive components in delaying or preventing the aging process and associated complications, while also covering different strategies and scientific evidence of possible synergistic effects of these studies, enabling the formulation of more effective natural drugs to intervene in aging and associated events. Chapters cover the broad areas of plant bioactive compounds in promoting healthy aging and longevity, including balancing glucose homeostasis, in cognitive impairments, age-related diseases, food trends and the anti-aging diet in Asia and other regions, as well as the social and economic impact of dietary patterns in aging interventions. Written by a team of global experts. Describes plant bioactives for specific age disorders Focuses on the discovery of new herbal origin drugs and potential druggable targets for the treatment of chronic diseases of world importance Includes cutting-edge research information on cell senescence during aging and assesses the plant bioactive compounds

Water Extraction of Bioactive Compounds

Herminia Dominguez,Maria Jesus Gonzalez Munoz
Water Extraction of Bioactive Compounds Book PDF

Author : Herminia Dominguez,Maria Jesus Gonzalez Munoz
Publisher : Elsevier
Page : 530 pages
File Size : 53,5 Mb
Release : 2017-09-20
Category : Science
ISBN : 9780128096154

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Water Extraction of Bioactive Compounds by Herminia Dominguez,Maria Jesus Gonzalez Munoz Pdf

Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources. The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers, adding greater fuel to a simultaneous search for efficient, green technologies to support this. Particularly promising are aqueous based methods, as water is a cheap, safe and abundant solvent. The book is a detailed guide to the fundamental concepts and necessary equipment needed to successfully undertake such processes, supported by application examples and highlighting the most influential variables. Part 1 begins with a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals, the need for standardization and a move toward more rational and greener techniques in the field, the development of plant-based extraction processes and pretreatments for the efficient extraction. Part 2 then reviews a broad range of available techniques, including sections on conventional hot water extraction and pressurized hot water extraction in a range of settings. Intensified processes are then discussed in detail, including sections on microwave-assisted processes, ultrasound-assisted processes and enzyme assisted extraction. Covers the theoretical background and range of techniques available to researchers, helping them to select the most appropriate extraction method for their needs Presents up-to-date and cutting edge applications by international experts Highlights current use and future potential for industrial scale applications Offers a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals

Botanical Leads for Drug Discovery

Bikarma Singh
Botanical Leads for Drug Discovery Book PDF

Author : Bikarma Singh
Publisher : Springer Nature
Page : 481 pages
File Size : 49,7 Mb
Release : 2020-10-05
Category : Medical
ISBN : 9789811559174

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Botanical Leads for Drug Discovery by Bikarma Singh Pdf

Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.

Bioactive Natural Products

Goutam Brahmachari
Bioactive Natural Products Book PDF

Author : Goutam Brahmachari
Publisher : World Scientific
Page : 695 pages
File Size : 54,5 Mb
Release : 2012
Category : Science
ISBN : 9789814335379

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Bioactive Natural Products by Goutam Brahmachari Pdf

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Plant-derived Bioactives

Mallappa Kumara Swamy
Plant derived Bioactives Book PDF

Author : Mallappa Kumara Swamy
Publisher : Springer Nature
Page : 592 pages
File Size : 44,5 Mb
Release : 2020-06-27
Category : Science
ISBN : 9789811523618

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Plant-derived Bioactives by Mallappa Kumara Swamy Pdf

Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, “Plant-derived Bioactives: Chemistry and Mode of Action” discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, “Plant-derived Bioactives: Production, Properties and Therapeutic Applications” explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of new drugs.

Natural Bio-active Compounds

Mohd Sayeed Akhtar,Mallappa Kumara Swamy,Uma Rani Sinniah
Natural Bio active Compounds Book PDF

Author : Mohd Sayeed Akhtar,Mallappa Kumara Swamy,Uma Rani Sinniah
Publisher : Springer Nature
Page : 608 pages
File Size : 42,5 Mb
Release : 2019-09-06
Category : Science
ISBN : 9789811371547

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Natural Bio-active Compounds by Mohd Sayeed Akhtar,Mallappa Kumara Swamy,Uma Rani Sinniah Pdf

Bioactive compounds produced by natural sources, such as plants, microbes, endophytic fungi, etc., can potentially be applied in various fields, including agriculture, biotechnology and biomedicine. Several bioactive compounds have proved to be invaluable in mediating plant-microbe interactions, and promoting plant growth and development. Due to their numerous health-promoting properties, these compounds have been widely used as a source of medication since ancient times. However, there is an unprecedented need to meet the growing demand for natural bioactive compounds in the flavor and fragrance, food, and pharmaceutical industries. Moreover, discovering new lead molecules from natural sources is essential to overcoming the rising number of new diseases. In this regard, natural bioactive compounds hold tremendous potential for new drug discovery. Therefore, this field of research has become a vital area for researchers interested in understanding the chemistry, biosynthetic mechanisms, and pharmacological activities of these bioactive metabolites. This book describes the basics of bioactive plant compounds, their chemical properties, and their pharmacological biotechnological properties with regard to various human diseases and applications in the drug, cosmetics and herbal industries. It offers a valuable asset for all students, educators, researchers, and healthcare experts involved in agronomy, ecology, crop science, molecular biology, stress physiology, and natural products.

Biologically Active Natural Products

Stephen J. Cutler,Horace G. Cutler
Biologically Active Natural Products Book PDF

Author : Stephen J. Cutler,Horace G. Cutler
Publisher : CRC Press
Page : 296 pages
File Size : 43,7 Mb
Release : 1999-07-27
Category : Medical
ISBN : 9781420048650

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Biologically Active Natural Products by Stephen J. Cutler,Horace G. Cutler Pdf

Biologically Active Natural Products: Pharmaceuticals demonstrates the connections between agrochemicals and pharmaceuticals and explores the use of plants and plant products in the formulation and development of pharmaceuticals. Experts from around the world examine a multitude of topics, including evaluation of extracts from tropical plants for p

Bioactive Natural Products in Drug Discovery

Anonim
Bioactive Natural Products in Drug Discovery Book PDF

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 55,5 Mb
Release : 2020
Category : Drug development
ISBN : 9811513953

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Bioactive Natural Products in Drug Discovery by Anonim Pdf

This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the books closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the books goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.