The Role Of Non Coding Rnas In Gastrointestinal Cancers

Author : Kanjoormana Aryan Manu,Divya P. Kumar,Muzafar Ahmad Macha
Publisher : Frontiers Media SA
Page : 223 pages
File Size : 50,5 Mb
Release : 2024-03-08
Category : Medical
ISBN : 9782832546147

Get Book

The Role of non-coding RNAs in Gastrointestinal Cancers by Kanjoormana Aryan Manu,Divya P. Kumar,Muzafar Ahmad Macha Pdf

Gastrointestinal malignancies encompass a large number of tumor types, and collectively are responsible for a significant portion of new cancer cases annually. According to the IARC database, colorectal cancer alone is responsible for approximately 10% of new cases of cancer worldwide annually. There is significant heterogeneity across the various tumor types, with different pathways and factors involved in oncogenesis, as well as varying degrees of prognosis depending on the tumor type. Non-coding RNAs (ncRNAs) contribute to a significant portion of the human transcriptome, and of particular interest are the micro-RNAs (miRNAs), long ncRNAs (lncRNAs), and circular ncRNAs (circRNAs). With the advent of next-generation sequencing and new technologies such a minimally invasive biopsy techniques, there is a growing body of evidence elucidating the role of ncRNAs in the progression of various form of gastrointestinal cancers. Furthermore, in addition to their relevance to cancer progression, these ncRNAs have important potential as biomarkers and prognostic markers for various GI cancers.

Author : Peixin Dong,Junming Yue,Feng Wang,Lei Chang
Publisher : Frontiers Media SA
Page : 288 pages
File Size : 52,6 Mb
Release : 2022-07-13
Category : Science
ISBN : 9782889762750

Get Book

Non-coding RNAs in Gastrointestinal and Gynecological Cancers: New Insights Into the Mechanisms of Cancer Therapeutic Resistance by Peixin Dong,Junming Yue,Feng Wang,Lei Chang Pdf

Author : Petra Faltejskova,Ondrej Slaby
Publisher : LAP Lambert Academic Publishing
Page : 104 pages
File Size : 49,5 Mb
Release : 2012-07
Category : Electronic
ISBN : 3659189715

Get Book

Non-Coding Rnas in Gastrointestinal Cancer by Petra Faltejskova,Ondrej Slaby Pdf

Digestive tumours are the most frequent malignant tumours in the world and the leading cause of a cancer-related death. They are tough to treat once they have formed and many are not found until they have already spread to other parts of the body. Therefore, new biomarkers enabling early diagnosis of asymptomatic disease, accurate differentiation among particular clinical stages and individualization of therapy are sorely needed. With improved methods to explore the transcriptome, different types of non-coding RNAs have been identified. It was proved that these molecules are highly deregulated in cancer tissue and involved in important molecular and biological processes such as differentiation, proliferation, apoptosis, migration or cell cycle. Moreover, detailed analyses revealed that they could serve as new molecular markers useful for cancer classification, prognostic stratification, and drug response prediction. Non-coding RNAs in Gastrointestinal Cancer offers a comprehensive collection of current information about the role of non-coding RNAs in gastrointestinal cancer pathogenesis and illustrates, how this knowledge may be useful in medical practice.

Author : Muller Fabbri
Publisher : Springer Science & Business Media
Page : 287 pages
File Size : 47,5 Mb
Release : 2013-10-28
Category : Medical
ISBN : 9781461484448

Get Book

Non-coding RNAs and Cancer by Muller Fabbri Pdf

The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.

Author : Ondrej Slaby,George A. Calin
Publisher : Springer
Page : 252 pages
File Size : 43,5 Mb
Release : 2016-08-29
Category : Medical
ISBN : 9783319420592

Get Book

Non-coding RNAs in Colorectal Cancer by Ondrej Slaby,George A. Calin Pdf

This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.

Author : Lütfi Tutar,Sumer Aras,Esen Tutar
Publisher : BoD – Books on Demand
Page : 150 pages
File Size : 47,7 Mb
Release : 2020-03-04
Category : Medical
ISBN : 9781789856552

Get Book

Non-Coding RNAs by Lütfi Tutar,Sumer Aras,Esen Tutar Pdf

Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.

Author : Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu
Publisher : Springer Nature
Page : 238 pages
File Size : 52,5 Mb
Release : 2020-07-21
Category : Medical
ISBN : 9789811544316

Get Book

Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers by Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu Pdf

This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Author : Giovanni Blandino,Hernandes F. Carvalho,Jawed A. Siddiqui,Valeria Poli
Publisher : Frontiers Media SA
Page : 256 pages
File Size : 45,7 Mb
Release : 2023-01-05
Category : Medical
ISBN : 9782832510667

Get Book

Roles Of Non-coding RNAs In Tumor Growth And Development by Giovanni Blandino,Hernandes F. Carvalho,Jawed A. Siddiqui,Valeria Poli Pdf

Author : Hui Ling,George A. Calin
Publisher : Elsevier Inc. Chapters
Page : 510 pages
File Size : 49,8 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9780128061220

Get Book

Cancer Genomics by Hui Ling,George A. Calin Pdf

The discovery of microRNA (miRNA) involvement in cancer a decade ago, and the more recent findings of long non-coding RNAs in human diseases, challenged the long-standing view that RNAs without protein-coding potential are simply “junk” transcription within the human genome. These findings evidently changed the dogma that “DNA makes RNA makes protein” by showing that RNAs themselves can be essential regulators of cellular function and play key roles in cancer development. MiRNAs are evolutionarily conserved short single-stranded transcripts of 19–24 nucleotides in length. They do not code for proteins, but change the final output of protein-coding genes by regulating their transcriptional and/or translation process. Ultraconserved genes (UCGs) are non-coding RNAs with longer length (>200bp) that are transcribed from the ultraconserved genomic region. Both miRNAs and UCGs are located within cancer-associated genomic regions (CAGRs) and can act as tumor suppressors or oncogenes. In this chapter, we present principles and concepts that have been identified over the last decade with respect to our understanding of the function of non-coding RNAs, and summarize recent findings on the role of miRNAs and UCGs in cancer development. Finally, we will conclude by discussing the translational potential of this knowledge into clinical settings such as cancer diagnosis, prognosis and treatment.

Author : Yujing Li,Ge Shan,Zhao-Qian Teng,Thomas S. Wingo
Publisher : Frontiers Media SA
Page : 346 pages
File Size : 42,6 Mb
Release : 2020-07-08
Category : Electronic
ISBN : 9782889638321

Get Book

Non-Coding RNAs and Human Diseases by Yujing Li,Ge Shan,Zhao-Qian Teng,Thomas S. Wingo Pdf

Author : Subash Gupta,Kishore Challagundla
Publisher : Academic Press
Page : 479 pages
File Size : 45,6 Mb
Release : 2022-01-19
Category : Science
ISBN : 9780128245514

Get Book

Clinical Applications of Noncoding RNAs in Cancer by Subash Gupta,Kishore Challagundla Pdf

Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. Presents a beginning chapter summary to help readers understand the content thoroughly Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy Discusses one cancer type per chapter making the content easy to reference

Author : Zsolt Kovacs,Simona Gurzu,Raluca Ioana Stefan-van Staden,Cornelia Braicu
Publisher : Frontiers Media SA
Page : 682 pages
File Size : 43,9 Mb
Release : 2023-06-05
Category : Medical
ISBN : 9782832526378

Get Book

Advanced Molecular Targets in the Diagnosis and Treatment of Gastrointestinal Cancers by Zsolt Kovacs,Simona Gurzu,Raluca Ioana Stefan-van Staden,Cornelia Braicu Pdf

Gastrointestinal cancers are among the most common cancer types, based on the Cancer Genome Atlas. GI cancers are within the most frequent malignancy, with almost 150.000 new cases in 2020. On one hand a big number of researches are focused on the diagnosis, new diagnostic approaches in upper and lower gastrointestinal tract cancers. On the other hand in the last 10 years several papers had been published about the possible therapeutic targets, pointing to precision and personalized medicine.

Author : Erwei Song
Publisher : Springer
Page : 458 pages
File Size : 46,5 Mb
Release : 2016-07-04
Category : Medical
ISBN : 9789811014987

Get Book

The Long and Short Non-coding RNAs in Cancer Biology by Erwei Song Pdf

The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.

Author : Jayprokas Chakrabarti,Sanga Mitra
Publisher : Academic Press
Page : 576 pages
File Size : 47,5 Mb
Release : 2017-10-13
Category : Medical
ISBN : 9780128134375

Get Book

Cancer and Noncoding RNAs by Jayprokas Chakrabarti,Sanga Mitra Pdf

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field

Author : Aamir Ahmad,Palmiro Poltronieri,Shahab Uddin
Publisher : Frontiers Media SA
Page : 445 pages
File Size : 45,7 Mb
Release : 2023-10-30
Category : Medical
ISBN : 9782832526125

Get Book

lncRNAs in Cancer Metastasis and Therapy Resistance by Aamir Ahmad,Palmiro Poltronieri,Shahab Uddin Pdf

lncRNAs (long non-coding RNAs) are the relatively longer (more than 200 nucleotides long) subtypes of ncRNAs (non-coding RNAs) i.e the RNAs that do not code for any proteins. However, even without themselves being translated, lncRNAs impact the cellular gene expressions and functions in ways that are just beginning to be explored. The metastasis of human cancers as well as acquired resistance against the administered therapeutics are two major factors responsible for the cancer-associated mortality.