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The Selected Papers of Denis Noble CBE FRS by Denis Noble Pdf
This is a scientific and philosophical autobiography written around a collection of Denis Noble's most significant papers. It traces a remarkable journey from na ve reductionism to a rigorous systems approach to living systems. It is rigorous because Denis Noble was one of the first biologists to construct computer models of cells and organs of the body. His theoretical work is entirely mathematically based, with no room for ambiguity. Far from the denigration of the systems approach as holistic 'hand-waving', his work is now regarded by pharmaceutical companies and regulators as the gold standard of modelling in the development of new medication. Systems Biology is an idea in search of a definition. This book explains why this is true: it is an approach rather than a subject. Denis Noble's work is one of the clearest examples of the systems approach in practice since it reveals the nature of some of the forms of downward causation in multilevel analysis. The story will delight readers who like to see how scientific controversy is resolved, since many of the developments described in each chapter were highly controversial when they occurred.
"This book describes the revolutionary efforts underway to build virtual humans - from cells and organs to whole bodies and populations. Virtual human technology has extraordinary potential, but also poses enormous computational challenges. Digital doppelgängers of patients will be able to usher in an era of truly personalized medicine, in which virtual drug trials can be conducted on thousands of digital twins, and "health-casts" can give you an idea of what a change in diet and lifestyle would really mean for you. Your "virtual you" will change your healthcare and potentially extend your lifespan (while also raising philosophical and ethical questions). However, numerous challenges and problems need to be solved to build such virtual versions of humans and to make truly personalized and predictive medicine possible. These challenges largely reside in the domains of the computer and physical sciences, and they are the real focus of this book. Building a "virtual you" touches on a wide range of deep scientific issues: how detailed the models need to be; what is currently possible to model; the problems inherent to simulating chaos and complexity; how to stitch together different kinds of mathematical models; the need for the realization of new forms of computing, such as quantum computation; and how all this relates to the limits of what we can simulate digitally and the future of computer modeling. The book ends on a provocative note, claiming that although we will be able to go far with next generation exascale and quantum computers, we will need to return to the technology of analog machines in order to simulate the complexity of the human body and perhaps harness the properties of special metamaterials to solve equations by manipulating beams of light"--
Animal Locomotion by Malcolm S. Gordon,Reinhard Blickhan,John O. Dabiri,John J. Videler Pdf
Animal Locomotion: Physical Principles and Adaptations is a professional-level, state of the art review and reference summarizing the current understanding of macroscopic metazoan animal movement. The comparative biophysics, biomechanics and bioengineering of swimming, flying and terrestrial locomotion are placed in contemporary frameworks of biodiversity, evolutionary process, and modern research methods, including mathematical analysis. The intended primary audience is advanced-level students and researchers primarily interested in and trained in mathematics, physical sciences and engineering. Although not encyclopedic in its coverage, anyone interested in organismal biology, functional morphology, organ systems and ecological physiology, physiological ecology, molecular biology, molecular genetics and systems biology should find this book useful.
Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information
What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life.
The Language of Symmetry by Benedict Rattigan,Denis Noble,Afiq Hatta Pdf
The Language of Symmetry is a re-assessment of the structure and reach of symmetry, by an interdisciplinary group of specialists from the arts, humanities, and sciences at Oxford University. It explores, amongst other topics: order and chaos in the formation of planetary systems entropy and symmetry in physics group theory, fractals, and self-similarity symmetrical structures in western classical music how biological systems harness disorder to create order This book aims to open up the scope of interdisciplinary work in the study of symmetry and is intended for scholars of any background - whether it be science, arts, or philosophy.
Exosomes by Larry Edelstein,John R. Smythies,Peter J. Quesenberry,Denis Noble Pdf
Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference source for clinicians, physicians, and research scientists who wish to gain insight into the most recent advances in this rapidly growing field. The exosome revolution may well be the greatest advance in physiology and medicine since antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a major breakthrough in our understanding of how cells function. Provides readers with a broad and timely overview of exosomes in health and disease, closing with a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. Summarizes the most recent laboratory and clinical findings on exosomes across numerous medical disciplines, thereby offering readers a broad-ranging and solid foundation for prospective investigative efforts Twenty-one chapters authored by a global team of peer-acknowledged experts, each representing a key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing
"In this accessible and engaging introduction, [John Lennox] guides us through the great debates about science and faith, and offers incisive assessments of the issues." Alister McGrath, Professor of Science and Religion, University of Oxford Is the rigorous pursuit of scientific knowledge really compatible with a sincere faith in God? Building on the arguments put forward in God’s Undertaker: Has Science Buried God?, Prof John Lennox examines afresh the plausibility of a Christian theistic worldview in the light of some of the latest developments in scientific understanding. Prof Lennox focuses on the areas of evolutionary theory, the origins of life and the universe, and the concepts of mind and consciousness to provide a detailed and compelling introduction to the science and religion debate. He also offers his own reasoning as to why he continues to be convinced by a Christian approach to explaining these phenomena. Robust in its reasoning, but respectful in tone, this book is vital reading for anyone exploring the relationship between science and God.
James A. Shapiro proposes an important new paradigm for understanding biological evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular evidence that tests the conventional scientific view of evolution based on the neo-Darwinian synthesis, shows why this view is inadequate to today's evidence, and presents a compelling alternative view of the evolutionary process that reflects the shift in life sciences towards a more information- and systems-based approach in Evolution: A View from the 21st Century. Shapiro integrates advances in symbiogenesis, epigenetics, and saltationism into a unified approach that views evolutionary change as an active cell process, regulated epigenetically and capable of making rapid large changes by horizontal DNA transfer, inter-specific hybridization, whole genome doubling, symbiogenesis, or massive genome restructuring. Evolution marshals extensive evidence in support of a fundamental reinterpretation of evolutionary processes, including more than 1,100 references to the scientific literature. Shapiro's work will generate extensive discussion throughout the biological community, and may significantly change your own thinking about how life has evolved. It also has major implications for evolutionary computation, information science, and the growing synthesis of the physical and biological sciences.
Synergistic Selection: How Cooperation Has Shaped Evolution And The Rise Of Humankind by Corning Peter A Pdf
"Nothing about the evolution of biological complexity makes sense except in the light of synergy." Peter Corning's new book is being hailed as a major contribution to what is perhaps the greatest shift in our understanding of evolution since The Origin of Species. It's a tour de force that takes us on a synergy-guided tour of the history of life. As Corning puts it, "life on Earth has been a synergistic phenomenon from the get go." Corning also shows how synergy has been a key to human evolution, including the rise of complex modern societies. "Cooperation may have been the vehicle, but synergy was the driver." As we now face a tipping point and another major transition in evolution, Corning offers us a synergy-based road-map to the future. "One of the great take-home lessons from the epic of evolution is that cooperation produces synergy, and synergy is the way forward. The arc of evolution bends toward synergy." Contents: Explaining Complexity A New View of Evolution How Cooperation Trumps Competition Evolution as a "Combination of Labor" A Tale of Two Theories The Major Transitions in Evolution The Self-Made Man I: Australopithecine Entrepreneurs The Self-Made Man II: From erectus to Homo sapiens The Rise of Complex Societies The Next Major Transition Readership: Undergraduate, graduate students and the general public interested in general science, general life sciences, evolutionary biology, human biology/anthropology/primatology, and public policy. Keywords: Synergy;Cooperation;Complexity;Evolution;Natural Selection;Human Evolution;Major Transitions in Evolution;Cultural Evolution;Multi-Level SelectionReview: "This magnificent book reveals the critical role of synergy in evolution and in all of biology, including especially in humankind. Synergy is fundamental in so many areas of science and knowledge. And in his final chapter, on how to change our current dysfunctional course as a species and avoid the destruction of our planet, Peter Corning offers us a unique and hopeful new vision." Anthony Trewavas, FRS Emeritus Professor, Institute of Molecular Plant Science, University of Edinburgh and author of Plant Behaviour and Intelligence "Peter Corning's approach is wise and he is astonishingly well read. The scope of his excellent book is broad and ambitious, running from the origins of life to modern economics in human societies. Many of his examples are described in clear and fascinating detail ... He writes extremely well and I read every word with great pleasure and interest ... I am full of admiration and strongly recommend it." Sir Patrick Bateson, FRS Emeritus Professor of Biology, Cambridge University president of the Zoological Society of London and the author of (among others) Behaviour, Development and Evolution "This is an important book. It offers a solution to a problem that has been central to evolutionary biology for half a century, with implications that reach down to the foundations of evolutionary theory. Corning argues that the huge and disproportionate advantages that arise when labor is combined could account for the rise of ever higher levels of organization in the history of life. The book is also well written, a pleasure to read." Daniel W McShea Professor of Biology, Duke University and co-author of Biology's First Law "Peter Corning's book is a marvelous addition to the growing literature about the emerging alternative to gene-centric neo-Darwinism in evolutionary biology. We would not exist were it not for the cooperative behaviour of livin
The Selected Papers of Sir Alan Fersht by Alan Fersht Pdf
The beginning of Sir Alan Fersht's career coincided with the birth of modern protein science based on structural biology, which started in earnest momentum in the 1960s. He worked in the then Mecca of molecular biology, and was one of the first protein chemists to exploit the new area of structural biology. The papers are interlaced with personal comments on how each article was important in his career and how he each article was important in his career and how he was influenced by the galaxy of legendary scientists in the MRC. --Book Jacket.