Exosomes

Author : Larry Edelstein,John R. Smythies,Peter J. Quesenberry,Denis Noble
Publisher : Academic Press
Page : 548 pages
File Size : 53,8 Mb
Release : 2019-10-16
Category : Science
ISBN : 9780128160541

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Exosomes by Larry Edelstein,John R. Smythies,Peter J. Quesenberry,Denis Noble Pdf

Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference source for clinicians, physicians, and research scientists who wish to gain insight into the most recent advances in this rapidly growing field. The exosome revolution may well be the greatest advance in physiology and medicine since antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a major breakthrough in our understanding of how cells function. Provides readers with a broad and timely overview of exosomes in health and disease, closing with a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. Summarizes the most recent laboratory and clinical findings on exosomes across numerous medical disciplines, thereby offering readers a broad-ranging and solid foundation for prospective investigative efforts Twenty-one chapters authored by a global team of peer-acknowledged experts, each representing a key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing

Author : Faisal A. Alzahrani,Islam M. Saadeldin
Publisher : Springer Nature
Page : 373 pages
File Size : 45,7 Mb
Release : 2020-11-20
Category : Medical
ISBN : 9789811565991

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Role of Exosomes in Biological Communication Systems by Faisal A. Alzahrani,Islam M. Saadeldin Pdf

This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.

Author : Yaoliang Tang,Buddhadeb Dawn
Publisher : Academic Press
Page : 288 pages
File Size : 52,9 Mb
Release : 2015-09-02
Category : Medical
ISBN : 9780128004975

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Mesenchymal Stem Cell Derived Exosomes by Yaoliang Tang,Buddhadeb Dawn Pdf

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Author : Andrew F Hill
Publisher : Humana
Page : 0 pages
File Size : 48,5 Mb
Release : 2016-12-10
Category : Science
ISBN : 1493967266

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Exosomes and Microvesicles by Andrew F Hill Pdf

This volume covers methods for the analysis of extracellular vesicles (EV) that can be applied to isolated EVs from a wide variety of sources. This includes the use of electron microscopy, tunable resistance pulse sensing, and nanoparticle tracking analysis. The chapters in this book discuss EV cargoes containing proteins and genomic materials using a number of different approaches, and isolating EVs from platelets and neuronal cells and tissues. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and comprehensive, Exosomes and Microvesicles: Methods and Protocols is a valuable resource containing methodologies for anyone interested in researching EVs.

Author : Konstantin Glebov,Michel Salzet,Oleg Shupliakov
Publisher : Frontiers Media SA
Page : 267 pages
File Size : 40,8 Mb
Release : 2022-06-06
Category : Science
ISBN : 9782889719303

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Exosomes in Brain Health and Disease by Konstantin Glebov,Michel Salzet,Oleg Shupliakov Pdf

Author : Hongyun Wang,Junjie Xiao,Yunlong Huang
Publisher : Frontiers Media SA
Page : 151 pages
File Size : 55,5 Mb
Release : 2022-11-23
Category : Medical
ISBN : 9782832506905

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Exosomes in Cardiovascular Diseases: Mechanism, Diagnosis and Therapy by Hongyun Wang,Junjie Xiao,Yunlong Huang Pdf

Author : Suman Dutta,Gal Bitan,Kendall Van Keuren-Jensen,Satish Balasaheb Nimse
Publisher : Frontiers Media SA
Page : 259 pages
File Size : 52,6 Mb
Release : 2022-10-19
Category : Science
ISBN : 9782832502884

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Exosomes: Message in a Vesicle by Suman Dutta,Gal Bitan,Kendall Van Keuren-Jensen,Satish Balasaheb Nimse Pdf

Author : Robert Steven Conlan,Deyarina Gonzalez,Bruna Corradetti,Ines Mendes Pinto
Publisher : Frontiers Media SA
Page : 243 pages
File Size : 44,9 Mb
Release : 2021-10-01
Category : Science
ISBN : 9782889713769

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Exosomes as Therapeutic Systems by Robert Steven Conlan,Deyarina Gonzalez,Bruna Corradetti,Ines Mendes Pinto Pdf

Author : Ling-Qing Yuan,Qifu Li,Zhaohui Lyu,Jufeng Xia
Publisher : Frontiers Media SA
Page : 98 pages
File Size : 50,9 Mb
Release : 2022-04-07
Category : Medical
ISBN : 9782889749126

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The Role of Exosomes in Metabolic and Endocrine Disease by Ling-Qing Yuan,Qifu Li,Zhaohui Lyu,Jufeng Xia Pdf

Author : Mahmood Khan,Nazish Sayed,Prasanna Krishnamurthy,Yaoliang Tang
Publisher : Frontiers Media SA
Page : 123 pages
File Size : 41,7 Mb
Release : 2020-12-18
Category : Science
ISBN : 9782889661794

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Wireless Intercellular Communications in Cardiac Pathology: The Role of Exosomes by Mahmood Khan,Nazish Sayed,Prasanna Krishnamurthy,Yaoliang Tang Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Mansoor M. Amiji,Rajagopal Ramesh
Publisher : Academic Press
Page : 0 pages
File Size : 41,8 Mb
Release : 2018-05-11
Category : Medical
ISBN : 0128127740

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Diagnostic and Therapeutic Applications of Exosomes in Cancer by Mansoor M. Amiji,Rajagopal Ramesh Pdf

Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer.

Author : Huang-Ge Zhang
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 41,8 Mb
Release : 2012-09-06
Category : Medical
ISBN : 9781461436973

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Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication by Huang-Ge Zhang Pdf

In multicellular organisms, communication between cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercellular communication has recently become the subject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. They are also being studied as prognostic markers for cancer.

Author : Amin Tamadon,Reza Shirazi,Nader Tanideh
Publisher : Frontiers Media SA
Page : 137 pages
File Size : 45,8 Mb
Release : 2022-03-16
Category : Science
ISBN : 9782889744718

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Stem Cell-Derived Exosome Therapy of Microbial Diseases: From Bench to Bed by Amin Tamadon,Reza Shirazi,Nader Tanideh Pdf

Author : Debalina Bhattacharya,Mainak Mukhopadhyay,Kursad Turksen
Publisher : Elsevier
Page : 378 pages
File Size : 44,6 Mb
Release : 2024-04-15
Category : Science
ISBN : 9780443140075

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Exosomal RNA by Debalina Bhattacharya,Mainak Mukhopadhyay,Kursad Turksen Pdf

Exosomal RNA: Role in Human Diseases and Therapy provides an in-depth study of exosomes and their RNA in the context of a variety of diseases. The book explores the diagnostic and therapeutic potential of exosomal RNA as biomarkers across a range of different conditions, including cancer, type 2 diabetes, cardiovascular and renal disease, as well as bacterial infections and tissue repair. The link between exosomal RNA expression and neurodegenerative disease is also explored. The book goes on to share the significance of exosomal RNA in preserving cellular function, with special attention given to their role in the autophagy process. This book gives an overview of the isolation, characterization, and potential applications of exosomal RNA, providing researchers with an understanding of how they can be manipulated and utilized for the treatment of various diseases and conditions. This is an ideal reference for researchers in the field of molecular biology, cell biology, and related fields, as well as those involved in the development of therapeutics and personalized medicine. Provides an introduction into exosomal RNA and their potential as predictive and diagnostic biomarkers for various conditions Considers exosomal RNA in a variety of human disorders, including metabolic diseases, inflammatory diseases, and cancer Discusses the role of exosomal RNA in preserving the cellular environment and its role in the autophagy process

Author : Torben Heick Jensen
Publisher : Springer Science & Business Media
Page : 161 pages
File Size : 41,7 Mb
Release : 2011-06-29
Category : Medical
ISBN : 9781441978417

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RNA Exosome by Torben Heick Jensen Pdf

The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions. The exosome was discovered more than a decade ago by Phil Mitchell and David Tollervey by its ability to trim the 3’end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account they laid out the events surrounding this identification and the subsequent birth of the research field. In the chapter by Kurt Januszyk and Christopher Lima the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea are discussed in large part through presentation of structures.