The Somatotrophic Axis In Brain Function

Author : Fred Nyberg
Publisher : Elsevier
Page : 384 pages
File Size : 52,9 Mb
Release : 2005-12-12
Category : Medical
ISBN : 9780080498164

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The Somatotrophic Axis in Brain Function by Fred Nyberg Pdf

The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression. This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science. Contents are well balanced and cover a variety of relevant topics from basic to clinical research International selection of authors, with a good representation of the research on growth hormones A timely publication which will be useful to scientists in both basic and clinical research

Author : Hari Shanker Sharma
Publisher : Academic Press
Page : 472 pages
File Size : 48,7 Mb
Release : 2009-11-05
Category : Science
ISBN : 0080922902

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New Concepts of Psychostimulants Induced Neurotoxicity by Hari Shanker Sharma Pdf

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.

Author : Mark J. Ashley,David A. Hovda
Publisher : CRC Press
Page : 768 pages
File Size : 54,7 Mb
Release : 2017-07-28
Category : Medical
ISBN : 9781498710329

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Traumatic Brain Injury by Mark J. Ashley,David A. Hovda Pdf

The fourth edition of this text constitutes a continuation of 20 years of coverage of traumatic brain injury, and broadens the discussion of acquired brain injury. Within TBI, the paradigm shift from an injury occurring at a point in time to a disease entity of a chronic nature is changing the discussion of diagnosis, management, treatment and outcome assessment. Disease specification that differentiates TBIs by the mechanism of injury, the exact nature of the injury, the extent of injury, presence of co-morbidities and their exact nature, gender, age, race, and genome are emerging as crucial. Disease differentiation has impacted diagnosis, treatment and outcome.

Author : Michael B. Ranke,David Anthony Price,Edward O. Reiter
Publisher : Karger Medical and Scientific Publishers
Page : 534 pages
File Size : 50,9 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9783805582568

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Growth Hormone Therapy in Pediatrics by Michael B. Ranke,David Anthony Price,Edward O. Reiter Pdf

For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.

Author : Anders Juul,Jens O. L. Jorgensen
Publisher : Cambridge University Press
Page : 536 pages
File Size : 45,6 Mb
Release : 2000-04-27
Category : Medical
ISBN : 0521641888

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Growth Hormone in Adults by Anders Juul,Jens O. L. Jorgensen Pdf

This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.

Author : P. Michael Conn
Publisher : Elsevier
Page : 1103 pages
File Size : 55,9 Mb
Release : 2011-04-28
Category : Medical
ISBN : 9780080460062

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Handbook of Models for Human Aging by P. Michael Conn Pdf

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Author : Kathleen Keller
Publisher : SAGE
Page : 1041 pages
File Size : 52,8 Mb
Release : 2008
Category : Body size
ISBN : 9781412952385

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Encyclopedia of Obesity by Kathleen Keller Pdf

Obesity is a serious health issue and is a key discussion and research point in several disciplines from the social sciences to the health sciences and even in physical education. This text is a much-needed authoritative reference source covering major issues of, and relating to, obesity.

Author : Amritava Ghosh,Sowrabha Bhat,Sarita Bajaj,Sujoy Ghosh
Publisher : Jaypee Brothers Medical Publishers
Page : 318 pages
File Size : 46,9 Mb
Release : 2019-09-30
Category : Medical
ISBN : 9789389188257

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MCQs in Endocrinology for DM Entrance Examination by Amritava Ghosh,Sowrabha Bhat,Sarita Bajaj,Sujoy Ghosh Pdf

Author : Jens O. L. Jørgensen,Jens Sandahl Christiansen
Publisher : Karger Medical and Scientific Publishers
Page : 241 pages
File Size : 40,6 Mb
Release : 2005-01-01
Category : Science
ISBN : 9783805579926

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Growth Hormone Deficiency in Adults by Jens O. L. Jørgensen,Jens Sandahl Christiansen Pdf

It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

Author : Michael Wilkinson,S. Ali Imran
Publisher : Cambridge University Press
Page : 207 pages
File Size : 43,8 Mb
Release : 2019-01-03
Category : Medical
ISBN : 9781316645192

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Clinical Neuroendocrinology by Michael Wilkinson,S. Ali Imran Pdf

A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.

Author : Waneen Wyrick Spirduso,Leonard W. Poon,Wojtek J. Chodzko-Zajko
Publisher : Human Kinetics
Page : 304 pages
File Size : 44,9 Mb
Release : 2007
Category : Cognition
ISBN : 0736057862

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Exercise and Its Mediating Effects on Cognition by Waneen Wyrick Spirduso,Leonard W. Poon,Wojtek J. Chodzko-Zajko Pdf

This title seeks to expand on reader's understanding by examining whether and how physical activity could indirectly affect cognitive function by influencing mediators that provide physical and mental resources for cognition.

Author : Constantine A. Stratakis
Publisher : Academic Press
Page : 312 pages
File Size : 43,8 Mb
Release : 2021-06-01
Category : Medical
ISBN : 9780128145388

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Gigantism and Acromegaly by Constantine A. Stratakis Pdf

Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism

Author : Eli Y Adashi,Michael O. Thorner
Publisher : Springer Science & Business Media
Page : 338 pages
File Size : 40,7 Mb
Release : 1995-06-23
Category : Medical
ISBN : 0387944192

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The Somatotrophic Axis and the Reproductive Process in Health and Disease by Eli Y Adashi,Michael O. Thorner Pdf

For many years now, our understanding of the somatotrophic and reproduc tive axes has evolved essentially independently, both fields of study reaching a highly advanced, although far from complete, level of under standing. Along the way, however, it became apparent that in some circumstances the reproductive and somatotrophic axes may be inter dependent. Inklings to this effect were at times feeble and at other times more convincing. Among those inklings are the clinical recognition by pediatric endocrinologists of the apparent association between isolated GH deficiency and delayed puberty, as well as of the apparent permissive, pUberty-promoting property of GH. Equally important is a body of experi mental studies establishing the ovary of multiple species as a site of GH reception and action. Arguing against an essential role for GH in the reproductive process is the observation that individuals who have GH resistance of the Laron variety are fertile arid that isolated GH deficiency does not constitute an absolute barrier to the attainment of sexual maturation and fertility. The intraovarian insulin-like growth factor (IGF) hypothesis proposes that IGFs may serve as amplifiers of gonadotropin action. Although the dependence of intraovarian IGFs on systemic GH action has never been unequivocally demonstrated, that leap of faith has often been made. The intraovarian IGF hypothesis serves as the rationale for the adjunctive use of GH in the induction of ovulation.

Author : S. R. Pandi-Perumal,Milton Kramer
Publisher : Cambridge University Press
Page : 128 pages
File Size : 51,5 Mb
Release : 2010-04-01
Category : Medical
ISBN : 9781139483704

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Sleep and Mental Illness by S. R. Pandi-Perumal,Milton Kramer Pdf

The diagnosis of mental illness is frequently accompanied by sleep problems; conversely, people experiencing sleep problems may subsequently develop mental illness. Sleep and Mental Illness looks at this close correlation and considers the implications of research findings that have emerged in the last few years. Additionally, it surveys the essential concepts and practical tools required to deal with sleep and co-morbid psychiatric problems. The volume is divided into three main sections: basic science, neuroendocrinology, and clinical science. Included are over 30 chapters on topics such as neuropharmacology, insomnia, depression, dementia, autism, and schizophrenia. Relevant questionnaires for the assessment of sleep disorders, including quality-of-life measurement tools, are provided. There is also a summary table of drugs for treating sleep disorders. This interdisciplinary text will be of interest to clinicians working in psychiatry, behavioral sleep medicine, neurology, pulmonary and critical care medicine.

Author : Antonino Belfiore,Derek LeRoith
Publisher : Springer
Page : 0 pages
File Size : 54,7 Mb
Release : 2018-02-08
Category : Medical
ISBN : 3319446746

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Principles of Endocrinology and Hormone Action by Antonino Belfiore,Derek LeRoith Pdf

This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.