The Toxicant Induction Of Irritant Asthma Rhinitis And Related Conditions

Author : William J. Meggs
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 51,8 Mb
Release : 2014-01-24
Category : Medical
ISBN : 9781461490449

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The Toxicant Induction of Irritant Asthma, Rhinitis, and Related Conditions by William J. Meggs Pdf

Untoward reactions to environmental chemicals, particularly when a subject reports difficulties with exposures to chemicals of diverse classes involving more than one organ system, have been poorly understood and an area of great controversy. Studies of airway inflammation induced by respiratory irritants have established neurogenic inflammation as the mechanism for irritant asthma and rhinitis. Remodeling of the airway after an acute irritant exposure can lead to a heightened sensitivity to irritants that persists. Recognition that rhinitis, while sometimes regarded as a trivial disease, is associated with extra-airway manifestations such as fatigue and disturbances of sleep, mood, and cognition, further elucidates how chemical exposures can be serious for susceptible individuals. This book reviews current scientific understanding of irritant airway inflammation and related conditions, including cardiovascular effects of particulate exposures, airborne contact dermatitis and irritant dermatitis, and the brain as a target organ for both allergic and irritant reactions. It is essential reading for physicians and other healthcare workers caring for patients with environmental intolerances. Allergists, toxicologists, occupational and environmental physicians, and pulmonologists will find the materials particularly valuable. Patients and advocates for those with chemical intolerances will also find the book of interest.

Author : Dinesh Kumar Chellappan,Kavita Pabreja,Md. Faiyazuddin
Publisher : Springer Nature
Page : 652 pages
File Size : 46,9 Mb
Release : 2022-03-23
Category : Medical
ISBN : 9789811643927

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Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases by Dinesh Kumar Chellappan,Kavita Pabreja,Md. Faiyazuddin Pdf

This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.

Author : Jean Deslauriers,Farid M. Shamji,Bill Nelems
Publisher : Elsevier Health Sciences
Page : 128 pages
File Size : 42,9 Mb
Release : 2018-08-01
Category : Medical
ISBN : 9780323613972

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Fundamentals of Airway Surgery, Part II, An Issue of Thoracic Surgery Clinics E-Book by Jean Deslauriers,Farid M. Shamji,Bill Nelems Pdf

This issue of Thoracic Surgery Clinics of North America, guest edited by Drs. Jean Deslauriers, Farid Shamji, and Bill Nelems, is the second of two devoted to Fundamentals of Airway Surgery. The editors have assembled expert authors to review the following topics: From Open to Bedside Percutaneous Tracheostomy; Anterior Mediastinal Tracheostomy: Past, Present, and Future; Extended Sleeve Resections; Bronchoplasties at the Segmental Level; Challenges of Carinal Resection and Reconstruction; Carinal Pneumonectomy; Management of Post-Pneumonectomy Broncho-Pleural Fistula: From Thoracoplasty to Trans-Sternal Closure; Tracheal Transplantation: State of the Art and Key Role of Blood Supply in its Success; Autologous Tracheal Replacement; Pathophysiology and Predictors of Bronchial Complications After Lung Transplantation; Management of Bronchial Complications After Lung Transplantation and Late Sequelae; Experiences with Prosthetic Airway Replacement: From the Use of Marlex Meshes to Tissue Engineering; Management of Acquired Benign Tracheo-Esophageal Fistulas; Strategies in the Treatment of Malignant Tracheoesophageal Fistulas; Recognition and Management of Life-Threatening Tracheo-Vascular Fistulae and How to Prevent Them; Principles of Urgent Management of Acute Airway Obstruction; Tracheo-Bronchial Injuries Secondary to Blunt Chest Trauma; Cricothyroid Approach for Emergency Access to the Airway; Use of Silicone Tubes in the Management of Complex Airway Problems; Management of the Airway after Tracheal Reconstruction; Importance of a Team Effort in the Success of Airway Surgery; and more!

Author : David C. Gaze
Publisher : BoD – Books on Demand
Page : 594 pages
File Size : 45,5 Mb
Release : 2023-08-23
Category : Medical
ISBN : 9781803561165

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Novel Pathogenesis and Treatments for Cardiovascular Disease by David C. Gaze Pdf

This book provides a comprehensive overview of cardiovascular diseases (CVDs) and associated conditions. It is organized into three sections on “Cardiovascular Pathophysiology”, “Cardiovascular Diagnostics”, and “Cardiovascular Treatments”. Chapters address such topics as the role of obesity in CVD, cardiotoxicity, cardio-oncology, CVD in different disease states, modalities for detecting CVD, interventional strategies to prevent or treat CVD, and much more.

Author : Robyn E. O'Hehir,Stephen T Holgate,Aziz Sheikh
Publisher : Elsevier Health Sciences
Page : 421 pages
File Size : 48,5 Mb
Release : 2015-12-09
Category : Medical
ISBN : 9780323392730

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Middleton's Allergy Essentials E-Book by Robyn E. O'Hehir,Stephen T Holgate,Aziz Sheikh Pdf

For decades, health care practitioners have relied on Middleton’s Allergy as their go-to reference for comprehensive information on allergic disorders. Now Middleton’s Allergy Essentials, by Drs. Robyn E. O'Hehir, Stephen T. Holgate, and Aziz Sheikh, offers a concise resource that’s both easily accessible and highly authoritative. Perfect for clinicians in primary and secondary care settings, this practical volume covers what is most useful in your daily practice, with a strong emphasis on disease diagnosis and management. A practical approach to evaluation, differential diagnosis, and treatment of allergic disorders, focused specifically on what the non-specialist needs to know for everyday practice. Each chapter begins with a handy summary of key concepts to help you quickly identify important information. Coverage of today’s hot topics includes asthma, drug allergies, food allergies and gastrointestinal disorders, anaphylaxis, atopic dermatitis, and allergic contact dermatitis. Concise sections on mechanisms are included where relevant, keeping you up to date with this rapidly evolving field. Authored by the same internationally recognized experts that produce Middleton’s Allergy, the definitive text in the field. Ideal for physicians, residents, general and family practitioners, nurse practitioners, primary care doctors, hospitalists, general internists – anyone who is called upon to make effective diagnostic and treatment decisions regarding allergic disorders.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Jet-Propulsion Fuel 8
Publisher : National Academies Press
Page : 229 pages
File Size : 41,5 Mb
Release : 2003-02-14
Category : Nature
ISBN : 0309168708

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Toxicologic Assessment of Jet-Propulsion Fuel 8 by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Jet-Propulsion Fuel 8 Pdf

This report provides a critical review of toxicologic, epidemiologic, and other relevant data on jet-propulsion fuel 8, a type of fuel in wide use by the U.S. Department of Defense (DOD), and an evaluation of the scientific basis of DOD’s interim permissible exposure level of 350 mg/m3

Author : Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig
Publisher : Academic Press
Page : 714 pages
File Size : 40,5 Mb
Release : 2009-11-23
Category : Medical
ISBN : 0080919324

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Fundamentals of Toxicologic Pathology by Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig Pdf

Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists. 25% brand new information, fully revised throughout New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology New color photomicrographs detailing specific toxicant-induced diseases in animals Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels

Author : Susan M. Tarlo,Olivier Vandenplas,David I. Bernstein,Jean-Luc Malo
Publisher : CRC Press
Page : 377 pages
File Size : 54,9 Mb
Release : 2021-09-12
Category : Medical
ISBN : 9781000414134

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Asthma in the Workplace by Susan M. Tarlo,Olivier Vandenplas,David I. Bernstein,Jean-Luc Malo Pdf

Key Features Comprehensive coverage of all aspects of work-related asthma, including historical aspects, epidemiology and risk factors, mechanisms and genetics, other types of work-related asthma conditions and variants, hypersensitivity pneumonitis, occupational urticaria and dermatitis Assessment of the worker and workplace along with management of the worker, prevention and medicolegal aspects Of interest not only to pulmonologists, but also for industrial hygienists, researchers, lawyers and other health professionals in the field of work-related conditions Detailed information about specific agents, including a variety of high- and low-molecular weight agents

Author : Elisabeth Heseltine,Jerome Rosen
Publisher : WHO Regional Office Europe
Page : 247 pages
File Size : 46,7 Mb
Release : 2009
Category : Architecture
ISBN : 9789289041683

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WHO Guidelines for Indoor Air Quality by Elisabeth Heseltine,Jerome Rosen Pdf

Microbial pollution is a key element of indoor air pollution. It is caused by hundreds of species of bacteria and fungi, in particular filamentous fungi (mould), growing indoors when sufficient moisture is available. This document provides a comprehensive review of the scientific evidence on health problems associated with building moisture and biological agents. The review concludes that the most important effects are increased prevalences of respiratory symptoms, allergies and asthma as well as perturbation of the immunological system. The document also summarizes the available information on the conditions that determine the presence of mould and measures to control their growth indoors. WHO guidelines for protecting public health are formulated on the basis of the review. The most important means for avoiding adverse health effects is the prevention (or minimization) of persistent dampness and microbial growth on interior surfaces and in building structures. [Ed.]

Author : Anonim
Publisher : Unknown
Page : 1724 pages
File Size : 46,6 Mb
Release : 2000
Category : Environmental health
ISBN : RUTGERS:39030033070899

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Environmental Health Perspectives by Anonim Pdf

Author : Carrie Redlich,Paul Blanc,Ware Kuschner,Mridu Gulati
Publisher : Elsevier Health Sciences
Page : 240 pages
File Size : 52,5 Mb
Release : 2012-11-12
Category : Medical
ISBN : 9781455747252

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Occupational Pulmonology, An Issue of Clinics in Chest Medicine - E-Book by Carrie Redlich,Paul Blanc,Ware Kuschner,Mridu Gulati Pdf

This issue of Clinics in Chest Medicine, Guest Edited by Carrie A. Redlich, MD, MPH, Paul Blanc, MD, MSPH, Mridu Gulati, MD, and Ware Kuschner, MD, will focus on Occupational and Environmental Lung Diseases, with article topics including: asthma, hypersensitivity pneumonitis, and other immune-mediated lung disease; Work-exacerbated asthma; Occupational COPD; Indoor fuel exposure and the lung in both the developed and developing worlds; New (and newly recognized) occupational and environmental causes of selected chronic parenchymal and terminal airway diseases; Occupational rhinitis and other work-related upper respiratory tract conditions; Military service and lung disease; Ambient air pollution; Protecting the lungs from microbes, particles and other inhalational exposures; and Exhaled breath and induce sputum analysis in assessing the effects of occupational and environmental exposures.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 52,7 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : David I. Bernstein,Jean-Luc Malo
Publisher : CRC Press
Page : 450 pages
File Size : 42,8 Mb
Release : 2013-05-10
Category : Medical
ISBN : 9781841849256

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Asthma in the Workplace by David I. Bernstein,Jean-Luc Malo Pdf

Occupational factors are responsible for a large percentage of cases of asthma in adults of working age. Any irritant generated at high concentrations can cause occupational asthma, and early diagnosis is critical because cure is still possible at this stage. This latest edition of Asthma in the Workplace reflects the rapid pace of discovery and research in workplace asthma that has taken place in recent years. This Fourth Edition retains the international flavor of prior editions, with contributions from editors and contributors from around the world. Several chapters commence with clinical histories and workplace scenarios relevant to the focus of the chapter, making it particularly germane for primary care providers to develop skills in early recognition of the disease. Topics discussed include: Definitions, historical background, epidemiology, genetics, pathophysiology, and animal models Guidelines for assessing the worker and the workplace, and proposed guidelines for management, including compensation aspects Medicolegal aspects, prevention, and surveillance Detailed information about specific agents, including a variety of high- and low-molecular weight agents Other types of work-related asthma conditions, such as irritant-induced asthma, eosinophilic bronchitis, and occupational rhinitis This new edition has been significantly restructured and places a greater emphasis on the clinical aspects of management and treatment. This heightened focus on practical considerations makes it a truly comprehensive, hands-on resource for practitioners and researchers in this fast-moving field.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Draft IRIS Assessment of Formaldehyde
Publisher : National Academies Press
Page : 204 pages
File Size : 48,9 Mb
Release : 2011-05-31
Category : Science
ISBN : 9780309211963

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Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Draft IRIS Assessment of Formaldehyde Pdf

Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.

Author : Peter J Baxter,Tar-Ching Aw,Anne Cockcroft,Paul Durrington,J Malcolm Harrington
Publisher : CRC Press
Page : 1324 pages
File Size : 53,8 Mb
Release : 2010-10-29
Category : Medical
ISBN : 9781444128437

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Hunter's Diseases of Occupations, Tenth Edition by Peter J Baxter,Tar-Ching Aw,Anne Cockcroft,Paul Durrington,J Malcolm Harrington Pdf

Winner of the 2011 BMA book awards: medicine category In the five decades since its first publication, Hunter's Diseases of Occupations has remained the pre-eminent text on diseases caused by work, universally recognized as the most authoritative source of information in the field. It is an important guide for doctors in all disciplines who may encounter occupational diseases in their practice, covering topics as diverse as work and stress, asbsetos-related disease, working at high altitude and major chemical incidents, many of which are highly topical. The Tenth Edition of Hunter's Diseases of Occupations has been fully revised and updated, presenting all practitioners considering an occupational cause for a patient's condition with comprehensive coverage of work-related diseases as they present in modern and developing industralised societies. It draws on the wide-ranging and in-depth clinical knowledge and experience, and acadmic excellence, of top experts in the field.