Review Of The Environmental Protection Agency S Draft Iris Assessment Of Formaldehyde

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Draft IRIS Assessment of Formaldehyde
Publisher : National Academies Press
Page : 204 pages
File Size : 48,9 Mb
Release : 2011-05-31
Category : Science
ISBN : 9780309211963

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Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Draft IRIS Assessment of Formaldehyde Pdf

Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review the IRIS Process
Publisher : National Academies Press
Page : 170 pages
File Size : 44,7 Mb
Release : 2014-06-25
Category : Political Science
ISBN : 9780309304177

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Review of EPA's Integrated Risk Information System (IRIS) Process by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review the IRIS Process Pdf

The Integrated Risk Information System (IRIS) is a program within the US Environmental Protection Agency (EPA) that is responsible for developing toxicologic assessments of environmental contaminants. An IRIS assessment contains hazard identifications and dose-response assessments of various chemicals related to cancer and noncancer outcomes. Although the program was created to increase consistency among toxicologic assessments within the agency, federal, state, and international agencies and other organizations have come to rely on IRIS assessments for setting regulatory standards, establishing exposure guidelines, and estimating risks to exposed populations. Over the last decade, the National Research Council (NRC) has been asked to review some of the more complex and challenging IRIS assessments, including those of formaldehyde, dioxin, and tetrachloroethylene. In 2011, an NRC committee released its review of the IRIS formaldehyde assessment. Like other NRC committees that had reviewed IRIS assessments, the formaldehyde committee identified deficiencies in the specific assessment and more broadly in some of EPA's general approaches and specific methods. Although the committee focused on evaluating the IRIS formaldehyde assessment, it provided suggestions for improving the IRIS process and a roadmap for its revision in case EPA decided to move forward with changes to the process. Congress directed EPA to implement the report's recommendations and then asked the National Research Council to review the changes that EPA was making (or proposing to make) in response to the recommendations. Review of EPA's Integrated Risk Information System (IRIS) Process provides an overview of some general issues associated with IRIS assessments. This report then addresses evidence identification and evaluation for IRIS assessments and discusses evidence integration for hazard evaluation and methods for calculating reference values and unit risks. The report makes recommendations and considerations for future directions. Overall, Review of EPA's Integrated Risk Information System Process finds that substantial improvements in the IRIS process have been made, and it is clear that EPA has embraced and is acting on the recommendations in the NRC formaldehyde report. The recommendations of this report should be seen as building on the progress that EPA has already made.

Author : National Academies of Sciences Engineering and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Review of Epa's 2022 Draft Formaldehyde Assessment
Publisher : Unknown
Page : 0 pages
File Size : 53,9 Mb
Release : 2024-05-09
Category : Electronic
ISBN : 0309706556

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Review of Epa's 2022 Draft Formaldehyde Assessment by National Academies of Sciences Engineering and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Review of Epa's 2022 Draft Formaldehyde Assessment Pdf

Formaldehyde is widely present in the environment and is one of the highest production chemicals by volume, used in manufactured goods including wood products, permanent press fabrics, and household products. It is also formed by combustion sources and is present in smoke from cigarettes and other tobacco products, and in emissions from gas stoves and open fireplaces. In carrying out its mission to protect human health, the U.S. Environmental Protection Agency (EPA) identifies and characterizes the health hazards of chemicals found in the environment through its Integrated Risk Information System (IRIS) Program, which has reviewed the human health hazards resulting from formaldehyde exposure in several assessments. This report is a continuation of guidance from the National Academies on draft IRIS assessments of formaldehyde and other aspects of the IRIS program. This report reviews the 2022 Draft Assessment with regard to its adequacy and transparency in evaluating the scientific literature, use of appropriate methods to synthesize the current state-of-the science, and presentations of conclusions that are supported by the scientific evidence. The report concludes that the 2022 Draft Assessment follows the advice of prior National Academies reports and that its findings on hazard and quantitative risk are supported by the evidence identified. However, revisions are needed to ensure that users can find and follow the methods used in each step of the assessment for each health outcome.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 42,9 Mb
Release : 2023
Category : Electronic
ISBN : 0309706564

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Review of EPA's 2022 Draft Formaldehyde Assessment by Anonim Pdf

Author : National Research Council (U.S.). Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens,National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology
Publisher : National Academy Press
Page : 178 pages
File Size : 44,9 Mb
Release : 2014
Category : Medical
ISBN : 0309301785

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Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens by National Research Council (U.S.). Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens,National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology Pdf

Introduction -- Review of the styrene profile in the National Toxicology Program 12th report on carcinogens -- Independent assessment of styrene -- Biographic Information on the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens -- Statement of task of the Committee to Review the Styrene Assessment in the National Toxicology Program 12th report on carcinogens -- Review of the literature search used in the National Toxicology Program 12th report on carcinogens -- Literature search strategies used in support of the committee's independent assessment of styrene.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Inorganic Arsenic
Publisher : National Academies Press
Page : 128 pages
File Size : 46,8 Mb
Release : 2013-11-20
Category : Nature
ISBN : 9780309297097

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Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Inorganic Arsenic Pdf

The US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS) program develops toxicologic assessments of environmental contaminants. IRIS assessments provide hazard identification and dose-response assessment information. The information is then used in conjunction with exposure information to characterize risks to public health and may be used in risk-based decisionmaking, in regulatory actions, and for other risk-management purposes. Since the middle 1990s, EPA has been in the process of updating the IRIS assessment of inorganic arsenic. In response to a congressional mandate for an independent review of the IRIS assessment of inorganic arsenic, EPA requested that the National Research Council convene a committee to conduct a two-phase study. Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic is the report of the first phase of that study. This report evaluates critical scientific issues in assessing cancer and noncancer effects of oral exposure to inorganic arsenic and offers recommendations on how the issues could be addressed in EPA's IRIS assessment.

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review Advances Made to the IRIS Process
Publisher : National Academies Press
Page : 130 pages
File Size : 44,8 Mb
Release : 2018-04-11
Category : Political Science
ISBN : 9780309474948

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Progress Toward Transforming the Integrated Risk Information System (IRIS) Program by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review Advances Made to the IRIS Process Pdf

Over the past several years, the US Environmental Protection Agency (EPA) has been transforming the procedures of its Integrated Risk Information System (IRIS), a program that produces hazard and doseâ€'response assessments of environmental chemicals and derives toxicity values that can be used to estimate risks posed by exposures to them. The transformation was initiated after suggestions for program reforms were provided in a 2011 report from the National Academies of Sciences, Engineering, and Medicine that reviewed a draft IRIS assessment of formaldehyde. In 2014, the National Academies released a report that reviewed the IRIS program and evaluated the changes implemented in it since the 2011 report. Since 2014, new leadership of EPA's National Center for Environmental Assessment (NCEA) and IRIS program has instituted even more substantive changes in the IRIS program in response to the recommendations in the 2014 report. Progress Toward Transforming the Integrated Risk Information System Program: A 2018 Evaluation reviews the EPA's progress toward addressing the past recommendations from the National Academies.

Author : Anonim
Publisher : Unknown
Page : 94 pages
File Size : 42,7 Mb
Release : 1998
Category : Health risk assessment
ISBN : UOM:39015043186363

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EPA 630/R by Anonim Pdf

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Science for EPA's Future
Publisher : National Academies Press
Page : 188 pages
File Size : 40,5 Mb
Release : 2012-12-21
Category : Political Science
ISBN : 9780309264891

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Science for Environmental Protection by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Science for EPA's Future Pdf

In anticipation of future environmental science and engineering challenges and technologic advances, EPA asked the National Research Council (NRC) to assess the overall capabilities of the agency to develop, obtain, and use the best available scientific and technologic information and tools to meet persistent, emerging, and future mission challenges and opportunities. Although the committee cannot predict with certainty what new environmental problems EPA will face in the next 10 years or more, it worked to identify some of the common drivers and common characteristics of problems that are likely to occur. Tensions inherent to the structure of EPA's work contribute to the current and persistent challenges faced by the agency, and meeting those challenges will require development of leading-edge scientific methods, tools, and technologies, and a more deliberate approach to systems thinking and interdisciplinary science. Science for Environmental Protection: The Road Ahead outlines a framework for building science for environmental protection in the 21st century and identified key areas where enhanced leadership and capacity can strengthen the agency's abilities to address current and emerging environmental challenges as well as take advantage of new tools and technologies to address them. The foundation of EPA science is strong, but the agency needs to continue to address numerous present and future challenges if it is to maintain its science leadership and meet its expanding mandates.

Author : United States Government Accountability Office
Publisher : Createspace Independent Publishing Platform
Page : 90 pages
File Size : 47,9 Mb
Release : 2018-01-24
Category : Electronic
ISBN : 1984159399

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Chemical Assessments by United States Government Accountability Office Pdf

Chemical Assessments: Low Productivity and New Interagency Review Process Limit the Usefulness and Credibility of EPA's Integrated Risk Information System

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Toxicological Assessment of Tetrachloroethylene
Publisher : National Academies Press
Page : 187 pages
File Size : 54,8 Mb
Release : 2010-03-18
Category : Nature
ISBN : 9780309152358

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Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Toxicological Assessment of Tetrachloroethylene Pdf

Tetrachloroethylene is a volatile, chlorinated organic hydrocarbon that is widely used as a solvent in the dry-cleaning and textile-processing industries and as an agent for degreasing metal parts. It is an environmental contaminant that has been detected in the air, groundwater, surface waters, and soil. In June 2008, the U.S. Environmental Protection Agency released its draft Toxicological Review of Tetrachloroethylene (Perchloroethylene) (CAS No. 127-18-4) in Support of Summary Information on the Integrated Risk Information System (IRIS). The draft IRIS assessment provides quantitative estimates of cancer and noncancer effects of exposure to tetrachloreothylene, which will be used to establish airquality and water-quality standards to protect public health and to set cleanup standards for hazardous waste sites. At the request of EPA, the National Research Council conducted an independent scientific review of the draft IRIS assessment of tetrachloroethylene from toxicologic, epidemiologic, and human clinical perspectives. The resulting book evaluates the adequacy of the EPA assessment, the data and methods used for deriving the noncancer values for inhalation and oral exposures and the oral and inhalation cancer unit risks posed by tetrachloroethylene; evaluates whether the key studies underlying the draft IRIS assessment are of requisite quality, reliability, and relevance to support the derivation of the reference values and cancer risks; evaluates whether the uncertainties in EPA's risk assessment were adequately described and, where possible, quantified; and identifies research that could reduce the uncertainty in the current understanding of human health effects associated with tetrachloroethylene exposure.

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review DOD's Approach to Deriving an Occupational Exposure Limit for TCE
Publisher : National Academies Press
Page : 77 pages
File Size : 42,5 Mb
Release : 2020-01-13
Category : Nature
ISBN : 9780309499248

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Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review DOD's Approach to Deriving an Occupational Exposure Limit for TCE Pdf

Trichloroethylene (TCE) is a solvent that is used as a degreasing agent, a chemical intermediate in refrigerant manufacture, and a component of spot removers and adhesives. It is produced in mass quantities but creates dangerous vapors and is an environmental contaminant at many industrial and government facilities, including facilities run by the U.S. Department of Defense (DoD). It is important to determine the safe occupational exposure level (OEL) for the solvent in order to protect the health of workers who are exposed to its vapors. However, there are concerns that the current occupational standards insufficiently protect workers from these health threats. Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene makes recommendations to improve the DoD's approach to developing an OEL for TCE, strengthen transparency of the process, and improve confidence in the final OEL value. This report reviews the DoD's approach using a literature review, evidence synthesis based on weight of evidence [WOE], point-of-departure derivation, physiologically based pharmacokinetic modeling, extrapolation tools, and explores other elements of the process of deriving an OEL for TCE. It examines scientific approaches to developing exposure values and cancer risk levels, defining the scope of the problem, and improving hazard identification.

Author : National Academies Of Sciences Engineeri,National Academies of Sciences Engineering and Medicine,Division On Earth And Life Studies,Board On Environmental Studies And Toxic,Committee to Review Epa's Tsca Systematic Review Guidance Document
Publisher : National Academies Press
Page : 128 pages
File Size : 45,6 Mb
Release : 2021-11-16
Category : Nature
ISBN : 0309683866

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The Use of Systematic Review in Epa's Toxic Substances Control ACT Risk Evaluations by National Academies Of Sciences Engineeri,National Academies of Sciences Engineering and Medicine,Division On Earth And Life Studies,Board On Environmental Studies And Toxic,Committee to Review Epa's Tsca Systematic Review Guidance Document Pdf

Systematic review - a scientific investigation that focuses on a specific question and uses explicit, prespecified scientific methods to identify, select, assess, and summarize the findings of similar but separate studies - has become the foundation for assessing evidence to be used for decision making in a variety of health contexts, including health care and public health. At the request of the Environmental Protection Agency (EPA), this publication reviews EPA's 2018 guidance document Application of Systematic Review in TSCA (Toxic Substances and Control Act) Risk Evaluations and associated materials to determine whether the process is comprehensive, workable, objective, and transparent.

Author : United States. Congress. House. Committee on Science, Space, and Technology (2011). Subcommittee on Investigations and Oversight
Publisher : Unknown
Page : 328 pages
File Size : 53,5 Mb
Release : 2011
Category : Computers
ISBN : MINN:31951D035563557

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EPA's IRIS Program by United States. Congress. House. Committee on Science, Space, and Technology (2011). Subcommittee on Investigations and Oversight Pdf

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Improving Risk Analysis Approaches Used by the U.S. EPA
Publisher : National Academies Press
Page : 422 pages
File Size : 40,7 Mb
Release : 2009-03-24
Category : Political Science
ISBN : 9780309120463

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Science and Decisions by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Improving Risk Analysis Approaches Used by the U.S. EPA Pdf

Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.